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Personal profile

Research interests

I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.

How and what drives gene expression evolution and what are the consequences of particular gene activity levels? Gene activity regulation is a major factor for understanding normal processes of development and senescence, disease states, and how individuals learn and cope with environmental events. Changes in gene activity are also thought to account for a large proportion of the differences in phenotype observed between species. Current research projects revolve around the following questions: Are the properties of highly expressed genes the result of ongoing selective pressures within mammalian lineages? What variables modulate patterns of gene activity divergence on a genomic scale? How do changes in gene context after gene duplication or genomic rearrangements affect gene transcription? Is gene expression noisy and is most co-expression a consequence of such noise owing to chromatin remodeling? What is the effect of repeats
insertion on gene regulation? To address these and related questions, I analyse large scale datasets using comparative genomics approaches and bioinformatics tools.


Willing to supervise PhD

I am always happy to hear from prospective graduate students and postdoctoral fellows, for more information please go to: http://people.bath.ac.uk/au207/

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Projects 2007 2019

Population Genetics group conference at Bath

Urrutia, A.

Project: UK charityScientific event

Responses to changing environments in Kentish plover

Urrutia, A. & Maher, K.

Project: Central government, health and local authoritiesResearch

Unravelling the Impact of El Nino on Waterborne Diseases in South America

Urrutia, A. & Martinez-Urtaza, J.


Project: Research council

waterborne disease
El Nino

Research Output 2001 2017

11 Citations

Alternative splicing and the evolution of phenotypic novelty

Bush, S. J., Chen, L., Tovar-Corona, J. M. & Urrutia, A. O. 5 Feb 2017 In : Proceedings of the Royal Society B: Biological Sciences. 372, 1713, 20150474

Research output: Contribution to journalReview article

alternative splicing
Alternative Splicing
Gene Duplication
developmental biology
Developmental Biology
evolutionary biology
1 Citations

Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

Monzón Sandoval, J., Castillo Morales, A., Urrutia, A. & Gutierrez, H. 12 May 2016 In : BMC Developmental Biology. 16, 13

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Human Development

Neocortex expansion is linked to size variations in gene families with chemotaxis, cell-cell signalling and immune response functions in mammals

Castillo-Morales, A., Monzón-Sandoval, J., de Sousa, A. A., Urrutia, A. O. & Gutierrez, H. 2016 In : Open Biology. 6, 10, 3489039

Research output: Contribution to journalArticle

Open Access
Cell signaling
8 Citations

Optimization of next-generation sequencing transcriptome annotation for species lacking sequenced genomes

Ockendon, N. F., O'Connell, L. A., Bush, S. J., Monzón Sandoval, J., Barnes, H., Szekely, T., Hofmann, H. A., Dorus, S. & Urrutia, A. O. Mar 2016 In : Molecular Ecology Resources. 16, 2, p. 446-458

Research output: Contribution to journalArticle

Open Access