• 5 WEST 3.08

Accepting PhD Students

1988 …2019
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Research Output 1988 2019

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Article
2019

Amyloid peptide β 1-42 induces integrin α IIb β 3 activation, platelet adhesion, and thrombus formation in a NADPH Oxidase-Dependent Manner

Abubaker, A. A., Vara, D., Visconte, C., Eggleston, I., Torti, M., Canobbio, I. & Pula, G., 14 Mar 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 12 p., 1050476.

Research output: Contribution to journalArticle

Open Access

Development of a peptide-based fluorescent probe for biological heme monitoring

Newton, L. D., Pascu, S. I., Tyrrell, R. M. & Eggleston, I. M., 21 Jan 2019, In : Organic and Biomolecular Chemistry. 17, 3, p. 467-471 5 p.

Research output: Contribution to journalArticle

Open Access
2018
1 Citation (Scopus)

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

Claudin-2
Dextrans
Permeability
Myosin Light Chains
Peptides

Codelivery of a cytotoxin and photosensitiser: Via a liposomal nanocarrier: A novel strategy for light-triggered cytosolic release

Yaghini, E., Dondi, R., Edler, K. J., Loizidou, M., Macrobert, A. J. & Eggleston, I. M., 21 Nov 2018, In : Nanoscale. 10, 43, p. 20366-20376 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Myosin Light Chains
Intestinal Mucosa
Phosphorylation
Tight Junctions
Peptides
2017
NADPH Oxidase
Amyloid beta-Peptides
Superoxides
Oxidation-Reduction
Flow Cytometry
6 Citations (Scopus)

Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

Yaghini, E., Dondi, R., Tewari, K. M., Loizidou, M., Eggleston, I. M. & MacRobert, A. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 6059.

Research output: Contribution to journalArticle

Open Access
Medical nanotechnology
Photosensitizing Agents
Photodynamic therapy
Membranes
Cell-Penetrating Peptides
2015
8 Citations (Scopus)

A fluorescent Arg–Gly–Asp (RGD) peptide–naphthalenediimide (NDI) conjugate for imaging integrin αvβ3in vitro

Hu, Z., Arrowsmith, R. L., Tyson, J. A., Mirabello, V., Ge, H., Eggleston, I. M., Botchway, S. W., Pantos, D. & Pascu, S. I., 25 Apr 2015, In : Chemical Communications. 51, 32, p. 6901-6904 4 p.

Research output: Contribution to journalArticle

Open Access
File
Integrins
Tryptophan
Peptides
Amino acids
Imaging techniques
20 Citations (Scopus)

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation

Taverner, A., Dondi, R., Almansour, K., Laurent, F., Owens, S-E., Eggleston, I. M., Fotaki, N. & Mrsny, R. J., 28 Jul 2015, In : Journal of Controlled Release. 210, p. 189-197

Research output: Contribution to journalArticle

Open Access
File
Myosin Light Chains
Phosphoric Monoester Hydrolases
Phosphorylation
Insulin
Peptides
5 Citations (Scopus)

The use of dipeptide derivatives of 5-aminolaevulinic acid promotes their entry to tumor cells and improves tumor selectivity of photodynamic therapy

Di Venosa, G., Vallecorsa, P., Giuntini, F., Mamone, L., Batlle, A., Vanzuli, S., Juarranz, A., MacRobert, A. J., Eggleston, I. M. & Casas, A., 1 Feb 2015, In : Molecular Cancer Therapeutics. 14, 2, p. 440-451 12 p.

Research output: Contribution to journalArticle

Aminolevulinic Acid
Dipeptides
Photochemotherapy
Neoplasms
Prodrugs
2014
30 Citations (Scopus)

Fluorescence lifetime imaging and FRET-induced intracellular redistribution of tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser

Yaghini, E., Giuntini, F., Eggleston, I. M., Suhling, K., Seifalian, A. M. & MacRobert, A. J., 26 Feb 2014, In : Small. 10, 4, p. 782-792 11 p.

Research output: Contribution to journalArticle

Quantum Dots
Photosensitizing Agents
Photosensitizers
Optical Imaging
Energy Transfer
2013

A comparative study of the antiprolifrative activity of thiosemicarbazone iron chelators in skin cells

Reelfs, O., Young, B., Aroun, A., Hoffmann, M., Miri, S. A., Richardson, D. R., Eggleston, I. & Pourzand, C., Apr 2013, In : American Journal of Hematology. 88, 5, p. E170-E170

Research output: Contribution to journalArticle

Open Access
File
2012
31 Citations (Scopus)

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

Schimpl, M., Rush, C., Betou, M., Eggleston, I. M., Recklies, A. & Van aalten, D. F., 15 Aug 2012, In : Biochemical Journal. 446, 1, p. 149-157

Research output: Contribution to journalArticle

Chitinases
Catalytic Domain
oligochitosan
Acetylglucosamine
Human Genome
30 Citations (Scopus)

Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate

Wang, J. T. -W., Giuntini, F., Eggleston, I. M., Bown, S. G. & MacRobert, A. J., 30 Jan 2012, In : Journal of Controlled Release. 157, 2, p. 305-313 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cell-Penetrating Peptides
Photosensitizing Agents
Porphyrins
Proteins
Fluorescence
2011
29 Citations (Scopus)

Analyzing airway inflammation with chemical biology: Dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E., 27 May 2011, In : Chemistry & Biology. 18, 5, p. 569-579 11 p.

Research output: Contribution to journalArticle

Open Access
File
Dissection
Chitinases
Inflammation
Pharmaceutical Preparations
Scaffolds
8 Citations (Scopus)

Bisdionin C-A Rationally Designed, Submicromolar Inhibitor of Family 18 Chitinases

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M. B., Rush, C., Eggleston, I. & van Aalten, D. M. F., 2011, In : ACS Medicinal Chemistry Letters. 2, 6, p. 428 432 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Fluorescent copper(II), gallium(III) and indium(III) bis(thiosemicarbazonates): Radiolabeling, cellular confocal fluorescence and PET imaging studies

Arrowsmith, R. L., Zeglis, B. M., Viola-Villegas, N., Divilov, V., Jones, M., Waghorn, P. A., Phillips, F. L., Mindt, T. L., Eggleston, I. M., Botchway, S. W., Dilworth, J. R., Aigbirhio, F. I., Lewis, J. S. & Pascu, S. I., Sep 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, Supplement 1, p. S59

Research output: Contribution to journalArticle

39 Citations (Scopus)

Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway

Webb, C., Upadhyay, A., Giuntini, F., Eggleston, I., Furutani-Seiki, M., Ishima, R. & Bagby, S., 26 Apr 2011, In : Biochemistry. 50, 16, p. 3300-3309 10 p.

Research output: Contribution to journalArticle

Protein Isoforms
Ligands
Peptides
Protein Interaction Domains and Motifs
Proteins
2010
37 Citations (Scopus)

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Bourre, L., Giuntini, F., Eggleston, I. M., Mosse, C. A., MacRobert, A. J. & Wilson, M., 2010, In : Photochemical & Photobiological Sciences. 9, 12, p. 1613-1620 8 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
human immunodeficiency virus
Porphyrins
porphyrins
peptides
21 Citations (Scopus)

Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor

Rush, C. L., Schuttelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F., 22 Dec 2010, In : Chemistry & Biology. 17, 12, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

Chitinases
Biological Products
Aspergillus fumigatus
Machinery
Chitin
17 Citations (Scopus)

Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs

Reelfs, O., Eggleston, I. M. & Pourzand, C., Mar 2010, In : Current Drug Metabolism. 11, 3, p. 242-249 8 p.

Research output: Contribution to journalArticle

Prodrugs
Chelation
Skin
Iron
Pharmaceutical Preparations
2009
25 Citations (Scopus)

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxicα,β-unsaturated aldehyde acrolein

Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D., 2009, In : Carcinogenesis. 30, 10, p. 1754-1762 9 p.

Research output: Contribution to journalArticle

Acrolein
Aldehydes
NF-E2-Related Factor 2
Genes
Fibroblasts
27 Citations (Scopus)
Prodrugs
Peptides
Dipeptides
Aminolevulinic Acid
Caco-2 Cells
13 Citations (Scopus)

Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. & MacRobert, A. J., 2009, In : British Journal of Cancer. 100, 5, p. 723-731 9 p.

Research output: Contribution to journalArticle

Aminolevulinic Acid
RNA Interference
Porphyrins
Peptides
prolyl oligopeptidase
27 Citations (Scopus)

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 21 Jan 2009, In : Organic and Biomolecular Chemistry. 7, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

Chitinases
Cyclic Peptides
Solid-Phase Synthesis Techniques
Biological Products
Scaffolds
102 Citations (Scopus)

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. & Hayes, J. D., 15 Jun 2009, In : Toxicology and Applied Pharmacology. 237, 3, p. 267-280 14 p.

Research output: Contribution to journalArticle

Peroxides
Fibroblasts
Oxidation-Reduction
Transcription Factors
Glutathione
2008
31 Citations (Scopus)

5-aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. & MacRobert, A. J., 2008, In : Molecular Cancer Therapeutics. 7, 6, p. 1720-1729 10 p.

Research output: Contribution to journalArticle

Photosensitivity Disorders
Aminolevulinic Acid
Photochemotherapy
Prodrugs
Peptides

A novel approach to improve cellular delivery of 5-aminolaevulinic acid: New ALA-containing peptide prodrugs for photodynamic therapy

Giuntini, F., Bourre, L., Wilson, M., MacRobert, A. J. & Eggleston, I. M., Aug 2008, In : Journal of Peptide Science. 14, 8 (Suppl S), p. 156-156 1 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Convenient preparation of N-maleoyl amino acid succinimido esters using N-trifluoroacetoxysuccinimide

Paterson, M. J. & Eggleston, I. M., 2008, In : Synthetic Communications. 38, 2, p. 303-308 6 p.

Research output: Contribution to journalArticle

Cyclization
Esterification
Esters
Derivatives
Amino Acids

Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence

Giuntini, F., Bourre, L., MacRobert, A. J., Wilson, M. & Eggleston, I. M., 15 Nov 2008, In : Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 875, 2, p. 562-566 5 p.

Research output: Contribution to journalArticle

Aminolevulinic Acid
Esters
Fluorescence
Prodrugs
Formaldehyde
43 Citations (Scopus)

Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F., 21 Mar 2008, In : Chemistry & Biology. 15, 3, p. 295-301 7 p.

Research output: Contribution to journalArticle

Dissection
Chitinases
Biological Products
Peptides
Anti-Asthmatic Agents

Synthesis of cyclic peptide chitinase inhibitors: Natural products,with chemotherapeutic potential

Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. M., 2008, In : Journal of Peptide Science. 14, 8 (Suppl S), p. 13-13 1 p.

Research output: Contribution to journalArticle

252 Citations (Scopus)

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

Hayes, J. D., Kelleher, M. O. & Eggleston, I. M., 2008, In : European Journal of Nutrition. 47, p. 73-88 16 p.

Research output: Contribution to journalArticle

Isothiocyanates
Glucosinolates
Indoles
Phytochemicals
NF-E2-Related Factor 2
2007

Cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Nathubhai, A. & Eggleston, I. M., 2007, In : Biopolymers. 88, p. 576-576 1 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

Allwood, M. B., Cannan, B., van Aalten, D. M. F. & Eggleston, I. M., 2007, In : Tetrahedron. 63, p. 12294-12302 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

Dixon, M. J., Bourre, L., MacRobert, A. J. & Eggleston, I. M., 2007, In : Bioorganic & Medicinal Chemistry Letters. 17, 16, p. 4518-4522 5 p.

Research output: Contribution to journalArticle

Aminolevulinic Acid
Solid-Phase Synthesis Techniques
Photodynamic therapy
Photochemotherapy
Prodrugs
2006
14 Citations (Scopus)

First synthesis of argadin: A nanomolar inhibitor of family-18 chitinases

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2006, In : European Journal of Organic Chemistry. 22, p. 5002-5006 5 p.

Research output: Contribution to journalArticle

Chitinases
inhibitors
peptides
Aspergillus
histidine
70 Citations (Scopus)

Oriented immobilisation of engineered single-chain antibodies to develop biosensors for virus detection

Torrance, L., Ziegler, A., Pittman, H., Paterson, M., Toth, R. & Eggleston, I. M., 2006, In : Journal of Virological Methods. 134, p. 164-170 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, C., Lloyd, C. & Eggleston, I. M., 2006, In : Journal of Biological Chemistry. 281, 37, p. 27278-27285 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Specificity of the trypanothione-dependent Leishmania major glyoxalase 1: structure and biochemical comparison with the human enzyme

Ariza, A., Vickers, T. J., Greig, N., Armour, K. A., Dixon, M. J., Eggleston, I. M., Fairlamb, A. H. & Bond, C. S., 2006, In : Molecular Microbiology. 59, 4, p. 1239-1248 10 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. & van Aalten, D. M. F., 2006, In : EMBO Journal. 25, 1569, p. 1578 1 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Time-dependent inhibitors of trypanothione reductase. Analogues of the spermidine alkaloid lunarine and related natural products

Hamilton, C. J., Saravanamuthu, A., Poupat, C., Fairlamb, A. H. & Eggleston, I. M., 2006, In : Bioorganic and Medicinal Chemistry. 14, p. 2266-2278 13 p.

Research output: Contribution to journalArticle

Spermidine
Biological Products
Alkaloids
Enantiomers
Scaffolds
2005
14 Citations (Scopus)

An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

Rogers, L. M. A., McGivern, P. G., Butler, A. R., MacRobert, A. J. & Eggleston, I. M., 2005, In : Tetrahedron. 61, p. 6951-6958 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2005, In : Bioorganic & Medicinal Chemistry Letters. 15, 21, p. 4717-4721 5 p.

Research output: Contribution to journalArticle

Chitinases
Biological Products
Aspergillus fumigatus
Aspergillus
X-Rays
59 Citations (Scopus)

Natural product family 18 chitinase inhibitors

Andersen, O. A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F., 2005, In : Natural Product Reports. 22, p. 563-579 17 p.

Research output: Contribution to journalArticle

2004
112 Citations (Scopus)

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F., 2004, In : Journal of Medicinal Chemistry. 47, p. 5713-5720 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Very short and efficient syntheses of the spermine alkaloid kukoamine A and analogs using isolable succinimidyl cinnamates

Garnelis, T., Athanassopoulos, C. M., Papaioannou, D., Eggleston, I. M. & Fairlamb, A. H., 2004, In : Chemistry Letters. 34, 2, p. 264-265 2 p.

Research output: Contribution to journalArticle

2003
26 Citations (Scopus)

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

Hamilton, C. J., Saravanamuthu, A., Fairlamb, A. H. & Eggleston, I. M., 2003, In : Bioorganic and Medicinal Chemistry. 11, p. 3683-3693 11 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Ellman's reagent-mediated regeneration of trypanothione in situ: substrate economoic microplate and time-dependent inhibition assays for trypanothione reductase

Hamilton, C. J., Saravanamuthu, A., Eggleston, I. M. & Fairlamb, A. H., 2003, In : Biochemical Journal. 369, p. 529-537 9 p.

Research output: Contribution to journalArticle

2002
27 Citations (Scopus)