Photo of Helen Paine

Helen Paine

Dr

  • 5 WEST 2.35

20132015
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Personal profile

Research interests

I qualified as a Pharmacist in 2009 following a split pre-registration position with AstraZeneca and the University Hospitals of Leicester NHS trust. Post-qualification, the majority of my Pharmacy experience has been in the community.

I have always been interested in the design of new medicines and as such, in 2013, I completed a PhD in Medicinal Chemistry where I developed and tested new potential anti-cancer medicines which work through inhibition of the tankyrases; enzymes involved in the regulation of telomere length. Throughout my PhD I was involved in teaching undergraduates here at Bath and having thoroughly enjoyed this experience, went on to complete a formal teaching qualification (PGCE) in 2014. I am particularly interested in how Pharmacy education can be delivered to undergraduates using creative and innovative techniques and approaches. 

In my current role as a Part Time Teaching Fellow, I am involved in delivering teaching and assessing pharmacy undergraduates within several areas of the degree programme. I am also responsible for the design of ‘Problem-based learning’ in the new MPharm course and ensuring that Pharmacy Practice and the Science that underpins all of our discipline is seamlessly integrated.

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Tankyrases Chemical Compounds
Molecular modeling Chemical Compounds
Benzamides Chemical Compounds
Deprotonation Chemical Compounds
Niacinamide Chemical Compounds
Cyclization Chemical Compounds
beta Catenin Chemical Compounds
Poly(ADP-ribose) Polymerases Chemical Compounds

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Research Output 2013 2015

13 Citations (Scopus)

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sep 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journalArticle

File
Tankyrases
Benzamides
Deprotonation
Molecular modeling
Niacinamide
11 Citations (Scopus)
Open Access
File
Cyclization
3-nitrobenzoic acid
Poly(ADP-ribose) Polymerases
Water
Lead compounds