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Helen Paine

Dr

  • 5 WEST 2.35

20132015
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Research Output 2013 2015

2015
15 Citations (Scopus)
117 Downloads (Pure)

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journal › Article

Open Access
File
Tankyrases
Benzamides
Deprotonation
Molecular modeling
Niacinamide
2014

Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver

Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. & Woon, E. C. Y., 2014, Patent No. WO2014087165-A1

Research output: Patent

2013
12 Citations (Scopus)
106 Downloads (Pure)

One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sep 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.

Research output: Contribution to journal › Article

Open Access
File
Cyclization
3-nitrobenzoic acid
Poly(ADP-ribose) Polymerases
Water
Lead compounds