Projects per year
Personal profile
Research interests
The mammalian genome contains many thousand non-coding RNA (ncRNA) loci in addition to protein coding genes. Long ncRNAs (lncRNAs) are a class of polymerase II transcribed ncRNA molecules, greater than 200 nucleotides in length, which do not code for protein. LncRNA loci can be genomically located within exons or introns, transcribed in a sense or anti-sense orientation relative to protein coding genes, or they may be intergenic.
The function of the vast majority of these transcripts is unknown. Nuclear localised intergenic lncRNAs, however, are emerging as an important class of transcriptional and chromatin regulators with proposed roles in the control of normal cellular growth and differentiation as well as in cancer. These transcripts were originally discovered to function in cis to regulate the expression of nearby genes on the same chromosome. However, it is now apparent that lncRNAs can function in trans to regulate large scale gene expression programmes across multiple chromosomes and on different alleles from where they are expressed.
The focus of my research is to:
- Identify novel lncRNA transcriptional regulators of growth and differentiation from a dataset of vertebrate conserved central nervous system expressed lncRNAs.
- Characterise the role of lncRNAs in regulating melanoma growth and invasion, an extremely aggressive type of skin cancer.
- Investigate the genome-wide transcriptional regulatory functions of trans-acting lncRNAs, to determine the general principles of lncRNA genomic targeting and their mechanisms of transcriptional and chromatin regulation.
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Projects
Bringing Light Sheet Fluorescence Microscopy to the University of Bath
Kelsh, R., Gebhard, S., Jones, B. & Vance, K.
1/07/19 → 30/06/20
Project: Research council
Functional characterisation of a new candidate melanoma oncogene
Skin Cancer Research Fund (SCARF)
1/04/18 → 31/03/19
Project: UK charity
Identification of New Long Non-Coding RNA Regulators of Melanoma Growth and Invasion
1/10/16 → 30/09/17
Project: Research council
Investigating the Principles of Trans-acting Long Non-Coding RNA Genomic Targting and Chromatin Regulation
3/05/16 → 2/05/19
Project: Research council
Research Output
The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor
Coe, E. A., Tan, J. Y., Shapiro, M., Louphrasitthiphol, P., Bassett, A. R., Marques, A. C., Goding, C. R. & Vance, K. W., 27 Dec 2019, In : Plos Genetics. 15, 12, e1008501.Research output: Contribution to journal › Article
Open Access
The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis
Pavlaki, I., Alammari, F., Sun, B., Clark, N., Sirey, T., Lee, S., Woodcock, D. J., Ponting, C. P., Szele, F. G. & Vance, K. W., 15 May 2018, In : The EMBO Journal. 37, 10, p. 1-16 16 p., e98219.Research output: Contribution to journal › Article
Open Access
11
Citations
(Scopus)
Mapping long noncoding RNA chromatin occupancy using capture hybridization analysis of RNA targets (CHART)
Vance, K. W., 24 Sep 2016, Enhancer RNAs: Methods and Protocols. Andersson Orom, U. (ed.). New York, U. S. A.: Springer, p. 39-50 12 p. (Methods in Molecular Biology; vol. 1468).Research output: Chapter in Book/Report/Conference proceeding › Chapter
5
Citations
(Scopus)
The emerging role of long non-coding RNAs in cutaneous melanoma
Leucci, E., Coe, E. A., Marine, J-C. & Vance, K. W., 1 Nov 2016, In : Pigment Cell & Melanoma Research. 29, 6, p. 619-626Research output: Contribution to journal › Article
28
Citations
(Scopus)
Conserved cis-regulatory modules control robustness in Msx1 expression at single cell resolution
Vance, K. W., Woodcock, D. J., Reid, J. E., Bretschneider, T., Ott, S. & Koentges, G., 4 Sep 2015, In : Genome biology and evolution. 7, 9, 44 p.Research output: Contribution to journal › Article
Open Access
File
30
Downloads
(Pure)
Thesis
Identification and characterisation of MITF-regulated long non-coding RNA candidate regulators of melanoma
Author: Coe, E., 1 Apr 2020Supervisor: Vance, K. (Supervisor) & Murrell, A. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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