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Research Output 2006 2017

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Article
2017
2 Citations (Scopus)

An historical perspective on the pioneering experiments of John Saunders

Tickle, C., 15 Jun 2017, In : Developmental Biology.

Research output: Contribution to journalArticle

Ectoderm
Extremities
Feathers
Embryology
Thumb
1 Citation (Scopus)
developmental biology
Developmental Biology
evolutionary biology
Genomics
genomics
2016
4 Citations (Scopus)
107 Downloads (Pure)

A strategy to discover new organizers identifies a putative heart organizer

Anderson, C., Khan, M. A. F., Wong, F., Solovieva, T., Oliveira, N. M. M., Baldock, R. A., Tickle, C., Burt, D. W. & Stern, C. D., 25 Aug 2016, In : Nature Communications. 7, 12656.

Research output: Contribution to journalArticle

Open Access
File
Embryonic Organizers
Endoderm
embryos
Mesoderm
Chick Embryo
2015
8 Citations (Scopus)
104 Downloads (Pure)

A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis

Lee, J. M., Cho, K. W., Kim, E. J., Tang, Q., Kim, K. S., Tickle, C. & Jung, H. S., Sep 2015, In : Oncotarget. 6, 26, p. 22048-22059 12 p.

Research output: Contribution to journalArticle

Open Access
File
Human Mammary Glands
Carcinogenesis
Breast
Breast Neoplasms
MicroRNAs
32 Citations (Scopus)

How the embryo makes a limb: determination, polarity and identity

Tickle, C., Oct 2015, In : Journal Of Anatomy. 227, 4, p. 418-430

Research output: Contribution to journalArticle

Forelimb
Hindlimb
limbs (animal)
bud
Mesoderm
2014
14 Citations (Scopus)

Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis

Suda, N., Itoh, T., Nakato, R., Shirakawa, D., Bando, M., Katou, Y., Kataoka, K., Shirahige, K., Tickle, C. & Tanaka, M., Jul 2014, In : Development. 141, p. 2885-2894 10 p.

Research output: Contribution to journalArticle

Limb Buds
Morphogenesis
Extremities
Apoptosis
Chromatin Immunoprecipitation
20 Citations (Scopus)

Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock

Chinnaiya, K., Tickle, C. & Towers, M., Jul 2014, In : Nature Communications. 5, p. 1 - 8 8 p., 4320.

Research output: Contribution to journalArticle

limbs
clocks
Clocks
Cell Cycle
Extremities
2013
8 Citations (Scopus)

eChickAtlas: an introduction to the database

Wong, F., Welten, M. C. M., Anderson, C., Bain, A. A., Liu, J., Wicks, M. N., Pavlovska, G., Davey, M. G., Murphy, P., Davidson, D., Tickle, C. A., Stern, C. D., Baldock, R. A. & Burt, D. W., May 2013, In : Genesis. 51, 5, p. 365-371

Research output: Contribution to journalArticle

Atlases
Databases
Gene Expression
Optical Tomography
RNA Sequence Analysis
15 Citations (Scopus)

The Sonic hedgehog gradient in the developing limb

Tickle, C. & Barker, H., Mar 2013, In : Wiley Interdisciplinary Reviews: Developmental Biology. 2, 2, p. 275-290 16 p.

Research output: Contribution to journalArticle

Hedgehogs
Extremities
Vertebrates
Limb Buds
Mammals
2012
48 Citations (Scopus)

Gradients of signalling in the developing limb

Towers, M., Wolpert, L. & Tickle, C., Apr 2012, In : Current Opinion in Cell Biology. 24, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Extremities
Tretinoin
Morphogenesis
27 Citations (Scopus)

Retinoic acid signaling and the initiation of mammary gland development

Cho, K. W., Kwon, H. J., Shin, J. O., Lee, J. M., Cho, S. W., Tickle, C. & Jung, H. S., 1 May 2012, In : Developmental Biology. 365, 1, p. 259-266 8 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Tretinoin
Embryonic Structures
citral
Breast
2011
12 Citations (Scopus)

3D expression patterns of cell cycle genes in the developing chick wing and comparison with expression patterns of genes implicated in digit specification

Welten, M., Pavlovska, G., Chen, Y., Teruoka, Y., Fisher, M., Bangs, F., Towers, M. & Tickle, C., May 2011, In : Developmental Dynamics. 240, 5, p. 1278-1288 11 p.

Research output: Contribution to journalArticle

cdc Genes
Gene Expression
Genes
Hedgehogs
Optical Tomography
15 Citations (Scopus)

Comparative analysis of 3D expression patterns of transcription factor genes and digit fate maps in the developing chick wing

Fisher, M., Downie, H., Welten, M. C. M., Delgado, I., Bain, A., Planzer, T., Sherman, A., Sang, H. & Tickle, C., 22 Apr 2011, In : PLoS ONE. 6, 4, e18661.

Research output: Contribution to journalArticle

Optical Tomography
Transcription Factors
transcription factors
Genes
buds
47 Citations (Scopus)

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

Bangs, F., Antonio, N., Thongnuek, P., Welten, M., Davey, M. G., Briscoe, J. & Tickle, C., 1 Aug 2011, In : Development. 138, 15, p. 3261-3272 12 p.

Research output: Contribution to journalArticle

Chickens
Hedgehogs
Genes
Cilia
Extremities
42 Citations (Scopus)

Insights into bird wing evolution and digit specification from polarizing region fate maps

Towers, M., Signolet, J., Sherman, A., Sang, H. & Tickle, C., Aug 2011, In : Nature Communications. 2, 426.

Research output: Contribution to journalArticle

birds
Hedgehogs
digits
Birds
wings
66 Citations (Scopus)

Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

Cho, S. W., Kwak, S., Woolley, T. E., Lee, M. J., Kim, E. J., Baker, R. E., Kim, H. J., Shin, J. S., Tickle, C., Maini, P. K. & Jung, H. S., 2011, In : Development. 138, 9, p. 1807-1816 10 p.

Research output: Contribution to journalArticle

Hedgehogs
Tooth
Jaw
Hair
Vertebrates
12 Citations (Scopus)

Micro-magnetic resonance imaging study of live quail embryos during embryonic development

Duce, S., Morrison, F., Welten, M., Baggott, G. & Tickle, C., Jan 2011, In : Magnetic Resonance Imaging. 29, 1, p. 132-139 8 p.

Research output: Contribution to journalArticle

Quail
Magnetic resonance
Magnetic resonance imaging
Embryonic Development
Embryonic Structures
1 Citation (Scopus)

Seven ages of the PhD

Gosling, R., Tickle, C., Running, S. W., Yao, T. D., Dinnyes, A., Osowole, A. A. & Cule, E., 21 Apr 2011, In : Nature. 472, 7343, p. 283-286 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development

Dunn, I. C., Paton, I. R., Clelland, A. K., Sebastian, S., Johnson, E. J., McTeir, L., Windsor, D., Sherman, A., Sang, H., Burt, D. W., Tickle, C. & Davey, M. G., May 2011, In : Developmental Dynamics. 240, 5, p. 1163-1172 10 p.

Research output: Contribution to journalArticle

Allelic Imbalance
Polydactyly
Hedgehogs
Chickens
Extremities
2010

A new mouse ciliopathy with a deletion in the Talpid3 gene, first identified in chicken

Bangs, F. & Tickle, C., Feb 2010, In : Genetics Research. 92, 1, p. 78 1 p.

Research output: Contribution to journalArticle

Cilia
Chickens
Genes
Extremities
Phenotype
18 Citations (Scopus)

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos

Mcdonald, L. A., Gerrelli, D., Fok, Y., Hurst, L. D. & Tickle, C., Jun 2010, In : Journal Of Anatomy. 216, 6, p. 683-691 9 p.

Research output: Contribution to journalArticle

limbs (animal)
fins
gene expression
Vertebrates
limb
35 Citations (Scopus)

Enhancer elements upstream of the SHOX gene are active in the developing limb

Durand, C., Bangs, F., Signolet, J., Decker, E., Tickle, C. & Rappold, G., May 2010, In : European Journal of Human Genetics. 18, 5, p. 527-532 6 p.

Research output: Contribution to journalArticle

Extremities
Cornea
Genes
Chickens
Limb Buds
15 Citations (Scopus)

Identification of genes downstream of the Shh signalling in the developing chick wing and syn-expressed with Hoxd13 using microarray and 3D computational analysis

Bangs, F., Welten, M., Davey, M. G., Fisher, M., Yin, Y. L., Downie, H., Paton, B., Baldock, R., Burt, D. W. & Tickle, C., Sep 2010, In : Mechanisms of Development. 127, 9-12, p. 428-441 14 p.

Research output: Contribution to journalArticle

Genes
Chick Embryo
Multigene Family
Gene Expression
Cilia
9 Citations (Scopus)

Micro-magnetic resonance imaging and embryological analysis of wild-type andpmamutant mice with clubfoot

Duce, S., Madrigal, L., Schmidt, K., Cunningham, C., Liu, G., Barker, S., Tennant, G., Tickle, C., Chudek, S. & Miedzybrodzka, Z., Jan 2010, In : Journal Of Anatomy. 216, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

Clubfoot
muscular atrophy
Muscular Atrophy
magnetic resonance imaging
muscle
2009
39 Citations (Scopus)

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C., 2009, In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Oxidoreductases
Extremities
Cholesterol
Forelimb
3 Citations (Scopus)

Expression of E2F transcription factor family genes during chick wing development

Towers, M., Fisunov, G. & Tickle, C., Oct 2009, In : Gene Expression Patterns. 9, 7, p. 528-531 4 p.

Research output: Contribution to journalArticle

E2F Transcription Factors
Chickens
Genes
Embryology
Cell Cycle Checkpoints
37 Citations (Scopus)

Generation of pattern and form in the developing limb

Towers, M. & Tickle, C., 2009, In : International Journal of Developmental Biology. 53, 5-6, p. 805-812 8 p.

Research output: Contribution to journalArticle

Extremities
Adhesiveness
Chick Embryo
Cell Biology
Vertebrates
2 Citations (Scopus)

Grafting of apical ridge and polarizing region

Tickle, C., 2009, In : Methods in Molecular Biology. 461, p. 313-323 11 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Growing models of vertebrate limb development

Towers, M. & Tickle, C., 2009, In : Development. 136, 2, p. 179-190 12 p.

Research output: Contribution to journalArticle

Vertebrates
Extremities
Fingers
Thumb
Molecular Biology

Insights into the developmental basis of congenital talipes equinovarus from pma mice

Miedzybrodzka, Z., Lindstrom, N., McIntosh, R., Duce, S., Sapsford, H., Chudek, J. A., Tickle, C., Vargesson, N. & Collinson, J. M., Sep 2009, In : Journal of Medical Genetics. 46, Suppl 1, p. S63-S63

Research output: Contribution to journalArticle

83 Citations (Scopus)

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 2009, In : Development. 136, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

Cilia
Neural Tube
Hedgehogs
Basal Bodies
Chickens
2008
39 Citations (Scopus)

Integrating technologies for comparing 3D gene expression domains in the developing chick limb

Fisher, M. E., Clelland, A. K., Bain, A., Baldock, R. A., Murphy, P., Downie, H., Tickle, C., Davidson, D. R. & Buckland, R. A., 2008, In : Developmental Biology. 317, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

Optical Tomography
Extremities
Atlases
Technology
Gene Expression
133 Citations (Scopus)

Integration of growth and specification in chick wing digit-patterning

Towers, M., Mahood, R., Yin, Y. L. & Tickle, C., 2008, In : Nature. 452, 7189, p. 882-U7

Research output: Contribution to journalArticle

Stem Cells
Growth
2007
3 Citations (Scopus)

Application of sonic hedgehog to the developing chick limb

Eva, T. & Tickle, C., 2007, In : Methods in Molecular Biology. 397, p. 23-33

Research output: Contribution to journalArticle

Hedgehogs
Hedgehog Proteins
Limb Buds
Extremities
Morphogenesis
90 Citations (Scopus)

Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patient

Sabherwal, N., Bangs, F., Ralph, R., Birgit, W., Karin, J., Eva, T., Georg, H., Christiane, S., Berthold, H., Hetty, K., Johannes, K., Tickle, C. & Gudrun, R., 2007, In : Human Molecular Genetics. 16, 2, p. 210-222

Research output: Contribution to journalArticle

Chickens
Extremities
Phenotype
Genes
Limb Buds
23 Citations (Scopus)

Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling

Eva, T., Turner, R., Sanz-Ezquerro, J. J., Warner, A. & Tickle, C., 1 May 2007, In : Developmental Biology. 305, 1

Research output: Contribution to journalArticle

Hedgehogs
Cyclic AMP-Dependent Protein Kinases
Extremities
Limb Buds
Colforsin
26 Citations (Scopus)

Micro-magnetic resonance imaging of avian embryos

Li, X., Liu, J., Davey, M., Duce, S., Jaberi, N., Liu, G., Davidson, G., Tenent, S., Mahood, R., Brown, P., Cunningham, C., Bain, A., Beattie, K., Mcdonald, L. A., Schmidt, K., Towers, M., Tickle, C. & Chudek, S., Dec 2007, In : Journal Of Anatomy. 211, 6, p. 798-809

Research output: Contribution to journalArticle

magnetic resonance imaging
embryo
embryo (animal)
Quail
Embryonic Structures
47 Citations (Scopus)

The chicken as a model for embryonic development

Davey, M. G. & Tickle, C., 2007, In : Cytogenetic and Genome Research. 117, 1-4, p. 231-239

Research output: Contribution to journalArticle

Embryonic Development
Chickens
Embryonic Structures
Developmental Biology
Neural Crest
8 Citations (Scopus)

The expression of Fat-1 cadherin during chick limb development

Terence, S., Hateren, N. V., Tickle, C. & Wilson, S., 2007, In : International Journal of Developmental Biology. 51, p. 173-176

Research output: Contribution to journalArticle

Cadherins
Limb Buds
Extremities
Fats
Mesoderm
2006
33 Citations (Scopus)

Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements

Eva, T., Bangs, F., Rudiger, B., Elizabeth, F., Gudrun, R. & Tickle, C., 15 Oct 2006, In : Developmental Biology. 298, 2, p. 585-596

Research output: Contribution to journalArticle

Limb Buds
Homeobox Genes
Extremities
Cartilage
Chickens
108 Citations (Scopus)

Making digit patterns in the vertebrate limb

Tickle, C., Jan 2006, In : Nature Reviews Molecular Cell Biology. 7, p. 45-53

Research output: Contribution to journalArticle

Thumb
Fingers
Vertebrates
Extremities
Hand
39 Citations (Scopus)

Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos

Tickle, C., Terence, S., Maria, K., Lunn, S., Maxwell, E., Iain, K., Elizabeth, F., Kate, S. & Stephen, K., Jul 2006, In : FEBS Letters. 580, 17, p. 4242-4245

Research output: Contribution to journalArticle

Calcineurin
Mitogen-Activated Protein Kinase Kinases
Embryonic Structures
Extremities
Feedback
89 Citations (Scopus)

The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

Davey, M., Paton, R., Yin, Y., Schmidt, M., Bangs, F., Morrice, D., Terence, S., Buxton, P., Stamataki, D., Tanaka, M., Münsterberg, A., Briscoe, J., Tickle, C. & Burt, D., 2006, In : Genes & Development. 20, p. 1365-1377

Research output: Contribution to journalArticle

Hedgehog Proteins
Hedgehogs
Chickens
Embryonic Structures
Genes
9 Citations (Scopus)

The expression of Flrt3 during chick limb development

Terence, S. & Tickle, C., 2006, In : International Journal of Developmental Biology. 50, p. 701-704

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Mesoderm
Fibronectins
Extremities
Limb Buds