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Jonathan Nzakizwanayo

Dr

20142019

Research output per year

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Personal profile

Research interests

My research interests focus on host-microbe interactions and the study of pathogenesis, diagnosis and control of bacterial infections.

My emphasis is on elucidating host-microbe interactions in probiotic bacteria by investigating mechanisms of interactions in modulation of epithelial cell health, and in neurotransmitter signalling in the gut.

Another area of my research interest is in studying pathogenesis, diagnosis and prevention of Medical device associated infections. A particular focus on catheter associated urinary tract infections (CAUTI), and the use of bacteriophages (bacterial viruses) therapy to control these infections. Furthermore I am studying the role of efflux systems in bacterial virulence and pathogenesis in CAUTI; efflux systems are target for development of antimicrobial agents.

In addition, I have been interested in studying pathogenesis and diagnosis of wound infections using novel ex vivo wound models, quantification of bacterial toxin gene expression, and use of third generation genome sequencing techniques for early detection of infection.

Education/Academic qualification

Pharmacy & Biomolecular Sciences, Doctor of Science, University of Brighton

15 Jan 201022 May 2014

Award Date: 29 Jan 2019

Biotechnology, Master of Science, University of Strathclyde

28 Sep 200730 Aug 2008

Award Date: 8 Nov 2008

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Research Output

An In Vitro Bladder Model for Studying Catheter- Associated Urinary Tract Infection and Associated Analysis of Biofilms

Nzakizwanayo, J., Pelling, H., Milo, S. & Jones, B., 16 Jul 2019, Proteus mirabilis - Methods and Protocols. Pearson, M. (ed.). Springer Nature, p. 139-158 20 p. (Methods in Molecular Biology; vol. 2021).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacterial biofilm formation on indwelling urethral catheters

Pelling, H., Nzakizwanayo, J., Milo, S., Denham, E. L., MacFarlane, W. M., Bock, L. J., Sutton, J. M. & Jones, B. V., 1 Apr 2019, In : Letters in Applied Microbiology. 68, 4, p. 277-293 17 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
12 Downloads (Pure)

De-repression of the smvA efflux system arises in clinical isolates of Proteus mirabilis and reduces susceptibility to chlorhexidine and other biocides

Pelling, H., Bock, L. J., Nzakizwanayo, J., Wand, M. E., Denham, E. L., MacFarlane, W. M., Sutton, J. M. & Jones, B. V., 21 Nov 2019, In : Antimicrobial Agents and Chemotherapy. 63, 12, p. 1-15 15 p., e01535-19.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
173 Downloads (Pure)

Genomic and Ecogenomic Characterization of Proteus mirabilis Bacteriophages

Jones, B. & Nzakizwanayo, J., 6 Aug 2019, In : Frontiers in Microbiology. 10, p. 1-14 14 p., 1783.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)