Projects per year
Personal profile
Research interests
Banafshé Larijani has been Director of the Centre for Therapeutics Innovation (CTI) at the University of Bath (2019-2025); an internationally faced research and innovation Centre with the mission to transform innovation, arising from transdisciplinary research to quantitative diagnostics & medicines-design, leading to precision medicine.
She is now leading the newly formed international Consortium for Precision Health at University of Bath (CPH), with the vision to be the flagship of precision translational research at University of Bath, where academics and clinicians/surgeons work symbiotically, to succeed in delivering personalised treatment to patients.
Professor Larijani's laboratory, Cell Biophysics, is a cutting-edge cross-disciplinary platform, that has drawn upon the physical sciences to develop novel avenues for investigation of biological processes in signalling pathways.
The outcomes of her fundamental research, involving the application of quantitative imaging (FRET-FLIM) for investigating molecular mechanisms and dynamics of phosphoinositide-modifying and phosphoinositide-dependant enzymes have resulted in their application to various clinical objectives.
While in Northern Spain (2014-2018), the cancer diagnostic/prognostic company, she co-founded and directed, FASTBASE SOLUTIONS S.L., won European and French Awards for best “predictive cancer diagnostic test”.
Her team have employed quantitative molecular biology to investigate in situ molecular mechanisms in the various signalling pathways. These studies led to applying molecular imaging methods in clinical environments. Their endeavour being to address pertinent questions regarding the exploitation of functional proteomics, as opposed to expressional proteomics in diagnostics and prognostics of various types of pathologies.
She has trained 26 PhD Students, three of whom were clinicians. As senior author, she has published more than 97 primary research articles, majority leading to novel concepts in nuclear envelope biogenesis, lipid signalling and cancer biology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology and Biochemistry , Doctor of Science, University of Massachusetts
Award Date: 4 May 1999
External positions
Co-Founder, Co-Director and Chief Scientific Officer , FASTBASE SOLUTIONS Ltd
1 Nov 2015 → 30 Sept 2021
Keywords
- QC Physics
- Biophysics
- QH301 Biology
- Biochemistry
- Signal Transduction
- Membrane Biology
- Quantitative imaging
- Lipid signalling
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Collaborations and top research areas from the last five years
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Entrepreneur in Residence
Ward, S. (PI), Eccleston, C. (CoI), Gill, R. (CoI) & Larijani, B. (CoI)
8/01/24 → 8/01/26
Project: Research council
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MITIGATE: HUMAN INNERVATED, VASCULARIZED, AND IMMUNIZED TUMOURS-ON-CHIP AS SURROGATES FOR ANIMAL TESTING
Larijani, B. (CoPI), Carter, E. (CoPI), Estrela, P. (CoPI) & Ferrer, A. (PI)
Project: EU Commission
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Toward Functional Biomarkers of Response to Neoadjuvant Oncolytic Virus in Stage II Melanoma: Immune-Förster Resonance Energy Transfer and the Dynamic Tumor Immune Microenvironment
Kirane, A. R., Lee, D., Lowe, M., Usman Ahmad, M., Sharma, S., Serasanambati, M., Applebee, C. J., Safrygina, E., Betof Warner, A., Wang, J., Le, S., Larijani, B. & Maverakis, E., 2 Jan 2025, In: JCO Oncology Advances. 2, 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatial Functional Mapping of Hypoxia Inducible Factor Heterodimerisation and Immune checkpoint regulators in clear cell Renal Cell Carcinoma
Safrygina, E., Applebee, C., McIntyre, A., Padget, J. & Larijani, B., 9 Feb 2024, In: BJC Reports. 11 p., 10.Research output: Contribution to journal › Article › peer-review
Open Access -
Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation
Miles, J., Soubeyran, I., Marliot, F., Pangon, N., Italiano, A., Bellera, C., Ward, S. G., Pagès, F., Palussière, J. & Larijani, B., 31 Dec 2022, In: Cancers. 14, 23, 5738.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantification of protein-protein interactions and activation dynamics: A new path to predictive biomarkers
Larijani, B. & Miles, J., 30 Apr 2022, In: Biophysical Chemistry. 283, 106768.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (SciVal)64 Downloads (Pure) -
The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology
Larijani, B., Pytowski, L. & Vaux, D. J., 1 Feb 2022, In: Biochimica Et Biophysica Acta-Biomembranes. 1864, 1, 183780.Research output: Contribution to journal › Review article › peer-review
Open Access5 Citations (SciVal)