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20022022
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Personal profile

Research interests

My main research interests are in the areas of insulin and exercise signalling, insulin resistance and glucose metabolism in physiological and pathophysiological conditions. My research brings new cellular and molecular approaches to study the pathophysiology of chronic metabolic conditions and helps understand the impact of nutritional and physiological changes on the development and treatments of insulin resistance, type 2 diabetes and metabolic syndrome.

For several years now, I have investigated the mechanism of glucose transporter (GLUT4) vesicle trafficking. Insulin signalling plays a pivotal role in this process. Therefore, mapping GLUT4 trafficking is critical to understanding the cellular defects in diabetes. The identification of the key molecules linking insulin signalling and GLUT4 trafficking is a major challenge in the GLUT4 research field. The reason this challenge remains is mainly due to the complexity of the insulin-signalling cascade. The next major challenge in this area is to identify the small GTPases of the Rab family of proteins responsible for insulin induced GLUT4 translocation. This is the aim of my current research grant from the MRC.

To achieve this aim I am using a cross-disciplinary approach, combining cellular and molecular studies with a human intervention study in order to translate the molecular findings into whole body physiological functions. We are using cellular models of adipose cells to investigate the molecular interactions between Rab3 and other proteins in the cell that act as links between insulin action at its receptor and the GLUT4 transporter. We will investigate how these interactions are affected by treatment with proinflammatory cytokines, including TNFα, or other molecules known to induce the state of insulin resistance. These experiments will allow us to understand the mechanisms of action of Rab3 in the context of the development of the insulin-resistant state. We will also investigate in humans, undergoing a diet and exercise intervention programme, whether Rab3 is affected in a manner that reveals underlying mechanisms involved in the control of insulin sensitivity in adipose tissues and skeletal muscles. The outcome from this project will have important implications for our understanding of the mechanisms of the development of peripheral tissues insulin resistance and for the development of new, targeted therapies for treatment of insulin resistant subjects and people with type 2 diabetes. This study will also be a springboard to inform further investigations into the development of insulin resistance and the cross-talk between chronic inflammation, obesity and the onset of type 2 diabetes.

Willing to supervise PhD

Identification of new biomarkers of insulin resistance and type 2 diabetes.
Development of human skeletal muscle satellite cell model for in vitro assessment of metabolic health.

Education/Academic qualification

Doctor of Philosophy, Université Grenoble Alpes

Keywords

  • QP Physiology
  • Glucose metabolism
  • glucose transporters
  • Diabetes
  • Insulin signalling
  • Insulin resistance
  • Rab GTPases
  • membrane trafficking
  • skeletal muscle
  • adipocyes
  • obesity
  • Type 2 diabetes
  • GLUT4
  • Cell Biology
  • Biochemistry
  • Tissue culture
  • exocytosis
  • endocytosis

Fingerprint Dive into the research topics where Francoise Koumanov is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Adipocytes Medicine & Life Sciences
Facilitative Glucose Transport Proteins Medicine & Life Sciences
Breakfast Medicine & Life Sciences
Cell Membrane Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences

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Projects 2009 2022

Insulin
Membrane Fusion
Blood Glucose
Glucose Transporter Type 4
Glucose

Research Output 2002 2019

1 Citation (Scopus)

Fructose and metabolic health: governed by hepatic glycogen status?

Hengist, A., Koumanov, F. & Gonzalez, J., 15 Jul 2019, In : The Journal of Physiology. 597, 14, p. 3573-3585 13 p.

Research output: Contribution to journalReview article

Open Access

Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese. Breakfast, exercise and metabolic health

Edinburgh, R., Bradley, H., Abdullah, N-F., Robinson, S., Chrzanowski-Smith, O., Walhin, J-P., Joanisse, S., Manolopoulos, K., Philp, A., Hengist, A., Chabowski, A., Brodsky, F., Koumanov, F., Betts, J., Thompson, D., Wallis, G. & Gonzalez, J., 19 Oct 2019, In : Journal of Clinical Endocrinology & Metabolism. p. 1-47 47 p., dgz104.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
Open Access
Abdominal Subcutaneous Fat
Breakfast
Adipose Tissue
Fasting
Insulin
8 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
Breakfast
Fasting
Eating
Exercise
Glucose
14 Citations (Scopus)
113 Downloads (Pure)

Feeding Influences Adipose Tissue Responses to Exercise in Overweight Men

Chen, Y-C., Travers, R. L., Walhin, J-P., Gonzalez, J. T., Koumanov, F., Betts, J. A. & Thompson, D., 1 Jul 2017, In : American Journal of Physiology: Endocrinology and Metabolism. 313, 1, p. E84-E93 10 p.

Research output: Contribution to journalArticle

Open Access
File
Adipose Tissue
Exercise
Adipokines
Messenger RNA
AMP-Activated Protein Kinases

Datasets

Dataset for "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in overweight men"

Edinburgh, R. (Creator), Bradley, H. (Creator), Abdullah, N. (Creator), Robinson, S. (Creator), Chrzanowski-Smith, O. (Creator), Walhin, J. (Creator), Joanisse, S. (Creator), Manolopoulos, K. (Creator), Philp, A. (Creator), Hengist, A. (Creator), Chabowski, A. (Creator), Brodsky, F. (Creator), Koumanov, F. (Creator), Betts, J. (Creator), Thompson, D. (Creator), Wallis, G. (Creator), Gonzalez, J. (Creator), University of Bath, 19 Oct 2019

Dataset

Dataset for 'Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men: Pre-exercise feeding and postprandial glucose flux'

Edinburgh, R. (Creator), Hengist, A. (Creator), Smith, H. (Creator), Travers, R. (Creator), Koumanov, F. (Creator), Betts, J. (Creator), Thompson, D. (Creator), Walhin, J. (Creator), Wallis, G. (Creator), Hamilton, D. L. (Creator), Stevenson, E. (Creator), Tipton, K. (Creator), Gonzalez, J. (Creator), University of Bath, 27 Feb 2019

Dataset

Thesis

Ensilication of tetanus toxin C fragment for the development of thermostable vaccines

Author: Doekhie, A., 19 Jun 2019

Supervisor: Sartbaeva, A. (Supervisor), Van Den Elsen, J. (Supervisor) & Koumanov, F. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Investigating GLUT4 Trafficking in Muscle

Author: Fazakerley, D., 1 Jan 2010

Supervisor: Holman, G. (Supervisor) & Koumanov, F. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Investigation of Rab-GAPs as links between insulin signalling and GLUT4 translocation

Author: Roche, L., 16 Nov 2013

Supervisor: Holman, G. (Supervisor) & Koumanov, F. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Novel Proteins Associated with GLUT4 Vesicle Subcellular Traffic

Author: Pereira, V., 16 Sep 2014

Supervisor: Holman, G. (Supervisor) & Koumanov, F. (Supervisor)

Student thesis: Doctoral ThesisPhD

File