David Brown

2022

The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2

Brown, D., 30 Sept 2022, In: Molecular and Cellular Neuroscience. 122, 103760.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (SciVal)

2021

Senescent microglia: The key to the ageing brain?

Greenwood, E. K. & Brown, D. R., 1 May 2021, In: International Journal of Molecular Sciences. 22, 9, 4402.

Research output: Contribution to journal › Review article › peer-review

Open Access

44 Citations (SciVal)

2019

Microglia and the aging brain: are senescent microglia the key to neurodegeneration?

Angelova, D. M. & Brown, D. R., 1 Dec 2019, In: Journal of Neurochemistry. 151, 6, p. 676-688 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

183 Citations (SciVal)

166 Downloads (Pure)

2018

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia

Angelova, D. & Brown, D., 19 Dec 2018, In: ACS Chemical Neuroscience. 9, 12, p. 3137-3152 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

29 Citations (SciVal)

596 Downloads (Pure)

Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers

Angelova, D., Jones, H. & Brown, D., 1 Feb 2018, In: FASEB Journal. 32, 2, p. 995-1006 12 p.

Research output: Contribution to journal › Article › peer-review

File

10 Citations (SciVal)

149 Downloads (Pure)

Model Senescent Microglia Induce Disease Related Changes in Alpha-synuclein Expression and Activity

Angelova, D. & Brown, D., 1 Aug 2018, In: Biomolecules. 8, 3, p. 1-25 25 p., 67.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (SciVal)

2017

Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL

McDowall, J. S., Ntai, I., Honeychurch, K. C., Hart, J. P., Colin, P., Schneider, B. L. & Brown, D., 1 Dec 2017, In: Molecular and Cellular Neuroscience. 85, p. 1-11 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

21 Citations (SciVal)

315 Downloads (Pure)

Metals and Prions: Twenty years of mining the awe

Brown, D., 28 Apr 2017, Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. White, A. R., Aschner, M., Costa, L. G. & Bush, A. I. (eds.). London, U. K.: Elsevier Academic Press Inc, p. 95-115

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

2 Citations (SciVal)

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species

McDowall, J. S., Ntai, I., Hake, J., Whitley, P. R., Mason, J. M., Pudney, C. R. & Brown, D. R., 16 May 2017, In: Biochemistry. 56, 19, p. 2497–2505 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (SciVal)

186 Downloads (Pure)

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

Roberts, H. L., Schneider, B. L. & Brown, D. R., 1 Feb 2017, In: PLoS ONE. 12, 2, e0171925.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Citations (SciVal)

2016

Alpha-synuclein: relating metals to structure, function and inhibition

McDowall, J. S. & Brown, D. R., 1 Apr 2016, In: Metallomics. 8, 4, p. 385-397 13 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

2015

Iron, aging, and neurodegeneration

Angelova, D. M. & Brown, D., 6 Nov 2015, In: Metals. 5, 4, p. 2070-2092 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (SciVal)

Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease

Goñi, F., Mathiason, C. K., Yim, L., Wong, K., Hayes-Klug, J., Nalls, A., Peyser, D., Estevez, V., Denkers, N., Xu, J., Osborn, D. A., Miller, K. V., Warren, R. J., Brown, D. R., Chabalgoity, J. A., Hoover, E. A. & Wisniewski, T., Jan 2015, In: Vaccine. 33, 5, p. 726-733 8 p.

Research output: Contribution to journal › Article › peer-review

62 Citations (SciVal)

Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc

Pass, R., Frudd, K., Barnett, J. P., Blindauer, C. A. & Brown, D. R., Sept 2015, In: Molecular and Cellular Neuroscience. 68, p. 186-193 8 p.

Research output: Contribution to journal › Article › peer-review

File

7 Citations (SciVal)

287 Downloads (Pure)

Seeking a mechanism for the toxicity of oligomeric alpha-synuclein.

Roberts, H. & Brown, D., 2015, In: Biomolecules. 5

Research output: Contribution to journal › Article › peer-review

2014

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

Walsh, K. P., Minamide, L. S., Kane, S. J., Shaw, A. E., Brown, D. R., Pulford, B., Zabel, M. D., Lambeth, J. D., Kuhn, T. B. & Bamburg, J. R., 23 Apr 2014, In: PLoS ONE. 9, 4, p. e95995

Research output: Contribution to journal › Article › peer-review

Open Access

57 Citations (SciVal)

Nrf-2 regulation of prion protein expression is independent of oxidative stress

Cichon, A.-C. & Brown, D. R., Nov 2014, In: Molecular and Cellular Neuroscience. 63, p. 31-37 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

18 Citations (SciVal)

706 Downloads (Pure)

2013

Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level

Wright, J. A., Mchugh, P. C., Pan, S., Cunningham, A. & Brown, D. R., Nov 2013, In: Molecular and Cellular Neuroscience. 57, p. 33-41 9 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (SciVal)

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

Younan, N. D., Sarell, C. J., Davies, P., Brown, D. R. & Viles, J. H., May 2013, In: FASEB Journal. 27, 5, p. 1847-1858 12 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (SciVal)

α-Synuclein as a ferrireductase

Brown, D. R., Dec 2013, In: Biochemical Society Transactions. 41, 6, p. 1513-1517 5 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (SciVal)

2012

Brain Diseases and Metalloproteins

Brown, D. R., 31 Jul 2012, Pan Stanford Publishing. 438 p.

Research output: Book/Report › Book

4 Citations (SciVal)

Expression of immunohistochemical markers on microglia in Creutzfeldt-Jakob disease and Alzheimer's disease: Morphometric study and review of the literature

Wojtera, M., Sobów, T., Kłoszewska, I., Liberski, P. P., Brown, D. R. & Sikorska, B., 2012, In: Folia Neuropathologica. 50, 1, p. 74-84 11 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (SciVal)

Introduction

Brown, D. R., 31 Jul 2012, Brain Diseases and Metalloproteins . Brown, D. R. (ed.). Singapore: Pan Stanford Publishing, p. 1-10 11 p.

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway

Younan, N. D., Nadal, R. C., Davies, P., Brown, D. R. & Viles, J. H., 17 Aug 2012, In: Journal of Biological Chemistry. 287, 34, p. 28263-28275 13 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (SciVal)

Prion diseases, metals and antioxidants

Davies, P. & Brown, D. R., 31 Jul 2012, Brain Diseases and Metalloproteins . Brown, D. R. (ed.). Singapore: Pan Stanford Publishing, p. 249-293 45 p.

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

2 Citations (SciVal)

Prion protein expression alters APP cleavage without interaction with BACE-1

McHugh, P. C., Wright, J. A., Williams, R. J. & Brown, D. R., Oct 2012, In: Neurochemistry International. 61, 5, p. 672-680

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (SciVal)

232 Downloads (Pure)

Prion protein polymerisation triggered by manganese-generated prion protein seeds

Hesketh, S., Thompsett, A. R. & Brown, D. R., Jan 2012, In: Journal of Neurochemistry. 120, 1, p. 177-189 13 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

The catalytic redox activity of prion protein-cuII is controlled by metal exchange with the ZnII-Thiolate clusters of Zn7Metallothionein-3

Meloni, G., Crameri, A., Fritz, G., Davies, P., Brown, D. R., Kroneck, P. M. H. & Vašák, M., 18 Jun 2012, In: ChemBiochem. 13, 9, p. 1261-1265

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

2011

Contribution of individual histidines to prion protein copper binding

Davies, P., McHugh, P. C., Hammond, V. J., Marken, F. & Brown, D. R., 20 Dec 2011, In: Biochemistry. 50, 50, p. 10781-10791 11 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (SciVal)

Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein

Younan, N. D., Klewpatinond, M., Davies, P., Ruban, A. V., Brown, D. R. & Viles, J. H., 15 Jul 2011, In: Journal of Molecular Biology. 410, 3, p. 369-382 14 p.

Research output: Contribution to journal › Article › peer-review

55 Citations (SciVal)

Metal attenuating therapies in neurodegenerative disease

Mot, A. I., Wedd, A. G., Sinclair, L., Brown, D. R., Collins, S. J. & Brazier, M. W., Dec 2011, In: Expert Review of Neurotherapeutics. 11, 12, p. 1717-1745 29 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (SciVal)

Metals in neurodegenerative disease

Brown, D. R., 2011, In: Metallomics. 3, 3, p. 226-228 3 p.

Research output: Contribution to journal › Article

17 Citations (SciVal)

Prions and manganese: A maddening beast

Brown, D. R., Mar 2011, In: Metallomics. 3, 3, p. 229-238 10 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (SciVal)

The synucleins are a family of redox-active copper binding proteins

Davies, P., Wang, X. Y., Sarell, C. J., Drewett, A., Marken, F., Viles, J. H. & Brown, D. R., 11 Jan 2011, In: Biochemistry. 50, 1, p. 37-47 11 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (SciVal)

Transcriptional regulation of the beta-synuclein 5 '-promoter metal response element by metal transcription factor-1

McHugh, P. C., Wright, J. A. & Brown, D. R., 2011, In: PLoS ONE. 6, 2, e17354.

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

α-Synuclein is a cellular ferrireductase

Davies, P., Moualla, D. & Brown, D. R., Jan 2011, In: PLoS ONE. 6, 1, 7 p., e15814.

Research output: Contribution to journal › Article › peer-review

File

171 Citations (SciVal)

177 Downloads (Pure)

2010

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

Wang, X., Moualla, D., Wright, J. A. & Brown, D. R., May 2010, In: Journal of Neurochemistry. 113, 3, p. 704-714 11 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (SciVal)

Metalloproteins and neuronal death

Brown, D. R., 2010, In: Metallomics. 2, 3, p. 186-194 9 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (SciVal)

Oligomeric alpha-synuclein and its role in neuronal death

Brown, D. R., 2010, In: IUBMB Life. 62, 5, p. 334-339 6 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (SciVal)

Synuclein proteins and their roles as metal binding proteins

Wang, X. & Brown, D. R., 2010, Metals and Neurodegeneration. Huang, S. (ed.). Research Signpost, p. 177-210 34 p.

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

2009

Activation and repression of prion protein expression by key regions of intron 1

Wright, J. A., Mchugh, P. C., Stockbridge, M., Lane, S., Kralovicova, S. & Brown, D. R., Dec 2009, In: Cellular and Molecular Life Sciences (CMLS). 66, 23, p. 3809-3820 12 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (SciVal)

Brain proteins that mind metals: a neurodegenerative perspective

Brown, D. R., 2009, In: Dalton Transactions. 21, p. 4069-4076 8 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (SciVal)

Dynamics of a truncated prion protein, PrP(113-231), from 15N NMR relaxation: Order parameters calculated and slow conformational fluctuations localized to a distinct region

O'Sullivan, D. B. D., Jones, C. E., Abdelraheim, S., Brazier, M. W., Toms, H., Brown, D. R. & Viles, J. H., 2009, In: Protein Science. 18, 2, p. 410-423 14 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (SciVal)