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  • 4 Similar Profiles
Hepatocytes Medicine & Life Sciences
Pancreas Medicine & Life Sciences
Liver Medicine & Life Sciences
Metaplasia Medicine & Life Sciences
Barrett Esophagus Medicine & Life Sciences
Phenotype Medicine & Life Sciences
CCAAT-Enhancer-Binding Protein-beta Medicine & Life Sciences
Dexamethasone Medicine & Life Sciences

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Projects 2004 2018

University of Bath Industrial Strategy Acceleration Fund (ISAF)

Rocha, P., Moschou, D. & Tosh, D.

2/04/1831/07/18

Project: OtherInternational Collaboration

Cell Sorting Flow Cytomoetry

Kelsh, R. & Tosh, D.

1/09/1231/08/18

Project: UK charity

Advanced Inhibitors of Tankyrases

Tosh, D.

1/10/1530/09/16

Project: UK charity

Advanced Inhibitors of Tankyrases

Tosh, D.

1/10/1430/09/15

Project: UK charity

Research Output 1996 2018

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway

Burke, Z. D., Reed, K. R., Yeh, S-W., Meniel, V., Sansom, O. J., Clarke, A. R. & Tosh, D. 9 Feb 2018 In : Scientific Reports. 8, 1, 2735

Research output: Contribution to journalArticle

Open Access
beta Catenin
Glutamate-Ammonia Ligase
Liver
Ammonia
Carbamoyl-Phosphate Synthase (Ammonia)

Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins

Gratte, F. D., Pasic, S., Olynyk, J. K., Yeoh, G. C. T., Tosh, D., Coombe, D. R. & Tirnitz-Parker, J. E. E. 12 Mar 2018 In : Scientific Reports. 8, 1, 4385

Research output: Contribution to journalArticle

Open Access
Extracellular Matrix Proteins
Hepatocytes
Stem Cells
Serum
Liver
9 Citations

Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity

Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. & Threadgill, M. 26 Jan 2017 In : Journal of Medicinal Chemistry. 60, 2, p. 814-820

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Inhibitory Concentration 50
Protein Isoforms
Binding Sites
Glucose
2 Citations

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium

Colleypriest, B. J., Burke, Z. D., Griffiths, L. P., Chen, Y., Yu, W-Y., Jover, R., Bock, M., Biddlestone, L., Quinlan, J. M., Ward, S. G., Mark Farrant, J., Slack, J. M. W. & Tosh, D. 1 Jan 2017 In : Differentiation. 93, p. 39-49 11 p.

Research output: Contribution to journalArticle

Open Access
File
Barrett Esophagus
Metaplasia
Organ Culture Techniques
Epithelium
Phenotype

The Directed Differentiation of Human Embryonic Stem Cells to Lung Cell Lineages

Alaqel, A. 2017 341 p.

Research output: ThesisDoctoral Thesis

Open Access
File
Cell Lineage
Endoderm
Lung
Epithelial Cells
Stem Cells