Ian Blagbrough

Dr

  • 5 WEST 3.15

19942017
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Personal profile

Research interests

Together with my research group, we carry out cutting-edge, internationally competitive pharmaceutical science within a School of Pharmacy. We aim to answer key questions in my areas of interest which are:

  • molecular pharmaceutics, especially controlling polymers for drug and siRNA delivery
  • gene delivery and gene silencing
  • applied pharmaceutical analysis
  • phytochemical (natural products) research
  • target-led synthetic pharmaceutical and biological chemistry
  • collaborative research with regard to molecular pharmacology of inflammation, cancer, and CNS diseases

We apply pharmaceutical analysis and phytochemistry to the research areas of molecular pharmaceutics and medicinal chemistry in our design and control of novel nanoparticles for siRNA, gene, and drug delivery, nanomedicine based on lipospermines and biocompatible polymers using fluorescent probes which we have designed and prepared. We study these using confocal microscope analysis and cell biology (with Dr Charareh Pourzand).

We are also investigating nanofibres prepared by electrospinning to make novel controlled release devices(with Dr Paul De Bank).

We work on rational, target driven drug design in the area of polyamine conjugate analogue synthesis against cancer and for ligand-gated ion channel control, synthetic chemistry of target natural products with detailed pharmaceutical analysis.

We welcome applications from scientists with interests in pharmaceutical analysis, pharmaceutics, chemistry, and areas where the interdisciplinary approach will be successful. The support provided to students in the Blagbrough research group has recently been recognised with the Excellence in Doctoral Supervision Award 2016.

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Amides Medicine & Life Sciences

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Projects 2007 2015

Research Output 1994 2017

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T. 6 Nov 2017 In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
N-Methyl-3,4-methylenedioxyamphetamine
Imagery (Psychotherapy)
self-criticism
empathy
facial expression

Phytochemistry of hydroxycoumarins from Manihot esculenta Euphorbiaceae (cassava)

Alhalaseh, L. 16 Oct 2017 205 p.

Research output: ThesisDoctoral Thesis

Open Access
File
scopoletin
plant biochemistry
Manihot esculenta
Euphorbiaceae
cassava

Effect of mechanical denaturation on surface free energy of protein powders

Blagbrough, I. Oct 2016 In : Colloids and Surfaces B: Biointerfaces. 146, p. 700-706 7 p.

Research output: Contribution to journalArticle

Open Access
File
Denaturation
biopolymer denaturation
Powders
Free energy
free energy
13 Citations
Zein
Biofilms
Tetracycline
Staphylococcus aureus
Skin

Impurity profiling of illicit drugs

Alotaibi, M. R. M. 2016 211 p.

Research output: ThesisDoctoral Thesis

File
Street Drugs
Impurities
Ketamine
Bins
Law enforcement