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Research Output 2000 2019

2019

A century of bias in genetics and evolution

Hurst, L., 12 Jun 2019, In : Heredity. 123, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access

ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS

Wang, J., Izsvák, Z. & Hurst, L., 2019, Patent No. WO 2016/055519 A1(EP3204490, US2017313978), 7 Oct 2015, Priority date 7 Oct 2014, Priority No. 10 2014 114 558.5

Research output: Patent

Evidence for the Success of a Quantitative Assessment Instrument for Teaching Evolution in Primary Schools in England

Buchan, L., Hejmadi, M. & Hurst, L., 2019, Evolution Education Re-considered. Harms, U. & Reiss, M. (eds.). UK: Springer, p. 21-40 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

Ho, A. T. & Hurst, L. D., 17 Sep 2019, In : Plos Genetics. 15, 9, p. 1-32 32 p., e1008386.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The architecture of intra-organism mutation rate variation in plants

Hurst, L., 9 Apr 2019, In : PLoS Biology. 17, 4, p. e3000191 29 p., e3000191.

Research output: Contribution to journalArticle

Open Access
2018
4 Citations (Scopus)

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Mühlhausen, S., Schmitt, H. D., Pan, K. T., Plessmann, U., Urlaub, H., Hurst, L. D. & Kollmar, M., 9 Jul 2018, In : Current Biology. 28, 13, p. 2046-2057 18 p.

Research output: Contribution to journalArticle

Open Access
Ascoidea
RNA, Transfer, Ser
RNA, Transfer, Leu
codons
Codon
7 Citations (Scopus)

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., Ooi, N., O'Neill, A. J., Murray, E., Williams, P., Lubben, A., Reeksting, S., Meric, G., Pascoe, B., Sheppard, S. K., Recker, M., Hurst, L. D. & Massey, R. C., 18 Jul 2018, In : Genome Biology. 19, 1, p. 1-12 12 p., 94.

Research output: Contribution to journalArticle

Open Access
epistasis
antibiotic resistance
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Mupirocin
3 Citations (Scopus)

Exonic splice regulation imposes strong selection at synonymous sites

Savisaar, R. & Hurst, L., 1 Oct 2018, In : Genome Research. 28, 10, p. 1442-1454 13 p.

Research output: Contribution to journalArticle

Open Access
Mutation
Inborn Genetic Diseases
Genetic Selection
Codon
Nucleotides
8 Citations (Scopus)

Faster Evolving Primate Genes Are More Likely to Duplicate

O'Toole, Á. N., Hurst, L. D. & McLysaght, A., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

Open Access
primate
Primates
gene
Genes
genes

Human evolution is still happening – possibly faster than ever

Hurst, L. D., 14 Nov 2018, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
5 Citations (Scopus)
20 Downloads (Pure)
Open Access
File
gene targeting
pedigree
rice
genome
genes
2 Citations (Scopus)
Open Access
Permethrin
refining
codons
Codon
Terminator Codon
5 Citations (Scopus)
70 Downloads (Pure)

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

Mead, R., Hejmadi, M. & Hurst, L. D., 1 Feb 2018, In : Nature Ecology & Evolution. 2, 2, p. 388-394 7 p.

Research output: Contribution to journalArticle

Open Access
File
teaching
students
student
conflict
teachers
7 Citations (Scopus)
25 Downloads (Pure)

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Hurst, L., 1 Jan 2018, In : Nature Ecology & Evolution. 2, 1, p. 164-173 10 p.

Research output: Contribution to journalArticle

Open Access
File
plant and fungus
gene conversion
recombination
fungi
gene
2017
1 Citation (Scopus)
Open Access
Bacterial Genes
Terminator Codon
stop codon
Adenine
adenine
10 Citations (Scopus)
97 Downloads (Pure)

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
RNA-binding proteins
RNA-Binding Proteins
RNA
Maintenance
protein
14 Citations (Scopus)

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

Intergenic DNA
Genome
Staphylococcal Pneumonia
Bacterial Genomes
Untranslated RNA
4 Citations (Scopus)

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
somatic mutation
mutation
cancer
genome
Genome
16 Citations (Scopus)

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
constancy
Bombus
Mutation Rate
Genetic Recombination
recombination
7 Citations (Scopus)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Hurst, L., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
Trophoblasts
Pre-Eclampsia
Placenta
Genes
Transcriptome
12 Citations (Scopus)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L. D., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. & Johnen, S., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 302-314 13 p.

Research output: Contribution to journalArticle

Open Access
Plasmids
Epithelial Cells
Transgenes
Intravitreal Injections
Retinal Pigments
6 Citations (Scopus)

Estimating the prevalence of functional exonic splice regulatory information

Savisaar, R. & Hurst, L. D., 1 Sep 2017, In : Human Molecular Genetics. 136, 9, p. 1059-1078 20 p.

Research output: Contribution to journalArticle

Open Access
Exons
Nucleotides
Sequence Analysis
Pressure
Mutation
2 Citations (Scopus)

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals

Link, V., Aguilar-Gómez, D., Ramírez-Suástegui, C., Hurst, L. D. & Cortez, D., 1 Sep 2017, In : Genome biology and evolution. 9, 9, p. 2198-2210 13 p.

Research output: Contribution to journalArticle

Open Access
monotreme
Mammals
mutation
substitution
mammal
10 Citations (Scopus)

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance

Mead, R., Hejmadi, M. & Hurst, L. D., 23 May 2017, In : PLoS Biology. 15, 5, e2002255.

Research output: Contribution to journalArticle

Open Access
Teaching
Molecular Evolution
Students
students
Aptitude

The best way to get children to understand evolution is to teach genetics first, finds study

Hurst, L., Hejmadi, M. & Mead, R., 23 May 2017, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
2016
18 Citations (Scopus)
79 Downloads (Pure)
Open Access
File
single nucleotide polymorphism
Single Nucleotide Polymorphism
polymorphism
exons
Exons
12 Citations (Scopus)

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L. D. & Izsvák, Z., 1 Feb 2016, In : Nature Protocols. 11, 2, p. 327-346 20 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Endogenous Retroviruses
Cell Line
Induced Pluripotent Stem Cells
17 Citations (Scopus)
70 Downloads (Pure)

Mutation rate analysis via parent– progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Xie, Z., Wang, L., Wang, L., Wang, Z., Lu, Z., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161016.

Research output: Contribution to journalArticle

Open Access
File
mutagenicity
Mutation Rate
peaches
mutation
Genes
3 Citations (Scopus)
79 Downloads (Pure)

Mutation rate analysis via parent- progeny sequencing of the perennial peach. II. No evidence for recombination associated mutation

Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. & Hurst, L. D., 26 Oct 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1841, 20161785.

Research output: Contribution to journalArticle

Open Access
File
Mutation Rate
peaches
Genetic Recombination
recombination
mutation
24 Citations (Scopus)

Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity?

Izsvák, Z., Wang, J., Singh, M., Mager, D. L. & Hurst, L. D., 1 Jan 2016, In : Bioessays. 38, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Genes
Genome
Pluripotent Stem Cells
DNA Transposable Elements
6 Citations (Scopus)
80 Downloads (Pure)

Purifying selection on exonic splice enhancers in intronless genes

Savisaar, R. & Hurst, L. D., Jun 2016, In : Molecular Biology and Evolution. 33, 6, p. 1396-1418

Research output: Contribution to journalArticle

Open Access
File
gene
Introns
Genes
introns
genes

Why did sex evolve? Researchers edge closer to solving longstanding mystery

Hurst, L., 29 Feb 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access

Why is the X chromosome so odd? Traffic analogy helped us crack the mystery

Hurst, L. D. & Huminiecki, L., 11 Jan 2016, The Conversation.

Research output: Contribution to specialist publicationArticle

Open Access
Mystery
Chromosome
Traffic
Crack
Evolutionary
2015
38 Citations (Scopus)
83 Downloads (Pure)

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Sealey, K. L., Harris, S. R., Fry, N. K., Hurst, L. D., Gorringe, A. R., Parkhill, J. & Preston, A., Jul 2015, In : Journal of Infectious Diseases. 212, 2, p. 294-301 8 p.

Research output: Contribution to journalArticle

Open Access
File
Whooping Cough
Disease Outbreaks
Acellular Vaccines
Pertussis Vaccine
Vaccines
43 Citations (Scopus)

Neighboring genes show correlated evolution in gene expression

Ghanbarian, A. T. & Hurst, L. D., Jul 2015, In : Molecular Biology and Evolution. 32, 7, p. 1748-1766

Research output: Contribution to journalArticle

gene expression
Gene Expression
gene
Genes
Transcriptome
60 Citations (Scopus)
104 Downloads (Pure)

Parent-progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J., Zhang, X., Yuan, Y., Chen, J. Q., Hurst, L. D. & Tian, D., 23 Jul 2015, In : Nature. 523, 7561, p. 463-467 5 p.

Research output: Contribution to journalArticle

Open Access
File
heterozygosity
mutation
genome
homozygosity
multigene family
9 Citations (Scopus)
46 Downloads (Pure)

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

the FANTOM consortium & Huminiecki, L., 18 Dec 2015, In : PLoS Biology. 13, 12, p. 1-48 48 p., e1002315.

Research output: Contribution to journalArticle

Open Access
Mammalian Chromosomes
Haploidy
X Chromosome
X chromosome
Chromosomes
13 Citations (Scopus)
58 Downloads (Pure)
File
Introns
introns
genome
Population
Genome
2014
12 Citations (Scopus)

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Hurst, L. D., Sachenkova, O., Daub, C., Forrest, A. R. R. & Huminiecki, L., 31 Jul 2014, In : Genome Biology. 15, 7, 413.

Research output: Contribution to journalArticle

Open Access
Transcription Factors
transcription factors
divergence
promoter regions
Activating Transcription Factors
67 Citations (Scopus)

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

Jiang, C., Mithani, A., Belfield, E. J., Mott, R., Hurst, L. D. & Harberd, N. P., 1 Nov 2014, In : Genome Research. 24, 11, p. 1821-1829 9 p.

Research output: Contribution to journalArticle

Open Access
Cytosine
Arabidopsis
Genome
Mutation
INDEL Mutation
23 Citations (Scopus)
76 Downloads (Pure)

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

Yin, S., Yang, J., Lin, B., Deng, W., Zhang, Y., Yi, X., Shi, Y., Tao, Y., Cai, J., Wu, C-I., Zhao, G., Hurst, L. D., Zhang, J., Hu, L. & Kong, X., 12 Aug 2014, In : Scientific Reports. 4, 6036.

Research output: Contribution to journalArticle

Open Access
File
Exome
Non-Small Cell Lung Carcinoma
Mutation
Histone-Lysine N-Methyltransferase
Genes
13 Citations (Scopus)
87 Downloads (Pure)

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp

Charneski, C. A. & Hurst, L. D., Jan 2014, In : Molecular Biology and Evolution. 31, 1, p. 70-84 15 p.

Research output: Contribution to journalArticle

Open Access
File
Architectural Accessibility
membrane proteins
topology
Membrane Proteins
membrane
74 Citations (Scopus)
59 Downloads (Pure)

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849

Research output: Contribution to journalArticle

Open Access
154 Citations (Scopus)
107 Downloads (Pure)

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Wang, J., Xie, G., Singh, M., Tashakkori Ghanbarian, A., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N. V., Schumann, G. G., Chen, W., Lorincz, M. C., Ivics, Z., Hurst, L. D. & Izsvák, Z., 18 Dec 2014, In : Nature. 516, 7531, p. 405-409 5 p.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Primates
Stem Cells
Long Noncoding RNA
Therapeutic Human Experimentation
22 Citations (Scopus)

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

Schüler, A., Ghanbarian, A. T. & Hurst, L. D., 1 Dec 2014, In : Molecular Biology and Evolution. 31, 12, p. 3164-3183 20 p.

Research output: Contribution to journalArticle

Open Access
RNA Folding
Long Noncoding RNA
folding
RNA
Chromatin
2013
19 Citations (Scopus)

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, S. J., Kwon, T., Rogers, A., Hurst, L. & Ahringer, J., 9 May 2013, In : Plos Genetics. 9, 5, e1003330.

Research output: Contribution to journalArticle

phenotype
Phenotype
gene
Genes
genes
5 Citations (Scopus)
81 Downloads (Pure)

Evidence for deep phylogenetic conservation of exonic splice-related constraints: Splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

Wu, X., Tronholm, A., Fernandez Cáceres, E., Tovar-Corona, J. M., Chen, L., Urrutia, A. O. & Hurst, L. D., 2013, In : Genome biology and evolution. 5, 9, p. 1731-1745 15 p.

Research output: Contribution to journalArticle

Open Access
File
Phaeophyta
Phaeophyceae
brown alga
codons
Codon
49 Citations (Scopus)
X Chromosome Inactivation
inactivation
X-Linked Genes
gene
Genes
5 Citations (Scopus)

Open questions: A logic (or lack thereof) of genome organization

Hurst, L. D., 28 May 2013, In : BMC Biology. 11, 58.

Research output: Contribution to journalArticle