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Personal profile

Research interests

Research in the Williams group is mainly involved with the use of transition metals for the synthesis of useful organic molecules.  In particular, we have been developing reactions using ‘borrowing hydrogen.’  In this chemistry, ruthenium or iridium catalysts temporarily remove hydrogen to give an aldehyde.  This aldehyde then reacts to give an alkene (or imine) and the hydrogen is then returned to give a C-C or C-N bond.  These procedures allow alcohols to be used as alkylating agents in place of more conventional, but often toxic/mutagenic alkyl halides.

Individual Areas

  • Irreversible hydrogen transfer reactions
  • Deracemisation of secondary alcohols
  • C-N Bond formation from alcohols
  • C-C Bond formation from alcohols
  • Heterocycle synthesis
  • Amides and nitriles from oximes

Personal website

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Ruthenium Chemical Compounds
Alcohols Chemical Compounds
Hydrogen Chemical Compounds
Amines Chemical Compounds
Catalysts Chemical Compounds
Amides Chemical Compounds
Iridium Chemical Compounds
Carbon Monoxide Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2016

Global Mobility Scheme - Catalysis

Williams, J.

1/02/141/07/14

Project: Research-related fundingInternational Relations Office Funding

Dream Fellowship

Williams, J.

1/08/1110/05/13

Project: Research council

phosphine
Biofuels
Metals
Phosphines
Lanthanoid Series Elements
Pharmaceutical Preparations
Paclitaxel
Diphenhydramine
Molecules
Microwave heating

Research Output 1992 2017

10 Citations

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Sanz Sharley, D. D. & Williams, J. M. J., 11 Feb 2017, In : Chemical Communications. 53, 12, p. 2020-2023 4 p.

Research output: Contribution to journalArticle

Open Access
File
Formamides
Acetylation
Acylation
Amides
Acetic acid
3 Citations

A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Sanz Sharley, D. & Williams, J., 14 Sep 2017, In : Tetrahedron Letters. 58, 43, p. 4090 4093 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxylamines
2,2'-Dipyridyl
Nitriles
Oximes
Amides
1 Citations

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

Polidano, K., Reed-Berendt, B. G., Basset, A., Watson, A. J. A., Williams, J. M. J. & Morrill, L. C., 15 Dec 2017, In : Organic Letters. 19, 24, p. 6716-6719 4 p.

Research output: Contribution to journalArticle

Ruthenium
ruthenium
Hydrogen
chemistry
Ethers
5 Citations

Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides

Chapman, R., Lawrence, R., Williams, J. & Bull, S., 30 Aug 2017, p. 4908-4911.

Research output: Contribution to conferencePaper

Open Access
File
Formamides
Cyanides
Amines
Amino Acids
Peptides
21 Citations

A mild hydration of nitriles catalysed by copper(ii) acetate

Marcé, P., Lynch, J., Blacker, A. J. & Williams, J. M. J., 25 Jan 2016, In : Chemical Communications. 52, 7, p. 1436-1438 3 p.

Research output: Contribution to journalArticle

Nitriles
Amides
Hydration
Copper
Acetates

Thesis

Atom Economical and Environmentally Benign Metal Catalysed Synthesis

Author: Van Der Waals, D., 10 Jun 2014

Supervisor: Williams, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Catalytic approaches to the synthesis of amide bonds

Author: Allen, L., 1 Feb 2012

Supervisor: Williams, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Environmentally Benign Acylation Reactions

Author: Wakeham, R., 14 Apr 2014

Supervisor: Williams, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Lewis Acids for the Activation of Pyridines for Further Functionalisation

Author: Abou-Shehada, S., 9 Jun 2015

Supervisor: Williams, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Metal Catalysed Acyl Transfer Reactions of Amides

Author: Atkinson, B., 18 Feb 2015

Supervisor: Williams, J. (Supervisor)

Student thesis: Doctoral ThesisPhD

File