Projects per year
Personal profile
Research interests
My work aims to mitigate significant public health problems in infectious diseases using bioinformatics and the latest sequencing technologies. I learned the value of this while working at Public Health England and being involved in the implementation of the routine use of whole genome sequencing for surveillance and investigation of gastrointestinal bacteria in the UK. I also learned the potential of using the latest sequencing technologies while using portable nanopore sequencing for the Ebola epidemic. My current work centres around improving bacterial GWAS techniques for investigating phenotypes of significance to public health and also developing machine learning techniques for classifying antibiotic and phage resistance from sequencing data.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 4 Finished
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Convergent evolution of Enterobacteriaceae in epidemiological networks with high antimicrobial use
Cowley, L. (PI)
Biotechnology and Biological Sciences Research Council
1/08/21 → 1/11/24
Project: Research council
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Cabinet Office secondment, embedded scientist in COVID-19 Taskforce
Cowley, L. (PI)
1/06/20 → 31/03/22
Project: Central government, health and local authorities
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Machine learning models for automation of epidemiological typing prediction of bacterial isolates
Cowley, L. (PI)
The Academy of Medical Sciences
1/05/20 → 31/12/23
Project: UK charity
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Developing bacterial GWAS beyond traditional SNP and gene content diversity
Preston, A. (PI) & Cowley, L. (CoI)
1/04/20 → 31/12/23
Project: UK charity
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Genome-wide annotation of transcript boundaries using bacterial Rend-seq datasets
Lawaetz, A. C., Cowley, L. A. & Denham, E. L., 26 Apr 2024, In: Microbial Genomics. 10, 4, 001239.Research output: Contribution to journal › Article › peer-review
Open Access -
GWarrange: a pre- and post- genome-wide association studies pipeline for detecting phenotype-associated genome rearrangement events
Tam, Y. L., Cameron, S., Preston, A. & Cowley, L., 9 Jul 2024, In: Microbial Genomics. 10, 7, 001268.Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: The evolution and international spread of extensively drug resistant Shigella sonnei (Nature Communications, (2023), 14, 1, (1983), 10.1038/s41467-023-37672-w)
Mason, L. C. E., Greig, D. R., Cowley, L. A., Partridge, S. R., Martinez, E., Blackwell, G. A., Chong, C. E., De Silva, P. M., Bengtsson, R. J., Draper, J. L., Ginn, A. N., Sandaradura, I., Sim, E. M., Iredell, J. R., Sintchenko, V., Ingle, D. J., Howden, B. P., Lefèvre, S., Njamkepo, E. & Weill, F. X. & 3 others, , 31 Dec 2023, In: Nature Communications. 14, 1, 1 p., 2302.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Rapid geographical source attribution of Salmonella enterica serovar Enteritidis genomes using hierarchical machine learning
Bayliss, S. C., Locke, R. K., Jenkins, C., Chattaway, M. A., Dallman, T. J. & Cowley, L. A., 12 Apr 2023, In: eLife. 12, e84167.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (SciVal) -
The evolution and international spread of extensively drug resistant Shigella sonnei
Mason, L. C. E., Greig, D. R., Cowley, L. A., Partridge, S. R., Martinez, E., Blackwell, G. A., Chong, C. E., De Silva, P. M., Bengtsson, R. J., Draper, J. L., Ginn, A. N., Sandaradura, I., Sim, E. M., Iredell, J. R., Sintchenko, V., Ingle, D. J., Howden, B. P., Lefèvre, S., Njampeko, E. & Weill, F. X. & 3 others, , 30 Apr 2023, In: Nature Communications. 14, 1, 1 p., 1983.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (SciVal)