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Personal profile

Research interests

My research interests lie in using sequence data to study bacterial pathogens, both from a point of view of managing infections (molecular epidemiology) but also in terms of understanding fundamental evolutionary dynamics. The early part of my research career was spent generating and interpreting multilocus sequence typing (MLST) data for numerous species. I developed the BURST algorithm to help visualise these datasets (J Bacteriol. 186(5):1518-30). More recently, I have focussed on whole genome sequence (WGS) data, and was joint lead author on the first demonstration of WGS data for molecular epidemiology (Science 327: 5964 469-474). I am currently a PI on a large CRCUK project, headed by Prof Sharon Peacock, looking at implementing this technology into routine epidemiological surveillance, and was previously a work package leader on the FP7 Project TROCAR, headed by Prof Jordi Villa, which aimed to characterise and manage high risk antibiotic resistant clones in Europe.

I also have a strong interest in using whole genome sequencing (WGS) to understand and manage the spread of bacterial pathogens in animals. I was a PI on consortium funded under the insect pollinator initiative looking at the epidemiology of European Foul Brood in honeybees, and am currently PI on the BBSRC/NERC funded project wgs-aqua.net, which aims to deploy WGS to manage bacterial pathogens of aquaculture (in collaboration with Cefas, Weymouth, the University of Stirling and the Centre for Genomic Pathogen Surveillance, Wellcome Trust Sanger Institute).

In addition to molecular epidemiology, WGS data of bacterial pathogens can shed light on basic evolutionary questions concerning diversification; mutation, recombination and selection. Research questions include the strength of selection on intergenic sites, codon bias, context dependant mutation, the maintenance of GC content, INDEL formation, and gene essentiality.

I was awarded the Zoological Society of London Scientific Medal in 2010, and am an ISI highly cited researcher for 2015.

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  • 3 Similar Profiles
Multilocus Sequence Typing Medicine & Life Sciences
Staphylococcus aureus Medicine & Life Sciences
Genome Medicine & Life Sciences
Clone Cells Medicine & Life Sciences
Population Medicine & Life Sciences
Methicillin-Resistant Staphylococcus aureus Medicine & Life Sciences
Genotype Medicine & Life Sciences
Virulence Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2021

One Health Drivers of Antibacterial Resistance in Thailand

Feil, E.

1/05/1830/04/21

Project: Research council

ReNEW

Feil, E.

1/05/1730/04/20

Project: Research council

public health
early warning system
hazard
health status
infectious disease

AMR Global Development

Feil, E.

1/10/1731/03/18

Project: Research council

environmental fate
environmental effect
bacterium
health impact
antibiotics

Research Output 2001 2019

High tech research reveals preferential feeding in honey bees

Greco, M. K., Coates, B. & Feil, E. J., 31 Mar 2019, In : Journal of Apicultural Research. 58, 3, p. 471-477 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multi-locus sequence typing of Ixodes ricinus and its symbiont Candidatus Midichloria mitochondrii across Europe reveals evidence of local co-cladogenesis in Scotland

Al-Khafaji, A. M., Clegg, S. R., Pinder, A. C., Luu, L., Hansford, K. M., Seelig, F., Dinnis, R. E., Margos, G., Medlock, J. M., Feil, E. J., Darby, A. C., McGarry, J. W., Gilbert, L., Plantard, O., Sassera, D. & Makepeace, B. L., 1 Jan 2019, In : Ticks and Tick-Borne Diseases. 10, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

Using the wax moth larva Galleria mellonella infection model to detect emerging bacterial pathogens

Hernandez, R. J., Hesse, E., Dowling, A. J., Coyle, N. M., Feil, E. J., Gaze, W. H. & Vos, M., 4 Jan 2019, In : PeerJ. 6, 1, p. e6150 e6150.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis

Méric, G., Mageiros, L., Pensar, J., Laabei, M., Yahara, K., Pascoe, B., Kittiwan, N., Tadee, P., Post, V., Lamble, S., Bowden, R., Bray, J. E., Morgenstern, M., Jolley, K. A., Maiden, M. C. J., Feil, E. J., Didelot, X., Miragaia, M., de Lencastre, H., Moriarty, T. F. & 5 othersRohde, H., Massey, R., Mack, D., Corander, J. & Sheppard, S. K., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 5034.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access
Ofloxacin
Fluoroquinolones
Liquid chromatography
Fractionation
detection method

Thesis

A Bayesian Approach to Phylogenetic Networks

Author: Radice, R., 1 Jan 2011

Supervisor: Feil, E. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Analysing the Genetic Diversity of Ixodes ricinus ticks using Multilocus Sequence Typing

Author: Dinnis, R., 1 Sep 2010

Supervisor: Feil, E. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Enantiomeric Profiling of Chiral Biomarkers

Author: Castrignanó, E., 23 Nov 2016

Supervisor: Kasprzyk-Hordern, B. (Supervisor), Lubben, A. (Supervisor) & Feil, E. (Supervisor)

Student thesis: Doctoral ThesisPhD

Evolutionary dynamics of intergenic sites, pan-genomes, and introgression in bacteria

Author: Thorpe, H., 17 May 2018

Supervisor: Feil, E. (Supervisor) & Hurst, L. (Supervisor)

Student thesis: Doctoral ThesisPhD

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Patterns of Short-term Genome Evolution in E.coli and Shigellae

Author: Balbi, K., 1 Jul 2009

Supervisor: Feil, E. (Supervisor)

Student thesis: Doctoral ThesisPhD

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