Helen Paine – Research output — the University of Bath's research portal

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2 Article
2 Patent

4 results

2015
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In: Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.
Research output: Contribution to journal › Article › peer-review

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17 Citations (SciVal)

1086 Downloads (Pure)
2014
TANKYRASE INHIBITORS
Threadgill, M. D., Lloyd, M. D., Thompson, A. S., Nathubhai, A., Wood, P. J., Paine, H. A., Kumpan, E., Sunderland, P. T. & Chue Yen Woon, E., 12 Jun 2014, IPC No. C07D471/04, A61K31/4375, Patent No. WO2014087165, Priority date 6 Dec 2012, Priority No. GB201221971A
Research output: Patent
Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver
Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. & Woon, E. C. Y., 2014, Patent No. WO2014087165-A1
Research output: Patent
2013
One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sep 2013, In: Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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12 Citations (SciVal)

198 Downloads (Pure)