19972019

Research output per year

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Personal profile

Research interests

Clincial Trials

I pursue research into the design and analysis of clinical trials. I have worked on sequential methods, which are used to monitor trials and make decisions on when to stop a study. My book with Professor Bruce Turnbull, "Group Sequential Methods with Applications to Clinical Trials", is a standard text on this topic, widely used by practising statisticians. More recently, I have worked on adaptive clinical trial designs which allow a broader range of interim decision making, such as treatment selection or re-defining the target population, during the course of a trial. This research is informed by experience of clinical trial analysis at the Dana Farber Cancer Institute, Boston, consultancy with medical research institutes and pharmaceutical companies, and participation in clinical trial data monitoring committees. I am a member of the DIRECT consortium (funded by the EU Innovative Medicines Initiative) and the MASTERMIND project (funded by the MRC and ABPI), which are exploring personalised treatment strategies for patients with type 2 diabetes.

Image Analysis and MCMC

I also have interests in the statistical image analysis, spatial statistics and the computational methods used to fit complex models to large data sets. Here, the application areas range from medical and biological data to remote sensing and modelling the atmosphere. With motivation from these applications, I have worked on aspects of Markov chain Monte Carlo simulation, including perfect sampling, mode jumping and methods for sampling distributions which are almost confined to a subspace of the parameter space.

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Projects

MASTERMIND Strand 2 (Diabetes Research)

Jennison, C.

MRC

1/04/1430/06/16

Project: Research council

  • Research Output

    Authors' reply

    Jennison, C. & Turnbull, B. W., 30 Dec 2019, In : Statistics in medicine. 38, 30, p. 5670-5671 2 p.

    Research output: Contribution to journalLetter

    A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks

    Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R. & Curto, T., 1 Mar 2018, In : Biometrics. 74, 1, p. 40-48 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    120 Downloads (Pure)

    Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance

    Li, H., Wang, J., Luo, X., Grechko, J. & Jennison, C., 1 Sep 2018, In : Biometrical Journal. 60, 5, p. 893-902 10 p.

    Research output: Contribution to journalArticle

  • Rates of glycaemic deterioration in a real-world population with type 2 diabetes

    Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R., 1 Mar 2018, In : Diabetologia. 61, 3, p. 607-615 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    32 Downloads (Pure)

    A multi-stage drop-the-losers design for multi-arm clinical trials

    Wason, J., Stallard, N., Bowden, J. & Jennison, C., 1 Feb 2017, In : Statistical Methods in Medical Research. 26, 1, p. 508-524

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    117 Downloads (Pure)

    Thesis

    Adaptive Designs for Dose-Finding Trials

    Author: Temple, J., 31 Dec 2012

    Supervisor: Jennison, C. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Bayesian Decision Making in Adaptive Clinical Trials

    Author: Burnett, T., 2 Nov 2017

    Supervisor: Jennison, C. (Supervisor) & Harris, S. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Group sequential tests for delayed responses

    Author: Hampson, L., 1 Nov 2008

    Supervisor: Jennison, C. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    New methods for mode jumping in Markov chain Monte Carlo algorithms

    Author: Ibrahim, A., 1 Mar 2009

    Supervisor: Jennison, C. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Statistical Image Analysis in Cone-beam Computed Tomography

    Author: Doshi, S., 20 Jun 2014

    Supervisor: Jennison, C. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File