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Research Output

Article

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes

Koistinen, H. A., Galuska, D., Chibalin, A. V., Yang, J., Zierath, J. R., Holman, G. D. & Wallberg-Henriksson, H., 2003, In : Diabetes. 52, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

185 Citations (Scopus)

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Fazakerley, D. J., Lawrence, S. P., Lizunov, V. A., Cushman, S. W. & Holman, G. D., 1 Mar 2009, In : Journal of Cell Science. 122, 5, p. 727-734 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Altered GLUT4 subcellular trafficking in primary adipose cell cultures: Immunocytochemical evidence.

Malide, D., Tosh, D., Clark, A. E., Cushman, S. W. & Holman, G. D., 1996, In : Molecular Biology of the Cell. 7, p. 2636-2636 1 p.

Research output: Contribution to journalArticle

AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane

Koumanov, F., Richardson, J. D., Murrow, B. A. & Holman, G. D., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 16574-16582 9 p.

Research output: Contribution to journalArticle

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22 Citations (Scopus)
121 Downloads (Pure)

Association of AP1 adaptor complexes with GLUT4 vesicles

Gillingham, A. K., Koumanov, F., Pryor, P. R., Reaves, B. J. & Holman, G. D., 1999, In : Journal of Cell Science. 112, 24, p. 4793-4800 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
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20 Citations (Scopus)
94 Downloads (Pure)

Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: An example from glucose-transporter probes

Hashimoto, M., Yang, J. & Holman, G. D., 2001, In : ChemBiochem. 2, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin

Pryor, P. R., Liu, S. C. H., Clark, A. E., Yang, J., Holman, G. D. & Tosh, D., 2000, In : Biochemical Journal. 348, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

Buhl, E. S., Jessen, N., Schmitz, O., Pedersen, S. B., Pedersen, O., Holman, G. D. & Lund, S., 2001, In : Diabetes. 50, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H. & Al-hasani, H., Mar 2015, In : Diabetes. 64, 3, p. 746-759 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5

Yang, J., Dowden, J., Tatibouët, A., Hatanaka, Y. & Holman, G. D., 2002, In : Biochemical Journal. 367, 2, p. 533-539 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5

Tatibouet, A., Lefoix, M., Nadolny, J., Martin, O. R., Rollin, P., Yang, J. & Holman, G. D., 2001, In : Carbohydrate Research. 333, 4, p. 327-334 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4

Sandoval, I. V., Martinez-Arca, S., Valdueza, J., Palacios, S. & Holman, G. D., 2000, In : Journal of Biological Chemistry. 275, 51, p. 39874-39885 12 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

Sakamoto, K. & Holman, G. D., 1 Jul 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 295, 1, p. E29-E37

Research output: Contribution to journalArticle

284 Citations (Scopus)

Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580

Ribe, D., Yang, J., Patel, S., Koumanov, F. O., Cushman, S. W. & Holman, G. D., 2005, In : Endocrinology. 146, 4, p. 1713-1717 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

FGT-1 is The major glucose transporter in C. elegans and is central to aging pathways

Feng, Y., Williams, BG., Koumanov, F., Wolstenholme, AJ. & Holman, G. D., 1 Dec 2013, In : Biochemical Journal. 456, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sep 2012, In : PLoS ONE. 7, 9, e44141.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
118 Downloads (Pure)

Human podocytes rapidly utilize glucose by both GLUT1 and GLUT4 in response to insulin; with significant differences in glucose transporter levels occurring in diabetic nephropathy

Coward, R. J. M., Welsh, G. I., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2003, In : Journal of the American Society of Nephrology. 14, p. 388A-388A

Research output: Contribution to journalArticle

Identification of centaurin-alpha 2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle

Whitley, P., Gibbard, A. M., Koumanov, F., Oldfield, S., Kilgour, E. E., Prestwich, G. D. & Holman, G. D., Apr 2002, In : European Journal of Cell Biology. 81, 4, p. 222-230 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Identification of mammalian Vps24p as an effector of phosphatidylinosital 3,5-bisphosphate-dependent endosome compartmentalization

Whitley, P., Reaves, B. J., Hashimoto, M., Riley, A. M., Potter, B. V. L. & Holman, G. D., 2003, In : Journal of Biological Chemistry. 278, 40, p. 38786-38795

Research output: Contribution to journalArticle

123 Citations (Scopus)

Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring

Hashimoto, M., Yang, J., Hatanaka, Y., Sadakane, Y., Nakagomi, K. & Holman, G. D., 2002, In : Chemical & Pharmaceutical Bulletin. 50, 7, p. 1004-1006 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart

Miller, E. J., Li, J., Sinusas, K. M., Holman, G. D. & Young, L. H., 2007, In : American Journal of Physiology: Endocrinology and Metabolism. 292, 6, p. E1922-E1928

Research output: Contribution to journalArticle

15 Citations (Scopus)

Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones

Girniene, J., Tatibouet, A., Sackus, A., Yang, J., Holman, G. D. & Rollin, P., 2003, In : Carbohydrate Research. 338, 8, p. 711-719 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content

Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D. H., Zierath, J. R. & Krook, A., 2003, In : Cellular and Molecular Life Sciences (CMLS). 60, 5, p. 991-998 8 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
80 Citations (Scopus)
23 Citations (Scopus)

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In : Diabetologia. 58, 8, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
51 Downloads (Pure)

Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step

Koumanov, F., Jin, B., Yang, J. & Holman, G. D., 2005, In : Cell Metabolism. 2, 3, p. 179-189 11 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes

Yang, J., Gillingham, A. K., Hodel, A., Koumanov, F., Woodward, B. & Holman, G., 1 Dec 2002, In : American Journal of Physiology: Endocrinology and Metabolism. 283, 6, p. E1299-E1307

Research output: Contribution to journalArticle

30 Citations (Scopus)

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X. W., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 2003, In : Journal of Biological Chemistry. 278, 41, p. 39337-39348 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Investigation of the role of Kv1.3 as a potential regulator of peripheral insulin sensitivity

Gillings, A. S., Yang, J., Marley, A. E., Holman, G. D., Peckham, M., Kilgour, E. & Baldwin, S. A., 2006, In : Diabetologia. 49, p. 366-366 1 p.

Research output: Contribution to journalArticle

Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes

Fazakerley, D. J., Holman, G. D., Marley, A., James, D. E., Stockli, J. & Coster, A. C. F., 15 Jan 2010, In : Journal of Biological Chemistry. 285, 3, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Kinetics of GLUT4 trafficking in rat and human skeletal muscle

Karlsson, H. K. R., Chibalin, A. V., Koistinen, H. A., Yang, J., Koumanov, F., Wallberg-Henriksson, H., Zierath, J. R. & Holman, G. D., Apr 2009, In : Diabetes. 58, 4, p. 847-854 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
68 Citations (Scopus)
Open Access
7 Citations (Scopus)

Moving the insulin-regulated glucose transporter GLUT4 into and out of storage

Holman, G. D. & Sandoval, I. V., 2001, In : Trends in Cell Biology. 11, 4, p. 173-179 7 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Muscling in on GLUT4 kinetics

Stöckli, J., Fazakerley, D. J., Coster, A. C. F., Holman, G. D. & James, D. E., 2010, In : Communicative & Integrative Biology. 3, 3, p. 260-262 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In : European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.

Research output: Contribution to journalArticle

Open Access
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36 Citations (Scopus)
214 Downloads (Pure)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sep 2015, In : The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats

Collison, M., James, D. J., Graham, D., Holman, G. D., Connell, J. M. C., Dominiczak, A. F., Gould, G. W. & Salt, I. P., 2005, In : Diabetologia. 48, 3, p. 539-546 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Regulating the motor for GLUT4 vesicle traffic

Holman, G. D. & Sakamoto, K., 2008, In : Cell Metabolism. 8, 5, p. 344-346 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle

Li, J., Hu, X. Y., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D. & Young, L. H., 2004, In : American Journal of Physiology: Endocrinology and Metabolism. 287, 5, p. E834-E841

Research output: Contribution to journalArticle

148 Citations (Scopus)

Selective formation of 1,3-oxazolidine-2-thiones on ketohexose templates

Tatibouet, A., Lawrence, S., Rollin, P. & Holman, G. D., 2004, In : Synlett. 11, p. 1945-1948 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5

Tatibouet, A., Yang, J., Morin, C. & Holman, G. D., 2000, In : Bioorganic and Medicinal Chemistry. 8, 7, p. 1825-1833 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling

Hashimoto, M., Hatanaka, Y., Yang, J., Dhesi, J. & Holman, G. D., 2001, In : Carbohydrate Research. 331, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In : The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.

Research output: Contribution to journalArticle

Open Access
107 Citations (Scopus)
58 Downloads (Pure)

The causal role of breakfast in energy balance and health: A randomized controlled trial in obese adults

Chowdhury, E., Richardson, J., Holman, G. D., Tsintzas, K., Thompson, D. & Betts, J., 1 Mar 2016, In : The American Journal of Clinical Nutrition. 103, 3, p. 747-756 10 p.

Research output: Contribution to journalArticle

Open Access
56 Citations (Scopus)
62 Downloads (Pure)

The human glomerular podocyte is a novel target for insulin action

Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2005, In : Diabetes. 54, 11, p. 3095-3102 8 p.

Research output: Contribution to journalArticle

185 Citations (Scopus)

Thermal stability, storage and release of proteins with tailored fit in silica

Chen, Y-C., Smith, T., Hicks, R. H., Doekhie, A., Koumanov, F., Wells, S. A., Edler, K. J., van den Elsen, J., Holman, G. D., Marchbank, K. J. & Sartbaeva, A., 24 Apr 2017, In : Scientific Reports. 7, p. 1-8 8 p., 46568.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)