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Personal profile

Research interests

My research interests are mainly focussed around how pathogenic bacteria equip themselves to withstand stresses during survival and transmission. For my DPhil at the University of Sussex (2004-8) I studied the role of zinc in modulation of Streptomyces coelicolor ribosome structure under stressful conditions. As a postdoctoral researcher at the University of Swansea (2009 – 2012) I studied the role persistence and dormancy in chronic infection with Staphylococcus aureus. I moved on to the the Campy Lab at Swansea (2012 – 2016), where we we mined a database of sequenced Campylobacter isolates to study how pathogenic isolates evolve from non-pathogenic resevior populations.

 

In Bath I currently manage the sequencing facility at the Milner Centre for Evolution and work with Professor Sam Sheppard where we use genetics/genomics and phenotypic studies to address complex questions in the ecology, epidemiology and evolution of microbes. Our most recent interest focuses upon comparative genome analysis to describe the core and flexible genome of pathogenic bacteria (CampylobacterStaphylococcusHelicobacter and Escherichia coli) and how this is related to population genetic structuring, the maintenance of species, and the evolution of host/niche adaptation and virulence.

External positions

Honorary Researcher , Chiang Mai University

2015 → …

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Campylobacter coli Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2024

Research Output 2007 2019

Core genome sequence analysis to characterize Salmonella enterica serovar Rissen ST469 from a swine production chain

Prasertsee, T., Chuammitri, P., Deeudom, M., Chokesajjawatee, N., Santiyanont, P., Tadee, P., Nuangmek, A., Tadee, P., Sheppard, S., Pascoe, B. & Patchanee, P., 28 May 2019, In : International Journal of Food Microbiology.

Research output: Contribution to journalArticle

Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students

Royden, A., Ormandy, E., Pinchbeck, G., Pascoe, B., Hitchings, M. D., Sheppard, S. K. & Williams, N. J., 1 Jan 2019, In : Veterinary Record Open. 6, 1, e000307.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk

Berthenet, E., Yahara, K., Thorell, K., Pascoe, B., Meric, G., Mikhail, J. M., Engstrand, L., Enroth, H., Burette, A., Megraud, F., Varon, C., Atherton, J. C., Smith, S., Wilkinson, T. S., Hitchings, M. D., Falush, D. & Sheppard, S. K., 2 Aug 2018, In : BMC Biology. 16, 11 p., 84.

Research output: Contribution to journalArticle

Open Access
stomach neoplasms
Helicobacter pylori
Genome-Wide Association Study
Stomach Neoplasms
cancer
1 Citation (Scopus)

Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil

Marques Rossi, G. A., Silva, H. O., Gamero Aguilar, C. E., Rochetti, A. L., Pascoe, B., Méric, G., Mourkas, E., Hitchings, M. D., Mathias, L. A., De Azevedo Ruiz, V. L., Fukumasu, H., Sheppard, S. K. & Centola Vidal, A. M., 1 Feb 2018, In : FEMS Microbiology Letters. 365, 3, p. 1 - 9 9 p., fnx283.

Research output: Contribution to journalArticle

Open Access
File
Bacillus cereus
Brazil
Dairy Products
Milk
Equipment and Supplies
1 Citation (Scopus)

Convergent amino acid signatures in polyphyletic Campylobacter jejuni sub-populations suggest human niche tropism

Méric, G., McNally, A., Pessia, A., Mourkas, E., Pascoe, B., Mageiros, L., Vehkala, M., Corander, J. & Sheppard, S. K., 14 Feb 2018, In : Genome biology and evolution. p. 763-774

Research output: Contribution to journalArticle

Open Access
tropisms
Campylobacter jejuni
Tropism
subpopulation
human population