1988 …2019

Research output per year

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Article
2019

Amyloid peptide β 1-42 induces integrin α IIb β 3 activation, platelet adhesion, and thrombus formation in a NADPH Oxidase-Dependent Manner

Abubaker, A. A., Vara, D., Visconte, C., Eggleston, I., Torti, M., Canobbio, I. & Pula, G., 14 Mar 2019, In : Oxidative Medicine and Cellular Longevity. 2019, p. 1-12 12 p., 1050476.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Development of a peptide-based fluorescent probe for biological heme monitoring

Newton, L. D., Pascu, S. I., Tyrrell, R. M. & Eggleston, I. M., 21 Jan 2019, In : Organic and Biomolecular Chemistry. 17, 3, p. 467-471 5 p.

Research output: Contribution to journalArticle

Open Access
2018

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Codelivery of a cytotoxin and photosensitiser Via a liposomal nanocarrier: A novel strategy for light-triggered cytosolic release

Yaghini, E., Dondi, R., Edler, K. J., Loizidou, M., Macrobert, A. J. & Eggleston, I. M., 21 Nov 2018, In : Nanoscale. 10, 43, p. 20366-20376 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
4 Citations (Scopus)
2017
1 Citation (Scopus)

Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

Yaghini, E., Dondi, R., Tewari, K. M., Loizidou, M., Eggleston, I. M. & MacRobert, A. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 6059.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2015

A fluorescent Arg–Gly–Asp (RGD) peptide–naphthalenediimide (NDI) conjugate for imaging integrin αvβ3in vitro

Hu, Z., Arrowsmith, R. L., Tyson, J. A., Mirabello, V., Ge, H., Eggleston, I. M., Botchway, S. W., Pantos, D. & Pascu, S. I., 25 Apr 2015, In : Chemical Communications. 51, 32, p. 6901-6904 4 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
139 Downloads (Pure)

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation

Taverner, A., Dondi, R., Almansour, K., Laurent, F., Owens, S-E., Eggleston, I. M., Fotaki, N. & Mrsny, R. J., 28 Jul 2015, In : Journal of Controlled Release. 210, p. 189-197 9 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
43 Downloads (Pure)

The use of dipeptide derivatives of 5-aminolaevulinic acid promotes their entry to tumor cells and improves tumor selectivity of photodynamic therapy

Di Venosa, G., Vallecorsa, P., Giuntini, F., Mamone, L., Batlle, A., Vanzuli, S., Juarranz, A., MacRobert, A. J., Eggleston, I. M. & Casas, A., 1 Feb 2015, In : Molecular Cancer Therapeutics. 14, 2, p. 440-451 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Fluorescence lifetime imaging and FRET-induced intracellular redistribution of tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser

Yaghini, E., Giuntini, F., Eggleston, I. M., Suhling, K., Seifalian, A. M. & MacRobert, A. J., 26 Feb 2014, In : Small. 10, 4, p. 782-792 11 p.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)
2013

A comparative study of the antiprolifrative activity of thiosemicarbazone iron chelators in skin cells

Reelfs, O., Young, B., Aroun, A., Hoffmann, M., Miri, S. A., Richardson, D. R., Eggleston, I. & Pourzand, C., Apr 2013, In : American Journal of Hematology. 88, 5, p. E170-E170

Research output: Contribution to journalArticle

Open Access
File
33 Downloads (Pure)
2012

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

Schimpl, M., Rush, C., Betou, M., Eggleston, I. M., Recklies, A. & Van aalten, D. F., 15 Aug 2012, In : Biochemical Journal. 446, 1, p. 149-157

Research output: Contribution to journalArticle

37 Citations (Scopus)

Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate

Wang, J. T. -W., Giuntini, F., Eggleston, I. M., Bown, S. G. & MacRobert, A. J., 30 Jan 2012, In : Journal of Controlled Release. 157, 2, p. 305-313 9 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
118 Downloads (Pure)
2011

Analyzing airway inflammation with chemical biology: Dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E., 27 May 2011, In : Chemistry & Biology. 18, 5, p. 569-579 11 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
131 Downloads (Pure)

Bisdionin C-A Rationally Designed, Submicromolar Inhibitor of Family 18 Chitinases

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M. B., Rush, C., Eggleston, I. & van Aalten, D. M. F., 2011, In : ACS Medicinal Chemistry Letters. 2, 6, p. 428 432 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Fluorescent copper(II), gallium(III) and indium(III) bis(thiosemicarbazonates): Radiolabeling, cellular confocal fluorescence and PET imaging studies

Arrowsmith, R. L., Zeglis, B. M., Viola-Villegas, N., Divilov, V., Jones, M., Waghorn, P. A., Phillips, F. L., Mindt, T. L., Eggleston, I. M., Botchway, S. W., Dilworth, J. R., Aigbirhio, F. I., Lewis, J. S. & Pascu, S. I., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S59

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway

Webb, C., Upadhyay, A., Giuntini, F., Eggleston, I., Furutani-Seiki, M., Ishima, R. & Bagby, S., 26 Apr 2011, In : Biochemistry. 50, 16, p. 3300-3309 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2010

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Bourre, L., Giuntini, F., Eggleston, I. M., Mosse, C. A., MacRobert, A. J. & Wilson, M., 2010, In : Photochemical & Photobiological Sciences. 9, 12, p. 1613-1620 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor

Rush, C. L., Schuttelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F., 22 Dec 2010, In : Chemistry & Biology. 17, 12, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs

Reelfs, O., Eggleston, I. M. & Pourzand, C., Mar 2010, In : Current Drug Metabolism. 11, 3, p. 242-249 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2009

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxicα,β-unsaturated aldehyde acrolein

Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D., 2009, In : Carcinogenesis. 30, 10, p. 1754-1762 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
29 Citations (Scopus)

Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. & MacRobert, A. J., 2009, In : British Journal of Cancer. 100, 5, p. 723-731 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 21 Jan 2009, In : Organic and Biomolecular Chemistry. 7, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. & Hayes, J. D., 15 Jun 2009, In : Toxicology and Applied Pharmacology. 237, 3, p. 267-280 14 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)
2008

5-aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. & MacRobert, A. J., 2008, In : Molecular Cancer Therapeutics. 7, 6, p. 1720-1729 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

A novel approach to improve cellular delivery of 5-aminolaevulinic acid: New ALA-containing peptide prodrugs for photodynamic therapy

Giuntini, F., Bourre, L., Wilson, M., MacRobert, A. J. & Eggleston, I. M., Aug 2008, In : Journal of Peptide Science. 14, 8 (Suppl S), p. 156-156 1 p.

Research output: Contribution to journalArticle

Convenient preparation of N-maleoyl amino acid succinimido esters using N-trifluoroacetoxysuccinimide

Paterson, M. J. & Eggleston, I. M., 2008, In : Synthetic Communications. 38, 2, p. 303-308 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence

Giuntini, F., Bourre, L., MacRobert, A. J., Wilson, M. & Eggleston, I. M., 15 Nov 2008, In : Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 875, 2, p. 562-566 5 p.

Research output: Contribution to journalArticle

Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F., 21 Mar 2008, In : Chemistry & Biology. 15, 3, p. 295-301 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Synthesis of cyclic peptide chitinase inhibitors: Natural products,with chemotherapeutic potential

Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. M., 2008, In : Journal of Peptide Science. 14, 8 (Suppl S), p. 13-13 1 p.

Research output: Contribution to journalArticle

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

Hayes, J. D., Kelleher, M. O. & Eggleston, I. M., 2008, In : European Journal of Nutrition. 47, p. 73-88 16 p.

Research output: Contribution to journalArticle

267 Citations (Scopus)
2007

Cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Nathubhai, A. & Eggleston, I. M., 2007, In : Biopolymers. 88, p. 576-576 1 p.

Research output: Contribution to journalArticle

Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

Allwood, M. B., Cannan, B., van Aalten, D. M. F. & Eggleston, I. M., 2007, In : Tetrahedron. 63, p. 12294-12302 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

Dixon, M. J., Bourre, L., MacRobert, A. J. & Eggleston, I. M., 2007, In : Bioorganic & Medicinal Chemistry Letters. 17, 16, p. 4518-4522 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2006

First synthesis of argadin: A nanomolar inhibitor of family-18 chitinases

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2006, In : European Journal of Organic Chemistry. 22, p. 5002-5006 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Oriented immobilisation of engineered single-chain antibodies to develop biosensors for virus detection

Torrance, L., Ziegler, A., Pittman, H., Paterson, M., Toth, R. & Eggleston, I. M., 2006, In : Journal of Virological Methods. 134, p. 164-170 7 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, C., Lloyd, C. & Eggleston, I. M., 2006, In : Journal of Biological Chemistry. 281, 37, p. 27278-27285 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Specificity of the trypanothione-dependent Leishmania major glyoxalase 1: structure and biochemical comparison with the human enzyme

Ariza, A., Vickers, T. J., Greig, N., Armour, K. A., Dixon, M. J., Eggleston, I. M., Fairlamb, A. H. & Bond, C. S., 2006, In : Molecular Microbiology. 59, 4, p. 1239-1248 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. & van Aalten, D. M. F., 2006, In : EMBO Journal. 25, 1569, p. 1578 1 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)

Time-dependent inhibitors of trypanothione reductase. Analogues of the spermidine alkaloid lunarine and related natural products

Hamilton, C. J., Saravanamuthu, A., Poupat, C., Fairlamb, A. H. & Eggleston, I. M., 2006, In : Bioorganic and Medicinal Chemistry. 14, p. 2266-2278 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2005

An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

Rogers, L. M. A., McGivern, P. G., Butler, A. R., MacRobert, A. J. & Eggleston, I. M., 2005, In : Tetrahedron. 61, p. 6951-6958 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2005, In : Bioorganic & Medicinal Chemistry Letters. 15, 21, p. 4717-4721 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Natural product family 18 chitinase inhibitors

Andersen, O. A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F., 2005, In : Natural Product Reports. 22, p. 563-579 17 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2004

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F., 2004, In : Journal of Medicinal Chemistry. 47, p. 5713-5720 8 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Very short and efficient syntheses of the spermine alkaloid kukoamine A and analogs using isolable succinimidyl cinnamates

Garnelis, T., Athanassopoulos, C. M., Papaioannou, D., Eggleston, I. M. & Fairlamb, A. H., 2004, In : Chemistry Letters. 34, 2, p. 264-265 2 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2003

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

Hamilton, C. J., Saravanamuthu, A., Fairlamb, A. H. & Eggleston, I. M., 2003, In : Bioorganic and Medicinal Chemistry. 11, p. 3683-3693 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Ellman's reagent-mediated regeneration of trypanothione in situ: substrate economoic microplate and time-dependent inhibition assays for trypanothione reductase

Hamilton, C. J., Saravanamuthu, A., Eggleston, I. M. & Fairlamb, A. H., 2003, In : Biochemical Journal. 369, p. 529-537 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2002
27 Citations (Scopus)