• 5 WEST 3.06

20022020

Research output per year

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Personal profile

Research interests

We have various research interests and our main goal is the efficient synthesis of simplified analogues
of natural products, compounds obtained from nature which display various biological activities, as potential leads for potential therapeutics.

Education/Academic qualification

Doctor of Philosophy, University of Cambridge

Award Date: 1 Jan 2002

Bachelor of Science, University of Liverpool

Award Date: 1 Jan 1998

Keywords

  • medicinal chemistry
  • drug design and synthesis

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Projects

Research Output

  • 33 Article
  • 1 Book/Film/Article review

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In : ChemMedChem. 15, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Open Access
File
24 Downloads (Pure)

The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity

Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. & Lewis, S. E., 1 Jul 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 13, p. 2815-2819 5 p.

Research output: Contribution to journalArticle

Open Access
File
  • 8 Citations (Scopus)
    123 Downloads (Pure)

    Book Review: An introduction to medicinal chemistry (5th edition)

    Caggiano, L., 15 Aug 2013, Chemistry World.

    Research output: Contribution to specialist publicationBook/Film/Article review

    Design, synthesis and antiproliferative activity of indole analogues of indanocine.

    Tunbridge, G. A., Oram, J. & Caggiano, L., 2013, In : MedChemComm. 4, 11, p. 1452-1456

    Research output: Contribution to journalArticle

    Open Access
    File
  • 19 Citations (Scopus)
    116 Downloads (Pure)

    Mild and efficient capture and functionalisation of CO2 using silver(I) oxide and application to 13C-labelled dialkyl carbonates

    Tunbridge, G. A., Baruchello, R. & Caggiano, L., 14 Apr 2013, In : RSC Advances. 3, 14, p. 4613-4621 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    232 Downloads (Pure)

    Thesis

    Chalcone derivatives in cancer research and tissue engineering

    Author: Ciupa, A., 28 Feb 2013

    Supervisor: Caggiano, L. (Supervisor) & De Bank, P. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Design, Synthesis and Biological Evaluation of Narciclasine Analogues

    Author: Griffiths, N., 29 Sep 2015

    Supervisor: Caggiano, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Developing in vitro and in silico tools to predict the impact of gastrointestinal disease states on drug product performance

    Author: Effinger, A., 19 Feb 2020

    Supervisor: Fotaki, N. (Supervisor), O'Driscoll, C. M. O. (External person) (Supervisor), McAllister, M. (External person) (Supervisor) & Caggiano, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    Efficient synthesis of biologically active small molecules

    Author: Tunbridge, G., 11 Dec 2012

    Supervisor: Caggiano, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Pancreatic cancer drug discovery based upon (+)-grandifloracin

    Author: Alexander, B., 3 Apr 2019

    Supervisor: Caggiano, L. (Supervisor) & Lewis, S. (Supervisor)

    Student thesis: Doctoral ThesisPhD