Projects per year
Personal profile
Research interests
My work aims to mitigate significant public health problems in infectious diseases using bioinformatics and the latest sequencing technologies. I learned the value of this while working at Public Health England and being involved in the implementation of the routine use of whole genome sequencing for surveillance and investigation of gastrointestinal bacteria in the UK. I also learned the potential of using the latest sequencing technologies while using portable nanopore sequencing for the Ebola epidemic. My current work centres around improving bacterial GWAS techniques for investigating phenotypes of significance to public health and also developing machine learning techniques for classifying antibiotic and phage resistance from sequencing data.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Machine learning models for automation of epidemiological typing prediction of bacterial isolates
The Academy of Medical Sciences
1/05/20 → 30/04/23
Project: UK charity
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Developing bacterial GWAS beyond traditional SNP and gene content diversity
1/04/20 → 31/03/23
Project: UK charity
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Cabinet Office secondment, embedded scientist in COVID-19 Taskforce
1/06/20 → 31/03/22
Project: Central government, health and local authorities
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Transposable Element Insertions into the Escherichia coli Polysialic Acid Gene Cluster Result in Resistance to the K1F Bacteriophage
Styles, K. M., Locke, R. K., Cowley, L., Brown, A. T. & Sagona, A. P., 29 Jun 2022, In: Microbiology Spectrum. 10, 3, p. e0211221Research output: Contribution to journal › Article › peer-review
Open Access -
Acquisition and loss of ctx-m plasmids in shigella species associated with msm transmission in the uk
Locke, R. K., Greig, D. R., Jenkins, C., Dallman, T. J. & Cowley, L. A., 31 Aug 2021, In: Microbial Genomics. 7, 8, 000644.Research output: Contribution to journal › Article › peer-review
Open Access -
Genomics, social media and mobile phone data enable mapping of SARS-CoV-2 lineages to inform health policy in Bangladesh
Cowley, L. A., Afrad, M. H., Rahman, S. I. A., Mamun, M. M. A., Chin, T., Mahmud, A., Rahman, M. Z., Billah, M. M., Khan, M. H., Sultana, S., Khondaker, T., Baker, S., Banik, N., Alam, A. N., Mannoor, K., Banu, S., Chowdhury, A., Flora, M. S., Thomson, N. R., Buckee, C. O. & 2 others, , 31 Oct 2021, In: Nature Microbiology. 6, 10, p. 1271-1278 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing
Břinda, K., Callendrello, A., Ma, K. C., MacFadden, D. R., Charalampous, T., Lee, R. S., Cowley, L., Wadsworth, C. B., Grad, Y. H., Kucherov, G., O’Grady, J., Baym, M. & Hanage, W. P., 31 Mar 2020, In: Nature Microbiology. 5, 3, p. 455-464 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (SciVal) -
Laboratory findings, compassionate use of Favipiravir, and outcome in patients with Ebola virus disease, guinea, 2015—a retrospective observational study
Kerber, R., Lorenz, E., Duraffour, S., Sissoko, D., Rudolf, M., Jaeger, A., Cisse, S. D., Camara, A-M., Miranda, O., Castro, C., Bore, J. A., Koundouno, F. R., Reptis, J., Afrough, B., Becker-Ziaja, B., Hinzmann, J., Mertens, M., Vitoriano, I., Logue, C., Bottcher, J-P. & 53 others, , 15 Jul 2019, In: Journal of Infectious Diseases. 220, 2, p. 195-202 8 p.Research output: Contribution to journal › Article › peer-review
Open Access