Projects per year
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- 2 Similar Profiles
Steryl-Sulfatase
Medicine & Life Sciences
Derivatives
Chemical Compounds
Sulfatases
Medicine & Life Sciences
Aromatase
Medicine & Life Sciences
Aromatase Inhibitors
Medicine & Life Sciences
Cyclic ADP-Ribose
Medicine & Life Sciences
Inositol Phosphates
Chemical Compounds
Breast Neoplasms
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2018
Chemical Biology of Cellular Signalling using Polyphosphate Messengers
1/01/14 → 31/12/18
Project: UK charity
A 500 MHz NMR Spectrometer to Underpin Biological and Medicinal Chemistry Research in the Department of Pharmacy and Pharmacology
1/06/09 → 31/05/14
Project: UK charity
Cyclic Adenosine Diphosphoribose (cADPR) and Adenosine (ADPR) analogues in human T-lymphocyte chemical biology
1/11/08 → 31/12/13
Project: UK charity
CHEMICAL BIOLOGY, INOSITOL PHOSPHATES AND CELL SIGNALLING
Potter, B. & Riley, A.
1/08/07 → 30/06/14
Project: UK charity
Research Output 1979 2018
Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure
Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B. 2018 (Unpublished) In : Journal of Medicinal Chemistry. 49 p.Research output: Contribution to journal › Article
Quinazolinones
Tubulin
Steryl-Sulfatase
Antineoplastic Agents
Colchicine
2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist
Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H. 27 Jun 2017 In : Nature Chemical Biology. 13, p. 1036-1044Research output: Contribution to journal › Article
Open Access
File
Nicotinamide-Nucleotide Adenylyltransferase
Nicotinamide Mononucleotide
Adenosine Diphosphate Ribose
Glycoside Hydrolases
NAD
Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz-Fritsch-Bobbitt reaction with non-activated and moderately-activated systems
Mottinelli, M., Leese, M. P. & Potter, B. V. L. 6 Sep 2017 In : Beilstein Journal of Organic Chemistry. 13, p. 1871-1879 9 p.Research output: Contribution to journal › Article
Open Access
Tetrahydroisoquinolines
Cyclization
Alkylation
Alkaloids
Minerals
2
Citations
Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349
Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H. 16 Jun 2017 In : Biochemical journal. 474, 13, p. 2159-2175 BCJ20170091Research output: Contribution to journal › Article
Open Access
Adenosine Diphosphate Ribose
Ribose
Chemical activation
Ligands
Hydrogen Bonding
Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose”
Watt, J. M., Graeff, R., Thomas, M. P. & Potter, B. 23 Nov 2017 In : Scientific Reports. 7, 16100Research output: Contribution to journal › Article
Open Access
File
Inosine
Ribose
Diphosphates
Second Messenger Systems
Substrates