1979 …2018
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Steryl-Sulfatase Medicine & Life Sciences
Derivatives Chemical Compounds
Sulfatases Medicine & Life Sciences
Aromatase Medicine & Life Sciences
Aromatase Inhibitors Medicine & Life Sciences
Cyclic ADP-Ribose Medicine & Life Sciences
Inositol Phosphates Chemical Compounds
Breast Neoplasms Medicine & Life Sciences

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Projects 2007 2018

Research Output 1979 2018

Inositol Phosphates
Fluorescent Dyes
Catalytic Domain
Ligands
Phosphotransferases

Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

Dohle, W., Jourdan, F., Menchon, G., Prota, A., Foster, P. A., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. & Potter, B. 2018 (Unpublished) In : Journal of Medicinal Chemistry. 49 p.

Research output: Contribution to journalArticle

Quinazolinones
Tubulin
Steryl-Sulfatase
Antineoplastic Agents
Colchicine
6 Citations

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Fliegert, R., Bauche, A., Wolf Pérez, A-M., Watt, J. M., Rozewitz, M. D., Winzer, R., Janus, M., Gu, F., Rosche, A., Harneit, A., Flato, M., Moreau, C., Kirchberger, T., Wolters, V., Potter, B. V. L. & Guse, A. H. 2017 In : Nature Chemical Biology. 13, p. 1036-1044

Research output: Contribution to journalArticle

Open Access
File
Nicotinamide-Nucleotide Adenylyltransferase
Nicotinamide Mononucleotide
Adenosine Diphosphate Ribose
Glycoside Hydrolases
NAD
Open Access
Tetrahydroisoquinolines
Cyclization
Alkylation
Alkaloids
Minerals
3 Citations

Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349

Fliegert, R., Watt, J. M., Schöbel, A., Rozewitz, M. D., Moreau, C., Kirchberger, T., Thomas, M. P., Sick, W., Araujo, A. C., Harneit, A., Potter, B. V. L. & Guse, A. H. 16 Jun 2017 In : Biochemical journal. 474, 13, p. 2159-2175 BCJ20170091

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate Ribose
Ribose
Chemical activation
Ligands
Hydrogen Bonding