Projects per year
Personal profile
Research interests
My research focuses on design of peptide antagonists with high affinity and specificity for inhibiting protein-protein interactions. While forces driving stability are now well understood, much less is known about designing specificity. We use a Protein-fragment Complementation Assay (PCA), which utilises semi-rational design to select antagonists of Jun and Fos peptides that interact in the oncogenic Activator Protein-1 transcriptional regulator. We have devised a Competitive and Negative Design Initiative (CANDI) technique to increase target-specificity in the PCA system by expressing potential off-targets during selection. Peptides generated have allowed us to predict coiled coil stability and specificity based only the primary sequence, and to consequently design peptides. Our screening approach is also applied to a range of other therapeutically relevant systems that include β-amyloid and α-synuclein implicated in the pathogenesis of Alzheimer’s and Parkinson’s diseases, respectively.
Willing to supervise PhD
Ongoing projects related to the design and characterisation of peptide-based inhibitors of proteins involved in disease.
Education/Academic qualification
Biochemistry, Doctor of Philosophy, University of Bristol
Biochemistry, Bachelor of Science, University of Bristol
External positions
Alzheimer's Research UK Grant Review Board Member, Alzheimer's Research UK
Jul 2016 → Jun 2022BBSRC Core Member for Panel D, BBSRC
2016 → 2022EPSRC Associate Peer Review College, Engineering and Physical Sciences Research Council
2016 → 2021Editorial Board: Future Medicinal Chemistry
2011 → …Editorial Board: PLOS One
2010 → …Keywords
- peptide
- protein
- protein folding
- amyloid
- protein misfolding
- library screening
- Alzheimer's
- Cancer
- peptide mimetics
- protein-protein interactions
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Projects
Mining the (-)-epicatechin metabolome for Alzheimer's Therapeutics
2/09/19 → 1/03/22
Project: UK charity
A High Throughput Screen to Derive Functional Antagonists of Transcription Factor Cancer Targets.
1/12/18 → 28/02/21
Project: UK charity
A Generalised Approach to Derive Functionally Active Peptide Inhibitors of Transcription Factor Activity
1/10/18 → 30/09/21
Project: Research council
GW4 Biomed MRC DTP: Polyphenols as inhibitors of tau toxicity: protecting neuronal network function in AD
Williams, R., Mason, J. & Brown, J.
1/10/18 → 1/04/22
Project: Research council
Research Output
Coupling Computational and Intracellular Screening and Selection Towards Co-compatible cJun and cFos Antagonists
Lathbridge, A., Michalowska, A. & Mason, J., 4 Feb 2020, In : Biochemistry. 59, 4, p. 530-540Research output: Contribution to journal › Article
Open Access
File
17
Downloads
(Pure)
Single molecule imaging reveals cFos is capable of binding to and diffusing on DNA tightropes independently of cJun
Leech, J. T., Don, N. A., Mason, J. M. & Kad, N. M., 2020, (Unpublished) In : bioRxiv.Research output: Contribution to journal › Article
Alpha-Synuclein Structure and Parkinson's Disease – Lessons and Emerging Principles
Meade, R., Fairlie, D. P. & Mason, J., 22 Jul 2019, In : Molecular Neurodegeneration. 14, 1, p. 1-14 14 p., 29.Research output: Contribution to journal › Article
Open Access
7
Citations
(Scopus)
Combining Constrained Heptapeptide Cassettes With Computational Design to Create Coiled-coil Targeting Helical Peptides
Lathbridge, A. & Mason, J., 21 Jun 2019, In : ACS Chemical Biology. 14, 6, p. 1293-1304 12 p.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
40
Downloads
(Pure)
Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons
Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
40
Downloads
(Pure)
Thesis
Combining library screening approaches, and modifying peptides with helix constraints, to generate novel antagonists of oncogenic Activator Protein-1
Author: Baxter, D., 11 Jan 2017Supervisor: Mason, J. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Developing Neutron and X-ray Scattering Techniques to Investigate Amyloid Fibrils
Author: Eves, B., 3 Apr 2019Supervisor: Squires, A. (Supervisor), Mason, J. (Supervisor) & Doutch, J. (External person) (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Helical constraints and in silico library screening to develop novel antagonists of oncogenic Activator Protein-1
Author: Lathbridge, A., 19 Feb 2020Supervisor: Van Den Elsen, J. (Supervisor), Pudney, C. (Supervisor) & Mason, J. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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