Photo of Keith Vance

Keith Vance

Dr

  • 4 SOUTH 0.60A

19992020

Research output per year

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Personal profile

Research interests

The mammalian genome contains many thousand non-coding RNA (ncRNA) loci in addition to protein coding genes. Long ncRNAs (lncRNAs) are a class of polymerase II transcribed ncRNA molecules, greater than 200 nucleotides in length, which do not code for protein. LncRNA loci can be genomically located within exons or introns, transcribed in a sense or anti-sense orientation relative to protein coding genes, or they may be intergenic.

The function of the vast majority of these transcripts is unknown. Nuclear localised intergenic lncRNAs, however, are emerging as an important class of transcriptional and chromatin regulators with proposed roles in the control of normal cellular growth and differentiation as well as in cancer. These transcripts were originally discovered to function in cis to regulate the expression of nearby genes on the same chromosome. However, it is now apparent that lncRNAs can function in trans to regulate large scale gene expression programmes across multiple chromosomes and on different alleles from where they are expressed.

The focus of my research is to:

  1. Identify novel lncRNA transcriptional regulators of growth and differentiation from a dataset of vertebrate conserved central nervous system expressed lncRNAs.
  2. Characterise the role of lncRNAs in regulating melanoma growth and invasion, an extremely aggressive type of skin cancer.
  3. Investigate the genome-wide transcriptional regulatory functions of trans-acting lncRNAs, to determine the general principles of lncRNA genomic targeting and their mechanisms of transcriptional and chromatin regulation.

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Projects

Research Output

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

Coe, E. A., Tan, J. Y., Shapiro, M., Louphrasitthiphol, P., Bassett, A. R., Marques, A. C., Goding, C. R. & Vance, K. W., 27 Dec 2019, In : Plos Genetics. 15, 12, e1008501.

Research output: Contribution to journalArticle

Open Access

The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis

Pavlaki, I., Alammari, F., Sun, B., Clark, N., Sirey, T., Lee, S., Woodcock, D. J., Ponting, C. P., Szele, F. G. & Vance, K. W., 15 May 2018, In : The EMBO Journal. 37, 10, p. 1-16 16 p., e98219.

Research output: Contribution to journalArticle

Open Access
  • 11 Citations (Scopus)

    Mapping long noncoding RNA chromatin occupancy using capture hybridization analysis of RNA targets (CHART)

    Vance, K. W., 24 Sep 2016, Enhancer RNAs: Methods and Protocols. Andersson Orom, U. (ed.). New York, U. S. A.: Springer, p. 39-50 12 p. (Methods in Molecular Biology; vol. 1468).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 5 Citations (Scopus)

    The emerging role of long non-coding RNAs in cutaneous melanoma

    Leucci, E., Coe, E. A., Marine, J-C. & Vance, K. W., 1 Nov 2016, In : Pigment Cell & Melanoma Research. 29, 6, p. 619-626

    Research output: Contribution to journalArticle

  • 28 Citations (Scopus)

    Conserved cis-regulatory modules control robustness in Msx1 expression at single cell resolution

    Vance, K. W., Woodcock, D. J., Reid, J. E., Bretschneider, T., Ott, S. & Koentges, G., 4 Sep 2015, In : Genome biology and evolution. 7, 9, 44 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 30 Downloads (Pure)

    Thesis

    Identification and characterisation of MITF-regulated long non-coding RNA candidate regulators of melanoma

    Author: Coe, E., 1 Apr 2020

    Supervisor: Vance, K. (Supervisor) & Murrell, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File