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Helen Paine

Dr

  • 5 WEST 2.35

20132015
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Research Output 2013 2015

2015
15 Citations (Scopus)
107 Downloads (Pure)

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Benzamides
Deprotonation
Molecular modeling
Niacinamide
2013
12 Citations (Scopus)
96 Downloads (Pure)
Open Access
File
Cyclization
3-nitrobenzoic acid
Poly(ADP-ribose) Polymerases
Water
Lead compounds