• 5 WEST 3.15

19942019

Research output per year

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Personal profile

Research interests

Together with my research group, we carry out cutting-edge, internationally competitive pharmaceutical science within a School of Pharmacy. We aim to answer key questions in my areas of interest which are:

  • molecular pharmaceutics, especially controlling polymers for drug and siRNA delivery
  • gene delivery and gene silencing
  • applied pharmaceutical analysis
  • phytochemical (natural products) research
  • target-led synthetic pharmaceutical and biological chemistry
  • collaborative research with regard to molecular pharmacology of inflammation, cancer, and CNS diseases

We apply pharmaceutical analysis and phytochemistry to the research areas of molecular pharmaceutics and medicinal chemistry in our design and control of novel nanoparticles for siRNA, gene, and drug delivery, nanomedicine based on lipospermines and biocompatible polymers using fluorescent probes which we have designed and prepared. We study these using confocal microscope analysis and cell biology (with Dr Charareh Pourzand).

We are also investigating nanofibres prepared by electrospinning to make novel controlled release devices(with Dr Paul De Bank).

We work on rational, target driven drug design in the area of polyamine conjugate analogue synthesis against cancer and for ligand-gated ion channel control, synthetic chemistry of target natural products with detailed pharmaceutical analysis.

We welcome applications from scientists with interests in pharmaceutical analysis, pharmaceutics, chemistry, and areas where the interdisciplinary approach will be successful. The support provided to students in the Blagbrough research group has recently been recognised with the Excellence in Doctoral Supervision Award 2016.

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Projects

Research Output

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Naqi, H., Husbands, S. & Blagbrough, I., 7 Oct 2019, In : Analytical Methods. 11, 37, p. 4795-4807 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

Synthetic Cannabinoid Receptor Agonists Detection using Fluorescence Spectral Fingerprinting

May, B., Naqi, H., Tipping, M., Scott, J., Husbands, S., Blagbrough, I. & Pudney, C., 15 Oct 2019, In : Analytical Chemistry. 91, 20, p. 12971-12979 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Additive effects of 3,4-methylenedioxymethamphetamine (MDMA) and compassionate imagery on self-compassion in recreational users of ecstasy

Kamboj, S. K., Wallden, Y. S. E., Falconer, C. J., Alotaibi, M. R. M., Blagbrough, I., Husbands, S. & Freeman, T., 6 Nov 2017, In : Mindfulness. 9, 4, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Open Access
  • 4 Citations (Scopus)

    Thesis

    Design and development of pharmaceutical dosage forms for gene and siRNA delivery

    Author: Ghonaim, H., 1 Sep 2008

    Supervisor: Blagbrough, I. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Designing An Educational Intervention For Crack Users Depending On Pharmaceutical Analysis Results

    Author: Shehab, M. Z., 9 Oct 2014

    Supervisor: Blagbrough, I. (Supervisor), Rowan, M. (Supervisor) & Scott, J. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Impurity profiling of illicit drugs

    Author: Alotaibi, M. R. M., 26 Apr 2017

    Supervisor: Blagbrough, I. (Supervisor) & Husbands, S. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Medicinal chemistry of aminoglycosides

    Author: Al Khzem, A., 13 Feb 2019

    Supervisor: Blagbrough, I. (Supervisor) & Woodman, T. (Supervisor)

    Student thesis: Doctoral ThesisMPhil

    File

    Molecular genetic analysis of secondary metabolite biosynthesis in cassava as an economic and nutritious plant

    Author: Bayoumi, S., 1 Oct 2008

    Supervisor: Blagbrough, I. (Supervisor), Rowan, M. (Supervisor) & Beeching, J. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File