Research output per year
Research output per year
Personal profile
Research interests
My work broadly focuses on β-lactam antibiotic action and resistance in Gram-negative pathogens.
β-Lactams, the most prescribed antibiotic class worldwide, kill bacteria by binding and inhibiting Penicillin Binding Proteins (PBPs). β-Lactam resistance can be conferred by β-lactamases (BLAs), enzymes evolutionarily related to PBPs that inactivate the antibiotics, threatening their continued clinical efficacy.
I use interdisciplinary approaches in microbiology, biochemistry, structural biology, and biomolecular simulation to advance the understanding of PBP/BLA mechanisms and inhibition.
External positions
Honorary Research Fellow, University of Bristol
1 Sept 2023 → 31 Aug 2025
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Collaborations and top research areas from the last five years
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Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
Dulyayangkul, P., Beavis, T., Lee, W. W. Y., Ardagh, R., Edwards, F., Hamilton, F., Head, I., Heesom, K. J., Mounsey, O., Murarik, M., Pinweha, P., Reding, C., Satapoomin, N., Shaw, J. M., Takebayashi, Y., Tooke, C. L., Spencer, J., Williams, P. B. & Avison, M. B., 6 Jun 2024, In: PLoS Pathogens. 20, 6 , e1012235.Research output: Contribution to journal › Article › peer-review
Open Access -
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Tooke, C., Hinchliffe, P., Beer, M., Zinovjev, K., Colenso, C. K., Schofield, C., Mulholland, A. & Spencer, J., 5 Apr 2023, In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (SciVal) -
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
Hinchliffe, P., Tooke, C., Bethel, C. R., Wang, B., Arthur, C., Heesom, K. J., Shapiro, S., Schlatzer, D. M., Papp-Wallace, K. M., Bonomo, R. A. & Spencer, J., 25 May 2022, In: mBio. 13, 3, 16 p., e01793-21.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (SciVal) -
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
Lucic, A., Malla, T. R., Calvopiña, K., Tooke, C. L., Brem, J., McDonough, M. A., Spencer, J. & Schofield, C. J., 16 Mar 2022, In: Antibiotics. 11, 3Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (SciVal) -
Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics
Galdadas, I., Qu, S., Oliveira, A. S. F., Olehnovics, E., Mack, A. R., Mojica, M. F., Agarwal, P. K., Tooke, C. L., Gervasio, F. L., Spencer, J., Bonomo, R. A., Mulholland, A. J. & Haider, S., 23 Mar 2021, In: eLife. 10, 23 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Citations (SciVal)