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Research Output 1999 2019

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Article
2019

Alpha-Synuclein Structure and Parkinson's Disease – Lessons and Emerging Principles

Meade, R., Fairlie, D. P. & Mason, J., 22 Jul 2019, In : Molecular Neurodegeneration. 14, 1, 29.

Research output: Contribution to journalArticle

Open Access
13 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)

Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons

Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Open Access
File
2018
1 Citation (Scopus)

Computational Competitive and Negative Design to Derive a Specific cJun Antagonist

Lathbridge, A. & Mason, J., 23 Oct 2018, In : Biochemistry. 57, 42, p. 6108-6118 11 p.

Research output: Contribution to journalArticle

Peptide Library
Leucine Zippers
Computer Simulation
Screening
Cell Growth Processes
2017
8 Citations (Scopus)
89 Downloads (Pure)

Computational prediction and design to create iteratively larger heterospecific coiled coil sets

Crooks, R., Lathbridge, A., Panek, A. & Mason, J., 21 Mar 2017, In : Biochemistry. 56, 11, p. 1573-1584

Research output: Contribution to journalArticle

Open Access
File
Static Electricity
Dimers
Electrostatics
Software
Synthetic Biology
7 Citations (Scopus)
77 Downloads (Pure)

Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

Baxter, D., Perry, S., Hill, T., Kok, W., Zaccai, N., Brady, L., Fairlie, D. & Mason, J., 17 Aug 2017, In : ACS Chemical Biology. 12, 8, p. 2051-2061

Research output: Contribution to journalArticle

Open Access
File
Proto-Oncogenes
Peptides
Cell-Penetrating Peptides
Circular dichroism spectroscopy
Nuclear Localization Signals
1 Citation (Scopus)
51 Downloads (Pure)

Exploiting Overlapping Advantages of in vitro and in cellulo Selection Systems to Isolate a Novel High-affinity cJun Antagonist

Baxter, D., Ullman, C. G., Frigotto, L. & Mason, J. M., 20 Oct 2017, In : ACS Chemical Biology. 12, 10, p. 2579-2588

Research output: Contribution to journalArticle

Open Access
File
Libraries
Assays
Screening
Peptide Library
Cell-Free System
11 Citations (Scopus)
49 Downloads (Pure)

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species

McDowall, J. S., Ntai, I., Hake, J., Whitley, P. R., Mason, J. M., Pudney, C. R. & Brown, D. R., 4 May 2017, In : Biochemistry. 56, 19, p. 2497–2505 9 p.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Kinetics
Neurodegenerative diseases
Enzyme activity
Neurodegenerative Diseases
2016
10 Citations (Scopus)

Deriving heterospecific self-assembling protein-protein interactions using a computational interactome screen

Crooks, R. O., Baxter, D., Panek, A. S., Lubben, A. T. & Mason, J. M., 29 Jan 2016, In : Journal of Molecular Biology. 428, 2, Part A, p. 385-398

Research output: Contribution to journalArticle

Open Access
Peptides
Proteins
Software
Digital Libraries
Synthetic Biology
8 Citations (Scopus)
52 Downloads (Pure)

Downsizing the BAD BH3 peptide to small constrained alpha-helices with improved ligand efficiency

Shepperd, N. E., Harrison, R. S., Ruiz-Gomez, G., Abbenante, G., Mason, J. M. & Fairlie, D. P., 14 Dec 2016, In : Organic & Biomolecular Chemistry. 14, 46, p. 10939-10945

Research output: Contribution to journalArticle

Open Access
File
Ligands
Peptides
Apoptosis
Peptidomimetics
Proteins
2015
21 Citations (Scopus)
62 Downloads (Pure)

Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation

Cheruvara, H., Allen-Baume, V. L., Kad, N. M. & Mason, J. M., 20 Mar 2015, In : Journal of Biological Chemistry. 290, 12, p. 7426-7435 10 p.

Research output: Contribution to journalArticle

Open Access
File
Peptide Library
alpha-Synuclein
Parkinson Disease
Screening
Agglomeration
2014
6 Citations (Scopus)
56 Downloads (Pure)

Intracellular selection of peptide inhibitors that target disulphide-bridged Aβ42 oligomers

Acerra, N., Kad, N. M., Cheruvara, H. & Mason, J. M., Sep 2014, In : Protein Science. 23, 9, p. 1262-1274 13 p.

Research output: Contribution to journalArticle

Open Access
File
Oligomers
Disulfides
Amyloid
Peptides
Cytotoxicity
6 Citations (Scopus)

Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions

Baxter, D., Ullman, C. & Mason, J., 6 Dec 2014, In : Future Medicinal Chemistry. 6, 18, p. 2073 2092 p.

Research output: Contribution to journalArticle

Libraries
Peptides
Proteins
Therapeutics
Proteomics
15 Citations (Scopus)
51 Downloads (Pure)

Retro-inversal of intracellular selected β-amyloid-interacting peptides: Implications for a novel Alzheimer’s disease treatment

Acerra, N., Kad, N. M., Griffith, D. A., Ott, S., Crowther, D. C. & Mason, J. M., 8 Apr 2014, In : Biochemistry. 53, 13, p. 2101-2111 11 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid beta-Peptides
Amyloid
Alzheimer Disease
Peptides
Assays
2013
11 Citations (Scopus)

Combining intracellular selection with protein-fragment complementation to derive Aβ interacting peptides

Acerra, N., Kad, N. M. & Mason, J. M., 1 Jul 2013, In : Protein Engineering Design and Selection. 26, 7, p. 463-470

Research output: Contribution to journalArticle

Amyloid
Peptides
Proteins
Poisons
Oligomers
24 Citations (Scopus)

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1

Rao, T., Ruiz-Gómez, G., Hill, T. A., Hoang, H. N., Fairlie, D. P. & Mason, J. M., 2013, In : PLoS ONE. 8, 3, p. e59415

Research output: Contribution to journalArticle

Transcription Factor AP-1
peptides
Peptides
proteins
epitopes
2012
5 Citations (Scopus)

The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c6A

Mason, J. M., Bendall, D. S., Howe, C. J. & Worrall, J. A. R., 1 Feb 2012, In : Biochimica Et Biophysica Acta-Proteins and Proteomics. 1824, 2, p. 311-318

Research output: Contribution to journalArticle

Cytochromes
Cytochromes c
Arabidopsis
Disulfides
Kinetics
2011
13 Citations (Scopus)

Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists

Worrall, J. A. R. & Mason, J. M., 1 Feb 2011, In : FEBS Journal. 278, 4, p. 663-672

Research output: Contribution to journalArticle

13 Citations (Scopus)

Truncation, randomization, and selection: Generation of a reduced length c-Jun antagonist that retains high interaction stability

Crooks, R. O., Rao, T. & Mason, J. M., 26 Aug 2011, In : Journal of Biological Chemistry. 286, 34, p. 29470-29479

Research output: Contribution to journalArticle

2010
91 Citations (Scopus)
2009
2 Citations (Scopus)

Peptides tailored to interfere with protein interaction and function

Mason, J. M., Muller, K. M. & Arndt, K. M., 2009, In : Chimica Oggi-Chemistry Today. 27, 2, p. 47-50

Research output: Contribution to journalArticle

24 Citations (Scopus)

Role of hydrophobic and electrostatic interactions in coiled coil stability and specificity

Mason, J. M., Hagemann, U. B. & Arndt, K. M., 3 Nov 2009, In : Biochemistry. 48, 43, p. 10380-10388

Research output: Contribution to journalArticle

2008
10 Citations (Scopus)

iPEP: Peptides designed and selected for interfering with protein interaction and function

Mason, J. M., Müller, K. M. & Arndt, KM., 1 Dec 2008, In : Biochemical Society Transactions. 36, 6, p. 1442-1447

Research output: Contribution to journalArticle

40 Citations (Scopus)

Selectional and mutational scope of peptides sequestering the Jun–Fos coiled-coil domain

Hagemann, U. B., Mason, J. M., Müller, K. M. & Arndt, K. M., 1 Aug 2008, In : Journal of Molecular Biology. 381, 1, p. 73-88

Research output: Contribution to journalArticle

2007
32 Citations (Scopus)

Improved stability of the Jun-Fos activator protein-1 coiled coil motif: a stopped-flow circular dichroism kinetic analysis

Mason, J. M., Hagemann, U. B. & Arndt, K. M., 10 Aug 2007, In : Journal of Biological Chemistry. 282, 32, p. 23015-23024

Research output: Contribution to journalArticle

41 Citations (Scopus)

Positive aspects of negative design: Simultaneous selection of specificity and interaction stability

Mason, J. M., Müller, K. M. & Arndt, K. M., 1 Apr 2007, In : Biochemistry. 46, 16, p. 4804-4814

Research output: Contribution to journalArticle

Proteins
Libraries
Assays
Static Electricity
Peptides
2006
23 Citations (Scopus)

Kinetics of an individual transmembrane helix during bacteriorhodopsin folding

Compton, E. L. R., Farmer, N. A., Lorch, M., Mason, J. M., Moreton, K. M. & Booth, P. J., 17 Mar 2006, In : Journal of Molecular Biology. 357, 1, p. 325-338

Research output: Contribution to journalArticle

Bacteriorhodopsins
Fluorescence
Protein Folding
Lipid Bilayers
Lipids
151 Citations (Scopus)

N-methylated peptide inhibitors of β-amyloid aggregation

Doig, A., Kokkoni, N., Stott, K., Amijee, H., Bottomley, J., Mason, J., Treherne, M. & Scopes, D., 2006, In : Alzheimer's & Dementia . 2, 3, p. s605

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Peptides
Poisons
Electron Microscopy
Alzheimer Disease
151 Citations (Scopus)

N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure

Kokkoni, N., Stott, K., Amijee, H., Mason, J. M. & Doig, A. J., 1 Aug 2006, In : Biochemistry. 45, 32, p. 9906-9918

Research output: Contribution to journalArticle

97 Citations (Scopus)
Leucine Zippers
Transcription Factor AP-1
Libraries
Temperature
Basic-Leucine Zipper Transcription Factors
2005
23 Citations (Scopus)

Low energy pathways and non-native interactions: The influence of artificial disulfide bridges on the mechanism of folding

Mason, J. M., Cliff, M. J., Sessions, R. B. & Clarke, A. R., 9 Dec 2005, In : Journal of Biological Chemistry. 280, 49, p. 40494-40499

Research output: Contribution to journalArticle

Disulfides
Proteins
Molecules
Electron energy levels
Ground state
2004
441 Citations (Scopus)

Coiled coil domains: Stability, specificity, and biological implications

Mason, J. M. & Arndt, K. M., 6 Feb 2004, In : ChemBiochem. 5, 2, p. 170-176

Research output: Contribution to journalArticle

P4-356 N-methylated peptide inhibitors of Aβ aggregation

Doig, A. J., Kokkoni, N., Mason, J. M., Amijee, H., Stott, K. & Treherne, M., 1 Jul 2004, In : Neurobiology of Aging. 25, 2, p. S576

Research output: Contribution to journalArticle

2003
111 Citations (Scopus)

Design strategies for anti-amyloid agents

Mason, J. M., Kokkoni, N., Stott, K. & Doig, A. J., 1 Aug 2003, In : Current Opinion in Structural Biology. 13, 4, p. 526-532

Research output: Contribution to journalArticle

Amyloid
Peptides
Poisons
Amyloidosis
Proline
2002
22 Citations (Scopus)

The influence of intramolecular bridges on the dynamics of a protein folding reaction

Mason, J. M., Gibbs, N., Sessions, R. B. & Clarke, A. R., 1 Oct 2002, In : Biochemistry. 41, 40, p. 12093-12099

Research output: Contribution to journalArticle

Protein folding
Protein Folding
Disulfides
Proteins
Protein Engineering
2000
23 Citations (Scopus)

Effects of mutations on the thermodynamics of a protein folding reaction: Implications for the mechanism of formation of the intermediate and transition states

Lorch, M., Mason, J. M., Sessions, R. B. & Clarke, A. R., 1 Mar 2000, In : Biochemistry. 39, 12, p. 3480-3485

Research output: Contribution to journalArticle

Protein folding
Protein Folding
Thermodynamics
Enthalpy
Entropy
1999
71 Citations (Scopus)

Effects of core mutations on the folding of a beta-sheet protein: implications for backbone organization in the I-state.

Lorch, M., Mason, J., Clarke, A. R. & Parker, M. J., 26 Jan 1999, In : Biochemistry. 38, 4, p. 1377-1385

Research output: Contribution to journalArticle

Immunoglobulins
Mutation
Biochemistry
Disulfides
Cysteine