Ian Blagbrough

Dr

  • 5 WEST 3.15

19942019
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Research Output 1994 2019

2019
1 Citation (Scopus)
Open Access
2017

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T., 6 Nov 2017, In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
N-Methyl-3,4-methylenedioxyamphetamine
Imagery (Psychotherapy)
self-criticism
empathy
facial expression
2016
3 Citations (Scopus)
20 Downloads (Pure)

Effect of mechanical denaturation on surface free energy of protein powders

Blagbrough, I., Oct 2016, In : Colloids and Surfaces B: Biointerfaces. 146, p. 700-706 7 p.

Research output: Contribution to journalArticle

Open Access
File
Denaturation
biopolymer denaturation
Powders
Free energy
free energy
22 Citations (Scopus)
Zein
Biofilms
Tetracycline
Staphylococcus aureus
Skin
2015
5 Citations (Scopus)
57 Downloads (Pure)
Open Access
File

Polycaprolactone Electrospun Nanofibers for Controlled Drug Delivery

Alhusein, N., De Bank, P. & Blagbrough, I., 2 Apr 2015, The Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Mishra, M. (ed.). 1 ed. CRC Press, Vol. 7. p. 5239-5249

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Zein-PCL Electrospun Triple-Layered Nanofibre Matrices For Localised Controlled Delivery of Tetracycline

Blagbrough, I., Alhusein, N. & De Bank, P., Jul 2015, (Unpublished).

Research output: Contribution to conferenceOther

2014
25 Downloads (Pure)
Open Access
File
Aminoglycosides
Nanoparticles
Small Interfering RNA
Lipids
Framycetin
2013

Antibiotic Electrospun Micro/Nanofibrous Wound Dressing Formulations - In Vitro Testing Against Biofilms

Alhusein, N., De Bank, P., Blagbrough, I. & Bolhuis, A., Sep 2013, (Unpublished).

Research output: Contribution to conferencePoster

Controlled Release of Tetracycline Hydrochloride from an Electrospun Triple-Layered Zein Nanofibre Matrix

Alhusein, N., Stone, L., Wu, V., Rassam, I., Blagbrough, I. & De Bank, P., Sep 2013, (Unpublished).

Research output: Contribution to conferencePoster

17 Citations (Scopus)
68 Downloads (Pure)
Open Access
File
Nanofibers
Biofilms
Tetracycline
Bacteria
Anti-Bacterial Agents

Role of PLGA-nanoparticles formulation to improve drug radioprotective activity in gamma-irradiated mice

Mohamed, A. I., El-Assal, M. I. A., Kassem, M. A., Blagbrough, I. S. & Ahmed, O. A. A., 2013, In : Latin American Journal of Pharmacy. 32, 6, p. 809-816 8 p.

Research output: Contribution to journalArticle

Radiation-Protective Agents
Nanoparticles
Penicillamine
Pharmaceutical Preparations
Polyglactin 910
74 Downloads (Pure)

siRNA and Gene Formulation for Efficient Gene Therapy

Blagbrough, I. S. & Metwally, A. A., 27 Feb 2013, Gene Therapy: Tools and Potential Applications. Molina, F. M. (ed.). InTech

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
Genetic Therapy
Small Interfering RNA
Genes
16 Citations (Scopus)
69 Downloads (Pure)
Open Access
File
Zein
Tetracycline
Anti-Bacterial Agents
Bandages
Methicillin-Resistant Staphylococcus aureus
2012

An Electrospun Triple-Layered PCL-PEVA-PCL Nanofibre Matrix Controlled Release Drug Delivery System

Alhusein, N., De Bank, P. & Blagbrough, I., Jul 2012, (Unpublished).

Research output: Contribution to conferenceOther

10 Citations (Scopus)
52 Downloads (Pure)

Asymmetrical N4,N9-Diacyl Spermines: SAR Studies of Nonviral Lipopolyamine Vectors for Efficient siRNA Delivery with Silencing of EGFP Reporter Gene

Blagbrough, I. S., Metwally, A. A. & Ghonaim, H. M., 2 Jul 2012, In : Molecular Pharmaceutics. 9, 7, p. 1853-1861 9 p.

Research output: Contribution to journalArticle

Open Access
File
Spermine
Reporter Genes
Small Interfering RNA
Fluorescein
Cell Line

Controlled Release of Tetracycline Hydrochloride From an Electrospun Triple Layered PCL-PEVA-PCL Nanofibre Matrix

Alhusein, N., Blagbrough, I. & De Bank, P., Mar 2012, (Unpublished).

Research output: Contribution to conferenceOther

7 Citations (Scopus)
57 Downloads (Pure)

Efficient silencing of EGFP reporter gene with siRNA delivered by asymmetrical N4,N9-diacyl spermines

Metwally, A. A., Reelfs, O., Pourzand, C. & Blagbrough, I. S., 2 Jul 2012, In : Molecular Pharmaceutics. 9, 7, p. 1862-1876 15 p.

Research output: Contribution to journalArticle

Open Access
File
Spermine
Reporter Genes
Small Interfering RNA
Lipids
Gene Silencing
26 Citations (Scopus)
40 Downloads (Pure)
Open Access
File
Tetracycline
Nanofibers
Anti-Bacterial Agents
Skin
Immersion
4 Citations (Scopus)
51 Downloads (Pure)

Quantitative silencing of EGFP reporter gene by self-assembled siRNA lipoplexes of LinOS and cholesterol

Metwally, A. A., Blagbrough, I. S. & Mantell, J. M., 5 Nov 2012, In : Molecular Pharmaceutics. 9, 11, p. 3384-3395 12 p.

Research output: Contribution to journalArticle

Open Access
File
Reporter Genes
Small Interfering RNA
Cholesterol
Spermine
Cell Survival

Release of Antibiotics from Electrospun Polymeric Nanofibrous Layers

Alhusein, N., Blagbrough, I. & De Bank, P., Sep 2012, (Unpublished).

Research output: Contribution to conferencePoster

2011
11 Citations (Scopus)

Asymmetrical N4,N9-diacyl spermines: SAR and their efficiency as siRNA delivery vectors compared with symmetrical mixtures

Metwally, A. A., Reelfs, O., Pourzand, C. & Blagbrough, I. S., Oct 2011, In : Human Gene Therapy. 22, 10, p. A84-A85

Research output: Contribution to journalArticle

7 Citations (Scopus)
59 Downloads (Pure)

Efficient gene silencing by self-assembled complexes of siRNA and symmetrical fatty acid amides of spermine

Metwally, A. A., Pourzand, C. & Blagbrough, I. A., Jun 2011, In : Pharmaceutics. 3, 2, p. 125-140 16 p.

Research output: Contribution to journalArticle

File
Spermine
Gene Silencing
Amides
Small Interfering RNA
Fatty Acids
31 Citations (Scopus)
Mesalamine
Sulfasalazine
Acetic Acid
Aspirin
Medicine
Pharmacy Research
7 Citations (Scopus)
50 Downloads (Pure)
File
Guanidines
Spermine
Gene Silencing
Amides
Small Interfering RNA

Self-assembled siRNA lipoplexes of LinOS-cholesterol mixtures: Enhanced siRNA uptake and gene silencing in HeLa cells

Metwally, A. A. & Blagbrough, I. S., Oct 2011, In : Human Gene Therapy. 22, 10, p. A81

Research output: Contribution to journalArticle

2010
40 Citations (Scopus)

Cassava: an appraisal of its phytochemistry and its biotechnological prospects

Blagbrough, I. S., Bayoumi, S. A. L., Rowan, M. G. & Beeching, J. R., Dec 2010, In : Phytochemistry. 71, 17-18, p. 1940-1951 12 p.

Research output: Contribution to journalArticle

Manihot
plant biochemistry
Glucosides
economic valuation
cassava
56 Citations (Scopus)

Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots

Bayoumi, S. A. L., Rowan, M. G., Beeching, J. R. & Blagbrough, I. S., Apr 2010, In : Phytochemistry. 71, 5-6, p. 598-604 7 p.

Research output: Contribution to journalArticle

Manihot
Metabolites
Biological Products
cassava
secondary metabolites

Efficient siRNA delivery and effective gene silencing by lipoplexes

Metwally, A. A., Pourzand, C. & Blagbrough, I. S., Dec 2010, In : Drug Discovery Today. 15, 23-24, p. 1090 1 p.

Research output: Contribution to journalArticle

Efficient siRNA delivery and gene silencing by unsymmetrical fatty acid amides of spermine

Metwally, A. A., Pourzand, C. & Blagbrough, I. S., Oct 2010, In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1220-1221 2 p.

Research output: Contribution to journalArticle

Spermine
Gene Silencing
Amides
Small Interfering RNA
Fatty Acids

Heterocyclic N-4, N-9-diacyl spermines: Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery

Ghonaim, H. M., Soltan, M. K. & Blagbrough, I. S., Oct 2010, In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1276-1277 2 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Genetic Therapy
Nanoparticles
Small Interfering RNA
15 Citations (Scopus)

N1,N12 -Diacyl Spermines: SAR Studies on Non-viral Lipopolyamine Vectors for Plasmid DNA and siRNA Formulation

Ghonaim, H. M., Li, S. & Blagbrough, I. S., Jan 2010, In : Pharmaceutical Research. 27, 1, p. 17-29 13 p.

Research output: Contribution to journalArticle

Self-assembled complex formulations of lipid-aminoglycoside conjugates: Nanoparticles for efficient gene and siRNA delivery

Ghonaim, H. M., Cheng, Y. X., Pourzand, C. & Blagbrough, I., Oct 2010, In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1295-1296 2 p.

Research output: Contribution to journalArticle

Aminoglycosides
Nanoparticles
Small Interfering RNA
Framycetin
Cholesterol
2009
28 Citations (Scopus)
68 Downloads (Pure)

Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery Strategies

Blagbrough, I. S. & Zara, C., 2009, In : Pharmaceutical Research. 26, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

File
Animal Disease Models
Gene therapy
Genetic Therapy
Small Interfering RNA
Animals
16 Citations (Scopus)

Design and synthesis of N 4,N 9-disubstituted spermines for non-viral siRNA delivery – structure-activity relationship studies of siFection efficiency versus toxicity

Soltan, M. K., Ghonaim, H. M., El Sadek, M., Abou Kull, M., El-aziz, L. A. & Blagbrough, I. S., Feb 2009, In : Pharmaceutical Research. 26, 2, p. 286-295 10 p.

Research output: Contribution to journalArticle

Spermine
Structure-Activity Relationship
Small Interfering RNA
Toxicity
Poisons
6 Citations (Scopus)

Quantitative determination of mebeverine HCl by NMR chemical shift migration

Blagbrough, I. S., Elmasry, M. S., Woodman, T. J., Saleh, H. M. & Kheir, A. A., 2009, In : Tetrahedron. 65, 25, p. 4930-4936 7 p.

Research output: Contribution to journalArticle

Quantitative HPLC analysis of mebeverine HCI and other GIT medicines stored in a monitored dosage system for polypharmacy

Elmasry, M. S., Saleh, H. M., Kheir, A. A., Blagbrough, I. & Rogers, P. J., 2009, In : International Journal of Pharmacy Practice. 17, Supplement 1, p. A111-A112

Research output: Contribution to journalArticle

12 Citations (Scopus)

Very long chain N4,N9-diacyl spermines: non-viral lipopolyamine V vectors for efficient plasmid DNA and siRNA delivery

Ghonaim, H. M., Li, S. & Blagbrough, I. S., 1 Jan 2009, In : Pharmaceutical Research. 26, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Spermine
Small Interfering RNA
Plasmids
Nanoparticles
DNA
2008
28 Citations (Scopus)
67 Downloads (Pure)

Biosynthesis of scopoletin and scopolin in cassava roots during post-harvest physiological deterioration: The E-Z-isomerisation stage

Bayoumi, S. A. L., Rowan, M. G., Blagbrough, I. S. & Beeching, J. R., Dec 2008, In : Phytochemistry. 69, 17, p. 2928-2936 9 p.

Research output: Contribution to journalArticle

File
Scopoletin
scopoletin
Manihot
isomerization
Biosynthesis
29 Citations (Scopus)

Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110δ-dependent mechanism

Farghaly, H. S. M., Blagbrough, I. S., Medina-Tato, D. A. & Watson, M. L., May 2008, In : Molecular Pharmacology. 73, 5, p. 1530-1537 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Interleukin-13
Smooth Muscle
Protein Isoforms
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
12 Citations (Scopus)

Investigation of biosynthetic pathways to hydroxycoumarins during post-harvest physiological deterioration in cassava roots by using stable isotope labelling

Bayoumi, S. A. L., Rowan, M. G., Beeching, J. R. & Blagbrough, I. S., 15 Dec 2008, In : ChemBiochem. 9, 18, p. 3013-3022 10 p.

Research output: Contribution to journalArticle

ferulic acid
7-hydroxycoumarin
Isotope Labeling
Manihot
Hydroxylation

The effect of PI3K inhibition on IL-13-induced arginase I expression in mice tracheal segments

Farghaly, H., Causton, B., Blagbrough, I. & Watson, M. L., 2008, In : Fundamental & Clinical Pharmacology. 22, p. 14-14 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Varying the chain length in N4,N9-diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA formulation

Ghonaim, H. M., Ahmed, O. A. A., Pourzand, C. & Blagbrough, I. S., 1 Dec 2008, In : Molecular Pharmaceutics. 5, 6, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

2007

Chain length modulation in symmetrical lipopolyamines and the effect on nanoparticle formulations for gene delivery

Ghonaim, H. M., Li, S., Soltan, M. K., Pourzand, C. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A36-A36

Research output: Contribution to journalArticle

Design and synthesis of nitrogen heterocyclic diacyl lipospermines for gene delivery

Soltan, M. K. & Blagbrough, I. S., 2007, In : Journal of Pharmacy and Pharmacology. 59, p. A50-A50

Research output: Contribution to journalArticle