• MILNER CENTRE 0.18

Accepting PhD Students

20052018
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Personal profile

Research interests

My research focuses on genetic mechanisms underlying the speciation process. I investigate hybrid male sterility, a key reproductive barrier between house mouse subspecies, using a combination of experimental and bioinformatic approaches. Linking genotype to phenotype and fitness in nature is the ultimate goal of most evolutionary genetics research, but is rarely accomplished in practice.

My research integrates laboratory studies of strains derived from mice wild-caught in a hybrid zone with population genomics of natural hybrid and pure populations. This strategy will enable me to elucidate the molecular and developmental mechanisms underlying reproductive barriers in detail, and infer the evolutionary history and dynamics of the causative genes.

My long-term goals are to:

  • identify variation in genes and gene networks contributing to reproductive isolation in natural populations of house mice.
  • characterise the effects of these genetic variants on protein abundance, structure, and function.
  • measure the effects of isolation traits and alleles on organismal fitness.  

Fingerprint Dive into the research topics where Leslie Turner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Mus musculus Agriculture & Biology
hybrid zone Earth & Environmental Sciences
Peromyscus Medicine & Life Sciences
subspecies Earth & Environmental Sciences
Genes Medicine & Life Sciences
gene Earth & Environmental Sciences
Infertility Medicine & Life Sciences
Reproductive Isolation Medicine & Life Sciences

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Research Output 2005 2018

2 Citations (Scopus)
13 Downloads (Pure)

Using the Mus musculus hybrid zone to assess covariation and genetic architecture of limb bone lengths

Škrabar, N., Turner, L. M., Pallares, L. F., Harr, B. & Tautz, D., 1 Jul 2018, In : Molecular Ecology Resources. 18, 4, p. 908-921 14 p.

Research output: Contribution to journalArticle

Open Access
File
limb bones
hybrid zone
Mus musculus
limb
bone
1 Citation (Scopus)

Genomic regions controlling shape variation in the first upper molar of the house mouse

Pallares, L. F., Ledevin, R., Pantalacci, S., Turner, L., Steingrimsson, E. & Renaud, S., 10 Nov 2017, In : eLife. 6, p. 1-18 18 p., e29510.

Research output: Contribution to journalArticle

Open Access
Tooth
Genes
Microphthalmia-Associated Transcription Factor
Genome-Wide Association Study
13 Citations (Scopus)
Open Access
hybrid zone
Molecular Evolution
Mus musculus
interspecific variation
hybridization
40 Citations (Scopus)

Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome

Wang, J., Kalyan, S., Steck, N., Turner, L. M., Harr, B., Künzel, S., Vallier, M., Häsler, R., Franke, A., Oberg, H-H., Ibrahim, S. M., Grassl, G. A., Kabelitz, D. & Baines, J. F., 4 Mar 2015, In : Nature Communications. 6, p. 1-10 10 p., 6440.

Research output: Contribution to journalArticle

Open Access
vertebrates
Pathology
Gene expression
mice
Vertebrates
32 Citations (Scopus)

Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

Turner, L. M. & Harr, B., 9 Dec 2014, In : eLife. 3, p. 1 1 p., e02504.

Research output: Contribution to journalArticle

Open Access
Chromosome Mapping
Infertility
Genes
Gene expression
Testis