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Personal profile

Research interests

Research in the Frost group involves creating new chemical tools for catalysis and biosensing. We are dedicated to developing sustainable approaches to synthesis through efficient catalysis and we have made some creative and important contributions to this area. The delivery of distinct structural complexity with scalability in an efficient and innovative manner is central to drug discovery programmes. Tandem catalysis presents a number of opportunities for the synthetic chemist to improve chemical transformations. The realisation of new tandem synthetic methodology forms a significant part of our research programme. The objective is to produce highly functionalised drug-like molecules from readily available feedstocks. Current projects involve transition metal catalysed conjugate addition, cross-coupling and exploring new concepts and selectivities in C-H activation.

To date, only a very narrow range of cutting-edge synthetic methods has been exploited to prepare designer biomolecules, despite the great attractiveness and potential high impact of using adventurous chemistry to access (for instance) custom bioconjugation, novel biotracers and other new functionalised biochemical tools to aid drug discovery. The synthetic modification of proteins is a growing area at the interface of chemistry and biology. The selective conjugation of biochemical probes can help understand how a natural protein functions or change a proteins function entirely. The tethering of “capture” sites to proteins can help identify new inhibitors of protein-protein and protein-DNA binding which in turn can lead to new drugs. We have developed new synthetic methods and new reagents for the conjugation of functional molecules to proteins and oligonucleotides. We also lead an inter-disciplinary research program developing a bioelectronic approach to the detection of specific DNA segments and protein markers. This technology contributed to the launch of a University spin out Atlas Genetics Ltd, a diagnostic company developing ultra-rapid point-of-care tests for a range of infectious diseases.

Academic Biography

  • BSc(Hons) at the University of Loughborough 1987-1991
  • PhD in Asymmetric Catalysis (with Jonathan M. J. Williams) at the University of Loughborough-1991-1994.
  • Post-doctoral research fellowship with Prof. Philip D. Magnus at the University of Texas at Austin 1994-1996.
  • Lecturer/Reader/Professor at the University of Bath 1996–Present. 

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  • 14 Similar Profiles
Rhodium Chemical Compounds
phosphine Chemical Compounds
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Palladium Chemical Compounds
Catalysts Chemical Compounds
Ruthenium Chemical Compounds
Alkenes Chemical Compounds
rhodium Physics & Astronomy

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Projects 2005 2020

ReNEW

Kasprzyk-Hordern, B. & Frost, C.

1/05/1730/04/20

Project: Research council

public health
early warning system
hazard
health status
infectious disease

Novel Biosensors Based on Synthetic Recognition Elements Embedded in Redox Active SAMs

Frost, C. & James, T.

1/11/1431/10/15

Project: Central government, health and local authorities

Novel Biosensors Based on Synthetic Recognition Elements Embedded in Redox Active SAMs

Estrela, P., Frost, C. & James, T.

1/11/1431/10/15

Project: Central government, health and local authorities

MRC Confidence in Concept 2013

Frost, C.

1/10/1431/03/15

Project: Research council

Research Output 1991 2018

Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Leitch, J. A. & Frost, C. G., 11 Jun 2018, In : Synthesis (Germany). 50, 14, p. 2693-2706

Research output: Contribution to journalReview article

Aniline Compounds
Aniline
Transition metals
Agrochemicals
Rhodium
1 Citations

A Highly Regioselective Palladium-Catalyzed O,S Rearrangement of Cyclic Thiocarbonates

Mahy, W., Cabezas-Hayes, S., Kociok-Köhn, G. & Frost, C. G., 24 Nov 2017, In : European Journal of Organic Chemistry. 2017, 43, p. 6441-6444 4 p.

Research output: Contribution to journalArticle

Regioselectivity
Palladium
palladium
Crystal structure
Ligands

A peptide nucleic acid (PNA)-DNA ferrocenyl intercalator for electrochemical sensing

Gaiji, H., Jolly, P., Ustuner, S., Goggins, S., Abderrabba, M., Frost, C. & Estrela, P., Mar 2017, In : Electroanalysis. 29, 3, p. 917-922 6 p.

Research output: Contribution to journalArticle

Open Access
File
Intercalating Agents
Peptide Nucleic Acids
DNA
DNA sequences
Biosensors
50 Citations

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole

Leitch, J. A., Bhonoah, Y. & Frost, C. G., 1 Sep 2017, In : ACS Catalysis. 7, 9, p. 5618-5627 9 p.

Research output: Contribution to journalArticle

Open Access
File
Carbazoles
Agrochemicals
Indoles
Pyrroles
Scaffolds
3 Citations

Ratiometric electrochemical detection of hydrogen peroxide and glucose

Goggins, S., Apsey, E. A., Mahon, M. F. & Frost, C. G., 21 Feb 2017, In : Organic and Biomolecular Chemistry. 15, 11, p. 2459-2466 8 p.

Research output: Contribution to journalArticle

Open Access
Boronic Acids
Enzyme Assays
hydrogen peroxide
glucose
Hydrogen Peroxide

Thesis

Catalytic synthesis and modification of heterocycles

Author: Mahy, W., 18 Feb 2016

Supervisor: Frost, C. (Supervisor) & Plucinski, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Ceramic Nanostructured Catalysts

Author: Gilbank, A., 13 May 2015

Supervisor: Torrente Murciano, L. (Supervisor) & Frost, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Enzyme-Triggered Catalytic Signal Amplification

Author: Goggins, S., 23 Oct 2015

Supervisor: Frost, C. (Supervisor) & Bull, S. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Investigations into New Functionalised Thiosemicarbazones and Related Carbon Nanohybrids for the Imaging of Prostate Cancer

Author: Cortezon Tamarit, F., 1 Mar 2017

Supervisor: Pascu, S. (Supervisor), Estrela, P. (Supervisor), Tyrrell, R. (Supervisor) & Frost, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

Oligonucleotide-based biosensors for the detection of prostate cancer biomarkers

Author: Jolly, P., 15 Oct 2016

Supervisor: Estrela, P. (Supervisor) & Frost, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

File