Projects per year
My research focuses on genetic mechanisms underlying the speciation process. I investigate hybrid male sterility, a key reproductive barrier between house mouse subspecies, using a combination of experimental and bioinformatic approaches. Linking genotype to phenotype and fitness in nature is the ultimate goal of most evolutionary genetics research, but is rarely accomplished in practice.
My research integrates laboratory studies of strains derived from mice wild-caught in a hybrid zone with population genomics of natural hybrid and pure populations. This strategy will enable me to elucidate the molecular and developmental mechanisms underlying reproductive barriers in detail, and infer the evolutionary history and dynamics of the causative genes.
My long-term goals are to:
- identify variation in genes and gene networks contributing to reproductive isolation in natural populations of house mice.
- characterise the effects of these genetic variants on protein abundance, structure, and function.
- measure the effects of isolation traits and alleles on organismal fitness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Sero, J., Cevik, V., Gurevich, D., Jungwirth, U., Kelsh, R., Koumanov, F., Kyprianou, A., Laabei, M., Licchesi, J., Murrell, A., Pascu, S., Turner, L., Walko, G., Ward, A., Ward, S., Williams, R. & Zachariadis, M.
1/08/22 → 31/07/23
Project: Research council
- 18 Article
Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid miceDoms, S., Fokt, H., Rühlemann, M. C., Chung, C. J., Kuenstner, A., Ibrahim, S. M., Franke, A., Turner, L. M. & Baines, J. F., 19 Jul 2022, In: eLife. 11, e75419.
Research output: Contribution to journal › Article › peer-reviewOpen Access
Morgan, K., Harr, B., White, M. A., Payseur, B. A. & Turner, L., 1 Jun 2020, In: Molecular Biology and Evolution. 37, 6, p. 1547-1562 16 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Citations (SciVal)
Using the Mus musculus hybrid zone to assess covariation and genetic architecture of limb bone lengthsŠkrabar, N., Turner, L. M., Pallares, L. F., Harr, B. & Tautz, D., 1 Jul 2018, In: Molecular Ecology Resources. 18, 4, p. 908-921 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (SciVal)74 Downloads (Pure)
Pallares, L. F., Ledevin, R., Pantalacci, S., Turner, L., Steingrimsson, E. & Renaud, S., 9 Nov 2017, In: eLife. 6, p. 1-18 18 p., e29510.
Research output: Contribution to journal › Article › peer-reviewOpen Access4 Citations (SciVal)
Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differencesPallares, L. F., Turner, L. M. & Tautz, D., Jun 2016, In: Development Genes and Evolution. 226, 3, p. 173-186 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access16 Citations (SciVal)