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Research Output 1996 2018

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Article
2018
6 Citations (Scopus)
Open Access
Abdominal Subcutaneous Fat
Breakfast
Adipose Tissue
Fasting
Insulin
2017
14 Citations (Scopus)
58 Downloads (Pure)

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Inhibitory Concentration 50
Protein Isoforms
Binding Sites
Glucose
4 Citations (Scopus)

Thermal stability, storage and release of proteins with tailored fit in silica

Chen, Y-C., Smith, T., Hicks, R. H., Doekhie, A., Koumanov, F., Wells, S. A., Edler, K. J., van den Elsen, J., Holman, G. D., Marchbank, K. J. & Sartbaeva, A., 24 Apr 2017, In : Scientific Reports. 7, p. 1-8 8 p., 46568.

Research output: Contribution to journalArticle

Open Access
Refrigeration
Freeze Drying
Silicon Dioxide
Vaccines
Hot Temperature
2016
48 Citations (Scopus)
62 Downloads (Pure)

The causal role of breakfast in energy balance and health: A randomized controlled trial in obese adults

Chowdhury, E., Richardson, J., Holman, G. D., Tsintzas, K., Thompson, D. & Betts, J., 1 Mar 2016, In : The American Journal of Clinical Nutrition. 103, 3, p. 747-756 10 p.

Research output: Contribution to journalArticle

Open Access
Breakfast
Randomized Controlled Trials
Fasting
Health
Thermogenesis
2015
34 Citations (Scopus)

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H. & Al-hasani, H., Mar 2015, In : Diabetes. 64, 3, p. 746-759 14 p.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
GTPase-Activating Proteins
Insulin
Glucose
Skeletal Muscle
6 Citations (Scopus)
51 Downloads (Pure)

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In : Diabetologia. 58, 8, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

Open Access
Adipocytes
Insulin
Guanosine Triphosphate
Cell Membrane
Intracellular Membranes
26 Citations (Scopus)
123 Downloads (Pure)

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In : European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.

Research output: Contribution to journalArticle

Open Access
File
Exercise
Appetite
Glycogen
Phosphorylation
AMP-Activated Protein Kinases
18 Citations (Scopus)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sep 2015, In : The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.

Research output: Contribution to journalArticle

Open Access
Facilitative Glucose Transport Proteins
Adipocytes
Proteomics
Tumors
Insulin
2014
94 Citations (Scopus)
58 Downloads (Pure)

The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In : The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.

Research output: Contribution to journalArticle

Open Access
Breakfast
Randomized Controlled Trials
Health
Fasting
Thermogenesis
2013
15 Citations (Scopus)

FGT-1 is The major glucose transporter in C. elegans and is central to aging pathways

Feng, Y., Williams, BG., Koumanov, F., Wolstenholme, AJ. & Holman, G. D., 1 Dec 2013, In : Biochemical Journal. 456, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Aging of materials
Caenorhabditis elegans
Protein Isoforms
Glucose
2012
12 Citations (Scopus)

GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sep 2012, In : PLoS ONE. 7, 9, e44141.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
adipocytes
Sorting
Adipocytes
traffic
2011
22 Citations (Scopus)
77 Downloads (Pure)

AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane

Koumanov, F., Richardson, J. D., Murrow, B. A. & Holman, G. D., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 16574-16582 9 p.

Research output: Contribution to journalArticle

File
Phosphotyrosine
Cell membranes
Fusion reactions
Cell Membrane
Insulin
20 Citations (Scopus)
62 Downloads (Pure)
File
Breakfast
Baths
Fasting
Randomized Controlled Trials
Energy Intake
2010
40 Citations (Scopus)

Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes

Fazakerley, D. J., Holman, G. D., Marley, A., James, D. E., Stockli, J. & Coster, A. C. F., 15 Jan 2010, In : Journal of Biological Chemistry. 285, 3, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Skeletal Muscle Fibers
A 769662
Insulin
Kinetics
9 Citations (Scopus)

Muscling in on GLUT4 kinetics

Stöckli, J., Fazakerley, D. J., Coster, A. C. F., Holman, G. D. & James, D. E., 2010, In : Communicative & Integrative Biology. 3, 3, p. 260-262 3 p.

Research output: Contribution to journalArticle

insulin
Insulin
kinetics
adipocytes
Adipocytes
14 Citations (Scopus)
71 Downloads (Pure)

Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling

Lawrence, S. P., Holman, G. D. & Koumanov, F., 15 Dec 2010, In : Biochemical Journal. 432, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

File
Cardiac Myocytes
Chemical activation
Insulin
Phosphatidylinositols
1-Phosphatidylinositol 4-Kinase
2009
27 Citations (Scopus)

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Fazakerley, D. J., Lawrence, S. P., Lizunov, V. A., Cushman, S. W. & Holman, G. D., 1 Mar 2009, In : Journal of Cell Science. 122, 5, p. 727-734 8 p.

Research output: Contribution to journalArticle

Sarcolemma
Cardiac Myocytes
Insulin
Clathrin
Anti-Idiotypic Antibodies
39 Citations (Scopus)

Kinetics of GLUT4 trafficking in rat and human skeletal muscle

Karlsson, H. K. R., Chibalin, A. V., Koistinen, H. A., Yang, J., Koumanov, F., Wallberg-Henriksson, H., Zierath, J. R. & Holman, G. D., Apr 2009, In : Diabetes. 58, 4, p. 847-854 8 p.

Research output: Contribution to journalArticle

Exocytosis
Skeletal Muscle
Insulin
Muscles
Quadriceps Muscle
2008
277 Citations (Scopus)

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

Sakamoto, K. & Holman, G. D., 1 Jul 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 295, 1, p. E29-E37

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
GTPase-Activating Proteins
Phosphotransferases
Glucose Transporter Type 4
Insulin
6 Citations (Scopus)

Regulating the motor for GLUT4 vesicle traffic

Holman, G. D. & Sakamoto, K., 2008, In : Cell Metabolism. 8, 5, p. 344-346 3 p.

Research output: Contribution to journalArticle

Mechanical Phenomena
Insulin
Multiprotein Complexes
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Facilitative Glucose Transport Proteins
2007
14 Citations (Scopus)

Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart

Miller, E. J., Li, J., Sinusas, K. M., Holman, G. D. & Young, L. H., 2007, In : American Journal of Physiology: Endocrinology and Metabolism. 292, 6, p. E1922-E1928

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Glucose
Insulin
Cardiac Myocytes
Physiological Stress
10 Citations (Scopus)
2006

Investigation of the role of Kv1.3 as a potential regulator of peripheral insulin sensitivity

Gillings, A. S., Yang, J., Marley, A. E., Holman, G. D., Peckham, M., Kilgour, E. & Baldwin, S. A., 2006, In : Diabetologia. 49, p. 366-366 1 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
AMP-Activated Protein Kinases
Facilitative Glucose Transport Proteins
Metformin
Endocytosis
Cardiac Myocytes
2005
30 Citations (Scopus)

Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580

Ribe, D., Yang, J., Patel, S., Koumanov, F. O., Cushman, S. W. & Holman, G. D., 2005, In : Endocrinology. 146, 4, p. 1713-1717 5 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
3-O-Methylglucose
79 Citations (Scopus)
AMP-Activated Protein Kinases
Exocytosis
Endocytosis
Cardiac Myocytes
Metabolism
78 Citations (Scopus)

Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step

Koumanov, F., Jin, B., Yang, J. & Holman, G. D., 2005, In : Cell Metabolism. 2, 3, p. 179-189 11 p.

Research output: Contribution to journalArticle

Membrane Fusion
Cell Membrane
Insulin
Cytoplasm
SNARE Proteins
2 Citations (Scopus)

Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats

Collison, M., James, D. J., Graham, D., Holman, G. D., Connell, J. M. C., Dominiczak, A. F., Gould, G. W. & Salt, I. P., 2005, In : Diabetologia. 48, 3, p. 539-546 8 p.

Research output: Contribution to journalArticle

Inbred SHR Rats
Biological Availability
Stroke
Insulin
Cell Membrane
179 Citations (Scopus)

The human glomerular podocyte is a novel target for insulin action

Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2005, In : Diabetes. 54, 11, p. 3095-3102 8 p.

Research output: Contribution to journalArticle

Podocytes
Insulin
Glomerular Filtration Barrier
Albuminuria
Diabetic Nephropathies
2004
145 Citations (Scopus)

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle

Li, J., Hu, X. Y., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D. & Young, L. H., 2004, In : American Journal of Physiology: Endocrinology and Metabolism. 287, 5, p. E834-E841

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Myocardium
Nitric Oxide
Glucose
Protein-Serine-Threonine Kinases
17 Citations (Scopus)

Selective formation of 1,3-oxazolidine-2-thiones on ketohexose templates

Tatibouet, A., Lawrence, S., Rollin, P. & Holman, G. D., 2004, In : Synlett. 11, p. 1945-1948 4 p.

Research output: Contribution to journalArticle

Thiones
Bioactivity
Fructose
Condensation
oxazolidine
2003
179 Citations (Scopus)

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes

Koistinen, H. A., Galuska, D., Chibalin, A. V., Yang, J., Zierath, J. R., Holman, G. D. & Wallberg-Henriksson, H., 2003, In : Diabetes. 52, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Skeletal Muscle
Glucose
Insulin
AMP-Activated Protein Kinases

Human podocytes rapidly utilize glucose by both GLUT1 and GLUT4 in response to insulin; with significant differences in glucose transporter levels occurring in diabetic nephropathy

Coward, R. J. M., Welsh, G. I., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2003, In : Journal of the American Society of Nephrology. 14, p. 388A-388A

Research output: Contribution to journalArticle

121 Citations (Scopus)

Identification of mammalian Vps24p as an effector of phosphatidylinosital 3,5-bisphosphate-dependent endosome compartmentalization

Whitley, P., Reaves, B. J., Hashimoto, M., Riley, A. M., Potter, B. V. L. & Holman, G. D., 2003, In : Journal of Biological Chemistry. 278, 40, p. 38786-38795

Research output: Contribution to journalArticle

Endosomes
Membranes
Proteins
Cells
Saccharomyces cerevisiae Proteins
37 Citations (Scopus)

Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones

Girniene, J., Tatibouet, A., Sackus, A., Yang, J., Holman, G. D. & Rollin, P., 2003, In : Carbohydrate Research. 338, 8, p. 711-719 9 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 5
Oxazolidinones
Thiones
Facilitative Glucose Transport Proteins
Fructose
85 Citations (Scopus)

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content

Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D. H., Zierath, J. R. & Krook, A., 2003, In : Cellular and Molecular Life Sciences (CMLS). 60, 5, p. 991-998 8 p.

Research output: Contribution to journalArticle

Muscle Cells
Cell Differentiation
Skeletal Muscle
Insulin
Facilitative Glucose Transport Proteins
53 Citations (Scopus)

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X. W., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 2003, In : Journal of Biological Chemistry. 278, 41, p. 39337-39348 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Facilitative Glucose Transport Proteins
Interleukin-3
Cell Survival
Cells
2002
43 Citations (Scopus)

Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5

Yang, J., Dowden, J., Tatibouët, A., Hatanaka, Y. & Holman, G. D., 2002, In : Biochemical Journal. 367, 2, p. 533-539 7 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 5
Photoaffinity Labels
Affinity Labels
Fructose
Ligands
20 Citations (Scopus)

Identification of centaurin-alpha 2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle

Whitley, P., Gibbard, A. M., Koumanov, F., Oldfield, S., Kilgour, E. E., Prestwich, G. D. & Holman, G. D., Apr 2002, In : European Journal of Cell Biology. 81, 4, p. 222-230 9 p.

Research output: Contribution to journalArticle

Myocardium
Carrier Proteins
Skeletal Muscle
Fats
Membranes
4 Citations (Scopus)

Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring

Hashimoto, M., Yang, J., Hatanaka, Y., Sadakane, Y., Nakagomi, K. & Holman, G. D., 2002, In : Chemical & Pharmaceutical Bulletin. 50, 7, p. 1004-1006 3 p.

Research output: Contribution to journalArticle

Substitution reactions
Glucose
Facilitative Glucose Transport Proteins
Adipocytes
Electrons
23 Citations (Scopus)
Cell membranes
Isoproterenol
Cytosol
Fusion reactions
Maintenance
29 Citations (Scopus)

Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes

Yang, J., Gillingham, A. K., Hodel, A., Koumanov, F., Woodward, B. & Holman, G., 1 Dec 2002, In : American Journal of Physiology: Endocrinology and Metabolism. 283, 6, p. E1299-E1307

Research output: Contribution to journalArticle

Cardiac Myocytes
Cytosol
Insulin
Glucose
Qa-SNARE Proteins
2001
14 Citations (Scopus)

Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: An example from glucose-transporter probes

Hashimoto, M., Yang, J. & Holman, G. D., 2001, In : ChemBiochem. 2, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Biotin
Membrane Proteins
Streptavidin
Avidin
152 Citations (Scopus)

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

Buhl, E. S., Jessen, N., Schmitz, O., Pedersen, S. B., Pedersen, O., Holman, G. D. & Lund, S., 2001, In : Diabetes. 50, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Aminoimidazole Carboxamide
Skeletal Muscle
Insulin
Glucose
Muscles
19 Citations (Scopus)

D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5

Tatibouet, A., Lefoix, M., Nadolny, J., Martin, O. R., Rollin, P., Yang, J. & Holman, G. D., 2001, In : Carbohydrate Research. 333, 4, p. 327-334 8 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 5
Sorbose
Fructose
Mannitol
Oxygen
80 Citations (Scopus)

Moving the insulin-regulated glucose transporter GLUT4 into and out of storage

Holman, G. D. & Sandoval, I. V., 2001, In : Trends in Cell Biology. 11, 4, p. 173-179 7 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Insulin
Cell Membrane
Blood Glucose
Protein Isoforms
44 Citations (Scopus)

Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling

Hashimoto, M., Hatanaka, Y., Yang, J., Dhesi, J. & Holman, G. D., 2001, In : Carbohydrate Research. 331, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Labeling
Glucose Transporter Type 1
Diazomethane
Derivatives
2000
54 Citations (Scopus)

Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin

Pryor, P. R., Liu, S. C. H., Clark, A. E., Yang, J., Holman, G. D. & Tosh, D., 2000, In : Biochemical Journal. 348, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Metformin
Endocytosis
Insulin
Insulin Receptor
Glucose
72 Citations (Scopus)

Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4

Sandoval, I. V., Martinez-Arca, S., Valdueza, J., Palacios, S. & Holman, G. D., 2000, In : Journal of Biological Chemistry. 275, 51, p. 39874-39885 12 p.

Research output: Contribution to journalArticle

Lysosome-Associated Membrane Glycoproteins
Facilitative Glucose Transport Proteins
Sorting
Leucine
Reading
32 Citations (Scopus)

Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5

Tatibouet, A., Yang, J., Morin, C. & Holman, G. D., 2000, In : Bioorganic and Medicinal Chemistry. 8, 7, p. 1825-1833 9 p.

Research output: Contribution to journalArticle

biochemistry
inhibitor
tolerance
probe
evaluation