Bernie Morley

Prof

  • 4 WEST 3.26

19922016
If you made any changes in Pure these will be visible here soon.

Research Output 1992 2016

2016
33 Citations (Scopus)

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation

Thornton, C. C., Al-Rashed, F., Calay, D., Birdsey, G. M., Bauer, A., Mylroie, H., Morley, B. J., Randi, A. M., Haskard, D. O., Boyle, J. J. & Mason, J. C., 1 Feb 2016, In : Annals of the Rheumatic Diseases. 75, 2, p. 439-448 10 p.

Research output: Contribution to journalArticle

Open Access
Cyclic AMP Response Element-Binding Protein
Methotrexate
Protein Kinases
Blood Vessels
Chemical activation
2009
40 Citations (Scopus)

A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells.

Rogers, NJ., Lees, MJ., Gabriel, L., Maniati, E., Rose, SJ., Potter, PK. & Morley, B. J., Feb 2009, In : The Journal of Immunology. 182, p. 1982-1990 9 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Macrophages
Congenic Mice
Scavenger Receptors
Disease Susceptibility
26 Citations (Scopus)

Selective up-regulation of intact, but not defective env RNAs of endogenous modified polytropic retrovirus by the Sgp3 locus of lupus-prone mice

Yoshinobu, K., Baudino, L., Santiago-Raber, ML., Morito, N., Dunand-Sauthier, I., Morley, B. J., Evans, LH. & Izui, S., 15 Jun 2009, In : The Journal of Immunology. 182, p. 8094-8103 10 p.

Research output: Contribution to journalArticle

Retroviridae
Up-Regulation
RNA
Serum
Endogenous Retroviruses
10 Citations (Scopus)

The role of iNKT cells in the immunopathology of systemic lupus erythematosus.

Gabriel, L., Morley, B. J. & Rogers, NJ., Sep 2009, In : Annals of the New York Academy of Sciences. 1173, Contemporary Challenges in Autoimmunity, p. 435-441 7 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
Systemic Lupus Erythematosus
Glycolipids
Autoimmune Diseases
2008

Alterations of the thymic environment in murine models of SLE

Maniati, E., Aw, D., Palmer, DB., Morley, B. J. & Rogers, NJ., Dec 2008, p. 113-113. 1 p.

Research output: Contribution to conferencePaper

Characterisation of T helper profile in a murine model of SLE

Gabriel, L., Mniati, E., Rose, SJ., Morley, B. J. & Rogers, NJ., Dec 2008, p. 96-96. 1 p.

Research output: Contribution to conferencePaper

30 Citations (Scopus)

Control of apoptosis in autoimmunity

Maniati, E., Potter, P., Rogers, NJ. & Morley, B. J., Jan 2008, In : The Journal of Pathology. 214, 2, p. 190-198 9 p.

Research output: Contribution to journalArticle

Autoimmunity
Apoptosis
Self Tolerance
Disease Susceptibility
Autoimmune Diseases
16 Citations (Scopus)

Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis

Baudino, L., Yoshinobu, K., Morito, N., Kikuchi, S., Fossati-Jimack, L., Morley, B. J., Vyse, TJ., Hirose, S., Jorgensen, TN., Tucker, RM., Roark, CL., Kotzin, BL., Evans, LH. & Izui, S., 15 Aug 2008, In : The Journal of Immunology. 181, p. 2846-2854 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Dissection
RNA
Serum
Congenic Mice

The role of iNKT cells in the immunopathology of systemic lupus erythematosus

Gabriel, L., Morley, B. J., Rogers, NJ., Shoenfeld, Y. (ed.) & Gershwin, ME. (ed.), 2008, p. 435-441. 7 p.

Research output: Contribution to conferencePaper

Natural Killer T-Cells
Systemic Lupus Erythematosus
Glycolipids
Autoimmune Diseases
Therapeutics

The role of NKT cells in the immunopathology of systemic lupus erythematosus

Gabriel, L., Maniati, E., Morley, B. J. & Rogers, NJ., Dec 2008, p. 111-111. 1 p.

Research output: Contribution to conferencePaper

The role of toll-like receptors in the BXSB model of SLE

Maniati, E., Gomes, MJ., Gabriel, L., Morley, B. J. & Rogers, NJ., Dec 2008, p. 112-113. 2 p.

Research output: Contribution to conferencePaper

2007
18 Citations (Scopus)

A comparison of the behavior of C57BL/6 and C57BL/10 mice

Deacon, RMJ., Thomas, CL., Rawlins, JNP. & Morley, B. J., May 2007, In : Behavioural Brain Research. 179, 2, p. 239-247 9 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Inbred Strains Mice
Allergy and Immunology
Research
Cognition
5 Citations (Scopus)

BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci

Gabriel, L., Haywood, MEK., Rose, SJ., Rogers, NJ., Izui, S. & Morley, B. J., Mar 2007, p. 72-72. 1 p.

Research output: Contribution to conferencePaper

5 Citations (Scopus)

BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.

Haywood, ME., Gabriel, L., Rose, SJ., Rogers, NJ., Izui, S. & Morley, B. J., Aug 2007, In : The Journal of Immunology. 179, p. 2428-2434 7 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 6
Inbred Strains Mice
Systemic Lupus Erythematosus

Lymphoid tissue distribution of DC subtypes in a murine model of SLE

Maniati, E., Rogers, NJ. & Morley, B. J., Mar 2007, p. 73-73. 1 p.

Research output: Contribution to conferencePaper

8 Citations (Scopus)

Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process.

Rogers, NJ., Gabriel, L., Nunes, CT., Rose, SJ., Thiruudaian, V., Boyle, J. & Morley, B. J., Dec 2007, In : Genes and Immunity. 8, p. 619-627 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Autoantibodies
Congenic Mice
Lupus Nephritis
Nephritis
11 Citations (Scopus)

The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes.

Rankin, J., Boyle, JJ., Rose, SJ., Gabriel, L., Lewis, M., Thiruudaian, V., Rogers, NJ., Izui, S. & Morley, B. J., Apr 2007, In : The Journal of Immunology. 178, p. 4395-4401 7 p.

Research output: Contribution to journalArticle

Antigen-Antibody Complex
Chromosomes, Human, Pair 13
Nephritis
Y Chromosome
Autoantibodies
2006
54 Citations (Scopus)

Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes.

Haywood, ME., Rose, SJ., Horswell, S., Lees, MJ., Fu, G., Walport, MJ. & Morley, B. J., Apr 2006, In : Genes and Immunity. 7, p. 250-263 14 p.

Research output: Contribution to journalArticle

Congenic Mice
Disease Susceptibility
Microarray Analysis
Gene Expression
Systemic Lupus Erythematosus
2005

Differential transcript profiling identifies candidate genes in the New Zealand model of systemic lupus erythematosus, including the B-cell transcription factor, Bach2.

Rigby, RJ., Horswell, S., Haywood, M., Shoulders, C., Morley, B. J. & Vyse, TJ., Jan 2005, p. S18-S19.

Research output: Contribution to conferencePaper

8 Citations (Scopus)

Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene

Choi, P., Xanthaki, D., Rose, SJ., Haywood, M., Reiser, H. & Morley, B. J., Jun 2005, In : Genes and Immunity. 6, p. 290-297 8 p.

Research output: Contribution to journalArticle

Genetic Linkage
Interleukin-4
T-Lymphocytes
Genes
Th2 Cells

Monocytosis in a murine model of SLE maps to the bottom of chromosome 1

Rogers, NJ., Nunes, CT., Rose, SJ. & Morley, B. J., Dec 2005, In : Immunology. 116, Suppl. 1, p. 10-10 1 p.

Research output: Contribution to journalArticle

The role of CD4 T cells in the loss of tolerance in a murine model of SLE

Rogers, NJ., Gabriel, L., Nunes, CT., Rose, J. & Morley, B. J., Mar 2005, p. I136-I136.

Research output: Contribution to conferencePaper

The Y-linked autoimmune accelerator (YAA) gene is sufficient to break immunological tolerance

Haywood, MEK., Rose, SJ., Rankin, JM., Izui, S., Rogers, NJ. & Morley, B. J., Mar 2005, p. I135-I135.

Research output: Contribution to conferencePaper

2004
17 Citations (Scopus)

A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c.

Rigby, RJ., Rozzo, SJ., Gill, H., Fernandez-Hart, T., Morley, B. J., Izui, S., Kotzin, BL. & Vyse, TJ., Apr 2004, In : The Journal of Immunology. 172, p. 5078-5085 8 p.

Research output: Contribution to journalArticle

New Zealand
Antibody Formation
Glycoproteins
Serum
Chromosomes, Human, Pair 4
44 Citations (Scopus)

Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.

Haywood, ME., Rogers, NJ., Rose, SJ., Boyle, J., McDermott, A., Rankin, JM., Thiruudaian, V., Lewis, MR., Fossati-Jimack, L., Izui, S., Walport, MJ. & Morley, B. J., Oct 2004, In : The Journal of Immunology. 173, p. 4277-4285 9 p.

Research output: Contribution to journalArticle

Congenic Mice
Chromosomes, Human, Pair 1
Dissection
Glomerulonephritis
Phenotype
15 Citations (Scopus)

Multiple loci are linked with anti-red blood cell antibody production in NZB mice − comparison with other phenotypes implies complex modes of action

Lee, NJ., Rigby, RJ., Gill, H., Boyle, JJ., Fossati-Jimack, L., Morley, B. J. & Vyse, TJ., Oct 2004, In : Clinical And Experimental Immunology. 138, p. 39-46 8 p.

Research output: Contribution to journalArticle

New Zealand
Antibody Formation
Erythrocytes
Anti-Idiotypic Antibodies
Phenotype
2002
3 Citations (Scopus)
Sialyltransferases
Chromosomes, Human, Pair 11
Genome
Genes
Superantigens
2001
37 Citations (Scopus)
Lupus Nephritis
Autoantigens
Autoantibodies
Glycoproteins
Antigen-Antibody Complex

Fine mapping genes for Fc γ receptor II and III in systemic lupus erythematosus

Roberton, CA., Morley, B. J. & Vyse, TJ., Oct 2001, In : The American Journal of Human Genetics. 69, p. 568-568 1 p.

Research output: Contribution to journalArticle

2000
173 Citations (Scopus)

Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII

Pritchard, NR., Cutler, AJ., Uribe, S., Chadban, SJ., Morley, B. J. & Smith, KGC., 15 Feb 2000, In : Current Biology. 10, 4, p. 227-230 4 p.

Research output: Contribution to journalArticle

Fc Receptors
Macrophages
lupus erythematosus
Haplotypes
IgG Receptors
20 Citations (Scopus)

Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines.

Stocker, CJ., Sugars, KL., Yarwood, H., Delikouras, A., Lechler, RI., Dorling, A., Landis, RC., Morley, B. J. & Haskard, DO., 27 Aug 2000, In : Transplantation. 70, 4, p. 579-586 8 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Organism Cloning
Swine
Endothelial Cells
Cytokines

Factor I

Morley, B. J., 2000, The Complement FactsBook. Morley, B. J. & Walport, MJ. (eds.). London: Elsevier Academic Press Inc, p. 83-86 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

69 Citations (Scopus)

Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

Haywood, ME., Hogarth, MB., Slingsby, JH., Rose, SJ., Allen, PJ., Thompson, EM., Maibaum, MA., Chandler, P., Davies, KA., Simpson, E., Walport, MJ. & Morley, B. J., Feb 2000, In : Arthritis & Rheumatism. 43, 2, p. 349-355 7 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Systemic Lupus Erythematosus
Phenotype
17 Citations (Scopus)

Lupus susceptibility loci map within regions of BXSB derived from the SB/Le parental strain.

Maibaum, MA., Haywood, ME., Walport, MJ. & Morley, B. J., Apr 2000, In : Immunogenetics. 51, 4-5, p. 370-372 3 p.

Research output: Contribution to journalArticle

The analysis of genetic susceptibility

Vyse, T. J. & Morley, B. J., 2000, HLA in Health and Disease. Lechler, R. & Warrens, A. (eds.). 6 ed. London: Elsevier Academic Press Inc, p. 107-128 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Complement Factsbook

Morley, B. J. (ed.) & Walport, MJ. (ed.), 2000, London: Elsevier Academic Press Inc.

Research output: Book/ReportBook

Complement Activation
Serine Proteases
Lectins
Introns
Exons
50 Citations (Scopus)

TNF-α, IL-4, and IFN-γ regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells.

Stocker, CJ., Sugars, KL., Harari, OA., Landis, RC., Morley, B. J. & Haskard, DO., Mar 2000, In : The Journal of Immunology. 164, p. 3309-3315 7 p.

Research output: Contribution to journalArticle

P-Selectin
E-Selectin
Interleukin-4
Swine
Endothelial Cells
1999

Candidate gene analysis in the lupus-prone mouse strain, BXSB.

Maibaum, MA., Fu, G., Haywood, MEK., Uribe, S., Rose, SJ., Sim, RB., Walport, MJ. & Morley, B. J., Oct 1999, In : The American Journal of Human Genetics. 65, p. A262-A262

Research output: Contribution to journalArticle

Genome-wide linkage analyses in the lupus-prone mouse strain, BXSB.

Haywood, MEK., Hogarth, MB., Slingsby, JH., Rose, SJ., Thompson, EM., Maibaum, MA., Walport, MJ. & Morley, B. J., Oct 1999, In : The American Journal of Human Genetics. 65, p. A105-A105

Research output: Contribution to journalArticle

1998

Molecular basis of hereditary factor I deficiency

Morley, B. J., Bartok, I., Spath, PJ., Vyse, TJ., Schneider, PM. & Walport, MJ., Apr 1998, In : Molecular Immunology. 35, 6-7, p. 344-344 1 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice

Hogarth, MB., Slingsby, JH., Allen, PJ., Thompson, EM., Chandler, P., Davies, KA., Simpson, E., Morley, B. J. & Walport, MJ., Sep 1998, In : The Journal of Immunology. 161, p. 2753-2761 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 3
Nephritis
8 Citations (Scopus)

Regulation of transcription of the TATA-less human complement component C4 gene

Vaishnaw, AK., Mitchell, TJ., Rose, SJ., Walport, MJ. & Morley, B. J., May 1998, In : The Journal of Immunology. 160, p. 4353-4360 8 p.

Research output: Contribution to journalArticle

Complement C4
Reporter Genes
NFI Transcription Factors
Gene Expression
Genes

Transcriptional regulation of the human C4 gene

Mitchell, TJ., Vaishnaw, AK., Rose, J., Walport, MJ. & Morley, B. J., Apr 1998, In : Molecular Immunology. 35, 6-7, p. 344-344 1 p.

Research output: Contribution to journalArticle

1997
82 Citations (Scopus)

Complement deficiency and autoimmunity

Walport, MJ., Davies, KA., Morley, B. J. & Botto, M., Apr 1997, In : Annals of the New York Academy of Sciences. 815, Issue B-Lymphocytes and Autoimmunity, p. 267-281 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Polymorphism in the Ly-17 alloantigenic system of the mouse FcgRII gene.

Slingsby, JH., Hogarth, MB., Walport, MJ. & Morley, B. J., Jul 1997, In : Immunogenetics. 46, 4, p. 361-362 2 p.

Research output: Contribution to journalArticle

1996
26 Citations (Scopus)

Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice

Hogarth, MB., Norsworthy, PJ., Allen, PJ., Trinder, PKE., Loos, M., Morley, B. J., Walport, MJ. & Davies, KA., May 1996, In : Clinical And Experimental Immunology. 104, 2, p. 241-246 6 p.

Research output: Contribution to journalArticle

Autoantibodies
Antibodies
Anti-Idiotypic Antibodies
Inbred MRL lpr Mouse
Inbred NZB Mouse
82 Citations (Scopus)

Homozygous hereditary C1q deficiency and systemic lupus erythematosus: A new family and the molecular basis of C1q deficiency in three families

Slingsby, JH., Norsworthy, P., Pearce, G., Vaishnaw, AK., Issler, H., Morley, B. J. & Walport, MJ., Apr 1996, In : Arthritis & Rheumatism. 39, 4, p. 663-670 8 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Codon
Mutation
Nonsense Codon
Amino Acids
33 Citations (Scopus)

IFN-gamma up-regulates expression of the complement components C3 and C4 by stabilization of mRNA

Mitchell, TJ., Naughton, M., Norsworthy, P., Davies, KA., Walport, MJ. & Morley, B. J., Jun 1996, In : The Journal of Immunology. 156, 11, p. 4429-4434 6 p.

Research output: Contribution to journalArticle

Complement C4
Complement C3
Up-Regulation
Messenger RNA
Hep G2 Cells

Localization of mtv44 to the centromeric region of mouse chromosome 11

Slingsby, JH., Dyson, PJ., Morley, B. J., Walport, MJ. & Simpson, E., Apr 1996, In : Mammalian Genome. 7, 4, p. 319-320 2 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family

Topaloglu, R., Bakkaloglu, A., Slingsby, JH., Mihatsch, MJ., Pascual, M., Norsworthy, P., Morley, B. J., Saatci, U., Schifferli, JA. & Walport, MJ., Aug 1996, In : Kidney International. 50, 2, p. 635-642 8 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Hepatitis B Vaccines
Mutation
Hematuria
Antibody Formation