Research output per year
Research output per year
Personal profile
Research interests
I qualified as a Pharmacist in 2009 following a split pre-registration position with AstraZeneca and the University Hospitals of Leicester NHS trust. Post-qualification, the majority of my Pharmacy experience has been in the community.
I have always been interested in the design of new medicines and as such, in 2013, I completed a PhD in Medicinal Chemistry where I developed and tested new potential anti-cancer medicines which work through inhibition of the tankyrases; enzymes involved in the regulation of telomere length. Throughout my PhD I was involved in teaching undergraduates here at Bath and having thoroughly enjoyed this experience, went on to complete a formal teaching qualification (PGCE) in 2014. I am particularly interested in how Pharmacy education can be delivered to undergraduates using creative and innovative techniques and approaches.
In my current role as a Part Time Teaching Fellow, I am involved in delivering teaching and assessing pharmacy undergraduates within several areas of the degree programme. I am also responsible for the design of ‘Problem-based learning’ in the new MPharm course and ensuring that Pharmacy Practice and the Science that underpins all of our discipline is seamlessly integrated.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D., 1 Sept 2015, In: Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (SciVal)1210 Downloads (Pure) -
TANKYRASE INHIBITORS
Threadgill, M. D. (Inventor), Lloyd, M. D. (Inventor), Thompson, A. S. (Inventor), Nathubhai, A. (Inventor), Wood, P. J. (Inventor), Paine, H. A. (Inventor), Kumpan, E. (Inventor), Sunderland, P. T. (Inventor) & Chue Yen Woon, E. (Inventor), 12 Jun 2014, IPC No. C07D471/04, A61K31/4375, Patent No. WO2014087165, Priority date 6 Dec 2012, Priority No. GB201221971AResearch output: Patent
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Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver
Threadgill, M. (Inventor), Lloyd, M. (Inventor), Thompson, A. (Inventor), Nathubhai, A. (Inventor), Wood, P. (Inventor), Paine, H. (Inventor), Kumpan, E. (Inventor), Sunderland, P. (Inventor) & Woon, E. C. Y. (Inventor), 2014, Patent No. WO2014087165-A1Research output: Patent
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One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D., 1 Sept 2013, In: Bioorganic and Medicinal Chemistry. 21, 17, p. 5218-5227 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (SciVal)277 Downloads (Pure)
Thesis
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Inhibitors of the tankyrases, triple-function targets in the cancer cell
Paine, H. (Author), Threadgill, M. (Supervisor), Lloyd, M. (Supervisor) & Thompson, A. (Supervisor), 6 Jun 2014Student thesis: Doctoral Thesis › PhD
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