Photo of Jonathan Nzakizwanayo

Jonathan Nzakizwanayo

Dr

20142019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

My research interests focus on host-microbe interactions and the study of pathogenesis, diagnosis and control of bacterial infections.

My emphasis is on elucidating host-microbe interactions in probiotic bacteria by investigating mechanisms of interactions in modulation of epithelial cell health, and in neurotransmitter signalling in the gut.

Another area of my research interest is in studying pathogenesis, diagnosis and prevention of Medical device associated infections. A particular focus on catheter associated urinary tract infections (CAUTI), and the use of bacteriophages (bacterial viruses) therapy to control these infections. Furthermore I am studying the role of efflux systems in bacterial virulence and pathogenesis in CAUTI; efflux systems are target for development of antimicrobial agents.

In addition, I have been interested in studying pathogenesis and diagnosis of wound infections using novel ex vivo wound models, quantification of bacterial toxin gene expression, and use of third generation genome sequencing techniques for early detection of infection.

Education/Academic qualification

Pharmacy & Biomolecular Sciences, Doctor of Science, University of Brighton

15 Jan 201022 May 2014

Biotechnology, Master of Science, University of Strathclyde

28 Sep 200730 Aug 2008

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Proteus mirabilis Medicine & Life Sciences
Biofilms Medicine & Life Sciences
Catheters Engineering & Materials Science
Urinary Catheters Medicine & Life Sciences
Bacteriophages Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Uropathogenic Escherichia coli Medicine & Life Sciences
Nucleotide Aptamers Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2014 2019

Bacterial biofilm formation on indwelling urethral catheters

Pelling, H., Nzakizwanayo, J., Milo, S., Denham, E. L., MacFarlane, W. M., Bock, L. J., Sutton, J. M. & Jones, B. V., 1 Apr 2019, In : Letters in Applied Microbiology. 68, 4, p. 277-293 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a high-throughput ex-vivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection

Alves, D. R., Booth, S. P., Scavone, P., Schellenberger, P., Salvage, J., Dedi, C., Thet, N. T., Jenkins, A. T. A., Waters, R., Ng, K. W., Overall, A. D. J., Metcalfe, A. D., Nzakizwanayo, J. & Jones, B. V., 15 Jun 2018, In : Frontiers in Cellular and Infection Microbiology. 8, JUN, 196.

Research output: Contribution to journalArticle

Open Access
Wound Infection
Biofilms
Swine
Skin
Wounds and Injuries
4 Citations (Scopus)

Resolution of habitat-associated ecogenomic signatures in bacteriophage genomes and application to microbial source tracking

Ogilvie, L. A., Nzakizwanayo, J., Guppy, F. M., Dedi, C., Diston, D., Taylor, H., Ebdon, J. & Jones, B. V., 2018, In : ISME Journal. 12, 4, p. 942-958 17 p.

Research output: Contribution to journalArticle

Open Access
bacteriophage
bacteriophages
Bacteriophages
Ecosystem
genome