• 5 WEST 3.08

Accepting PhD Students

1988 …2018
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Personal profile

Research interests

 

Synthesis of biologically active and functional peptide derivatives

We work on a range of projects involving both solution and solid phase peptide synthesis and the preparation of novel amino acid derivatives and peptidomimetics. This includes the synthesis of cyclic peptide natural products, novel peptides that can enhance the oral bioavailability of peptide therapeutics (collaboration with Prof. Randy Mrsny) and the development of peptide-based sensors for the measurement of intracellular heme levels (collaboration with Profs Sofia Pascu and Rex Tyrrell).

 

Peptide-targeted agents for photodynamic therapy and drug delivery

Photodynamic therapy (PDT) is a clinically approved approach for the treatment of various forms of cancer and pre-cancerous conditions.   PDT uses light to destroy abnormal or diseased tissue after the administration of a light-activated photosensitising drug (a photosensitiser).  In collaboration with Prof. Sandy MacRobert (University College London),   we are interested in using peptide chemistry to tailor the properties of photosensitisers to enhance their cellular uptake, control their sub-cellular localisation, or provide selective targeting, both for PDT and light-triggered drug delivery via photochemical internalisation (PCI). We are also working on peptide-based prodrugs of 5-aminolevulinic acid (ALA), which is a precursor of the natural porphyrin photosensitiser, protoporphyrin IX (PpIX), and is already widely used for clinical PDT.

 

Caged iron chelators as light-activated therapeutic agents

Exposure to UVA radiation from the sun is the principle risk factor associated with the onset of skin cancer. This can generate harmful free radicals and increased levels of redox-active labile iron that can induce severe damage to the skin. In collaboration with Dr Charareh Pourzand,  we are developing novel Caged Iron Chelators (CICs) which are iron-trapping compounds that only become active in human skin cells when exposed to physiologically relevant doses of UVA. CICs could thus complement and enhance the protection afforded by current UV blocking agents in sunscreens and daily-use skincare products. They also have potential for the targeted therapy of various iron-dependent disorders, including cancer.

 

Willing to supervise PhD

I am happy to discuss PhD projects in medicinal chemistry and peptide chemistry

Keywords

  • organic synthesis, peptide chemistry, medicinal chemistry, PDT

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Chitinases Chemical Compounds
Peptides Medicine & Life Sciences
Biological Products Chemical Compounds
Cyclic Peptides Chemical Compounds
Aminolevulinic Acid Medicine & Life Sciences
Photosensitizing Agents Chemical Compounds
Photochemotherapy Medicine & Life Sciences
Prodrugs Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2018

Iron chelation and skin ageing

Eggleston, I., Pourzand, C. & Gunn, D.

Project: Research councilIndividual grant

photostability
chelating agents
skin (animal)
metals
iron

Light-activated caged iron chelators for the therapy of age-related macular degeneration

Eggleston, I. & Pourzand, C.

1/06/1530/11/15

Project: Research councilInternally Funded Research

UVA-induced iron release and sunscreen protection

Eggleston, I. & Pourzand, C.

2/02/1531/07/15

Project: Research councilInternally Funded Research

Research Output 1988 2018

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour, K., Taverner, A., Turner, J., Eggleston, I. & Mrsny, R., 28 Oct 2018, In : Journal of Controlled Release. 288, p. 111-125 15 p.

Research output: Contribution to journalArticle

Claudin-2
Dextrans
Permeability
Myosin Light Chains
Peptides

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

Tewari, K. M. & Eggleston, I. M., 8 Oct 2018, In : Photochemical and Photobiological Sciences. 17, 11, p. 1553-1572 20 p.

Research output: Contribution to journalReview article

Open Access

Codelivery of a cytotoxin and photosensitiser: Via a liposomal nanocarrier: A novel strategy for light-triggered cytosolic release

Yaghini, E., Dondi, R., Edler, K. J., Loizidou, M., Macrobert, A. J. & Eggleston, I. M., 8 Nov 2018, In : Nanoscale. 10, 43, p. 20366-20376 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citations
Myosin Light Chains
Intestinal Mucosa
Phosphorylation
Tight Junctions
Peptides
NADPH Oxidase
Amyloid beta-Peptides
Superoxides
Oxidation-Reduction
Flow Cytometry

Thesis

Improving the Efficiency of Aminolevulinate-Photodynamic Therapy of Skin Cells by Combining UVA Irradiation and Potent Iron Chelating Agents

Author: Radka, T., 24 Feb 2014

Supervisor: Pourzand, C. (Supervisor) & Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation

Author: Almansour, K., 1 Sep 2017

Supervisor: Mrsny, R. (Supervisor) & Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Molecular probes for mammalian chitinases

Author: Nathubhai, A., 1 Mar 2010

Supervisor: Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

New probes for heme detection in biological systems

Author: Newton, L., 10 May 2018

Supervisor: Eggleston, I. (Supervisor), Tyrrell, R. (Supervisor) & Pascu, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

Synthesis and Biological Studies on ‘Smart’ Iron Chelator Molecules

Author: Young, B., 1 May 2013

Supervisor: Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File