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Personal profile

Research interests

Integral membrane proteins (MPs) are involved in a variety of essential cell functions e.g. cell-cell signaling and biomolecule transport across bilayers. MPs are targets for >60% of pharmaceutical drugs and provide specificity for drug delivery. Study of MPs is hindered by instability when removed from their bilayer environment which causes denaturation. Newer technologies use poly(styrene-co-maleic acid) (SMA) to form nanodiscs around MPs, creating a stable environment for structural characterisation. SMA nanodiscs provide an alternative to study MPs organisation and protein-protein interactions. Polymer synthesis allows the tailoring of polymer properties for specific applications and eliminate limitations observed in current polymers. My research focusses on what polymer properties are required for polymer nanodiscs to have enhanced properties for structural and functional studies, and whether interactions between protein-polymer and polymer-lipid affect the functionality of the MP in the nanodisc.

Education/Academic qualification

Biology, Bachelor of Science, Aston University

1 Sep 20111 Jun 2015

Keywords

  • SMA
  • Nanodiscs
  • Polymer
  • SMALP
  • Protein purification
  • Solubilisation
  • membrane protein

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Research Output

Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer

Hall, S. C. L., Clifton, L. A., Tognoloni, C., Morrison, K. A., Knowles, T. J., Kinane, C. J., Dafforn, T. R., Edler, K. J. & Arnold, T., 11 Apr 2020, In : Journal of Colloid and Interface Science. 574, p. 272-284 13 p.

Research output: Contribution to journalArticle

Open Access

Membrane protein extraction and purification using styrene–maleic acid (SMA) copolymer: effect of variations in polymer structure.

Morrison, K., Akram, A., Mathews, A., Khan, Z. A., Patel, J. H., Zhou, C., Hardy, D. J., Moore-Kelly, C., Patel, R., Odiba, V., Knowles, T. J., Javed, M. H., Chmel, N. P., Dafforn, T. R. & Rothnie, A. J., 25 Nov 2016, In : Biochemical Journal. 473, 23, p. 4349-4360 12 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Detergent-free purification of ABC (ATP-binding-cassette) transporters

Gulati, S., Jamshad, M., Knowles, T. J., Morrison, K., Downing, R., Cant, N., Collins, R., Koenderink, J. B., Ford, R. C., Overduin, M., Kerr, I. D., Dafforn, T. R. & Rothnie, A. J., 15 Jul 2014, In : Biochemical Journal. 461, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Thesis

GLUT4 extraction using poly(styrene-co-maleic acid): A test of functionality using biotinylated bis-glucose photoaffinity labelling.

Author: Morrison, K., 12 Dec 2018

Supervisor: Edler, K. (Supervisor), Whitley, P. (Supervisor), Price, G. J. (External person) (Supervisor) & Doutch, J. (External person) (Supervisor)

Student thesis: Masters ThesisMaster (MA)

Zwitterionic copolymers for Membrane protein extraction into Nanodiscs

Author: Morrison, K., 12 Dec 2018

Supervisor: Edler, K. (Supervisor), Whitley, P. (Supervisor), Price, G. J. (External person) (Supervisor) & Doutch, J. (External person) (Supervisor)

Student thesis: Masters ThesisMaster (MA)