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Personal profile

Research interests

My research focuses on design of peptide antagonists with high affinity and specificity for inhibiting protein-protein interactions. While forces driving stability are now well understood, much less is known about designing specificity. We use a Protein-fragment Complementation Assay (PCA), which utilises semi-rational design to select antagonists of Jun and Fos peptides that interact in the oncogenic Activator Protein-1 transcriptional regulator. We have devised a Competitive and Negative Design Initiative (CANDI) technique to increase target-specificity in the PCA system by expressing potential off-targets during selection. Peptides generated have allowed us to predict coiled coil stability and specificity based only the primary sequence, and to consequently design peptides. Our screening approach is also applied to a range of other therapeutically relevant systems that include β-amyloid and α-synuclein implicated in the pathogenesis of Alzheimer’s and Parkinson’s diseases, respectively.

Willing to supervise PhD

Ongoing projects related to the design and characterisation of peptide-based inhibitors of proteins involved in disease. 

Education/Academic qualification

Biochemistry, Doctor of Philosophy, University of Bristol

Biochemistry, Bachelor of Science, University of Bristol

External positions

Alzheimer's Research UK Grant Review Board Member, Alzheimer's Research UK

Jul 2016Jun 2022

BBSRC Core Member for Panel D, BBSRC

20162022

EPSRC Associate Peer Review College, Engineering and Physical Sciences Research Council

20162021

Editorial Board: Future Medicinal Chemistry

2011 → …

Editorial Board: PLOS One

2010 → …

Keywords

  • peptide
  • protein
  • protein folding
  • amyloid
  • protein misfolding
  • library screening
  • Alzheimer's
  • Cancer
  • peptide mimetics
  • protein-protein interactions

Fingerprint Dive into the research topics where Jody Mason is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Peptides Medicine & Life Sciences
Proteins Medicine & Life Sciences
Libraries Medicine & Life Sciences
Disulfides Chemical Compounds
Peptide Library Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Amyloid beta-Peptides Medicine & Life Sciences
Protein Folding Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2022

Research Output 1999 2019

Alpha-Synuclein Structure and Parkinson's Disease – Lessons and Emerging Principles

Meade, R., Fairlie, D. P. & Mason, J., 22 Jul 2019, In : Molecular Neurodegeneration. 14, 1, p. 1-14 14 p., 29.

Research output: Contribution to journalArticle

Open Access
13 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
27 Downloads (Pure)

Excitation-energy-dependent molecular beacon detects early stage neurotoxic aβ aggregates in the presence of cortical neurons

Gulácsy, C. E., Meade, R., Catici, D. A. M., Soeller, C., Pantos, G. D., Jones, D. D., Alibhai, D., Jepson, M., Valev, V. K., Mason, J. M., Williams, R. J. & Pudney, C. R., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Open Access
File

Twists or Turns: stabilising alpha vs beta turns in tetrapeptides

Hoang, H. N., Hill, T., Ruiz-Gómez, G., Diness, F., Mason, J., Wu, C., Abbenante, G., Shepherd, N. & Fairlie, D., 3 Oct 2019, In : Chemical Science. C9SC04153B.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Computational Competitive and Negative Design to Derive a Specific cJun Antagonist

Lathbridge, A. & Mason, J., 23 Oct 2018, In : Biochemistry. 57, 42, p. 6108-6118 11 p.

Research output: Contribution to journalArticle

Open Access
File
Peptide Library
Leucine Zippers
Computer Simulation
Screening
Cell Growth Processes

Thesis

Developing Neutron and X-ray Scattering Techniques to Investigate Amyloid Fibrils

Author: Eves, B., 3 Apr 2019

Supervisor: Squires, A. (Supervisor), Mason, J. (Supervisor) & Doutch, J. (External person) (Supervisor)

Student thesis: Doctoral ThesisPhD

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