• 5 WEST 2.49C

Accepting PhD Students

19982021

Research output per year

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Research Output

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Article
2020

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Open Access
2019

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C. P., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 8 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Citations (Scopus)
21 Downloads (Pure)
Open Access
2 Citations (Scopus)
2018

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. & Bailey, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2869-2880 12 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
45 Downloads (Pure)

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)
9 Downloads (Pure)
2016

Ethanol reversal of tolerance to the respiratory depressant effects of morphine

Hill, R., Lyndon, A., Withey, S., Roberts, J., Kershaw, Y., MacLachlan, J., Lingford-Hughes, A., Kelly, E., Bailey, C., Hickman, M. & Henderson, G., 1 Feb 2016, In : Neuropsychopharmacology. 41, 3, p. 762-773 12 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)
42 Downloads (Pure)
Open Access
7 Citations (Scopus)
86 Downloads (Pure)
2015

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 1 Jul 2015, In : Journal of Psychopharmacology . 29, 7, p. 812-821 10 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
118 Downloads (Pure)
Open Access
11 Citations (Scopus)

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., Aug 2015, In : Molecular Pharmacology. 88, 2, p. 347-356

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
87 Downloads (Pure)
2014
Open Access
File
27 Citations (Scopus)
175 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
65 Downloads (Pure)
2013

Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons

Llorente, J., Withey, S., Rivero, G., Cunningham, M., Cooke, A., Saxena, K., McPherson, J., Oldfield, S., Dewey, W. L., Bailey, C. P., Kelly, E. & Henderson, G., Aug 2013, In : Molecular Pharmacology. 84, 2, p. 252-260 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Reversal of morphine analgesic tolerance by ethanol in the mouse

Hull, L. C., Gabra, B. H., Bailey, C. P., Henderson, G. & Dewey, W. L., Jun 2013, In : Journal of Pharmacology and Experimental Therapeutics. 345, 3, p. 512-519 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Endomorphin-2: A biased agonist at the μ-opioid receptor

Rivero, G., Llorente, J., McPherson, J., Cooke, A., Mundell, S. J., McArdle, C. A., Rosethorne, E. M., Charlton, S. J., Krasel, C., Bailey, C. P., Henderson, G. & Kelly, E., 2012, In : Molecular Pharmacology. 82, 2, p. 178-188 11 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

μ-Opioid receptor desensitization: homologous or heterologous?

Llorente, J., Lowe, J. D., Sanderson, H. S., Tsisanova, E., Kelly, E., Henderson, G. & Bailey, C. P., Dec 2012, In : European Journal of Neuroscience. 36, 12, p. 3636-3642 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011

Lack of agonist-induced desensitization of mu-opioid receptors located at nerve terminals

Lowe, J. D. & Bailey, C. P., 2011, In : Pharmacological Reports. 63, 1, p. 235 1 p.

Research output: Contribution to journalArticle

Role of group II metabotropic receptors in long-term plasticity of presynaptic vesicular release at glutamatergic synapses

Zhang, X. L., Nicholls, R. E., Bailey, C. P., Upreti, C., Muller, W., Kandel, E. R. & Stanton, P. K., 2011, In : Current Neuropharmacology. 9, Supplement 1, p. 69 1 p.

Research output: Contribution to journalArticle

2010

The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy

Hull, L. C., Llorente, J., Gabra, B. H., Smith, F. L., Kelly, E., Bailey, C., Henderson, G. & Dewey, W. L., 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

μ-Opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization

McPherson, J., Rivero, G., Baptist, M., Llorente, J., Al-Sabah, S., Krasel, C., Dewey, W. L., Bailey, C. P., Rosethorne, E. M., Charlton, S. J., Henderson, G. & Kelly, E., Oct 2010, In : Molecular Pharmacology. 78, 4, p. 756-766 11 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)
2009
16 Citations (Scopus)

Involvement of PKCα and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of µ-opioid receptors in mature brain neurons

Bailey, C. P., Oldfield, S., Llorente, J., Caunt, C. J., Teschemacher, AG., Roberts, L., McArdle, CA., Smith, FL., Dewey, WL., Kelly, E. & Henderson, G., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

Bailey, C. P., Llorente, J., Gabra, B. H., Smith, F. L., Dewey, W. L., Kelly, E. & Henderson, G., Jan 2009, In : European Journal of Neuroscience. 29, 2, p. 307-318 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2008

Agonist-selective mechanisms of GPCR desensitization

Kelly, E., Bailey, C. P. & Henderson, G., 2008, In : British Journal of Pharmacology. 153, S1, p. S379-S388

Research output: Contribution to journalArticle

252 Citations (Scopus)

C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

Oldfield, S., Braksator, E., Rodriguez-Martin, I., Bailey, C. P., Donaldson, L. F., Henderson, G. & Kelly, E., 2008, In : Journal of Neurochemistry. 104, 4, p. 937-945 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Does alcohol increase the risk of overdose death: the need for a translational approach

Hickman, M., Lingford-Hughes, A., Bailey, C., Macleod, J., Nutt, D. & Henderson, G., 2008, In : Addiction. 103, 7, p. 1060-1062 3 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Functional selectivity in GPCR desensitization

Bailey, C., Henderson, G. & Kelly, E., 2008, In : Fundamental & Clinical Pharmacology. 22, p. 7-7 1 p.

Research output: Contribution to journalArticle

i2 inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses

Bailey, C. P., Nicholls, R. E., Zhang, X. L., Zhou, Z. Y., Muller, W., Kandel, E. R. & Stanton, P. K., 2008, In : Learning and Memory. 15, 4, p. 261-270 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Methadone: Does it really have low efficacy at mu-opioid receptors?

Rodriguez-Martin, I., Braksator, E., Bailey, C. P., Goodchild, S., Marrion, N. V., Kelly, E. & Henderson, G., Mar 2008, In : Neuroreport. 19, 5, p. 589-593 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Mu-opioid receptor internalisation: Studies using a pHluorin tag

Baptist, M., Braksator, E., Bailey, C., Kelly, E. & Henderson, G., 2008, In : Fundamental & Clinical Pharmacology. 22, p. 60-60 1 p.

Research output: Contribution to journalArticle

Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

Gabra, B. H., Bailey, C. P., Kelly, E., Smith, F. L., Henderson, G. & Dewey, W. L., 27 Jun 2008, In : Brain Research. 1217, p. 70-77 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2007

Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance

Gabra, B. H., Bailey, C. P., Kelly, E., Sanders, A. V., Henderson, G., Smith, F. L. & Dewey, W. L., 2007, In : Brain Research. 1159, p. 86-93 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Morphine tolerance: getting hooked

Bailey, C. P., 2007, In : The Biochemist. 29, p. 12-15 4 p.

Research output: Contribution to journalArticle

2006

Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells

Johnson, E. A., Oldfield, S., Braksator, E., Gonzalez-Cuello, A., Couch, D., Hall, K. J., Mundell, S. J., Bailey, C. P., Kelly, E. & Henderson, G., 2006, In : Molecular Pharmacology. 70, 2, p. 676-685 10 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

How important is protein kinase C in μ-opioid receptor desensitization and morphine tolerance?

Bailey, C. P., Smith, F. L., Kelly, E., Dewey, W. L. & Henderson, G., 2006, In : Trends in Pharmacological Sciences. 27, 11, p. 558-565 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

MGluR2 acts through inhibitory Gα subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses

Nicholls, R. E., Zhang, X. L., Bailey, C. P., Conklin, B. R., Kandel, E. R. & Stanton, P. K., 2006, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 103, 16, p. 6380-6385 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2005

Opioids: cellular mechanisms of tolerance and physical dependence

Bailey, C. P. & Connor, M., 2005, In : Current Opinion in Pharmacology. 5, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

200 Citations (Scopus)
2004
36 Citations (Scopus)

Protein kinase C activation enhances morphine-induced rapid desensitization of μ-opioid receptors in mature rat locus ceruleus neurons

Bailey, C. P., Kelly, E. & Henderson, G., 2004, In : Molecular Pharmacology. 66, 6, p. 1592-1598 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2003

Long-term depression of presynaptic release from the readily releasable vesicle pool induced by NMDA receptor-dependent retrograde nitric oxide

Stanton, P. K., Winterer, J., Bailey, C. P., Kyrozis, A., Raginov, I., Laube, G., Veh, R. W., Nguyen, C. Q. & Müller, W., 2003, In : Journal of Neuroscience. 23, 13, p. 5936-5944 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
16 Citations (Scopus)

μ-Opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine

Bailey, C. P., Couch, D., Johnson, E., Griffiths, K., Kelly, E. & Henderson, G., 2003, In : Journal of Neuroscience. 23, 33, p. 10515-10520 6 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2001

Alterations in mesolimbic dopamine function during the abstinence period following chronic ethanol consumption

Bailey, C. P., O'Callaghan, M. J., Croft, A. P., Manley, S. J. & Little, H. J., 2001, In : Neuropharmacology. 41, p. 989-999 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2000

Prolonged changes in neurochemistry of dopamine neurones after chronic ethanol consumption

Bailey, C. P., Andrews, N., McKnight, A. T., Hughes, J. & Little, H. J., 1 May 2000, In : Pharmacology Biochemistry and Behavior. 66, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1998

Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability

Bailey, C. P., Manley, S. J., Watson, W. P., Wonnacott, S., Molleman, A. & Little, H. J., 24 Aug 1998, In : Brain Research. 803, 1-2, p. 144-152 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Comparison of the effects of drugs on hyperexcitability induced in hippocampal slices by withdrawal from chronic ethanol consumption

Bailey, C. P., Molleman, A. & Little, H. J., 28 Jan 1998, In : British Journal of Pharmacology. 123, 2, p. 215-222 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)