Christopher Jennison

2024

Bayesian and Frequentist Approaches to Rescuing Disrupted Trials: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions

Kunz, C. U., Tarima, S., Rosner, G. L., Emsley, R., Bauer, M., Jennison, C., Rosenberger, J. L., Stallard, N., Zohar, S. & Flournoy, N., 19 Mar 2024, (E-pub ahead of print) In: Statistics in Biopharmaceutical Research. 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (SciVal)

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, E. L., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A. & Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Holst, J. J., Thomsen, H. S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, T., Holmes, E., Frost, G. & Pearson, E. R., 1 Sept 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 9, p. e1697-e1707

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Comment: Group Sequential Designs with Response-Adaptive Randomisation

Jennison, C., 31 May 2023, In: Statistical Science. 38, 2, p. 219-223 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

File

41 Downloads (Pure)

Discussion on “Adaptive enrichment designs with a continuous biomarker” by N. Stallard

Jennison, C., 31 Mar 2023, In: Biometrics. 79, 1, p. 26-30 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials

DIRECT consortium, 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (SciVal)

2022

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

Pavo, I. & IMI DIRECT consortium, 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 100477.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Citations (SciVal)

Joint modelling of longitudinal and time-to-event data applied to group sequential clinical trials

Jennison, C., Burdon, A. & Hampson, L., Nov 2022, (E-pub ahead of print) arXiv.

Research output: Working paper / Preprint › Preprint

Robust group sequential designs for trials with survival endpoints and delayed response

Ghosh, P., Ristl, R., König, F., Posch, M., Jennison, C., Götte, H., Schüler, A. & Mehta, C., 28 Feb 2022, In: Biometrical Journal. 64, 2, p. 343-360 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (SciVal)

154 Downloads (Pure)

2021

Adaptive enrichment trials: What are the benefits?

Burnett, T. & Jennison, C., 10 Feb 2021, In: Statistics in Medicine. 40, 3, p. 690-711 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (SciVal)

Optimizing subgroup selection in two-stage adaptive enrichment and umbrella designs

Ballarini, N. M., Burnett, T., Jaki, T., Jennison, C., König, F. & Posch, M., 30 May 2021, In: Statistics in Medicine. 40, 12, p. 2939-2956 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (SciVal)

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

IMI DIRECT consortium, 1 Feb 2021, In: Diabetes Care. 44, 2, p. 511-518 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

17 Citations (SciVal)

71 Downloads (Pure)

2020

A reference map of potential determinants for the human serum metabolome

The IMI DIRECT consortium, 3 Dec 2020, In: Nature. 588, 7836, p. 135-140 6 p.

Research output: Contribution to journal › Article › peer-review

258 Citations (SciVal)

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & Kokkola, T. & 17 others, Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., 1 Aug 2020, In: EBioMedicine. 58, 102932.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (SciVal)

83 Downloads (Pure)

TriMaster: Randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea - A MASTERMIND study protocol

Angwin, C., Jenkinson, C., Jones, A., Jennison, C., Henley, W., Farmer, A., Sattar, N., Holman, R. R., Pearson, E., Shields, B. & Hattersley, A., 21 Dec 2020, In: BMJ Open. 10, 12, e042784.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (SciVal)

2019

Authors' reply

Jennison, C. & Turnbull, B. W., 2 Dec 2019, In: Statistics in Medicine. 38, 30, p. 5670-5671 2 p.

Research output: Contribution to journal › Letter

Open Access

File

49 Downloads (Pure)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

IMI DIRECT consortium, 1 Sept 2019, In: Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (SciVal)

2018

A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R. & Curto, T., 1 Mar 2018, In: Biometrics. 74, 1, p. 40-48 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

15 Citations (SciVal)

389 Downloads (Pure)

Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance

Li, H., Wang, J., Luo, X., Grechko, J. & Jennison, C., 1 Sept 2018, In: Biometrical Journal. 60, 5, p. 893-902 10 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

Rates of glycaemic deterioration in a real-world population with type 2 diabetes

Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R., 1 Mar 2018, In: Diabetologia. 61, 3, p. 607-615 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

39 Citations (SciVal)

91 Downloads (Pure)

2017

A multi-stage drop-the-losers design for multi-arm clinical trials

Wason, J., Stallard, N., Bowden, J. & Jennison, C., 1 Feb 2017, In: Statistical Methods in Medical Research. 26, 1, p. 508-524

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Citations (SciVal)

188 Downloads (Pure)

Comparing oncology clinical programs by use of innovative designs and expected net present value optimization: which adaptive approach leads to the best result?

Parke, T., Marchenko, O., Anisimov, V., Ivanova, A., Jennison, C., Perevozskaya, I. & Song, G., 2017, In: Journal of Biopharmaceutical Statistics. 27, 3, p. 457-476 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (SciVal)

179 Downloads (Pure)

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study

Eibich, P., Green, A., Hattersley, A. T., Jennison, C., Lonergan, M. E., Pearson, E. R. & Gray, A. M., 1 Oct 2017, In: Diabetes Therapy. 8, 5, p. 1031-1045 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (SciVal)

2015

Adaptive sample size modification in clinical trials: start small then ask for more?

Jennison, C. & Turnbull, B. W., 20 Dec 2015, In: Statistics in Medicine. 34, 29, p. 3793-3810 18 p.

Research output: Contribution to journal › Article › peer-review

File

42 Citations (SciVal)

524 Downloads (Pure)

Impact of Phase 2b strategies on optimization of drug development programs

Jennison, C., Antonijevic, Z., Bolognese, J., Burman, C.-F., Chuang-Stein, C., Kimber, M., Marchenko, O., Patel, N. & Pinheiro, J., 2015, Optimization of Pharmaceutical R&D Programs and Portfolios: Design and Investment Strategy. Heidelberg: Springer, p. 83-103

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

Model free audit methodology for bias evaluation of tumour progression in oncology

Stone, A., Macpherson, E., Smith, A. & Jennison, C., 5 Nov 2015, In: Pharmaceutical Statistics. 14, 6, p. 455-463 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (SciVal)

257 Downloads (Pure)

Optimizing the Data Combination Rule for Seamless Phase II/III Clinical Trials

Hampson, L. & Jennison, C., 15 Jan 2015, In: Statistics in Medicine. 34, 1, p. 39-58 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (SciVal)

32 Downloads (Pure)

2014

Clinical and genetic determinants of progression of type 2 diabetes: A direct study

Zhou, K., Donnelly, L. A., Morris, A. D., Franks, P. W., Jennison, C., Palmer, C. N. A. & Pearson, E. R., Mar 2014, In: Diabetes Care. 37, 3, p. 718-724 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

60 Citations (SciVal)

162 Downloads (Pure)

2013

Group sequential tests for delayed responses (with discussion)

Hampson, L. V. & Jennison, C., Jan 2013, In: Journal of the Royal Statistical Society, Series B (Statistical Methodology). 75, 1, p. 3-54 52 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (SciVal)

Interim monitoring of clinical trials: decision theory, dynamic programming and optimal stopping

Jennison, C. & Turnbull, B. W., 2013, In: Kuwait Journal of Science. 40, 2, p. 43-59 17 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

2011

An adaptive seamless phase II/III design for oncology trials with subpopulation selection using correlated survival endpoints

Jenkins, M., Stone, A. & Jennison, C., 1 Jul 2011, In: Pharmaceutical Statistics. 10, 4, p. 347-356 10 p.

Research output: Contribution to journal › Article › peer-review

158 Citations (SciVal)

Mapping electron density in the ionosphere: a principal component MCMC algorithm

Khorsheed, E., Hurn, M. & Jennison, C., 1 Jan 2011, In: Computational Statistics & Data Analysis. 55, 1, p. 338-352 15 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

Three-dimensional Bayesian image analysis and confocal microscopy

Al-Awadhi, F., Hurn, M. & Jennison, C., Jan 2011, In: Journal of Applied Statistics. 38, 1, p. 29-46 18 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

2010

Optimal group-sequential designs for simultaneous testing of superiority and non-inferiority

Ohrn, F. & Jennison, C., 30 Mar 2010, In: Statistics in Medicine. 29, 7-8, p. 743-759 17 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

2007

Adaptive seamless designs: Selection and prospective testing of hypotheses

Jennison, C. & Turnbull, B. W., 2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1135-1161 27 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (SciVal)

2006

Adaptive and nonadaptive group sequential tests

Jennison, C. & Turnbull, B. W., 1 Mar 2006, In: Biometrika. 93, 1, p. 1-21 21 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (SciVal)

Are flexible designs sound? Discussion

Jennison, C. & Turnbull, B. W., 2006, In: Biometrics. 62, 3, p. 670-673 4 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: Opportunities and limitations

Jennison, C. & Turnbull, B. W., 2006, In: Biometrical Journal. 48, 4, p. 650-655 6 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

Discussion of "Executive Summary of the PhRMA Working Group on adaptive designs in clinical drug development"

Jennison, C. & Turnbull, B. W., 2006, In: Journal of Biopharmaceutical Statistics. 16 May-Jun, 3, p. 293-298 6 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

Efficient group sequential designs when there are several effect sizes under consideration

Jennison, C. & Turnbull, B. W., 30 Mar 2006, In: Statistics in Medicine. 25, 6, p. 917-932 16 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (SciVal)

2005

Meta-analyses and adaptive group sequential designs in the clinical development process

Jennison, C. & Turnbull, B. W., 2005, In: Journal of Biopharmaceutical Statistics. 15, 4, p. 537-558 22 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (SciVal)

2004

Improving the acceptance rate of reversible jump MCMC proposals

Al-Awadhi, F., Hurn, M. & Jennison, C., 2004, In: Statistics & Probability Letters. 69, 2, p. 189-198 10 p.

Research output: Contribution to journal › Article › peer-review

50 Citations (SciVal)

Inequalities in accessing hip joint replacement for people in need

Milner, P. C., Payne, J. N., Stanfield, R. C., Lewis, P. A., Jennison, C. & Saul, C., 2004, In: European Journal of Public Health. 14, 1, p. 58-62 5 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (SciVal)

Inequalities in access to knee joint replacements for people in need

Yong, P. F. K., Milner, P. C., Payne, J. N., Lewis, P. A. & Jennison, C., 2004, In: Annals of the Rheumatic Diseases. 63, 11, p. 1483-1489 7 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (SciVal)

Statistical image analysis for a confocal microscopy two-dimensional section of cartilage growth

Al-Awadhi, F., Jennison, C. & Hurn, M., Jan 2004, In: Journal of the Royal Statistical Society Series C-Applied Statistics. 53, 1, p. 31-49 19 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

2003

An evaluation of the safety and efficacy of simultaneous bilateral total knee arthroplasty

Leonard, L., Williamson, D. M., Ivory, J. P. & Jennison, C., 2003, In: Journal of Arthroplasty. 18, 8, p. 972-978 7 p.

Research output: Contribution to journal › Article › peer-review

95 Citations (SciVal)

Efficient construction of reversible jump Markov chain Monte Carlo proposal distributions - Discussion on the paper by Brooks, Giudici and Roberts

Robert, C. P., Meng, X. L., Moller, J., Rosenthal, J. S., Jennison, C., Hurn, M. A., Al-Awadhi, F., McCullagh, P., Andrieu, C., Doucet, A., Dellaportas, P., Papageorgiou, I., Ehlers, R. S., Erosheva, E. A., Fienberg, S. E., Forster, J. J., Gill, R. C., Friel, N., Green, P. & Hastie, D. & 4 others, King, R., Kunsch, H. R., Lazar, N. A. & Osinski, C., 2003, In: Journal of the Royal Statistical Society, Series B (Statistical Methodology). 65, p. 39-55 17 p.

Research output: Contribution to journal › Article › peer-review

Mid-course sample size modification in clinical trials based on the observed treatment effect

Jennison, C. & Turnbull, B. W., 30 Mar 2003, In: Statistics in Medicine. 22, 6, p. 971-993 22 p.

Research output: Contribution to journal › Article › peer-review

134 Citations (SciVal)

Optimal dynamic treatment regimes - Discussion on the paper by Murphy

Arjas, E., Jennison, C., Dawid, A. P., Cox, D. R., Cowell, R. G., Didelez, V., Gill, R. D., Kadane, J. B. & Robins, J. M., 2003, In: Journal of the Royal Statistical Society, Series B (Statistical Methodology). 65, p. 355-366 12 p.

Research output: Contribution to journal › Article › peer-review

2002

Optimal asymmetric one-sided group sequential tests

Barber, S. & Jennison, C., Mar 2002, In: Biometrika. 89, 1, p. 49-60 12 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (SciVal)

2001

A penalized likelihood approach to image warping - Discussion

Molchanov, I., Jennison, C., Ersboll, B. K., Hancock, E., Wilson, R., Horgan, G., Kent, J. T., Ashburner, J., Dryden, I. L., Petrou, M., Angulo, J. M., Berman, M., Coleman, R., Duta, N., Jain, A. K., Ghosh, J. K., Murthy, C. A., Gray, A., Gustafsson, J. & Rudemo, M. & 14 others, Hogg, D., Koch, I., Linney, A., Ramsay, J. O., Ramsay, T. O., Rao, M. M., Sebastiani, G., de Souza, K., Sun, C. M., Buckley, M., Titterington, D. M., Trubuil, A., Worsley, K. J. & Yu, K. M., 2001, In: Journal of the Royal Statistical Society, Series B (Statistical Methodology). 63, p. 492-514 23 p.

Research output: Contribution to journal › Article › peer-review

Christopher Jennison

Research output

Search results