• 5 WEST 3.15

19942019
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Research Output 1994 2019

2007

Chain length modulation in symmetrical lipopolyamines and the effect on nanoparticle formulations for gene delivery

Ghonaim, H. M., Li, S., Soltan, M. K., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A36-A36

Research output: Contribution to journalArticle

Design and synthesis of nitrogen heterocyclic diacyl lipospermines for gene delivery

Soltan, M. K. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A50-A50

Research output: Contribution to journalArticle

Efficient novel unsymmetrical lipopolyamine formulations for gene delivery

Ghonaim, H. M., Li, S., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A37-A37

Research output: Contribution to journalArticle

Formulation and delivery of fluorescent siRNA by lipospermine nanoparticle complex formation

Ghonaim, H. M., Li, S., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A36-A37

Research output: Contribution to journalArticle

Design and synthesis of novel diacyl lipospermines

Soltan, M. K. & Blagbrough, I. S., 2006, In : Journal of Pharmacy and Pharmacology. 58, p. A57-A58

Research output: Contribution to journalArticle

45 Citations (Scopus)

Formulation and delivery of p-EGFP DNA condensed by a synthetic lipospermine

Ahmed, O. A. A. & Blagbrough, I. S., 2006, In : Journal of Pharmacy and Pharmacology. 58, p. A63-A63

Research output: Contribution to journalArticle

24 Citations (Scopus)

Lipopolyamine-mediated single nanoparticle formation of calf thymus DNA analyzed by fluorescence correlation spectroscopy

Adjimatera, N., Kral, T., Hof, M. & Blagbrough, I. S., 2006, In : Pharmaceutical Research. 23, 7, p. 1564-1573 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
49 Downloads (Pure)

Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA

McLaggan, D., Adjimatera, N., Sepcic, K., Jaspars, M., MacEwan, D. J., Blagbrough, I. S. & Scott, R. H., 2006, In : BMC Biotechnology. 6, 6

Research output: Contribution to journalArticle

File
Porifera
Small Interfering RNA
Complementary DNA
Salts
Calcium
26 Citations (Scopus)
Spermine
Plasmids
Transfection
DNA
Cells
2005

Fluorescence techniques in non-viral gene therapy

Adjimatera, N., Neal, A. P. & Blagbrough, I. S., 2005, Fluorescence Spectroscopy in Biology: Advanced Methods and their Applications to Membranes, Proteins, DNA, and Cells. Hof, M., Hutterer, R. & Fidler, V. (eds.). Heidelberg: Springer, Vol. 3. p. 201-228 28 p. (Springer Series on Fluorescence).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescent lipopolyamines: A new class of molecular probes in non-viral gene therapy

Adjimatera, N., Neal, A. P., Pourzand, C. & Blagbrough, I. S., 2005, In : Abstracts of Papers of the American Chemical Society. 229, p. U117-U117

Research output: Contribution to journalArticle

19 Citations (Scopus)

N4,N9-dioleoyl spermine is a novel nonviral lipopolyamine vector for plasmid DNA formulation

Ahmed, O. A. A., Adjimatera, N., Pourzand, C. & Blagbrough, I. S., 2005, In : Pharmaceutical Research. 22, 6, p. 972-980 9 p.

Research output: Contribution to journalArticle

Spermine
Transfection
Plasmids
DNA
Cells

Sensing DNA nanocomplex delivery by fluorescent probes

Adjimatera, N., Neal, A. P. & Blagbrough, I. S., 2005, In : Abstracts of Papers of the American Chemical Society. 229, p. U140-U140

Research output: Contribution to journalArticle

2004

Fluorescence techniques in non-viral gene therapy: Using spermine and lipopolyamines as DNA delivery agents

Blagbrough, I. S., Adjimatera, N., Neal, A. P. & Haworth, I. S., 2004, In : Abstracts of Papers of the American Chemical Society. 227, p. U34-U34

Research output: Contribution to journalArticle

Spermine and lipopolyamines as gene delivery agents

Blagbrough, I. S., Adjimatera, N., Ahmed, O. A. A., Neal, A. P. & Pourzand, C. A., 2004, Neurotox '03: Neurotoxicological targets from Functional Genomics and Proteomics. Beadle, D. J., Mellor, I. R. & Usherwood, P. N. R. (eds.). Society of Chemical Industry, p. 147-159 13 p. (Functional Genomics and Proteomics).

Research output: Chapter in Book/Report/Conference proceedingChapter

46 Citations (Scopus)

Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy

Blagbrough, I. S., Geall, A. J. & Neal, A. P., 2003, In : Biochemical Society Transactions. 31, 2, p. 397-406 10 p.

Research output: Contribution to journalArticle

Gene therapy
Polyamines
Genetic Therapy
DNA
Fluorescent Dyes
2002

Design and synthesis of fluorescent steroidal lipopolyamine conjugates for monitoring gene delivery

Blagbrough, I. S. & Neal, A. P., 2002, Drug Discovery and Design: Medical Aspects. Matsoukas, J. & Mavromoustakos, T. (eds.). Amsterdam: IOS Press, Vol. 55. p. 64-75 12 p. (Biomedical and Health Research).

Research output: Chapter in Book/Report/Conference proceedingChapter

91 Citations (Scopus)

Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine

Delcros, J. G., Tomasi, S., Carrington, S., Martin, B., Renault, J., Blagbrough, I. S. & Uriac, P., 2002, In : Journal of Medicinal Chemistry. 45, 23, p. 5098-5111 14 p.

Research output: Contribution to journalArticle

Acridines
Spermine
Polyamines
Aminoacridines
Cricetulus
34 Citations (Scopus)

Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides

Geall, A. J., Al-Hadithi, D. & Blagbrough, I. S., 2002, In : Bioconjugate Chemistry. 13, p. 481-490 10 p.

Research output: Contribution to journalArticle

2001
21 Citations (Scopus)

[3H]-methyllycaconitine: a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors

Lind, R. J., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Davies, A. R. L., Clough, M. S., Earley, F. G. P., Reynolds, S. E. & Wonnacott, S., 2001, In : Insect Biochemistry and Molecular Biology. 31, 6-7, p. 533-542

Research output: Contribution to journalArticle

Affinity Labels
cholinergic receptors
Nicotinic Receptors
Invertebrates
binding sites

Sar of bile acid polyamine conjugates in binding and condensation of DNA

Blagbrough, I. S., Geall, A. J. & Al-Hadithi, D., 2001, In : Abstracts of Papers of the American Chemical Society. 221, p. U58-U58

Research output: Contribution to journalArticle

Synthesis, DNA binding, and pK(a) studies of cholesterol-polyamine carbamates

Blagbrough, I. S., Geall, A. J., Taylor, R. J., Earll, M. E. & Eaton, M. W., 2001, In : Abstracts of Papers of the American Chemical Society. 221, p. U58-U58

Research output: Contribution to journalArticle

2000
30 Citations (Scopus)

Cheno-, urso- and deoxycholic acid spermine conjugates: Relative binding affinities for calf thymus DNA

Blagbrough, I. S., Al-Hadithi, D. & Geall, A. J., 2000, In : Tetrahedron. 56, 21, p. 3439-3447 9 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Deoxycholic Acid
Spermine
Amides
Cholanes
48 Citations (Scopus)

Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes

Geall, A. J. & Blagbrough, I. S., 2000, In : Tetrahedron. 56, 16, p. 2449-2460 12 p.

Research output: Contribution to journalArticle

Polyamines
Amides
Lipids
Ethidium
Spermine
30 Citations (Scopus)

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Blagbrough, I. S., Geall, A. J. & David, S. A., 2000, In : Bioorganic & Medicinal Chemistry Letters. 10, 17, p. 1959-1962 4 p.

Research output: Contribution to journalArticle

Ethidium
Spermine
Lipopolysaccharides
Assays
Nitric Oxide
119 Citations (Scopus)
Gene therapy
Ethidium
Polyamines
Genetic Therapy
Quenching
58 Citations (Scopus)

Synthesis of cholesteryl polyamine carbamates: pK(a) studies and condensation of calf thymus DNA

Geall, A. J., Taylor, R. J., Earll, M. E., Eaton, M. A. W. & Blagbrough, I. S., 2000, In : Bioconjugate Chemistry. 11, 3, p. 314-326 13 p.

Research output: Contribution to journalArticle

Thymus
Carbamates
Polyamines
Condensation
DNA
1999
111 Citations (Scopus)

An autoradiographic study of the distribution of binding sites for the novel ∝7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain

Whiteaker, P., Davies, A. R. L., Marks, M. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Collins, A. C. & Wonnacott, S., 1 Aug 1999, In : European Journal of Neuroscience. 11, 8, p. 2689-2696

Research output: Contribution to journalArticle

226 Citations (Scopus)

Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors

Davies, A. R. L., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J. & Wonnacott, S., 15 May 1999, In : Neuropharmacology. 38, 5, p. 679-690

Research output: Contribution to journalArticle

1998
20 Citations (Scopus)
Benzoates
Nicotinic Receptors
Bungarotoxins
Mammals
Diterpenes
9 Citations (Scopus)

Selective probes for nicotinic acetylcholine receptors from substituted AE-bicyclic analogs of methyllycaconitine

Trigg, W. J., Hardick, D. J., Grangier, G., Wonnacott, S., Lewis, T., Rowan, M. G., Potter, B. V. L. & Blagbrough, I. S., 1998, Synthesis and Chemistry of Agrochemicals V. Baker, D. R., Fenyes, J. G., Basarab, G. S. & Hunt, D. A. (eds.). Washington, U. S. A.: Association for Computing Machinery, p. 194-205 (ACS Symposium Series; vol. 686).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
20 Citations (Scopus)

Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine

Grangier, G., Trigg, W. J., Lewis, T., Rowan, M. G., Potter, B. V. L. & Blagbrough, I. S., 1 Feb 1998, In : Tetrahedron Letters. 39, 8, p. 889-892

Research output: Contribution to journalArticle

9 Citations (Scopus)
22 Citations (Scopus)