• 5 WEST 3.15

19942019

Research output per year

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Research Output

2007

Chain length modulation in symmetrical lipopolyamines and the effect on nanoparticle formulations for gene delivery

Ghonaim, H. M., Li, S., Soltan, M. K., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A36-A36

Research output: Contribution to journalArticle

Design and synthesis of nitrogen heterocyclic diacyl lipospermines for gene delivery

Soltan, M. K. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A50-A50

Research output: Contribution to journalArticle

Efficient novel unsymmetrical lipopolyamine formulations for gene delivery

Ghonaim, H. M., Li, S., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A37-A37

Research output: Contribution to journalArticle

Formulation and delivery of fluorescent siRNA by lipospermine nanoparticle complex formation

Ghonaim, H. M., Li, S., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A36-A37

Research output: Contribution to journalArticle

2006
1 Citation (Scopus)

Design and synthesis of novel diacyl lipospermines

Soltan, M. K. & Blagbrough, I. S., 2006, In : Journal of Pharmacy and Pharmacology. 58, p. A57-A58

Research output: Contribution to journalArticle

Formulation and delivery of p-EGFP DNA condensed by a synthetic lipospermine

Ahmed, O. A. A. & Blagbrough, I. S., 2006, In : Journal of Pharmacy and Pharmacology. 58, p. A63-A63

Research output: Contribution to journalArticle

50 Citations (Scopus)

Lipopolyamine-mediated single nanoparticle formation of calf thymus DNA analyzed by fluorescence correlation spectroscopy

Adjimatera, N., Kral, T., Hof, M. & Blagbrough, I. S., 2006, In : Pharmaceutical Research. 23, 7, p. 1564-1573 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA

McLaggan, D., Adjimatera, N., Sepcic, K., Jaspars, M., MacEwan, D. J., Blagbrough, I. S. & Scott, R. H., 2006, In : BMC Biotechnology. 6, 6

Research output: Contribution to journalArticle

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17 Citations (Scopus)
84 Downloads (Pure)
26 Citations (Scopus)
2005

Fluorescence techniques in non-viral gene therapy

Adjimatera, N., Neal, A. P. & Blagbrough, I. S., 2005, Fluorescence Spectroscopy in Biology: Advanced Methods and their Applications to Membranes, Proteins, DNA, and Cells. Hof, M., Hutterer, R. & Fidler, V. (eds.). Heidelberg: Springer, Vol. 3. p. 201-228 28 p. (Springer Series on Fluorescence).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescent lipopolyamines: A new class of molecular probes in non-viral gene therapy

Adjimatera, N., Neal, A. P., Pourzand, C. & Blagbrough, I. S., 2005, In : Abstracts of Papers of the American Chemical Society. 229, p. U117-U117

Research output: Contribution to journalArticle

N4,N9-dioleoyl spermine is a novel nonviral lipopolyamine vector for plasmid DNA formulation

Ahmed, O. A. A., Adjimatera, N., Pourzand, C. & Blagbrough, I. S., 2005, In : Pharmaceutical Research. 22, 6, p. 972-980 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Sensing DNA nanocomplex delivery by fluorescent probes

Adjimatera, N., Neal, A. P. & Blagbrough, I. S., 2005, In : Abstracts of Papers of the American Chemical Society. 229, p. U140-U140

Research output: Contribution to journalArticle

2004

Fluorescence techniques in non-viral gene therapy: Using spermine and lipopolyamines as DNA delivery agents

Blagbrough, I. S., Adjimatera, N., Neal, A. P. & Haworth, I. S., 2004, In : Abstracts of Papers of the American Chemical Society. 227, p. U34-U34

Research output: Contribution to journalArticle

Spermine and lipopolyamines as gene delivery agents

Blagbrough, I. S., Adjimatera, N., Ahmed, O. A. A., Neal, A. P. & Pourzand, C. A., 2004, Neurotox '03: Neurotoxicological targets from Functional Genomics and Proteomics. Beadle, D. J., Mellor, I. R. & Usherwood, P. N. R. (eds.). Society of Chemical Industry, p. 147-159 13 p. (Functional Genomics and Proteomics).

Research output: Chapter in Book/Report/Conference proceedingChapter

Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy

Blagbrough, I. S., Geall, A. J. & Neal, A. P., 2003, In : Biochemical Society Transactions. 31, 2, p. 397-406 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2002

Design and synthesis of fluorescent steroidal lipopolyamine conjugates for monitoring gene delivery

Blagbrough, I. S. & Neal, A. P., 2002, Drug Discovery and Design: Medical Aspects. Matsoukas, J. & Mavromoustakos, T. (eds.). Amsterdam: IOS Press, Vol. 55. p. 64-75 12 p. (Biomedical and Health Research).

Research output: Chapter in Book/Report/Conference proceedingChapter

Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine

Delcros, J. G., Tomasi, S., Carrington, S., Martin, B., Renault, J., Blagbrough, I. S. & Uriac, P., 2002, In : Journal of Medicinal Chemistry. 45, 23, p. 5098-5111 14 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides

Geall, A. J., Al-Hadithi, D. & Blagbrough, I. S., 2002, In : Bioconjugate Chemistry. 13, p. 481-490 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2001

[3H]-methyllycaconitine: a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors

Lind, R. J., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Davies, A. R. L., Clough, M. S., Earley, F. G. P., Reynolds, S. E. & Wonnacott, S., 2001, In : Insect Biochemistry and Molecular Biology. 31, 6-7, p. 533-542

Research output: Contribution to journalArticle

22 Citations (Scopus)

Sar of bile acid polyamine conjugates in binding and condensation of DNA

Blagbrough, I. S., Geall, A. J. & Al-Hadithi, D., 2001, In : Abstracts of Papers of the American Chemical Society. 221, p. U58-U58

Research output: Contribution to journalArticle

Synthesis, DNA binding, and pK(a) studies of cholesterol-polyamine carbamates

Blagbrough, I. S., Geall, A. J., Taylor, R. J., Earll, M. E. & Eaton, M. W., 2001, In : Abstracts of Papers of the American Chemical Society. 221, p. U58-U58

Research output: Contribution to journalArticle

2000

Cheno-, urso- and deoxycholic acid spermine conjugates: Relative binding affinities for calf thymus DNA

Blagbrough, I. S., Al-Hadithi, D. & Geall, A. J., 2000, In : Tetrahedron. 56, 21, p. 3439-3447 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes

Geall, A. J. & Blagbrough, I. S., 2000, In : Tetrahedron. 56, 16, p. 2449-2460 12 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Blagbrough, I. S., Geall, A. J. & David, S. A., 2000, In : Bioorganic & Medicinal Chemistry Letters. 10, 17, p. 1959-1962 4 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
124 Citations (Scopus)

Synthesis of cholesteryl polyamine carbamates: pK(a) studies and condensation of calf thymus DNA

Geall, A. J., Taylor, R. J., Earll, M. E., Eaton, M. A. W. & Blagbrough, I. S., 2000, In : Bioconjugate Chemistry. 11, 3, p. 314-326 13 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1999

An autoradiographic study of the distribution of binding sites for the novel ∝7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain

Whiteaker, P., Davies, A. R. L., Marks, M. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Collins, A. C. & Wonnacott, S., 1 Aug 1999, In : European Journal of Neuroscience. 11, 8, p. 2689-2696

Research output: Contribution to journalArticle

113 Citations (Scopus)

Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors

Davies, A. R. L., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J. & Wonnacott, S., 15 May 1999, In : Neuropharmacology. 38, 5, p. 679-690

Research output: Contribution to journalArticle

227 Citations (Scopus)
1998
20 Citations (Scopus)

Selective probes for nicotinic acetylcholine receptors from substituted AE-bicyclic analogs of methyllycaconitine

Trigg, W. J., Hardick, D. J., Grangier, G., Wonnacott, S., Lewis, T., Rowan, M. G., Potter, B. V. L. & Blagbrough, I. S., 1998, Synthesis and Chemistry of Agrochemicals V. Baker, D. R., Fenyes, J. G., Basarab, G. S. & Hunt, D. A. (eds.). Washington, U. S. A.: Association for Computing Machinery, p. 194-205 (ACS Symposium Series; vol. 686).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)
1 Citation (Scopus)

Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine

Grangier, G., Trigg, W. J., Lewis, T., Rowan, M. G., Potter, B. V. L. & Blagbrough, I. S., 1 Feb 1998, In : Tetrahedron Letters. 39, 8, p. 889-892

Research output: Contribution to journalArticle

20 Citations (Scopus)
9 Citations (Scopus)
22 Citations (Scopus)