Projects per year
Personal profile
Research interests
Banafshé Larijani is the Director of the Centre for Therapeutic Innovation (CTI). Her laboratory, Cell Biophysics, is currently bridged between the Department of Pharmacy and Pharmacology at University of Bath and The Biophysics Institute (Instituto Biofisika) at the University of the Basque Country, Spain. Since 2002 she was Head of Cell Biophysics Laboratory at Cancer Research UK, was appointed Senior Scientist in 2012 and in 2014 was awarded an Ikerbasque Research Professorship where she moved her laboratory to the Biophysics Institute and the Research Centre for Experimental Marine Biology and Biotechnology (PiE) Bilbao, Spain. She holds adjunct professorships with Stony Brooks University NY and University of Massachusetts, Amherst MA, (USA).
Professor Larijani's laboratory is a cutting edge cross-disciplinary platform, which draws upon the physical sciences to develop novel avenues for investigation of biological processes in signalling. Her laboratory has led to paving a unique path by investigating the role of phosphoinositides and their metabolites, both as second messengers and as modulators of membrane morphology. The outcomes of her fundamental research involving the application of quantitative imaging (FRET-FLIM) for investigating molecular mechanisms of phosphoinositide-modifying and phosphoinositide-dependant enzymes have resulted in their application to various clinical objectives.
While in the Basque Country (2014) her laboratory and her new cancer diagnostic/prognostic company, FASTBASE SOLUTIONS Ltd, have been awarded 6 peer-reviewed grants. Prior to that all laboratory funding was based on core-funding at Cancer Research UK. Since 2002 she has more than published 90 primary research articles in the area of nuclear envelope biogenesis, lipid signalling and cancer biology and has over 2600 citations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology and Biochemistry , Doctor of Science, University of Massachusetts
Award Date: 4 May 1999
External positions
Chief Scientific Officer , FASTBASE SOLUTIONS Ltd
1 Nov 2015 → …
Keywords
- QC Physics
- Biophysics
- QH301 Biology
- Biochemistry
- Signal Transduction
- Membrane Biology
- Quantitative imaging
- Lipid signalling
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Quantification of protein-protein interactions and activation dynamics: A new path to predictive biomarkers
Larijani, B. & Miles, J., 30 Apr 2022, In: Biophysical Chemistry. 283, 106768.Research output: Contribution to journal › Article › peer-review
3 Citations (SciVal) -
The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology
Larijani, B., Pytowski, L. & Vaux, D. J., 1 Feb 2022, In: Biochimica Et Biophysica Acta-Biomembranes. 1864, 1, 183780.Research output: Contribution to journal › Article › peer-review
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The Fusion of Quantitative Molecular Proteomics and Immune-Oncology: A Step Towards Precision Medicine in Cancer Therapeutics
Miles, J., Ward, S. G. & Larijani, B., 30 Nov 2022, In: FEBS Letters. 596, 21, p. 2721-2735 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (SciVal) -
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts
Bortolomeazzi, M., Keddar, M. R., Montorsi, L., Acha-Sagredo, A., Benedetti, L., Temelkovski, D., Choi, S., Petrov, N., Todd, K., Wai, P., Kohl, J., Denner, T., Nye, E., Goldstone, R., Ward, S., Wilson, G. A., Al Bakir, M., Swanton, C., John, S., Miles, J., & 9 others , 31 Oct 2021, In: Gastroenterology. 161, 4, p. 1179-1193 15 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Citations (SciVal) -
Quantification of biomarker functionality predicts patient outcomes
Larijani, B., Miles, J., Ward, S. G. & Parker, P. J., 11 May 2021, In: British Journal of Cancer. 124, 10, p. 1618-1620 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access2 Citations (SciVal)