• 5 WEST 3.06

20022018
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Personal profile

Research interests

We have various research interests and our main goal is the efficient synthesis of simplified analogues
of natural products, compounds obtained from nature which display various biological activities, as potential leads for potential therapeutics.

Education/Academic qualification

Doctor of Philosophy, University of Cambridge

Bachelor of Science, University of Liverpool

Keywords

  • medicinal chemistry
  • drug design and synthesis

Fingerprint Dive into the research topics where Lorenzo Caggiano is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Derivatives Chemical Compounds
Biological Products Chemical Compounds
Iodides Chemical Compounds
Cross Reactions Medicine & Life Sciences
Cells Chemical Compounds
Bioactivity Chemical Compounds
Cell Line Medicine & Life Sciences
Prenylation Medicine & Life Sciences

Projects 2007 2018

Research Output 2002 2014

7 Citations (Scopus)

The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity

Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. & Lewis, S. E., 1 Jul 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 13, p. 2815-2819 5 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Products
HT29 Cells
Functional groups
grandifloracin
17 Citations (Scopus)

Design, synthesis and antiproliferative activity of indole analogues of indanocine.

Tunbridge, G. A., Oram, J. & Caggiano, L., 2013, In : MedChemComm. 4, 11, p. 1452-1456

Research output: Contribution to journalArticle

Open Access
File
Cells
Cell Line
Neoplasms
indanocine
indole
2 Citations (Scopus)

Mild and efficient capture and functionalisation of CO2 using silver(I) oxide and application to 13C-labelled dialkyl carbonates

Tunbridge, G. A., Baruchello, R. & Caggiano, L., 14 Apr 2013, In : RSC Advances. 3, 14, p. 4613-4621 9 p.

Research output: Contribution to journalArticle

Open Access
File
Carbonates
Carbon Monoxide
Silver
Oxides
Iodides
4 Citations (Scopus)

Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions

Ciupa, A., De Bank, P. A. & Caggiano, L., 7 Nov 2013, In : Chemical Communications. 49, 86, p. 10148-10150 3 p.

Research output: Contribution to journalArticle

Open Access
File
Agglomeration
Ions
maltol
17 Citations (Scopus)

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Ciupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. & Caggiano, L., 1 Jun 2013, In : MedChemComm. 4, 6, p. 956-961 6 p.

Research output: Contribution to journalArticle

Lead compounds
Cells
X Ray Crystallography
Tubulin
Tumor Cell Line

Thesis

Chalcone derivatives in cancer research and tissue engineering

Author: Ciupa, A., 28 Feb 2013

Supervisor: Caggiano, L. (Supervisor) & De Bank, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Design, Synthesis and Biological Evaluation of Narciclasine Analogues

Author: Griffiths, N., 29 Sep 2015

Supervisor: Caggiano, L. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Efficient synthesis of biologically active small molecules

Author: Tunbridge, G., 11 Dec 2012

Supervisor: Caggiano, L. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Pancreatic cancer drug discovery based upon (+)-grandifloracin

Author: Alexander, B., 3 Apr 2019

Supervisor: Caggiano, L. (Supervisor) & Lewis, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

Synthesis and evaluation of narciclasine analogues

Author: Judd, K., 1 Feb 2011

Supervisor: Caggiano, L. (Supervisor)

Student thesis: Doctoral ThesisPhD

File