Gyles Cozier

Dr

20102018
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Fingerprint Dive into the research topics where Gyles Cozier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Peptidyl-Dipeptidase A Medicine & Life Sciences
Carbonic Anhydrase II Medicine & Life Sciences
Angiotensin-Converting Enzyme Inhibitors Medicine & Life Sciences
Carbonic Anhydrase Inhibitors Medicine & Life Sciences
Phosphatidylinositol Phosphates Medicine & Life Sciences
Polyphosphates Medicine & Life Sciences
Phosphoric Monoester Hydrolases Chemical Compounds
Catalytic Domain Medicine & Life Sciences

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Research Output 2010 2018

2 Citations (Scopus)

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity

Cozier, G. E., Schwager, S. L., Sharma, R. K., Chibale, K., Sturrock, E. D. & Acharya, K. R., 24 Feb 2018, In : FEBS Journal.

Research output: Contribution to journalArticle

Open Access
Peptidyl-Dipeptidase A
Hydrophobic and Hydrophilic Interactions
Angiotensin-Converting Enzyme Inhibitors
Lysine
Catalytic Domain

How a DNA mimic catches and cleaves NF-kB

Acharya, K-R. & Cozier, G., 28 Sep 2018, In : Journal of Biological Chemistry. 293, 39, p. 15330-15331 2 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

Abrie, J. A., Moolman, W. J. A., Cozier, G. E., Schwager, S. L. U., Acharya, K. R. & Sturrock, E. D., 1 Apr 2018, In : Molecular Pharmacology. 93, 4, p. 344-354

Research output: Contribution to journalArticle

Open Access
Hominidae
Peptidyl-Dipeptidase A
Dimerization
Renin-Angiotensin System
Testis

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

Cozier, G., Arendse, L. B., Schwager, S. L., Sturrock, E. D. & Acharya, K-R., 21 Nov 2018, In : Journal of Medicinal Chemistry. 61, 22, p. 10141-10154 14 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

Fienberg, S., Cozier, G. E., Acharya, K. R., Chibale, K. & Sturrock, E. D., 11 Jan 2018, In : Journal of Medicinal Chemistry. 61, 1, p. 344-359 16 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angioedema
Metalloproteases
Angiotensin-Converting Enzyme Inhibitors
Cough