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Personal profile

Research interests

My research interests are mainly focussed around how pathogenic bacteria equip themselves to withstand stresses during survival and transmission. For my DPhil at the University of Sussex (2004-8) I studied the role of zinc in modulation of Streptomyces coelicolor ribosome structure under stressful conditions. As a postdoctoral researcher at the University of Swansea (2009 – 2012) I studied the role persistence and dormancy in chronic infection with Staphylococcus aureus. I moved on to the the Campy Lab at Swansea (2012 – 2016), where we we mined a database of sequenced Campylobacter isolates to study how pathogenic isolates evolve from non-pathogenic resevior populations.

 

In Bath I currently manage the sequencing facility at the Milner Centre for Evolution and work with Professor Sam Sheppard where we use genetics/genomics and phenotypic studies to address complex questions in the ecology, epidemiology and evolution of microbes. Our most recent interest focuses upon comparative genome analysis to describe the core and flexible genome of pathogenic bacteria (CampylobacterStaphylococcusHelicobacter and Escherichia coli) and how this is related to population genetic structuring, the maintenance of species, and the evolution of host/niche adaptation and virulence.

External positions

Honorary Researcher , Chiang Mai University

2015 → …

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Projects

Research Output

Agricultural intensification and the evolution of host specialism in the enteric pathogen Campylobacter jejuni

Mourkas, E., Taylor, A. J., Méric, G., Bayliss, S. C., Pascoe, B., Mageiros, L., Calland, J. K., Hitchings, M. D., Ridley, A., Vidal, A., Forbes, K. J., Strachan, N. J. C., Parker, C. T., Parkhill, J., Jolley, K. A., Cody, A. J., Maiden, M. C. J., Kelly, D. J. & Sheppard, S. K., 19 May 2020, In : Proceedings of the National Academy of Sciences. 117, 20, p. 11018-11028

Research output: Contribution to journalArticle

Open Access

High-resolution sweep metagenomics using fast probabilistic inference

Mäklin, T., Kallonen, T., David, S., Boinett, C. J., Pascoe, B., Méric, G., Aanensen, D. M., Feil, E. J., Baker, S., Parkhill, J., Sheppard, S. K., Corander, J. & Honkela, A., 30 Jan 2020, In : Wellcome Open Research. 5, p. 14

Research output: Contribution to journalArticle

Open Access

The emergence of plasmid-borne cfr-mediated linezolid resistant-staphylococci in Vietnam

Nguyen, L. T. T., Nguyen, K. N. T., Le, P. N. T. A., Cafini, F., Pascoe, B., Sheppard, S. K., Nguyen, T. B., Hoang, T. P. N., Nguyen, T. V., Pham, T. T. K., Morikawa, K., Nguyen, D. Q. & Duong, H. X., 27 Apr 2020, In : Journal of Global Antimicrobial Resistance.

Research output: Contribution to journalArticle

Open Access

Core genome sequence analysis to characterize Salmonella enterica serovar Rissen ST469 from a swine production chain

Prasertsee, T., Chuammitri, P., Deeudom, M., Chokesajjawatee, N., Santiyanont, P., Tadee, P., Nuangmek, A., Tadee, P., Sheppard, S. K., Pascoe, B. & Patchanee, P., 2 Sep 2019, In : International Journal of Food Microbiology. 304, p. 68-74 7 p.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)

Domestication of Campylobacter jejuni NCTC 11168

Pascoe, B., Williams, L. K., Calland, J. K., Meric, G., Hitchings, M. D., Dyer, M., Ryder, J., Shaw, S., Lopes, B. S., Chintoan-Uta, C., Allan, E., Vidal, A., Fearnley, C., Everest, P., Pachebat, J. A., Cogan, T. A., Stevens, M. P., Humphrey, T. J., Wilkinson, T. S., Cody, A. J. & 12 others, Colles, F. M., Jolley, K. A., Maiden, M. C. J., Strachan, N., Pearson, B. M., Linton, D., Wren, B. W., Parkhill, J., Kelly, D. J., van Vliet, A. H. M., Forbes, K. J. & Sheppard, S. K., 1 Jul 2019, In : Microbial Genomics. 5, 7, 000279.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)