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Research Output

2020

Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization

Doekhie, A., Dattani, R., Chen, Y-C., Yang, Y., Smith, A., Silve, A. P., Koumanov, F., Wells, S., Edler, K., Marchbank, K. J., Van Den Elsen, J. & Sartbaeva, A., 20 Feb 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle

2019
1 Downloads (Pure)

Structural Stabilisation of Disulphide-Linked Fluid-Phase C3d Dimers by Sbi Suggests a Novel B cell Subversion Strategy by Staphylococcus aureus

Wahid, A., Dunphy, R., Gibson, B., Back, C., Hallam, T., Alkhawaja, B., Harris, C., Crennell, S., Watts, A., Marchbank, K. & Van Den Elsen, J., Oct 2019, p. 437.

Research output: Contribution to conferencePaper

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Yang, Y., Back, C., Gräwert, M., Wahid, A., Denton, H., Kildani, R., Paulin, J., Wörner, K., Kaiser, W., Svergun, D., Sartbaeva, A., Watts, A., Marchbank, K. J. & Van Den Elsen, J., 11 Jan 2019, In : Frontiers in Immunology. 9, p. 1-17 17 p., 3139.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
47 Downloads (Pure)
2018

Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

Pereira Morais, M., Munir, O. K., Flower, S., Williams, R. J., James, T. & Van Den Elsen, J., 14 Nov 2018, Electrophoretic Separation of Proteins: Methods and Protocols. T. Kurien, B. & Hal Scofield, R. (eds.). New York, U. S. A.: Humana Press, p. 161-175 (Methods in Molecular Biology; vol. 1855).

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunogenic compositions comprising Sbi protein and uses thereof

Van Den Elsen, J., Watts, A. & Marchbank, K. J., 31 May 2018, Patent No. PCT/EP2017/080321, 31 May 2018

Research output: Patent

The rational design of affinity attenuated OmCI for the purification of Complement C5

Macpherson, A., Liu, X., Dedi, N., Kennedy, J., Carrington, B., Durrant, O., Heywood, S., van den Elsen, J. & Lawson, A. D. G., 7 Sep 2018, In : The Journal of biological chemistry. 293, 36, p. 14112-14121 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
52 Downloads (Pure)

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In : European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
22 Downloads (Pure)
2017

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J., 23 Feb 2017, In : Scientific Reports. 7, p. 1-12 12 p., 42874.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Thermal stability, storage and release of proteins with tailored fit in silica

Chen, Y-C., Smith, T., Hicks, R. H., Doekhie, A., Koumanov, F., Wells, S. A., Edler, K. J., van den Elsen, J., Holman, G. D., Marchbank, K. J. & Sartbaeva, A., 24 Apr 2017, In : Scientific Reports. 7, p. 1-8 8 p., 46568.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

University of Bath licences glycation detection kit

Van Den Elsen, J. & James, T., 21 Jul 2017, Bath UK : University of Bath.

Research output: Other contribution

Open Access

Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate

Back, C., Yang, Y., Wahid, A., Walters, R., Paulin, J., Graewert, M., Svergun, D., Marchbank, K. & Van Den Elsen, J., Sep 2017, p. 199.

Research output: Contribution to conferencePaper

2016

The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO-ubiquitin interactions

Catici, D. A. M., Amos, H. E., Yang, Y., van den Elsen, J. M. H. & Pudney, C. R., 20 Jun 2016, In : FEBS Journal. 283, 12, p. 2272-2284

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
144 Downloads (Pure)
2015

From insect to man: Photorhabdus sheds light on the emergence of human pathogenicity

Mulley, G., Beeton, M. L., Wilkinson, P., Vlisidou, I., Ockendon-Powell, N., Hapeshi, A., Tobias, N. J., Nollmann, F. I., Bode, H. B., Van Den Elsen, J., Ffrench-Constant, R. H. & Waterfield, N. R., 1 Dec 2015, In : PLoS ONE. 10, 12, e0144937.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Glycation alters ligand binding, enzymatic, and pharmacological properties of human albumin

Baraka-Vidot, J., Planesse, C., Meilhac, O., Militello, V., Van Den Elsen, J., Bourdon, E. & Rondeau, P., 19 May 2015, In : Biochemistry. 54, 19, p. 3051-3062 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2014
Open Access
28 Citations (Scopus)
64 Downloads (Pure)

Materials and methods for analysing glycation

Flower, S., James, T., Van Den Elsen, J. & Pereira, M., 25 Sep 2014, IPC No. C07B57/00; G01N27/447; G01N33/58; G01N33/68;, Patent No. US 2016/282355 A1 (WO2014147395 (A1)) EP2976313A1;, 19 Mar 2014, Priority date 20 Mar 2013, Priority No. 1305114.9

Research output: Patent

Open Access

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., 1 May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
80 Citations (Scopus)
59 Downloads (Pure)

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex

Marrott, N., Marshall, J. J. T., Svergun, DI., Crennell, S., Hough, D. W., Van Den Elsen, J. & Danson, M., 1 Nov 2014, In : Biochemical Journal. 463, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
132 Downloads (Pure)
2013

Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis

Pereira Morais, M. P., Marshall, D., Flower, S. E., Caunt, C. J., James, T. D., Williams, R. J., Waterfield, N. R. & Van Den Elsen, J. M. H., 27 Mar 2013, In : Scientific Reports. 3, p. 1-7 7 p., 1437.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Exploiting the reversible covalent bonding of boronic acids: Recognition, sensing, and assembly

Bull, S. D., Davidson, M. G., Van Den Elsen, J. M. H., Fossey, J. S., Jenkins, A. T. A., Jiang, Y-B., Kubo, Y., Marken, F., Sakurai, K., Zhao, J. & James, T. D., 19 Feb 2013, In : Accounts of Chemical Research. 46, 2, p. 312-326 15 p.

Research output: Contribution to journalArticle

353 Citations (Scopus)
2012

Analysis of protein glycation using phenylboronate acrylamide gel electrophoresis

Pereira Morais, M. P., Fossey, J. S., James, T. D. & van den Elsen, J., 2012, Protein Electrophoresis. Kurien, B. T. & Scofield, R. H. (eds.). 869 ed. Springer, p. 93-109 17 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Biotinylated boronic acid fluorophore conjugates: quencher elimination strategy for imaging and saccharide detection

D'Hooge, F., Elfeky, S. A., Flower, S., Pascu, S. I., Jenkins, A. T. A., van den Elsen, J., James, T. & Fossey, J., 2012, In : RSC Advances. 2, p. 3274-3280 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Coil-by-coil assembly of poly[acrylamide-co-3-(methacryl-amido)- phenylboronic acid] with polydiallyldimethyl-ammonium to give alizarin red S responsive films

Shariki, S., Cox, O. T. L., Tickell, D. A., James, T. D., Dale, S. E. C., Marken, F., Pereira Morais, M. P., Van Den Elsen, J. M. H. & Bending, S., 28 Sep 2012, In : Journal of Materials Chemistry. 22, 36, p. 18999-19006 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Priest, N. K., Rudkin, J. K., Feil, E. J., Van Den Elsen, J. M. H., Cheung, A., Peacock, S. J., Laabei, M., Lucks, D. A., Recker, M. & Massey, R. C., Nov 2012, In : Nature Reviews Microbiology. 10, 11, p. 791-797 7 p.

Research output: Contribution to journalReview article

42 Citations (Scopus)

Staphylococcus aureus Proteins Sbi and Efb Recruit Human Plasmin to Degrade Complement C3 and C3b

Koch, T. K., Reuter, M., Barthel, D., Böhm, S., Van Den Elsen, J., Kraiczy, P., Zipfel, P. F. & Skerka, C., 11 Oct 2012, In : PLoS ONE. 7, 10, e47638.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly

Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. & van den Elsen, J. M. H., Mar 2012, In : FEBS Journal. 279, 5, p. 713-723 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The development of boronic acids as sensors and separation tools

Fossey, J. S., D'Hooge, F., van den Elsen, J. M. H., Pereira Morais, M. P., Pascu, S. I., Bull, S. D., Marken, F., Jenkins, A. T. A., Jiang, Y-B. & James, T. D., Oct 2012, In : Chemical Record. 12, 5, p. 464-478

Research output: Contribution to journalArticle

53 Citations (Scopus)
2011

A crystal structure of the complex between human complement receptor 2 and its ligand C3d

van den Elsen, J. M. H. & Isenman, D. E., 29 Apr 2011, In : Science. 332, 6029, p. 608-611 4 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
11 Citations (Scopus)
2010

Analysis of protein glycation using phenylboronate acrylamide gel electrophoresis

Pereira Morais, M. P., Mackay, J. D., Bhamra, S. K., Buchanan, J. G., James, T. D., Fossey, J. S. & van den Elsen, J. M. H., 1 Jan 2010, In : Proteomics. 10, 1, p. 48-58 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance

Jones, R. T., Bakker, S. E., Stone, D., Shuttleworth, S. N., Bounds, S., McCart, C., Daborn, P. J., Ffrench-Constant, R. H. & van den Elsen, J. M. H., Oct 2010, In : Pest Management Science. 66, 10, p. 1106-1115 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
32 Citations (Scopus)

The interaction of serum albumin with cholesterol containing lipid vesicles

Meierhofer, T., van den Elsen, J. M. H., Cameron, P. J., Munoz-Berbel, X. & Jenkins, A. T. A., Jan 2010, In : Journal of Fluorescence. 20, 1, p. 371-376 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2009

A surface plasmon enhanced fluorescence sensor platform

Elfeky, S. A., D'Hooge, F., Poncel, L., Chen, W. B., Perera, S. P., van den Elsen, J. M. H., James, T. D., Jenkins, A. T. A., Cameron, P. J. & Fossey, J. S., 2009, In : New Journal of Chemistry. 33, 7, p. 1466-1469 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Dye displacement assay for saccharide detection with boronate hydrogels

Ma, W. M. J., Pereira Morais, M. P., D'Hooge, F., van den Elsen, J. M. H., Cox, J. P. L., James, T. D. & Fossey, J. S., 7 Feb 2009, In : Chemical Communications. 2009, 5, p. 532-534 3 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

IsaB, a new immunoglobulin-binding protein from Staphylococcus aureus

Clark, E., Upadhyay, A., Bagby, S. & van den Elsen, J., 2009, In : Molecular Immunology. 46, 14, p. 2834-2835 2 p.

Research output: Contribution to journalArticle

2008

Boronate affinity saccharide electrophoresis: A novel carbohydrate analysis tool

Jackson, T. R., Springall, J. S., Rogalle, D., Masurnoto, N., Li, H. C., D'Hooge, F., Perera, S. P., Jenkins, A. T. A., James, T. D., Fossey, J. S. & van den Elsen, J. M. H., 2008, In : Electrophoresis. 29, 20, p. 4185-4191 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus

Burman, J. D., Leung, E., Atkins, K. L., O'Seaghdha, M. N., Lango, L., Bernado, P., Bagby, S., Svergun, D. I., Foster, T. J., Isenman, D. E. & van den Elsen, J. M. H., 20 Jun 2008, In : Journal of Biological Chemistry. 283, 25, p. 17579-17593 15 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Polymerisation resistant synthesis of methacrylamido phenylboronic acids

D'Hooge, F., Rogalle, D., Thatcher, M. J., Perera, S., van den Elsen, J. M. H., Jenkins, T. A., James, T. & Fossey, J., 28 Jul 2008, In : Polymer. 49, 16, p. 3362-3365 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation

Atkins, K. L., Burman, J. D., Chamberlain, E. S., Cooper, J. E., Poutrel, B., Bagby, S., Jenkins, T. A., Feil, E. J. & van den Elsen, J. M. H., Mar 2008, In : Molecular Immunology. 45, 6, p. 1600-1611 12 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi

Upadhyay, A., Burman, J. D., Clark, E. A., Leung, E., Isenman, D. E., van den Elsen, J. M. H. & Bagby, S., 8 Aug 2008, In : Journal of Biological Chemistry. 283, 32, p. 22113-22120 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Structure–function analysis of the novel Staphylococcus aureus immune subversion protein Sbi

van den Elsen, J., Upadhyay, A., Burman, J., Leung, E., Clark, E., Isenman, D. & Bagby, S., 2008, In : Molecular Immunology. 45, 16, p. 4119 1 p., P71.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b

Haupt, K., Reuter, M., van den Elsen, J. M. H., Burman, J., Halbich, S., Richter, J., Skerka, C. & Zipfel, P. F., 2008, In : PLoS Pathogens. 4, 12, e1000250.

Research output: Contribution to journalArticle

File
92 Citations (Scopus)
117 Downloads (Pure)
2007

Novel applications for staphylococcus aureus SBI protein

Van Den Elsen, J., 6 Dec 2007, IPC No. A61K38/00, Patent No. W02007138328(A2), 31 May 2007, Priority date 31 May 2006, Priority No. 0610776.7

Research output: Patent

2005

Evolution of the genetic triplet code via two types of doublet codons

Wu, H-L., Bagby, S. & van den Elsen, J., 2005, In : Journal of Molecular Evolution. 61, 1, p. 54-64

Research output: Contribution to journalArticle

26 Citations (Scopus)

The structures of human complement fragments C3d and C4Ad and the functional insights that they have provided

Isenman, D. E. & Van Den Elsen, J., 2005, Structural Biology of the Complement System.. Morikis, D. & Lambris, J. D. (eds.). Boca Raton, FL, USA: Taylor and Francis, p. 111-142

Research output: Chapter in Book/Report/Conference proceedingChapter