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Personal profile

Research interests

My cross-departmental PhD research project aimed to provide progress towards reducing the number of vaccine-preventable deaths by improving the efficacy and thermal stability of tuberculosis and anthrax vaccines through two novel approaches, namely: 1) the use of a complement-activating staphylococcal protein as an adjuvant and 2) a silica-based protein thermostabilisation technique (ensilication). 

I am also interested in the roles of the complement system in immune tolerance and the strategies Staphylococcus aureus employs to evade the immune system. 

Education/Academic qualification

Biosciences, Master of Research, University of Bath

Award Date: 6 Dec 2016

Biology, Bachelor of Science, University of Bath

Award Date: 3 Jul 2015

Keywords

  • Q Science (General)
  • vaccines
  • adjuvants
  • complement system
  • Staphylococcus aureus
  • immune evasion

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Research Output

Structural Stabilisation of Disulphide-Linked Fluid-Phase C3d Dimers by Sbi Suggests a Novel B cell Subversion Strategy by Staphylococcus aureus

Wahid, A., Dunphy, R., Gibson, B., Back, C., Hallam, T., Alkhawaja, B., Harris, C., Crennell, S., Watts, A., Marchbank, K. & Van Den Elsen, J., Oct 2019, p. 437.

Research output: Contribution to conferencePaper

1 Citation (Scopus)
3 Downloads (Pure)

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Yang, Y., Back, C., Gräwert, M., Wahid, A., Denton, H., Kildani, R., Paulin, J., Wörner, K., Kaiser, W., Svergun, D., Sartbaeva, A., Watts, A., Marchbank, K. J. & Van Den Elsen, J., 11 Jan 2019, In : Frontiers in Immunology. 9, p. 1-17 17 p., 3139.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
49 Downloads (Pure)

Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate

Back, C., Yang, Y., Wahid, A., Walters, R., Paulin, J., Graewert, M., Svergun, D., Marchbank, K. & Van Den Elsen, J., Sep 2017, p. 199.

Research output: Contribution to conferencePaper

Thesis

Development of Thermostable Vaccine Conjugates Based on a Staphylococcal Immune Evasion Protein

Author: Wahid, A., 19 Feb 2020

Supervisor: Van Den Elsen, J. (Supervisor) & Sartbaeva, A. (Supervisor)

Student thesis: Doctoral ThesisPhD