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Personal profile

Research interests

Clincial Trials

I pursue research into the design and analysis of clinical trials. I have worked on sequential methods, which are used to monitor trials and make decisions on when to stop a study. My book with Professor Bruce Turnbull, "Group Sequential Methods with Applications to Clinical Trials", is a standard text on this topic, widely used by practising statisticians. More recently, I have worked on adaptive clinical trial designs which allow a broader range of interim decision making, such as treatment selection or re-defining the target population, during the course of a trial. This research is informed by experience of clinical trial analysis at the Dana Farber Cancer Institute, Boston, consultancy with medical research institutes and pharmaceutical companies, and participation in clinical trial data monitoring committees. I am a member of the DIRECT consortium (funded by the EU Innovative Medicines Initiative) and the MASTERMIND project (funded by the MRC and ABPI), which are exploring personalised treatment strategies for patients with type 2 diabetes.

Image Analysis and MCMC

I also have interests in the statistical image analysis, spatial statistics and the computational methods used to fit complex models to large data sets. Here, the application areas range from medical and biological data to remote sensing and modelling the atmosphere. With motivation from these applications, I have worked on aspects of Markov chain Monte Carlo simulation, including perfect sampling, mode jumping and methods for sampling distributions which are almost confined to a subspace of the parameter space.

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Projects 2006 2019

Biomarkers
Research
Type 2 Diabetes Mellitus
Therapeutics
Clinical Trials

MASTERMIND Strand 2 (Diabetes Research)

Jennison, C.

1/04/1430/06/16

Project: Research council

Research
Pharmaceutical Preparations
Therapeutics
Type 2 Diabetes Mellitus
Blood Glucose
electron paramagnetic resonance
electrons
valence
microwave absorption
magnetic fields

Research Output 1997 2018

1 Citations

A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R. & Curto, T., 1 Mar 2018, In : Biometrics. 74, 1, p. 40-48

Research output: Contribution to journalArticle

Open Access
File
Gatekeeping
Group Sequential Design
endpoints
Libraries
Familywise Error Rate

Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance

Li, H., Wang, J., Luo, X., Grechko, J. & Jennison, C., 1 Sep 2018, In : Biometrical Journal. 60, 5, p. 893-902 10 p.

Research output: Contribution to journalArticle

Group Sequential
Sequential Procedure
Testing
Familywise Error Rate
Bonferroni
2 Citations

Rates of glycaemic deterioration in a real-world population with type 2 diabetes

Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R., 1 Mar 2018, In : Diabetologia. 61, 3, p. 607-615 9 p.

Research output: Contribution to journalArticle

Open Access
Type 2 Diabetes Mellitus
Population
Antibodies
Electronic Health Records
Drug Combinations
4 Citations

A multi-stage drop-the-losers design for multi-arm clinical trials

Wason, J., Stallard, N., Bowden, J. & Jennison, C., 1 Feb 2017, In : Statistical Methods in Medical Research. 26, 1, p. 508-524

Research output: Contribution to journalArticle

Open Access
File
Clinical Trials
Sample Size
Group Sequential
Interim Analysis
Design

Bayesian Decision Making in Adaptive Clinical Trials

Burnett, T., 2017, 175 p.

Research output: ThesisDoctoral Thesis

Open Access
File
Clinical Trials
Decision Making
Bayes
Interim Analysis
Remainder

Thesis

Adaptive Designs for Dose-Finding Trials

Author: Temple, J., 31 Dec 2012

Supervisor: Jennison, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

Bayesian Decision Making in Adaptive Clinical Trials

Author: Burnett, T., 2 Nov 2017

Supervisor: Jennison, C. (Supervisor) & Harris, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

New methods for mode jumping in Markov chain Monte Carlo algorithms

Author: Ibrahim, A., 1 Mar 2009

Supervisor: Jennison, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Statistical Image Analysis in Cone-beam Computed Tomography

Author: Doshi, S., 20 Jun 2014

Supervisor: Jennison, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

File