Research output per year
Research output per year
- 1 - 50 out of 63 results
Search results
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2024
Exponential Combination of a and e/g Intracellular Peptide Libraries Identifies a Selective ATF3 Inhibitor
Yu, M., Tang, T. M. S., Ghamsari, L., Yuen, G., Scuoppo, C., Rotolo, J. A., Kappel, B. J. & Mason, J. M., 15 Mar 2024, In: ACS Chemical Biology. 19, 3, p. 753-762 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability
Hole, K., Zhu, B., Huggon, L., Brown, J. T., Mason, J. & Williams, R. J., 18 Jun 2024, In: Cell Death and Disease. 15, 6, 15 p., 429.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure) -
2023
A library-derived peptide inhibitor of the BZLF1 transcription factor
Madden, S., Brennan, A. & Mason, J. M., 2 Dec 2023, In: Journal of Peptide Science. 12 p., e3557.Research output: Contribution to journal › Article › peer-review
Open Access -
An N-terminal alpha-Synuclein fragment binds lipid vesicles to modulate lipid induced aggregation
Meade, R., Allen, S., Williams, C., Tang, S., Crump, M. P. & Mason, J., 20 Sept 2023, In: Cell Reports Physical Science. 4, 9, 101563.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (SciVal)142 Downloads (Pure) -
Development of a hydroxyflavone-labelled 4554W peptide probe for monitoring αS aggregation
Watt, K., Meade, R., James, T. & Mason, J., 31 Dec 2023, In: Scientific Reports. 13, 1, 10968.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (SciVal) -
Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins
Tang, S. & Mason, J., 25 Dec 2023, In: JACS Au. 3, 12, p. 3290-3296 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (SciVal)128 Downloads (Pure) -
2022
An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity
Brennan, A., Leech, J. T., Kad, N. M. & Mason, J. M., 25 Apr 2022, In: JACS Au. 2, 4, p. 996-1006 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (SciVal) -
Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants
Watt, K. J. C., Meade, R. M., Williams, R. J. & Mason, J. M., 31 Dec 2022, In: Journal of Biological Chemistry. 298, 12, 102565.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (SciVal)71 Downloads (Pure) -
Anticancer Activity of ST101, A Novel Antagonist of CCAAT/Enhancer Binding Protein b
Darvishi , E., Ghamsari, L., Leong, S., Ramirez, R., Koester, M., Gallagher, E., Yu, M., Mason, J., Merutka, G., Kappel, B. & Rotolo, J., Nov 2022, In: Molecular Cancer Therapeutics. 21, 11, p. 1632-1644 13 p., MCT-21-0962.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (SciVal) -
In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun
Leech, J., Brennan, A., Don, N., Mason, J. & Kad, N., 31 Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102229.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (SciVal)1 Downloads (Pure) -
Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants
Watt, K. J. C., Meade, R. M., Williams, R. J. & Mason, J. M., 15 Jun 2022, In: ACS Chemical Neuroscience. 13, 12, p. 1790-1804 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (SciVal)114 Downloads (Pure) -
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
Nadal-Bufi, F., Chan, L. Y., Mohammad, H. H., Mason, J. M., Salomon, C., Lai, A., Thompson, E. W., Craik, D. J., Kaas, Q. & Henriques, S. T., 31 Dec 2022, In: Cellular and Molecular Life Sciences (CMLS). 79, 12, 606.Research output: Contribution to journal › Article › peer-review
4 Citations (SciVal) -
The Effect of Helix-Inducing Constraints and Downsizing Upon a Transcription Block Survival Derived Functional cJun Antagonist
Brennan, A., Leech, J., Kad, N. M. & Mason, J. M., 19 Oct 2022, In: Cell Reports Physical Science. 3, 10, 101077.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (SciVal) -
2021
A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding
Meade, R. M., Watt, K. J. C., Williams, R. J. & Mason, J. M., 3 Dec 2021, In: Journal of Molecular Biology. 433, 24, 167323.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (SciVal)118 Downloads (Pure) -
A thermodynamic model for interpreting tryptophan excitation-energy-dependent fluorescence spectra provides insight into protein conformational sampling and stability
Kwok, A., Camacho, I., Winter, S., Knight, M., Meade, R., Turner, A., O'Hara, J., Mason, J., Arcus, V., Jones, A. & Pudney, C., 3 Dec 2021, In: Frontiers in Molecular Biosciences. 8, 778244.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)143 Downloads (Pure) -
Combined Computational and Intracellular Peptide Library Screening: Towards a Potent and Selective Fra1 Inhibitor
Yu, M., Ghamsari, L., Rotolo, J., Kappel, B. & Mason, J., 1 Apr 2021, In: RSC Chemical Biology. 2, 2, p. 656-668Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)83 Downloads (Pure) -
Designed beta-hairpins inhibit LDH5 oligomerization and enzymatic activity
Nadal-Bufi, F., Mason, J., Chan, L., Craik, D., Kaass, Q. & Henriques, S., 8 Apr 2021, In: Journal of Medicinal Chemistry. 64, 7, p. 3767–3779Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (SciVal)49 Downloads (Pure) -
Oral (−)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β
Hole, K., Staniaszek, L., Menon Balan, G., Mason, J., Brown, J. & Williams, R. J., 16 Jun 2021, In: Frontiers in Neuroscience. 15, p. 1-9 9 p., 697319.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (SciVal) -
2020
A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles
Meade, R., Williams, R. J. & Mason, J., 19 Aug 2020, In: Nature Partner Journal - Parkinson's disease. 6, 1, 17.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (SciVal)86 Downloads (Pure) -
Coupling Computational and Intracellular Screening and Selection Toward Co-compatible cJun and cFos Antagonists
Lathbridge, A., Michalowska, A. & Mason, J., 4 Feb 2020, In: Biochemistry. 59, 4, p. 530-540 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (SciVal)167 Downloads (Pure) -
Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
Torpey, J., Meade, R., Mistry, R., Mason, J. & Madine, J., 15 Oct 2020, In: Frontiers in Neuroscience. 14, 561462.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (SciVal)89 Downloads (Pure) -
Selective antagonism of cJun for cancer therapy
Brennan, A., Leech, J., Kad, N. & Mason, J., 11 Sept 2020, In: Journal of Experimental and Clinical Cancer Research. 39, 1, 1 p., 184.Research output: Contribution to journal › Article › peer-review
Open Access53 Citations (SciVal) -
Single molecule imaging reveals cFos is capable of binding to and diffusing on DNA tightropes independently of cJun
Leech, J. T., Don, N. A., Mason, J. M. & Kad, N. M., 2020, (Unpublished) In: bioRxiv.Research output: Contribution to journal › Article
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The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein
Meade, R., Morris, K., Watt, K., Williams, R. J. & Mason, J., 5 Dec 2020, In: Journal of Molecular Biology. 432, 24, 166706.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (SciVal)98 Downloads (Pure) -
2019
Alpha-Synuclein Structure and Parkinson's Disease – Lessons and Emerging Principles
Meade, R., Fairlie, D. P. & Mason, J., 22 Jul 2019, In: Molecular Neurodegeneration. 14, 1, p. 1-14 14 p., 29.Research output: Contribution to journal › Article › peer-review
Open Access284 Citations (SciVal) -
Combining Constrained Heptapeptide Cassettes With Computational Design to Create Coiled-coil Targeting Helical Peptides
Lathbridge, A. & Mason, J., 21 Jun 2019, In: ACS Chemical Biology. 14, 6, p. 1293-1304 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (SciVal)174 Downloads (Pure) -
Excitation-energy-dependent molecular beacon detects early stage neurotoxic Aβ aggregates in the presence of cortical neurons
Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In: ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)115 Downloads (Pure) -
Twists or Turns: stabilising alpha vs beta turns in tetrapeptides
Hoang, H. N., Hill, T., Ruiz-Gómez, G., Diness, F., Mason, J., Wu, C., Abbenante, G., Shepherd, N. & Fairlie, D., 7 Dec 2019, In: Chemical Science. 10, 45, p. 10595-10600 6 p., C9SC04153B.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (SciVal) -
2018
Computational Competitive and Negative Design to Derive a Specific cJun Antagonist
Lathbridge, A. & Mason, J., 23 Oct 2018, In: Biochemistry. 57, 42, p. 6108-6118 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (SciVal)81 Downloads (Pure) -
2017
Computational prediction and design for creating iteratively larger heterospecific coiled coil sets
Crooks, R., Lathbridge, A., Panek, A. & Mason, J., 21 Mar 2017, In: Biochemistry. 56, 11, p. 1573-1584Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (SciVal)306 Downloads (Pure) -
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Baxter, D., Perry, S., Hill, T., Kok, W., Zaccai, N., Brady, L., Fairlie, D. & Mason, J., 18 Aug 2017, In: ACS Chemical Biology. 12, 8, p. 2051-2061 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (SciVal)332 Downloads (Pure) -
Exploiting Overlapping Advantages of in vitro and in cellulo Selection Systems to Isolate a Novel High-affinity cJun Antagonist
Baxter, D., Ullman, C. G., Frigotto, L. & Mason, J. M., 20 Oct 2017, In: ACS Chemical Biology. 12, 10, p. 2579-2588Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)262 Downloads (Pure) -
Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species
McDowall, J. S., Ntai, I., Hake, J., Whitley, P. R., Mason, J. M., Pudney, C. R. & Brown, D. R., 16 May 2017, In: Biochemistry. 56, 19, p. 2497–2505 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (SciVal)174 Downloads (Pure) -
2016
Deriving heterospecific self-assembling protein-protein interactions using a computational interactome screen
Crooks, R. O., Baxter, D., Panek, A. S., Lubben, A. T. & Mason, J. M., 29 Jan 2016, In: Journal of Molecular Biology. 428, 2, Part A, p. 385-398 14 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (SciVal) -
Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency
Shepperd, N. E., Harrison, R. S., Ruiz-Gomez, G., Abbenante, G., Mason, J. M. & Fairlie, D. P., 14 Dec 2016, In: Organic & Biomolecular Chemistry. 14, 46, p. 10939-10945Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (SciVal)258 Downloads (Pure) -
2015
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation
Cheruvara, H., Allen-Baume, V. L., Kad, N. M. & Mason, J. M., 20 Mar 2015, In: Journal of Biological Chemistry. 290, 12, p. 7426-7435 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (SciVal)220 Downloads (Pure) -
2014
Intracellular selection of peptide inhibitors that target disulphide-bridged Aβ42 oligomers
Acerra, N., Kad, N. M., Cheruvara, H. & Mason, J. M., Sept 2014, In: Protein Science. 23, 9, p. 1262-1274 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (SciVal)171 Downloads (Pure) -
Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions
Baxter, D., Ullman, C. & Mason, J., 6 Dec 2014, In: Future Medicinal Chemistry. 6, 18, p. 2073 2092 p.Research output: Contribution to journal › Article › peer-review
12 Citations (SciVal) -
Retro-inversal of intracellular selected β-amyloid-interacting peptides: Implications for a novel Alzheimer’s disease treatment
Acerra, N., Kad, N. M., Griffith, D. A., Ott, S., Crowther, D. C. & Mason, J. M., 8 Apr 2014, In: Biochemistry. 53, 13, p. 2101-2111 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (SciVal)270 Downloads (Pure) -
2013
Combining intracellular selection with protein-fragment complementation to derive Aβ interacting peptides
Acerra, N., Kad, N. M. & Mason, J. M., 1 Jul 2013, In: Protein Engineering Design and Selection. 26, 7, p. 463-470Research output: Contribution to journal › Article › peer-review
16 Citations (SciVal) -
Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1
Rao, T., Ruiz-Gómez, G., Hill, T. A., Hoang, H. N., Fairlie, D. P. & Mason, J. M., 2013, In: PLoS ONE. 8, 3, p. e59415Research output: Contribution to journal › Article › peer-review
40 Citations (SciVal) -
2012
The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c6A
Mason, J. M., Bendall, D. S., Howe, C. J. & Worrall, J. A. R., 1 Feb 2012, In: Biochimica Et Biophysica Acta-Proteins and Proteomics. 1824, 2, p. 311-318Research output: Contribution to journal › Article › peer-review
11 Citations (SciVal) -
2011
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists
Worrall, J. A. R. & Mason, J. M., 1 Feb 2011, In: FEBS Journal. 278, 4, p. 663-672Research output: Contribution to journal › Article › peer-review
20 Citations (SciVal) -
Truncation, randomization, and selection: Generation of a reduced length c-Jun antagonist that retains high interaction stability
Crooks, R. O., Rao, T. & Mason, J. M., 26 Aug 2011, In: Journal of Biological Chemistry. 286, 34, p. 29470-29479Research output: Contribution to journal › Article › peer-review
38 Citations (SciVal) -
2010
Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention
Mason, J. M., 1 Dec 2010, In: Future Medicinal Chemistry. 2, 12, p. 1813-1822Research output: Contribution to journal › Article › peer-review
141 Citations (SciVal) -
2009
Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate
Mason, J. M., 1 Dec 2009, In: FEBS Journal. 276, 24, p. 7305-7318Research output: Contribution to journal › Article › peer-review
2 Citations (SciVal) -
Peptides tailored to interfere with protein interaction and function
Mason, J. M., Muller, K. M. & Arndt, K. M., 2009, In: Chimica Oggi-Chemistry Today. 27, 2, p. 47-50Research output: Contribution to journal › Article › peer-review
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Role of hydrophobic and electrostatic interactions in coiled coil stability and specificity
Mason, J. M., Hagemann, U. B. & Arndt, K. M., 3 Nov 2009, In: Biochemistry. 48, 43, p. 10380-10388Research output: Contribution to journal › Article › peer-review
29 Citations (SciVal) -
2008
iPEP: Peptides designed and selected for interfering with protein interaction and function
Mason, J. M., Müller, K. M. & Arndt, K., 1 Dec 2008, In: Biochemical Society Transactions. 36, 6, p. 1442-1447Research output: Contribution to journal › Article › peer-review
14 Citations (SciVal) -
Selectional and mutational scope of peptides sequestering the Jun–Fos coiled-coil domain
Hagemann, U. B., Mason, J. M., Müller, K. M. & Arndt, K. M., 1 Aug 2008, In: Journal of Molecular Biology. 381, 1, p. 73-88Research output: Contribution to journal › Article › peer-review
45 Citations (SciVal)