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Research Output

2018

Chemical biology probes of mammalian GLUT structure and function

Holman, G. D., 20 Nov 2018, In : The Biochemical journal. 475, 22, p. 3511-3534 24 p.

Research output: Contribution to journalReview article

Open Access
5 Citations (Scopus)
Open Access
6 Citations (Scopus)
2017

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 814-820 7 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
105 Downloads (Pure)

Identification of Insulin-Activated Rab Proteins in Adipose Cells Using Bio-ATB-GTP Photolabeling Technique

Koumanov, F. & Holman, G. D., 8 Dec 2017, Glucose Transport: Methods and Protocols. Lindkvist-Petersson, K. & Hansen, J. S. (eds.). New York City, USA: Humana Press, p. 137-150 14 p. (Methods in Molecular Biology; vol. 1713).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking

Zhou, Z., Menzel, F., Benninghoff, T., Chadt, A., Du, C., Holman, G. D. & Al-Hasani, H., 1 Jan 2017, In : FEBS Letters. 591, 1, p. 88-96 9 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)

Thermal stability, storage and release of proteins with tailored fit in silica

Chen, Y-C., Smith, T., Hicks, R. H., Doekhie, A., Koumanov, F., Wells, S. A., Edler, K. J., van den Elsen, J., Holman, G. D., Marchbank, K. J. & Sartbaeva, A., 24 Apr 2017, In : Scientific Reports. 7, p. 1-8 8 p., 46568.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Use of hexose photolabels to reveal the structure and function of glucose transporters

Holman, G. D., 2017, Photoaffinity labeling for structural probing within protein. Springer Japan, Vol. 978-4-431-56569-7. p. 183-196 14 p. 9

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

The causal role of breakfast in energy balance and health: A randomized controlled trial in obese adults

Chowdhury, E., Richardson, J., Holman, G. D., Tsintzas, K., Thompson, D. & Betts, J., 1 Mar 2016, In : The American Journal of Clinical Nutrition. 103, 3, p. 747-756 10 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)
62 Downloads (Pure)
2015

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Chadt, A., Immisch, A., De Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-cueni, D., Loffing, J., Joost, H. & Al-hasani, H., Mar 2015, In : Diabetes. 64, 3, p. 746-759 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

Koumanov, F., Pereira, V. J., Richardson, J. D., Sargent, S. L., Fazakerley, D. J. & Holman, G. D., 1 Aug 2015, In : Diabetologia. 58, 8, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
51 Downloads (Pure)

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K. A., Holman, G. D., Thompson, D. & Vollaard, N. B. J., Nov 2015, In : European Journal of Applied Physiology. 115, 11, p. 2321-2334 13 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
184 Downloads (Pure)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Fazakerley, D. J., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J. G., Thomas, K. C., Krycer, J. R., Prior, M. J., Parker, B. L., Murrow, B. A., Stöckli, J., Meoli, C. C., Holman, G. D. & James, D. E., 25 Sep 2015, In : The Journal of biological chemistry. 290, 39, p. 23528-23542 15 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)
2014

The causal role of breakfast in energy balance and health: A randomized controlled trial in lean adults

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 1 Aug 2014, In : The American Journal of Clinical Nutrition. 100, 2, p. 539-547 9 p.

Research output: Contribution to journalArticle

Open Access
103 Citations (Scopus)
58 Downloads (Pure)

The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults. ISRCTN31521726

Betts, J., Richardson, J. D., Chowdhury, E., Holman, G. D., Tsintzas, K. & Thompson, D., 2014, (Accepted/In press)

Research output: Non-textual formData set/Database

Open Access
File
68 Downloads (Pure)
2013

FGT-1 is The major glucose transporter in C. elegans and is central to aging pathways

Feng, Y., Williams, BG., Koumanov, F., Wolstenholme, AJ. & Holman, G. D., 1 Dec 2013, In : Biochemical Journal. 456, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

Koumanov, F., Pereira, V. J., Whitley, P. R. & Holman, G. D., 25 Sep 2012, In : PLoS ONE. 7, 9, e44141.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Reagent

Holman, G., 19 Apr 2012, IPC No. C07H19/20 , Patent No. WO2012049464 (A1), 13 Oct 2011, Priority date 13 Oct 2013, Priority No. 1017304.5

Research output: Patent

2011

AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane

Koumanov, F., Richardson, J. D., Murrow, B. A. & Holman, G. D., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 16574-16582 9 p.

Research output: Contribution to journalArticle

File
22 Citations (Scopus)
110 Downloads (Pure)
File
20 Citations (Scopus)
85 Downloads (Pure)
2010

Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes

Fazakerley, D. J., Holman, G. D., Marley, A., James, D. E., Stockli, J. & Coster, A. C. F., 15 Jan 2010, In : Journal of Biological Chemistry. 285, 3, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Muscling in on GLUT4 kinetics

Stöckli, J., Fazakerley, D. J., Coster, A. C. F., Holman, G. D. & James, D. E., 2010, In : Communicative & Integrative Biology. 3, 3, p. 260-262 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling

Lawrence, S. P., Holman, G. D. & Koumanov, F., 15 Dec 2010, In : Biochemical Journal. 432, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

File
16 Citations (Scopus)
99 Downloads (Pure)
2009

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Fazakerley, D. J., Lawrence, S. P., Lizunov, V. A., Cushman, S. W. & Holman, G. D., 1 Mar 2009, In : Journal of Cell Science. 122, 5, p. 727-734 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Kinetics of GLUT4 trafficking in rat and human skeletal muscle

Karlsson, H. K. R., Chibalin, A. V., Koistinen, H. A., Yang, J., Koumanov, F., Wallberg-Henriksson, H., Zierath, J. R. & Holman, G. D., Apr 2009, In : Diabetes. 58, 4, p. 847-854 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2008

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

Sakamoto, K. & Holman, G. D., 1 Jul 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 295, 1, p. E29-E37

Research output: Contribution to journalArticle

283 Citations (Scopus)

Regulating the motor for GLUT4 vesicle traffic

Holman, G. D. & Sakamoto, K., 2008, In : Cell Metabolism. 8, 5, p. 344-346 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2007

Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart

Miller, E. J., Li, J., Sinusas, K. M., Holman, G. D. & Young, L. H., 2007, In : American Journal of Physiology: Endocrinology and Metabolism. 292, 6, p. E1922-E1928

Research output: Contribution to journalArticle

15 Citations (Scopus)
10 Citations (Scopus)
2006

Investigation of the role of Kv1.3 as a potential regulator of peripheral insulin sensitivity

Gillings, A. S., Yang, J., Marley, A. E., Holman, G. D., Peckham, M., Kilgour, E. & Baldwin, S. A., 2006, In : Diabetologia. 49, p. 366-366 1 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2005

Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580

Ribe, D., Yang, J., Patel, S., Koumanov, F. O., Cushman, S. W. & Holman, G. D., 2005, In : Endocrinology. 146, 4, p. 1713-1717 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
79 Citations (Scopus)

Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step

Koumanov, F., Jin, B., Yang, J. & Holman, G. D., 2005, In : Cell Metabolism. 2, 3, p. 179-189 11 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats

Collison, M., James, D. J., Graham, D., Holman, G. D., Connell, J. M. C., Dominiczak, A. F., Gould, G. W. & Salt, I. P., 2005, In : Diabetologia. 48, 3, p. 539-546 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The human glomerular podocyte is a novel target for insulin action

Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2005, In : Diabetes. 54, 11, p. 3095-3102 8 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)
2004

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle

Li, J., Hu, X. Y., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D. & Young, L. H., 2004, In : American Journal of Physiology: Endocrinology and Metabolism. 287, 5, p. E834-E841

Research output: Contribution to journalArticle

146 Citations (Scopus)

Selective formation of 1,3-oxazolidine-2-thiones on ketohexose templates

Tatibouet, A., Lawrence, S., Rollin, P. & Holman, G. D., 2004, In : Synlett. 11, p. 1945-1948 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2003

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes

Koistinen, H. A., Galuska, D., Chibalin, A. V., Yang, J., Zierath, J. R., Holman, G. D. & Wallberg-Henriksson, H., 2003, In : Diabetes. 52, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Human podocytes rapidly utilize glucose by both GLUT1 and GLUT4 in response to insulin; with significant differences in glucose transporter levels occurring in diabetic nephropathy

Coward, R. J. M., Welsh, G. I., Holman, G. D., Kerjaschki, D., Tavare, J. M., Mathieson, P. W. & Saleem, M. A., 2003, In : Journal of the American Society of Nephrology. 14, p. 388A-388A

Research output: Contribution to journalArticle

Identification of mammalian Vps24p as an effector of phosphatidylinosital 3,5-bisphosphate-dependent endosome compartmentalization

Whitley, P., Reaves, B. J., Hashimoto, M., Riley, A. M., Potter, B. V. L. & Holman, G. D., 2003, In : Journal of Biological Chemistry. 278, 40, p. 38786-38795

Research output: Contribution to journalArticle

123 Citations (Scopus)

Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones

Girniene, J., Tatibouet, A., Sackus, A., Yang, J., Holman, G. D. & Rollin, P., 2003, In : Carbohydrate Research. 338, 8, p. 711-719 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content

Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D. H., Zierath, J. R. & Krook, A., 2003, In : Cellular and Molecular Life Sciences (CMLS). 60, 5, p. 991-998 8 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X. W., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 2003, In : Journal of Biological Chemistry. 278, 41, p. 39337-39348 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2002

Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5

Yang, J., Dowden, J., Tatibouët, A., Hatanaka, Y. & Holman, G. D., 2002, In : Biochemical Journal. 367, 2, p. 533-539 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Identification of centaurin-alpha 2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle

Whitley, P., Gibbard, A. M., Koumanov, F., Oldfield, S., Kilgour, E. E., Prestwich, G. D. & Holman, G. D., Apr 2002, In : European Journal of Cell Biology. 81, 4, p. 222-230 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring

Hashimoto, M., Yang, J., Hatanaka, Y., Sadakane, Y., Nakagomi, K. & Holman, G. D., 2002, In : Chemical & Pharmaceutical Bulletin. 50, 7, p. 1004-1006 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
23 Citations (Scopus)

Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes

Yang, J., Gillingham, A. K., Hodel, A., Koumanov, F., Woodward, B. & Holman, G., 1 Dec 2002, In : American Journal of Physiology: Endocrinology and Metabolism. 283, 6, p. E1299-E1307

Research output: Contribution to journalArticle

30 Citations (Scopus)
2001

Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: An example from glucose-transporter probes

Hashimoto, M., Yang, J. & Holman, G. D., 2001, In : ChemBiochem. 2, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

Buhl, E. S., Jessen, N., Schmitz, O., Pedersen, S. B., Pedersen, O., Holman, G. D. & Lund, S., 2001, In : Diabetes. 50, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)