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20092019
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Research Output 2009 2019

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Article
2019
1 Citation (Scopus)

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

Kühn, F. J. P., Watt, J. M., Potter, B. V. L. & Lückhoff, A., 21 Mar 2019, In : Scientific Reports. 9, 1, 4985.

Research output: Contribution to journalArticle

Open Access
2018
7 Citations (Scopus)

Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis

Vara, D., Watt, J. M., Fortunato, T., Mellor, H., Burgess, M., Wicks, K., Mace, K., Reeksting, S., Lubben, A., Wheeler-Jones, C. P. D. & Pula, G., 10 Jan 2018, In : Antioxidants & Redox Signaling. 28, 2, p. 110-130 21 p.

Research output: Contribution to journalArticle

Open Access
Deoxyribose
NF-kappa B
NADPH Oxidase
Chemical activation
Phosphates
1 Citation (Scopus)

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Zhang, B., Watt, J. M., Cordiglieri, C., Dammermann, W., Mahon, M., Flugel, A., Guse, A. H. & Potter, B., 13 Nov 2018, In : Scientific Reports. 8, 17 p., 16775.

Research output: Contribution to journalArticle

Open Access

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Potter, B., Thomas, M. & Watt, J. M., 15 Oct 2018, In : Scientific Reports. 8, 15268.

Research output: Contribution to journalArticle

Open Access
Ribose
Diphosphates
Adenosine
Cyclization
Adenine
2017
15 Citations (Scopus)

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H., 26 Jun 2017, In : Nature Chemical Biology. 13, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nicotinamide-Nucleotide Adenylyltransferase
Nicotinamide Mononucleotide
Adenosine Diphosphate Ribose
Glycoside Hydrolases
NAD
7 Citations (Scopus)

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H., 16 Jun 2017, In : Biochemical Journal. 474, 13, p. 2159-2175 BCJ20170091.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate Ribose
Ribose
Chemical activation
Ligands
Hydrogen Bonding
1 Citation (Scopus)
Open Access
File
Inosine
Ribose
Diphosphates
Second Messenger Systems
Substrates
7 Citations (Scopus)

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy

Kyratsous, N. I., Bauer, I. J., Zhang, G., Pesic, M., Bartholomäus, I., Mues, M., Fang, P., Wörner, M., Everts, S., Ellwart, J. W., Watt, J. M., Potter, B. V. L., Hohlfeld, R., Wekerle, H. & Kawakami, N., 1 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6381-E6389

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
Photons
Microscopy
T-Lymphocytes
Autoantigens
2015
2 Citations (Scopus)

Designer small molecules to target calcium signalling

Swarbrick, J. M., Riley, A. M., Mills, S. J. & Potter, B. V. L., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Calcium Signaling
Calcium
Molecules
Inositol 1,4,5-Trisphosphate Receptors
2014
18 Citations (Scopus)

'Click cyclic ADP-ribose': A neutral second messenger mimic

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. & Potter, B. V. L., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2458-2461 4 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic ADP-Ribose
Administrative data processing
Second Messenger Systems
Triazoles
Modulators
11 Citations (Scopus)

Cyclic adenosine 5′-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38

Swarbrick, J. M., Graeff, R., Zhang, H., Thomas, M. P., Hao, Q. & Potter, B. V. L., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8517-8529 13 p.

Research output: Contribution to journalArticle

Open Access
File
ADP-ribosyl Cyclase
Cyclic ADP-Ribose
Ribose
Hydrolases
Inosine Diphosphate
2013
19 Citations (Scopus)

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R., Wagner, G. K., Thomas, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q. & Potter, B. V. L., 19 Jun 2013, In : PLoS ONE. 8, 6, 15 p., e66247.

Research output: Contribution to journalArticle

Open Access
File
Inosine Diphosphate
Adenosine Diphosphate Ribose
Inosine
Ribose
ribose
19 Citations (Scopus)

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31 May 2013, In : Journal of Biological Chemistry. 288, 22, p. 16017-16030

Research output: Contribution to journalArticle

Calcium Signaling
Adrenergic Agents
Cardiac Arrhythmias
Calcium
Cardiac Myocytes
26 Citations (Scopus)

Structure–ativity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists

Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. & Potter, B. V. L., 27 Dec 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10079-10102

Research output: Contribution to journalArticle

2012
15 Citations (Scopus)
Ribose
Diphosphates
Adenosine
Second Messenger Systems
Membranes
2010
7 Citations (Scopus)

Synthesis of 4-C-Alkyl Inositol 1,4,5-Trisphosphates and 1,3,4,5-Tetrakisphosphates

Swarbrick, J. M. & Gaffney, P. R. J., 2 Jul 2010, In : Journal of Organic Chemistry. 75, 13, p. 4376-4386 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Inositol 1,4,5-Trisphosphate
Inositol
Hydroxyl Radical
Oxides
2009
11 Citations (Scopus)

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates

Swarbrick, J. M., Cooper, S., Bultynck, G. & Gaffney, P. R. J., 21 Apr 2009, In : Organic and Biomolecular Chemistry. 7, 8, p. 1709 - 1715 7 p.

Research output: Contribution to journalArticle

inositols
Inositol Phosphates
Inositol
phosphates
synthesis