Bernie Morley

Search results

• 2016

  Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation

  Thornton, C. C., Al-Rashed, F., Calay, D., Birdsey, G. M., Bauer, A., Mylroie, H., Morley, B. J., Randi, A. M., Haskard, D. O., Boyle, J. J. & Mason, J. C., 11 Jan 2016, In: Annals of the Rheumatic Diseases. 75, 2, p. 439-448 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Response Elements
  • Cyclic AMP
  • Methotrexate
  • Protein Kinases
  • Chemical activation
  54 Citations (Scopus)
• 2009

  A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells.

  Rogers, NJ., Lees, MJ., Gabriel, L., Maniati, E., Rose, SJ., Potter, PK. & Morley, B. J., Feb 2009, In: The Journal of Immunology. 182, p. 1982-1990 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Lupus Erythematosus
  • Macrophages
  • Congenic Mice
  • Scavenger Receptors
  • Disease Susceptibility
  43 Citations (Scopus)

• Selective up-regulation of intact, but not defective env RNAs of endogenous modified polytropic retrovirus by the Sgp3 locus of lupus-prone mice

  Yoshinobu, K., Baudino, L., Santiago-Raber, ML., Morito, N., Dunand-Sauthier, I., Morley, B. J., Evans, LH. & Izui, S., 15 Jun 2009, In: The Journal of Immunology. 182, p. 8094-8103 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retroviridae
  • Up-Regulation
  • RNA
  • Endogenous Retroviruses
  • Serum
  27 Citations (Scopus)

• The role of iNKT cells in the immunopathology of systemic lupus erythematosus.

  Gabriel, L., Morley, B. J. & Rogers, NJ., Sep 2009, In: Annals of the New York Academy of Sciences. 1173, Contemporary Challenges in Autoimmunity, p. 435-441 7 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Natural Killer T-Cells
  • Systemic Lupus Erythematosus
  • Cells
  • Glycolipids
  12 Citations (Scopus)
• 2008

  Control of apoptosis in autoimmunity

  Maniati, E., Potter, P., Rogers, NJ. & Morley, B. J., Jan 2008, In: The Journal of Pathology. 214, 2, p. 190-198 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoimmunity
  • Apoptosis
  • Self Tolerance
  • Disease Susceptibility
  • Autoimmune Diseases
  30 Citations (Scopus)

• Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis

  Baudino, L., Yoshinobu, K., Morito, N., Kikuchi, S., Fossati-Jimack, L., Morley, B. J., Vyse, TJ., Hirose, S., Jorgensen, TN., Tucker, RM., Roark, CL., Kotzin, BL., Evans, LH. & Izui, S., 15 Aug 2008, In: The Journal of Immunology. 181, p. 2846-2854 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Lupus Nephritis
  • Dissection
  • RNA
  • Serum
  • Congenic Mice
  17 Citations (Scopus)
• 2007

  A comparison of the behavior of C57BL/6 and C57BL/10 mice

  Deacon, RMJ., Thomas, CL., Rawlins, JNP. & Morley, B. J., May 2007, In: Behavioural Brain Research. 179, 2, p. 239-247 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Inbred C57BL Mouse
  • Inbred Strains Mice
  • Allergy and Immunology
  • Biomedical Research
  • Cognition
  23 Citations (Scopus)

• BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.

  Haywood, ME., Gabriel, L., Rose, SJ., Rogers, NJ., Izui, S. & Morley, B. J., Aug 2007, In: The Journal of Immunology. 179, p. 2428-2434 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Disease Susceptibility
  • Chromosomes, Human, Pair 5
  • Inbred Strains Mice
  • Microsatellite Repeats
  • Systemic Lupus Erythematosus
  6 Citations (Scopus)

• Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process.

  Rogers, NJ., Gabriel, L., Nunes, CT., Rose, SJ., Thiruudaian, V., Boyle, J. & Morley, B. J., Dec 2007, In: Genes and Immunity. 8, p. 619-627 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 1
  • Congenic Mice
  • Autoantibodies
  • Lupus Nephritis
  • Nephritis
  9 Citations (Scopus)

• The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes.

  Rankin, J., Boyle, JJ., Rose, SJ., Gabriel, L., Lewis, M., Thiruudaian, V., Rogers, NJ., Izui, S. & Morley, B. J., Apr 2007, In: The Journal of Immunology. 178, p. 4395-4401 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Antigen-Antibody Complex
  • Chromosomes, Human, Pair 13
  • Nephritis
  • Y Chromosome
  • Autoantibodies
  11 Citations (Scopus)
• 2006

  Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes.

  Haywood, ME., Rose, SJ., Horswell, S., Lees, MJ., Fu, G., Walport, MJ. & Morley, B. J., Apr 2006, In: Genes and Immunity. 7, p. 250-263 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Congenic Mice
  • Disease Susceptibility
  • Microarray Analysis
  • Systemic Lupus Erythematosus
  • Gene Expression
  65 Citations (Scopus)
• 2005

  Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene

  Choi, P., Xanthaki, D., Rose, SJ., Haywood, M., Reiser, H. & Morley, B. J., Jun 2005, In: Genes and Immunity. 6, p. 290-297 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Linkage
  • Interleukin-4
  • T-Lymphocytes
  • Genes
  • Th2 Cells
  8 Citations (Scopus)

• Monocytosis in a murine model of SLE maps to the bottom of chromosome 1

  Rogers, NJ., Nunes, CT., Rose, SJ. & Morley, B. J., Dec 2005, In: Immunology. 116, Suppl. 1, p. 10-10 1 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c.

  Rigby, RJ., Rozzo, SJ., Gill, H., Fernandez-Hart, T., Morley, B. J., Izui, S., Kotzin, BL. & Vyse, TJ., Apr 2004, In: The Journal of Immunology. 172, p. 5078-5085 8 p.

  Research output: Contribution to journal › Article › peer-review

  • New Zealand
  • Antibody Formation
  • Glycoproteins
  • Chromosomes, Human, Pair 4
  • Serum
  18 Citations (Scopus)

• Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.

  Haywood, ME., Rogers, NJ., Rose, SJ., Boyle, J., McDermott, A., Rankin, JM., Thiruudaian, V., Lewis, MR., Fossati-Jimack, L., Izui, S., Walport, MJ. & Morley, B. J., Oct 2004, In: The Journal of Immunology. 173, p. 4277-4285 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Congenic Mice
  • Chromosomes, Human, Pair 1
  • Dissection
  • Glomerulonephritis
  • Phenotype
  47 Citations (Scopus)

• Multiple loci are linked with anti-red blood cell antibody production in NZB mice − comparison with other phenotypes implies complex modes of action

  Lee, NJ., Rigby, RJ., Gill, H., Boyle, JJ., Fossati-Jimack, L., Morley, B. J. & Vyse, TJ., Oct 2004, In: Clinical And Experimental Immunology. 138, p. 39-46 8 p.

  Research output: Contribution to journal › Article › peer-review

  • New Zealand
  • Antibody Formation
  • Erythrocytes
  • Anti-Idiotypic Antibodies
  • Phenotype
  17 Citations (Scopus)
• 2002

  Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11

  Fu, G., Haywood, ME. & Morley, B. J., Mar 2002, In: Nucleic Acids Research. 30, p. 1394-1400 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialyltransferases
  • Chromosomes, Human, Pair 11
  • Genome
  • Genes
  • Superantigens
  3 Citations (Scopus)
• 2001

  Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice.

  Haywood, ME., Vyse, TJ., McDermott, A., Thompson, EM., Ida, A., Walport, MJ., Izui, S. & Morley, B. J., Aug 2001, In: The Journal of Immunology. 167, p. 1728-1733 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Lupus Nephritis
  • Autoantigens
  • Autoantibodies
  • Glycoproteins
  • Antigen-Antibody Complex
  37 Citations (Scopus)

• Fine mapping genes for Fc γ receptor II and III in systemic lupus erythematosus

  Roberton, CA., Morley, B. J. & Vyse, TJ., Oct 2001, In: The American Journal of Human Genetics. 69, p. 568-568 1 p.

  Research output: Contribution to journal › Article › peer-review
• 2000

  Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII

  Pritchard, NR., Cutler, AJ., Uribe, S., Chadban, SJ., Morley, B. J. & Smith, KGC., 15 Feb 2000, In: Current Biology. 10, 4, p. 227-230 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • lupus erythematosus
  • Fc Receptors
  • Haplotypes
  • IgG Receptors
  178 Citations (Scopus)

• Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines.

  Stocker, CJ., Sugars, KL., Yarwood, H., Delikouras, A., Lechler, RI., Dorling, A., Landis, RC., Morley, B. J. & Haskard, DO., 27 Aug 2000, In: Transplantation. 70, 4, p. 579-586 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Intercellular Adhesion Molecule-1
  • Organism Cloning
  • Swine
  • Endothelial Cells
  • Cytokines
  20 Citations (Scopus)

• Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

  Haywood, ME., Hogarth, MB., Slingsby, JH., Rose, SJ., Allen, PJ., Thompson, EM., Maibaum, MA., Chandler, P., Davies, KA., Simpson, E., Walport, MJ. & Morley, B. J., Feb 2000, In: Arthritis & Rheumatism. 43, 2, p. 349-355 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 13
  • Chromosomes, Human, Pair 1
  • Systemic Lupus Erythematosus
  • Chromosomes, Human, Pair 3
  • Phenotype
  70 Citations (Scopus)

• Lupus susceptibility loci map within regions of BXSB derived from the SB/Le parental strain.

  Maibaum, MA., Haywood, ME., Walport, MJ. & Morley, B. J., Apr 2000, In: Immunogenetics. 51, 4-5, p. 370-372 3 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• TNF-α, IL-4, and IFN-γ regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells.

  Stocker, CJ., Sugars, KL., Harari, OA., Landis, RC., Morley, B. J. & Haskard, DO., Mar 2000, In: The Journal of Immunology. 164, p. 3309-3315 7 p.

  Research output: Contribution to journal › Article › peer-review

  • E-Selectin
  • P-Selectin
  • Interleukin-4
  • Swine
  • Endothelial Cells
  55 Citations (Scopus)
• 1999

  Candidate gene analysis in the lupus-prone mouse strain, BXSB.

  Maibaum, MA., Fu, G., Haywood, MEK., Uribe, S., Rose, SJ., Sim, RB., Walport, MJ. & Morley, B. J., Oct 1999, In: The American Journal of Human Genetics. 65, p. A262-A262

  Research output: Contribution to journal › Article › peer-review

• Genome-wide linkage analyses in the lupus-prone mouse strain, BXSB.

  Haywood, MEK., Hogarth, MB., Slingsby, JH., Rose, SJ., Thompson, EM., Maibaum, MA., Walport, MJ. & Morley, B. J., Oct 1999, In: The American Journal of Human Genetics. 65, p. A105-A105

  Research output: Contribution to journal › Article › peer-review
• 1998

  Molecular basis of hereditary factor I deficiency

  Morley, B. J., Bartok, I., Spath, PJ., Vyse, TJ., Schneider, PM. & Walport, MJ., Apr 1998, In: Molecular Immunology. 35, 6-7, p. 344-344 1 p.

  Research output: Contribution to journal › Article › peer-review

• Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice

  Hogarth, MB., Slingsby, JH., Allen, PJ., Thompson, EM., Chandler, P., Davies, KA., Simpson, E., Morley, B. J. & Walport, MJ., Sep 1998, In: The Journal of Immunology. 161, p. 2753-2761 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 4
  • Chromosomes, Human, Pair 3
  • Chromosomes, Human, Pair 10
  • Nephritis
  104 Citations (Scopus)

• Regulation of transcription of the TATA-less human complement component C4 gene

  Vaishnaw, AK., Mitchell, TJ., Rose, SJ., Walport, MJ. & Morley, B. J., May 1998, In: The Journal of Immunology. 160, p. 4353-4360 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Complement C4
  • Reporter Genes
  • NFI Transcription Factors
  • Gene Expression
  • Genes
  8 Citations (Scopus)

• Transcriptional regulation of the human C4 gene

  Mitchell, TJ., Vaishnaw, AK., Rose, J., Walport, MJ. & Morley, B. J., Apr 1998, In: Molecular Immunology. 35, 6-7, p. 344-344 1 p.

  Research output: Contribution to journal › Article › peer-review
• 1997

  Complement deficiency and autoimmunity

  Walport, MJ., Davies, KA., Morley, B. J. & Botto, M., Apr 1997, In: Annals of the New York Academy of Sciences. 815, Issue B-Lymphocytes and Autoimmunity, p. 267-281 15 p.

  Research output: Contribution to journal › Article › peer-review
  83 Citations (Scopus)

• Polymorphism in the Ly-17 alloantigenic system of the mouse FcgRII gene.

  Slingsby, JH., Hogarth, MB., Walport, MJ. & Morley, B. J., Jul 1997, In: Immunogenetics. 46, 4, p. 361-362 2 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)
• 1996

  Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice

  Hogarth, MB., Norsworthy, PJ., Allen, PJ., Trinder, PKE., Loos, M., Morley, B. J., Walport, MJ. & Davies, KA., May 1996, In: Clinical And Experimental Immunology. 104, 2, p. 241-246 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoantibodies
  • Antibodies
  • Anti-Idiotypic Antibodies
  • Inbred MRL lpr Mouse
  • Inbred NZB Mouse
  27 Citations (Scopus)

• Homozygous hereditary C1q deficiency and systemic lupus erythematosus: A new family and the molecular basis of C1q deficiency in three families

  Slingsby, JH., Norsworthy, P., Pearce, G., Vaishnaw, AK., Issler, H., Morley, B. J. & Walport, MJ., Apr 1996, In: Arthritis & Rheumatism. 39, 4, p. 663-670 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Lupus Erythematosus
  • Codon
  • Nonsense Codon
  • Mutation
  • Amino Acids
  83 Citations (Scopus)

• IFN-gamma up-regulates expression of the complement components C3 and C4 by stabilization of mRNA

  Mitchell, TJ., Naughton, M., Norsworthy, P., Davies, KA., Walport, MJ. & Morley, B. J., Jun 1996, In: The Journal of Immunology. 156, 11, p. 4429-4434 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Complement C4
  • Complement C3
  • Up-Regulation
  • Messenger RNA
  • Hep G2 Cells
  34 Citations (Scopus)

• Localization of mtv44 to the centromeric region of mouse chromosome 11

  Slingsby, JH., Dyson, PJ., Morley, B. J., Walport, MJ. & Simpson, E., Apr 1996, In: Mammalian Genome. 7, 4, p. 319-320 2 p.

  Research output: Contribution to journal › Article › peer-review

• Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family

  Topaloglu, R., Bakkaloglu, A., Slingsby, JH., Mihatsch, MJ., Pascual, M., Norsworthy, P., Morley, B. J., Saatci, U., Schifferli, JA. & Walport, MJ., Aug 1996, In: Kidney International. 50, 2, p. 635-642 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin A
  • Hepatitis B Vaccines
  • Mutation
  • Hematuria
  • Antibody Formation
  44 Citations (Scopus)

• The molecular basis of hereditary complement factor I deficiency

  Vyse, TJ., Morley, B. J., Bartok, I., Theodoridis, EL., Davies, KA., Webster, AD. & Walport, MJ., Feb 1996, In: Journal of Clinical Investigation. 97, 4, p. 925-933 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Complement Factor I Deficiency
  • Pedigree
  • Histidine
  • Thymine Nucleotides
  • Mutation
  72 Citations (Scopus)

• The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization

  Petry, F., McClive, PJ., Botto, M., Morley, B. J., Morahan, G. & Loos, M., Apr 1996, In: Immunogenetics. 43, 6, p. 370-376 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 4
  • Genes
  • Southern Blotting
  • DNA
  • Complement C1q
  11 Citations (Scopus)

• Tissue specific transcriptional control of the human complement C4 gene is directed by the first 126bp of the promoter

  Mitchell, TJ., Vaishnaw, AK., Rose, SJ., Walport, MJ. & Morley, B. J., Nov 1996, In: Immunology. 89, p. A3-A3

  Research output: Contribution to journal › Article › peer-review
• 1995

  DNase I hypersensitivity mapping and promoter polymorphism analysis of human C4

  Vaishnaw, AK., Hargreaves, R., Campbell, RD., Morley, B. J. & Walport, MJ., Apr 1995, In: Immunogenetics. 41, 6, p. 354-358 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Deoxyribonuclease I
  • Major Histocompatibility Complex
  • HLA-B57 antigen
  • Hypersensitivity
  • Complement C4

• Molecular-basis of complete functional C1Q deficiency in 3 patients

  Slingsby, JH., Pearce, GJ., Norsworthy, PJ., Davies, KA., Issler, H., Morley, B. J. & Walport, MJ., Sep 1995, In: Arthritis & Rheumatism. 38, Suppl. S, p. 184-184 1 p.

  Research output: Contribution to journal › Article › peer-review

• New microsatellite polymorphisms identified between C57BL/6, C57BL/10, and C57BL/KsJ inbred mouse strains.

  Slingsby, JH., Hogarth, MB., Simpson, E., Walport, MJ. & Morley, B. J., Jan 1995, In: Immunogenetics. 43, 1-2, p. 72-75 4 p.

  Research output: Contribution to journal › Article › peer-review
• 1994

  Hereditary complement factor I deficiency

  Vyse, TJ., Spath, PJ., Davies, KA., Morley, B. J., Philippe, P., Athanassiou, P., Giles, CM. & Walport, MJ., Jul 1994, In: QJM: An International Journal of Medicine. 87, p. 385-401 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Complement Factor I Deficiency
  • Siblings
  • Serum
  • Immunoglobulin G
  • Infection

• The organization of the human complement factor I gene (IF): a member of the serine protease gene family

  Vyse, TJ., Bates, GP., Walport, MJ. & Morley, B. J., 1 Nov 1994, In: Genomics. 24, 1, p. 90-98 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Complement Factor I
  • Serine Proteases
  • Exons
  • Genes
  • Complement C7
• 1992

  A simple method for identifying complement component C3 polymorphisms

  Hohler, T., Botto, M., Routier, R., Morley, B. J. & Walport, MJ., Feb 1992, In: British Journal of Rheumatology. 31, 10, p. 10-10 1 p.

  Research output: Contribution to journal › Article › peer-review

• Homozygous hereditary C3 deficiency due to a partial gene deletion.

  Botto, M., Fong, KY., So, AK., Barlow, R., Routier, R., Morley, B. J. & Walport, MJ., 1 Jun 1992, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 89, 11, p. 4957-4961 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Deletion
  • Base Pairing
  • Restriction Mapping
  • Transformed Cell Line
  • Frameshift Mutation