Chris Bailey

2019

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C. P., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 8 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics.

Research output: Contribution to journal › Article

2 Citations (Scopus)

21 Downloads (Pure)

Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine-conditioned place preference and associated changes in AMPA receptor binding

Wright, V. L., Georgiou, P., Bailey, A., Heal, D. J., Bailey, C. P. & Wonnacott, S., 3 Jun 2019, In : Addiction Biology. 24, 4, p. 590-603 14 p.

Research output: Contribution to journal › Article

Open Access

AMPA Receptors

Nicotinic Receptors

Morphine

Hippocampus

Recurrence

2 Citations (Scopus)

Simultaneous Transdermal Delivery of Buprenorphine Hydrochloride and Naltrexone Hydrochloride by Iontophoresis

Cordery, S., Husbands, S., Bailey, C., Guy, R. & Delgado-Charro, M., 3 Jun 2019, In : Molecular Pharmaceutics. 16, 6, p. 2808-2816 9 p.

Research output: Contribution to journal › Article

Open Access

2018

9 Citations (Scopus)

39 Downloads (Pure)

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. & Bailey, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2869-2880 12 p.

Research output: Contribution to journal › Article

Open Access

File

Buprenorphine

kappa Opioid Receptor

Narcotic Antagonists

mu Opioid Receptor

Analgesia

Effects of kappa opioid receptor agonists and acute stress on brain regions implicated in the response to stress and drugs of abuse

Ma, Q., Wonnacott, S., Bailey, S. & Bailey, C., 1 Aug 2018, In : Journal of Psychopharmacology . 32, 8 (Supplement), p. A124

Research output: Contribution to journal › Meeting abstract

166 Downloads (Pure)

Emerging areas of opioid pharmacology

Kelly, E., Henderson, G. & Bailey, C. P., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2715-2716 2 p.

Research output: Contribution to journal › Editorial

File

Opioid Analgesics

Pharmacology

Narcotics

Baths

Research

Investigating the effects of sex on depression-related behaviour evoked by kappa opioid receptor activation in the forced swim test

Lalji, H., Sadler, A., Bailey, C. & Bailey, S., 1 Aug 2018, In : Journal of Psychopharmacology . 32, 8 (Supplement), p. A123

Research output: Contribution to journal › Meeting abstract

kappa Opioid Receptor

Depression

Psychopharmacology

Inbred C57BL Mouse

Sex Characteristics

34 Citations (Scopus)

9 Downloads (Pure)

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journal › Article

Open Access

mu Opioid Receptor

Respiration

Morphine

Arrestin

Tidal Volume

2017

Gender differences in kappa opioid receptor activated brain networks implicated in the response to stress and drugs of abuse

Ma, Q., Wonnacott, S., Bailey, S. & Bailey, C., 1 Aug 2017, (Accepted/In press) In : Journal of Psychopharmacology . 31, 8, p. A132

Research output: Contribution to journal › Meeting abstract

Investigating the effects of gender on anxiety related behaviour evoked by kappa opioid receptor activation in the elevated plus maze

Lalji, H., Almatroudi, A. M. I., Bailey, C. & Bailey, S., 1 Aug 2017, (Accepted/In press) In : Journal of Psychopharmacology . 31, 8, p. A21

Research output: Contribution to journal › Meeting abstract

2016

26 Citations (Scopus)

42 Downloads (Pure)

Ethanol reversal of tolerance to the respiratory depressant effects of morphine

Hill, R., Lyndon, A., Withey, S., Roberts, J., Kershaw, Y., MacLachlan, J., Lingford-Hughes, A., Kelly, E., Bailey, C., Hickman, M. & Henderson, G., 1 Feb 2016, In : Neuropsychopharmacology. 41, 3, p. 762-773 12 p.

Research output: Contribution to journal › Article

Open Access

6 Citations (Scopus)

86 Downloads (Pure)

Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity

Udakis, M., Wright, V., Wonnacott, S. & Bailey, C. P., 1 Jun 2016, In : Neuropharmacology. 105, p. 618-629 12 p.

Research output: Contribution to journal › Article

Open Access

Nicotinic Receptors

Cholinergic Agents

Long-Term Potentiation

Acetylcholine

Acetylcholinesterase

29 Downloads (Pure)

Investigating the roles of kappa opioid receptors in neurochemical changes caused by stress and drugs of abuse

Ma, Q., Wonnacott, S., Bailey, S. & Bailey, C., 2016, In : pA2Online.

Research output: Contribution to journal › Meeting abstract

File

kappa Opioid Receptor

Street Drugs

Green Fluorescent Proteins

Prefrontal Cortex

Nucleus Accumbens

2015

33 Citations (Scopus)

107 Downloads (Pure)

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 1 Jul 2015, In : Journal of Psychopharmacology . 29, 7, p. 812-821 10 p.

Research output: Contribution to journal › Article

Open Access

File

Buprenorphine

Naltrexone

Antidepressive Agents

kappa Opioid Receptor

Opiate Alkaloids

10 Citations (Scopus)

Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area

Lowe, J. D. & Bailey, C. P., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 469-481 13 p.

Research output: Contribution to journal › Article

Open Access

Ventral Tegmental Area

mu Opioid Receptor

Ala(2)-MePhe(4)-Gly(5)-enkephalin

Methionine Enkephalin

GABAergic Neurons

30 Citations (Scopus)

78 Downloads (Pure)

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., Aug 2015, In : Molecular Pharmacology. 88, 2, p. 347-356

Research output: Contribution to journal › Article

Open Access

File

G-Protein-Coupled Receptor Kinase 3

G-Protein-Coupled Receptor Kinase 2

Locus Coeruleus

mu Opioid Receptor

Ala(2)-MePhe(4)-Gly(5)-enkephalin

The antidepressant-like effects of BU10119, a novel kappa opioid receptor antagonist, in the novelty-induced hypophagia task in mice

Bailey, S., Almatroudi, A. M. I., Bailey, C. & Husbands, S., 2015, Neuroscience Meeting Planner : Society for Neuroscience. 774.09

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

kappa Opioid Receptor

Narcotic Antagonists

Buprenorphine

Naltrexone

Antidepressive Agents

2014

27 Citations (Scopus)

162 Downloads (Pure)

A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. & Bailey, C. P., 1 Jul 2014, In : Addiction Biology. 19, 4, p. 575-586 12 p.

Research output: Contribution to journal › Article

Open Access

File

Buprenorphine

Naltrexone

Drug Combinations

Cocaine

Morphine

Combination Treatment With Buprenorphine/Naltrexone, A Functional Kappa Opioid Receptor Antagonist, Produces Antidepressant-Like Effects In Mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., Aug 2014, In : Journal of Psychopharmacology . 28, 8, p. A101 1 p.

Research output: Contribution to journal › Meeting abstract

11 Citations (Scopus)

55 Downloads (Pure)

Novel approaches for the treatment of psychostimulant and opioid abuse-focus on opioid receptor-based therapies

Bailey, C. P. & Husbands, S. M., Nov 2014, In : Expert Opinion on Drug Discovery. 9, 11, p. 1333-1344 12 p.

Research output: Contribution to journal › Article

Open Access

File

Opioid Receptors

Opioid Analgesics

Recurrence

Street Drugs

Therapeutics

The antidepressant-like effects of combination buprenorphine/naltrexone in the novelty-induced hypophagia task in mice

Bailey, S., Almatroudi, A. M. I., Bailey, C. & Husbands, S., 2014, Neuroscience Meeting Planner: Society for Neuroscience. Online

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Buprenorphine

Naltrexone

Antidepressive Agents

kappa Opioid Receptor

Narcotic Antagonists

2013

Establishing the combination of buprenorphine and naltrexone as a functional kappa opioid receptor antagonist in mice

Almatroudi, A., Husbands, S. M., Bailey, C. P. & Bailey, S. J., 2013, In : Proceedings of the British Pharmacological Society.

Research output: Contribution to journal › Meeting abstract

11 Citations (Scopus)

Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons

Llorente, J., Withey, S., Rivero, G., Cunningham, M., Cooke, A., Saxena, K., McPherson, J., Oldfield, S., Dewey, W. L., Bailey, C. P., Kelly, E. & Henderson, G., Aug 2013, In : Molecular Pharmacology. 84, 2, p. 252-260 9 p.

Research output: Contribution to journal › Article

Locus Coeruleus

Morphine

Ethanol

Neurons

Guanosine 5'-O-(3-Thiotriphosphate)

16 Citations (Scopus)

Reversal of morphine analgesic tolerance by ethanol in the mouse

Hull, L. C., Gabra, B. H., Bailey, C. P., Henderson, G. & Dewey, W. L., Jun 2013, In : Journal of Pharmacology and Experimental Therapeutics. 345, 3, p. 512-519 8 p.

Research output: Contribution to journal › Article

Morphine

Opioid Analgesics

Analgesics

Ethanol

gamma-Aminobutyric Acid

2012

59 Citations (Scopus)

Endomorphin-2: A biased agonist at the μ-opioid receptor

Rivero, G., Llorente, J., McPherson, J., Cooke, A., Mundell, S. J., McArdle, C. A., Rosethorne, E. M., Charlton, S. J., Krasel, C., Bailey, C. P., Henderson, G. & Kelly, E., 2012, In : Molecular Pharmacology. 82, 2, p. 178-188 11 p.

Research output: Contribution to journal › Article

mu Opioid Receptor

Arrestin

Ala(2)-MePhe(4)-Gly(5)-enkephalin

GTP-Binding Proteins

HEK293 Cells

13 Citations (Scopus)

μ-Opioid receptor desensitization: homologous or heterologous?

Llorente, J., Lowe, J. D., Sanderson, H. S., Tsisanova, E., Kelly, E., Henderson, G. & Bailey, C. P., Dec 2012, In : European Journal of Neuroscience. 36, 12, p. 3636-3642 6 p.

Research output: Contribution to journal › Article

mu Opioid Receptor

Locus Coeruleus

GTP-Binding Proteins

G-Protein-Coupled Receptor Kinases

Protein Subunits

2011

Elucidating agonist-selective mechanisms of G protein-coupled receptor desensitization

Bailey, C. P. & Kelly, E., 4 Aug 2011, Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Stevens, C. W. (ed.). Humana Press, p. 323-346 24 p. (Neuromethods; vol. 60).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Lack of agonist-induced desensitization of mu-opioid receptors located at nerve terminals

Lowe, J. D. & Bailey, C. P., 2011, In : Pharmacological Reports. 63, 1, p. 235 1 p.

Research output: Contribution to journal › Article

Role of group II metabotropic receptors in long-term plasticity of presynaptic vesicular release at glutamatergic synapses

Zhang, X. L., Nicholls, R. E., Bailey, C. P., Upreti, C., Muller, W., Kandel, E. R. & Stanton, P. K., 2011, In : Current Neuropharmacology. 9, Supplement 1, p. 69 1 p.

Research output: Contribution to journal › Article

Transdermal delivery of a buprenorphine/naltrexone combination for the treatment of polydrug abuse

Taverner, A., Cordery, S., Husbands, S. M., Guy, R. H., Delgado-Charro, B. M. & Bailey, C. P., Jan 2011, In : Pharmacological Reports. 63, 1, p. 257 1 p.

Research output: Contribution to journal › Meeting abstract

Buprenorphine

Naltrexone

Morphine

Therapeutics

Aptitude

2010

46 Citations (Scopus)

The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy

Hull, L. C., Llorente, J., Gabra, B. H., Smith, F. L., Kelly, E., Bailey, C., Henderson, G. & Dewey, W. L., 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 1127-1135 9 p.

Research output: Contribution to journal › Article

G-Protein-Coupled Receptor Kinases

Ala(2)-MePhe(4)-Gly(5)-enkephalin

Cyclic GMP-Dependent Protein Kinases

Protein Kinase C

Opioid Analgesics

150 Citations (Scopus)

μ-Opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization

McPherson, J., Rivero, G., Baptist, M., Llorente, J., Al-Sabah, S., Krasel, C., Dewey, W. L., Bailey, C. P., Rosethorne, E. M., Charlton, S. J., Henderson, G. & Kelly, E., Oct 2010, In : Molecular Pharmacology. 78, 4, p. 756-766 11 p.

Research output: Contribution to journal › Article

mu Opioid Receptor

GTP-Binding Proteins

Phosphorylation

Arrestin

G-Protein-Coupled Receptors

2009

16 Citations (Scopus)

Glutamate-induced post-activation inhibition of locus coeruleus neurons is mediated by AMPA/kainate receptors and sodium-dependent potassium currents

Zamalloa, T., Bailey, C. P. & Pineda, J., 2009, In : British Journal of Pharmacology. 156, 4, p. 649-661 13 p.

Research output: Contribution to journal › Article

Kainic Acid Receptors

AMPA Receptors

Locus Coeruleus

Glutamic Acid

Potassium

64 Citations (Scopus)

Involvement of PKCα and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of µ-opioid receptors in mature brain neurons

Bailey, C. P., Oldfield, S., Llorente, J., Caunt, C. J., Teschemacher, AG., Roberts, L., McArdle, CA., Smith, FL., Dewey, WL., Kelly, E. & Henderson, G., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 157-164 8 p.

Research output: Contribution to journal › Article

G-Protein-Coupled Receptor Kinase 2

mu Opioid Receptor

Opioid Receptors

Morphine

Ala(2)-MePhe(4)-Gly(5)-enkephalin

63 Citations (Scopus)

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

Bailey, C. P., Llorente, J., Gabra, B. H., Smith, F. L., Dewey, W. L., Kelly, E. & Henderson, G., Jan 2009, In : European Journal of Neuroscience. 29, 2, p. 307-318 12 p.

Research output: Contribution to journal › Article

Locus Coeruleus

mu Opioid Receptor

Morphine

Neurons

protein kinase D

2008

250 Citations (Scopus)

Agonist-selective mechanisms of GPCR desensitization

Kelly, E., Bailey, C. P. & Henderson, G., 2008, In : British Journal of Pharmacology. 153, S1, p. S379-S388

Research output: Contribution to journal › Article

13 Citations (Scopus)

C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

Oldfield, S., Braksator, E., Rodriguez-Martin, I., Bailey, C. P., Donaldson, L. F., Henderson, G. & Kelly, E., 2008, In : Journal of Neurochemistry. 104, 4, p. 937-945 9 p.

Research output: Contribution to journal › Article

30 Citations (Scopus)

Does alcohol increase the risk of overdose death: the need for a translational approach

Hickman, M., Lingford-Hughes, A., Bailey, C., Macleod, J., Nutt, D. & Henderson, G., 2008, In : Addiction. 103, 7, p. 1060-1062 3 p.

Research output: Contribution to journal › Article

Opiate Alkaloids

Heroin

Alcohols

Morphine

Epidemiologic Studies

Functional selectivity in GPCR desensitization

Bailey, C., Henderson, G. & Kelly, E., 2008, In : Fundamental & Clinical Pharmacology. 22, p. 7-7 1 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Gα_i2 inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses

Bailey, C. P., Nicholls, R. E., Zhang, X. L., Zhou, Z. Y., Muller, W., Kandel, E. R. & Stanton, P. K., 2008, In : Learning and Memory. 15, 4, p. 261-270 10 p.

Research output: Contribution to journal › Article

Cyclic GMP

Adenylyl Cyclases

Synapses

Hippocampus

GTP-Binding Proteins

15 Citations (Scopus)

Methadone: Does it really have low efficacy at mu-opioid receptors?

Rodriguez-Martin, I., Braksator, E., Bailey, C. P., Goodchild, S., Marrion, N. V., Kelly, E. & Henderson, G., Mar 2008, In : Neuroreport. 19, 5, p. 589-593 5 p.

Research output: Contribution to journal › Article

mu Opioid Receptor

Methadone

Guanosine 5'-O-(3-Thiotriphosphate)

G Protein-Coupled Inwardly-Rectifying Potassium Channels

Calcium-Activated Potassium Channels

Mu-opioid receptor internalisation: Studies using a pHluorin tag

Baptist, M., Braksator, E., Bailey, C., Kelly, E. & Henderson, G., 2008, In : Fundamental & Clinical Pharmacology. 22, p. 60-60 1 p.

Research output: Contribution to journal › Article

26 Citations (Scopus)

Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

Gabra, B. H., Bailey, C. P., Kelly, E., Smith, F. L., Henderson, G. & Dewey, W. L., 27 Jun 2008, In : Brain Research. 1217, p. 70-77 8 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Understanding causal pathways: A response to the commentaries

Hickman, M., Lingford-Hughes, A., Bailey, C., Macleod, J., Nutt, D. & Henderson, G., 1 Jul 2008, In : Addiction. 103, 7, p. 1067-1068 2 p.

Research output: Contribution to journal › Comment/debate

2007

14 Citations (Scopus)

Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance

Gabra, B. H., Bailey, C. P., Kelly, E., Sanders, A. V., Henderson, G., Smith, F. L. & Dewey, W. L., 2007, In : Brain Research. 1159, p. 86-93 8 p.

Research output: Contribution to journal › Article

Morphine tolerance: getting hooked

Bailey, C. P., 2007, In : The Biochemist. 29, p. 12-15 4 p.

Research output: Contribution to journal › Article

2006

122 Citations (Scopus)

Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells

Johnson, E. A., Oldfield, S., Braksator, E., Gonzalez-Cuello, A., Couch, D., Hall, K. J., Mundell, S. J., Bailey, C. P., Kelly, E. & Henderson, G., 2006, In : Molecular Pharmacology. 70, 2, p. 676-685 10 p.

Research output: Contribution to journal › Article

67 Citations (Scopus)

How important is protein kinase C in μ-opioid receptor desensitization and morphine tolerance?

Bailey, C. P., Smith, F. L., Kelly, E., Dewey, W. L. & Henderson, G., 2006, In : Trends in Pharmacological Sciences. 27, 11, p. 558-565 8 p.

Research output: Contribution to journal › Article

mu Opioid Receptor

Morphine

Protein Kinase C

Opiate Alkaloids

Social Problems

26 Citations (Scopus)

MGluR2 acts through inhibitory Gα subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses

Nicholls, R. E., Zhang, X. L., Bailey, C. P., Conklin, B. R., Kandel, E. R. & Stanton, P. K., 2006, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 103, 16, p. 6380-6385 6 p.

Research output: Contribution to journal › Article

2005

196 Citations (Scopus)

Opioids: cellular mechanisms of tolerance and physical dependence

Bailey, C. P. & Connor, M., 2005, In : Current Opinion in Pharmacology. 5, 1, p. 60-68 9 p.

Research output: Contribution to journal › Article