Projects per year
Personal profile
Research interests
My work broadly focuses on β-lactam antibiotic action and resistance in Gram-negative pathogens.
β-Lactams, the most prescribed antibiotic class worldwide, kill bacteria by binding and inhibiting Penicillin Binding Proteins (PBPs). β-Lactam resistance can be conferred by β-lactamases (BLAs), enzymes evolutionarily related to PBPs that inactivate the antibiotics, threatening their continued clinical efficacy.
I use interdisciplinary approaches in microbiology, biochemistry, structural biology, and biomolecular simulation to advance the understanding of PBP/BLA mechanisms and inhibition.
External positions
Honorary Research Fellow, University of Bristol
1 Sept 2023 → 31 Aug 2030
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Collaborations and top research areas from the last five years
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Understanding ß-lactam antibiotic action and resistance in Klebsiella pneumoniae through penicillin binding protein characterisation.
Tooke, C. (PI)
1/07/25 → 30/06/30
Project: Research council
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Reimagining Spaces: The 4S Pavilion
Holt, C. (CoPI), Tooke, C. (PI), Littleford-Colquhoun, B. (CoPI), Da Luz Batalha, I. (CoPI), Tang, S. (CoPI) & Sanz-Maestro, A. (Researcher CoI)
18/11/25 → 31/07/26
Project: Research-related funding
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Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Tooke, C., Hinchliffe, P., Beer, M., Zinovjev, K., Colenso, C. K., Schofield, C., Mulholland, A. & Spencer, J., 5 Apr 2023, In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
Open Access30 Link opens in a new tab Citations (SciVal) -
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
Hinchliffe, P., Tooke, C., Bethel, C. R., Wang, B., Arthur, C., Heesom, K. J., Shapiro, S., Schlatzer, D. M., Papp-Wallace, K. M., Bonomo, R. A. & Spencer, J., 25 May 2022, In: mBio. 13, 3, 16 p., e01793-21.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Citations (SciVal) -
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
Butryn, A., Simon, P. S., Aller, P., Hinchliffe, P., Massad, R. N., Leen, G., Tooke, C. L., Bogacz, I., Kim, I.-S., Bhowmick, A., Brewster, A. S., Devenish, N. E., Brem, J., Kamps, J. J. A. G., Lang, P. A., Rabe, P., Axford, D., Beale, J. H., Davy, B. & Ebrahim, A. & 16 others, , 22 Jul 2021, In: Nature Communications. 12, 1, 4461.Research output: Contribution to journal › Article › peer-review
Open Access58 Link opens in a new tab Citations (SciVal) -
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance
Tooke, C. L., Hinchliffe, P., Bonomo, R. A., Schofield, C. J., Mulholland, A. J. & Spencer, J., 30 Nov 2020, In: The Journal of biological chemistry. 296, p. 100126 14 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Link opens in a new tab Citations (SciVal) -
Drop-on-fixed-target reaction initiation approach for serial and time-resolved crystallography
Kamps, J. J. A. G., Hinchliffe, P., Glerup, J., Freeman, E. I., Lang, P. A., Tooke, C. L., Beer, M., Parkinson, L., Gu, D. H., Park, S., Devenish, N., Zhou, T., Shilova, A., Kaur, S., Rabe, P., Schofield, C. J., Spencer, J., Park, J., Owen, R. L. & Orville, A. M. & 1 others, , 1 Jul 2026, In: IUCrJ. 13, p. 471-484 14 p.Research output: Contribution to journal › Article › peer-review
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