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Personal profile

Research interests

My research interests lie in using sequence data to study bacterial pathogens, both from a point of view of managing infections (molecular epidemiology) but also in terms of understanding fundamental evolutionary dynamics. The early part of my research career was spent generating and interpreting multilocus sequence typing (MLST) data for numerous species. I developed the BURST algorithm to help visualise these datasets (J Bacteriol. 186(5):1518-30). More recently, I have focussed on whole genome sequence (WGS) data, and was joint lead author on the first demonstration of WGS data for molecular epidemiology (Science 327: 5964 469-474). I am currently a PI on a large CRCUK project, headed by Prof Sharon Peacock, looking at implementing this technology into routine epidemiological surveillance, and was previously a work package leader on the FP7 Project TROCAR, headed by Prof Jordi Villa, which aimed to characterise and manage high risk antibiotic resistant clones in Europe.

I also have a strong interest in using whole genome sequencing (WGS) to understand and manage the spread of bacterial pathogens in animals. I was a PI on consortium funded under the insect pollinator initiative looking at the epidemiology of European Foul Brood in honeybees, and am currently PI on the BBSRC/NERC funded project wgs-aqua.net, which aims to deploy WGS to manage bacterial pathogens of aquaculture (in collaboration with Cefas, Weymouth, the University of Stirling and the Centre for Genomic Pathogen Surveillance, Wellcome Trust Sanger Institute).

In addition to molecular epidemiology, WGS data of bacterial pathogens can shed light on basic evolutionary questions concerning diversification; mutation, recombination and selection. Research questions include the strength of selection on intergenic sites, codon bias, context dependant mutation, the maintenance of GC content, INDEL formation, and gene essentiality.

I was awarded the Zoological Society of London Scientific Medal in 2010, and am an ISI highly cited researcher for 2015.

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Projects

EDGE

Feil, E.

1/05/2030/04/21

Project: Research council

ReNEW

Feil, E.

Engineering and Physical Sciences Research Council

1/05/1731/12/20

Project: Research council

  • Research Output

    Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters

    Castrignanò, E., Yang, Z., Feil, E. J., Bade, R., Castiglioni, S., Causanilles, A., Gracia-Lor, E., Hernandez, F., Plósz, B. G., Ramin, P., Rousis, N. I., Ryu, Y., Thomas, K. V., de Voogt, P., Zuccato, E. & Kasprzyk-Hordern, B., 15 May 2020, In : Water Research. 175, p. 115653 115653.

    Research output: Contribution to journalArticle

    High-resolution sweep metagenomics using fast probabilistic inference

    Mäklin, T., Kallonen, T., David, S., Boinett, C. J., Pascoe, B., Méric, G., Aanensen, D. M., Feil, E. J., Baker, S., Parkhill, J., Sheppard, S. K., Corander, J. & Honkela, A., 30 Jan 2020, In : Wellcome Open Research. 5, p. 14

    Research output: Contribution to journalArticle

    Open Access

    Monitoring Infectious Diseases in Near-Real-Time for Rapid Outbreak Response

    Boxall-Clasby, J., Kasprzyk-Hordern, B., Estrela, P., Feil, E. & Barden, R., 2020, (In preparation).

    Research output: Contribution to conferencePoster

    The role of stereochemistry of antibiotic agents in the development of antibiotic resistance in the environment

    Elder, F. C. T., Feil, E. J., Snape, J. N., Gaze, W. H. & Kasprzyk-Hordern, B. A., 30 Jun 2020, In : Environment International. 139, 105681.

    Research output: Contribution to journalReview article

    Open Access

    Description of klebsiella spallanzanii sp. Nov. and of klebsiella pasteurii sp. nov.

    Merla, C., Rodrigues, C., Passet, V., Corbella, M., Thorpe, H. A., Kallonen, T. V. S., Zong, Z., Marone, P., Bandi, C., Sassera, D., Corander, J., Feil, E. J. & Brisse, S., 25 Oct 2019, In : Frontiers in Microbiology. 10, p. 1-9 9 p., 2360.

    Research output: Contribution to journalArticle

    Open Access
    5 Citations (Scopus)

    Thesis

    A Bayesian Approach to Phylogenetic Networks

    Author: Radice, R., 1 Jan 2011

    Supervisor: Feil, E. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Analysing the Genetic Diversity of Ixodes ricinus ticks using Multilocus Sequence Typing

    Author: Dinnis, R., 1 Sep 2010

    Supervisor: Feil, E. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Enantiomeric Profiling of Chiral Biomarkers

    Author: Castrignanó, E., 23 Nov 2016

    Supervisor: Kasprzyk-Hordern, B. (Supervisor), Lubben, A. (Supervisor) & Feil, E. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Evolutionary dynamics of intergenic sites, pan-genomes, and introgression in bacteria

    Author: Thorpe, H., 17 May 2018

    Supervisor: Feil, E. (Supervisor) & Hurst, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Patterns of Short-term Genome Evolution in E.coli and Shigellae

    Author: Balbi, K., 1 Jul 2009

    Supervisor: Feil, E. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File