Projects per year
Personal profile
Research interests
Clincial Trials
I pursue research into the design and analysis of clinical trials. I have worked on sequential methods, which are used to monitor trials and make decisions on when to stop a study. My book with Professor Bruce Turnbull, "Group Sequential Methods with Applications to Clinical Trials", is a standard text on this topic, widely used by practising statisticians. More recently, I have worked on adaptive clinical trial designs which allow a broader range of interim decision making, such as treatment selection or re-defining the target population, during the course of a trial. This research is informed by experience of clinical trial analysis at the Dana Farber Cancer Institute, Boston, consultancy with medical research institutes and pharmaceutical companies, and participation in clinical trial data monitoring committees. I am a member of the DIRECT consortium (funded by the EU Innovative Medicines Initiative) and the MASTERMIND project (funded by the MRC and ABPI), which are exploring personalised treatment strategies for patients with type 2 diabetes.
Image Analysis and MCMC
I also have interests in the statistical image analysis, spatial statistics and the computational methods used to fit complex models to large data sets. Here, the application areas range from medical and biological data to remote sensing and modelling the atmosphere. With motivation from these applications, I have worked on aspects of Markov chain Monte Carlo simulation, including perfect sampling, mode jumping and methods for sampling distributions which are almost confined to a subspace of the parameter space.
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Projects
- 4 Finished
IAA: Mathematical Investigation into the Methods used in Classical Quantitative Risk Assessment in the Energy and Process Industries
Shardlow, T., Budd, C., Jennison, C., Lindgren, F. & Scheichl, R.
Engineering and Physical Sciences Research Council
1/05/14 → 31/01/15
Project: Research council
ELECTRON SPIN RESONANCE IMAGING: A FUNCTIONAL IMAGING TOOL FOR BIOMEDICAL SCIENCE
Wolverson, D., Clarke, C., Davies, J., Jennison, C. & Rodger, D.
1/10/06 → 31/03/10
Project: Research council
Research Output
Authors' reply
Jennison, C. & Turnbull, B. W., 30 Dec 2019, In : Statistics in medicine. 38, 30, p. 5670-5671 2 p.Research output: Contribution to journal › Letter
A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R. & Curto, T., 1 Mar 2018, In : Biometrics. 74, 1, p. 40-48 9 p.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
120
Downloads
(Pure)
Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance
Li, H., Wang, J., Luo, X., Grechko, J. & Jennison, C., 1 Sep 2018, In : Biometrical Journal. 60, 5, p. 893-902 10 p.Research output: Contribution to journal › Article
Rates of glycaemic deterioration in a real-world population with type 2 diabetes
Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R., 1 Mar 2018, In : Diabetologia. 61, 3, p. 607-615 9 p.Research output: Contribution to journal › Article
Open Access
File
11
Citations
(Scopus)
32
Downloads
(Pure)
A multi-stage drop-the-losers design for multi-arm clinical trials
Wason, J., Stallard, N., Bowden, J. & Jennison, C., 1 Feb 2017, In : Statistical Methods in Medical Research. 26, 1, p. 508-524Research output: Contribution to journal › Article
Open Access
File
8
Citations
(Scopus)
117
Downloads
(Pure)
Thesis
Adaptive Designs for Dose-Finding Trials
Author: Temple, J., 31 Dec 2012Supervisor: Jennison, C. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Bayesian Decision Making in Adaptive Clinical Trials
Author: Burnett, T., 2 Nov 2017Supervisor: Jennison, C. (Supervisor) & Harris, S. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Group sequential tests for delayed responses
Author: Hampson, L., 1 Nov 2008Supervisor: Jennison, C. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
New methods for mode jumping in Markov chain Monte Carlo algorithms
Author: Ibrahim, A., 1 Mar 2009Supervisor: Jennison, C. (Supervisor)
Student thesis: Doctoral Thesis › PhD
File
Statistical Image Analysis in Cone-beam Computed Tomography
Author: Doshi, S., 20 Jun 2014Supervisor: Jennison, C. (Supervisor)
Student thesis: Doctoral Thesis › PhD
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