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Personal profile

Research interests

The research program in my laboratory has its primary focus on characterization of iron-related early cellular events promoting various pathological types of damage to human skin cells either as a result of acute/chronic exposure to oxidizing agents such as ultraviolet A (UVA, 320-400nm) radiation and hydrogen peroxide or as a result of alteration in iron homeostasis observed in a series of iron-related skin disorders such as skin cancer and Psoriasis. The results obtained from these studies provide us with valuable knowledge to design a series of synthetic small molecules with iron chelation and antioxidant properties that may be used as therapeutic tools to prevent the promotion or progression of such disorders.

Current research in my laboratory focuses on:

Design and study of novel ‘light-activated caged-iron chelators’

We have developed a series of novel light-activated ‘caged’ iron chelators that minimize the side effects of prolonged siderophore exposure. These compounds are inactive due to temporary blockade of the iron binding site and only become activated upon exposure to an external light source. Current research involves the evaluation of both photoprotective and therapeutic potential of CICs in both monolayer and organotypic (artificial) three dimensional skin cultures.

Design and study of novel ‘organelle-targeted’ iron sensors/chelators

Recent studies of a range of human disorders as well as cellular studies with environmental oxidizing agents such as UVA have indicated that mitochondrial and lysosomal redox active and chelatable labile iron plays a key role in conferring cellular sensitivity to oxidative damage and the resulting pathologies and cell death. Iron chelators that target specifically the mitochondrial and lysosomal iron could therefore be beneficial both as preventive and therapeutic agents. Current research involves the evaluation of the exact role of subcellular labile iron distribution (or misdistribution) in oxidative injuries and iron-related disorders.

Fingerprint Dive into the research topics where Charareh Pourzand is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Iron Medicine & Life Sciences
Spermine Medicine & Life Sciences
Small Interfering RNA Medicine & Life Sciences
Oxidative stress Chemical Compounds
Skin Chemical Compounds
Radiation Medicine & Life Sciences
Gene Silencing Medicine & Life Sciences
Chelation Chemical Compounds

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Projects 2002 2018

Iron chelation and skin ageing

Eggleston, I., Pourzand, C. & Gunn, D.

Project: Research councilIndividual grant

photostability
chelating agents
skin (animal)
metals
iron

Light-activated caged iron chelators for the therapy of age-related macular degeneration

Eggleston, I. & Pourzand, C.

1/06/1530/11/15

Project: Research councilInternally Funded Research

Research Output 1990 2019

The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A

Pourzand, C., Reelfs, O., Abbate, V., Hider, R. C. & POOK, M., 1 Mar 2019, In : Metallomics. 11, 3, p. 656-665 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

A powerful mitochondria-targeted iron chelator affords high photoprotection against solar ultraviolet A radiation

Reelfs, O., Abbate, V., Hider, R. C. & Pourzand, C., 1 Aug 2016, In : Journal Of Investigative Dermatology. 136, 8, p. 1692-1700 9 p.

Research output: Contribution to journalArticle

Open Access

Characterisation Of A Novel Hexadentate Iron Chelator For Skin Photoprotection

Reelfs, O., Abbate, V., Hider, R. C. & Pourzand, C., 2016.

Research output: Contribution to conferenceAbstract

Clinical Iron Chelators For Skin Photoprotection As Light-Activated Caged Iron Chelators

Houshmandyar, S., Reelfs, O., Radka, T., Eggleston, I. & Pourzand, C., 2016.

Research output: Contribution to conferenceAbstract

Thesis

A Comparative study of the antiproliferative activity of iron chelators PIH, SIH and their light-activated caged derivatives in skin cells

Author: Aroun, A., 1 Nov 2010

Supervisor: Pourzand, C. (Supervisor) & Reelfs, O. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Clinically relevant in vitro dissolution/release testing for parenteral formulations

Author: Diaz De Leon Ortega, R., 3 Apr 2019

Supervisor: Pourzand, C. (Supervisor) & Fotaki, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

Improving the Efficiency of Aminolevulinate-Photodynamic Therapy of Skin Cells by Combining UVA Irradiation and Potent Iron Chelating Agents

Author: Radka, T., 24 Feb 2014

Supervisor: Pourzand, C. (Supervisor) & Eggleston, I. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

Targeted dendrimeric prodrugs for 5-Aminolaevulinic acid photodynamic therapy

Author: Tewari, K. M., 23 Nov 2016

Supervisor: Eggleston, I. (Supervisor) & Pourzand, C. (Supervisor)

Student thesis: Doctoral ThesisPhD

File

The role of iron in rheumatoid arthritis

Author: Averill, A., 1 Aug 2008

Supervisor: Pourzand, C. (Supervisor) & Hall, N. (Supervisor)

Student thesis: Doctoral ThesisPhD

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