Projects per year
Personal profile
Research interests
I am an experienced developmental geneticist and molecular biologist aiming to discover mechanisms explaining the developmental origins of health and disease, using the mouse as a model. Through more than twenty years working in Professor Andrew Ward’s group my particular interest has come to lie in how genes that are regulated by genomic imprinting function in mother and offspring during prenatal and early postnatal life to influence body composition (i.e. fat and lean proportions) and metabolic health in later life. I have focused on the gene Grb10 (Growth Factor Receptor Bound Protein 10) because of its importance in fetal growth, lean mass accrual and insulin signalling and its link with nutrient sensing via regulation of and by MTOR.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- developmental biology
- genomic imprinting
- genetics
- epigenetics
- metabolism
- physiology
- cancer
- aging
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance
Rienecker, K. D. A., Chavasse, A. T., Moorwood, K., Ward, A. & Isles, A. R., 1 Jan 2020, In: Genes, Brain and Behavior. 19, 1, e12571.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (SciVal)33 Downloads (Pure) -
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Manaf Ali, A., Lopez de Cerain Salsamendi, A., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A-K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C., & 153 others , Jun 2015, In: Carcinogenesis. 36 Suppl 1, p. S254-S296Research output: Contribution to journal › Article › peer-review
Open Access219 Citations (SciVal) -
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling
Engström, W., Darbre, P., Eriksson, S., Gulliver, L., Hultman, T., Karamouzis, M. V., Klaunig, J. E., Mehta, R., Moorwood, K., Sanderson, T., Sone, H., Vadgama, P., Wagemaker, G., Ward, A., Singh, N., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Colacci, A. M., Vaccari, M., & 12 others , Jun 2015, In: Carcinogenesis. 36 , Suppl 1, p. S38-S60Research output: Contribution to journal › Article › peer-review
28 Citations (SciVal) -
Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes
Madon-Simon, M., Cowley, M., Garfield, A. S., Moorwood, K. & Ward, A., 31 Dec 2014, In: BMC Biology. 12, 22 p., 771.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (SciVal)159 Downloads (Pure) -
Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup
Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. & Ward, A., 28 Feb 2014, In: PLoS Biology. 12, 2, p. 1-13 13 p., e1001799.Research output: Contribution to journal › Article › peer-review
Open Access39 Citations (SciVal)50 Downloads (Pure)