Projects per year
Personal profile
Research interests
I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.
How and what drives gene expression evolution and what are the consequences of particular gene activity levels? Gene activity regulation is a major factor for understanding normal processes of development and senescence, disease states, and how individuals learn and cope with environmental events. Changes in gene activity are also thought to account for a large proportion of the differences in phenotype observed between species. Current research projects revolve around the following questions: Are the properties of highly expressed genes the result of ongoing selective pressures within mammalian lineages? What variables modulate patterns of gene activity divergence on a genomic scale? How do changes in gene context after gene duplication or genomic rearrangements affect gene transcription? Is gene expression noisy and is most co-expression a consequence of such noise owing to chromatin remodeling? What is the effect of repeats
insertion on gene regulation? To address these and related questions, I analyse large scale datasets using comparative genomics approaches and bioinformatics tools.
Willing to supervise doctoral students
I am always happy to hear from prospective graduate students and postdoctoral fellows, for more information please go to: http://people.bath.ac.uk/au207/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 9 Finished
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Imprinted genes defining a novel mammalian growth regulatory axis
28/05/19 → 29/12/22
Project: Research council
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Transcriptional Signatures of Cognitive Decline in an Alzheimer's Disease Model
12/07/17 → 7/09/21
Project: Research council
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Causes and Implications of Adult Sex Ratio in Mammels
Szekely, T., Urrutia, A. & Wolf, J.
1/03/17 → 28/02/20
Project: Research council
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Unravelling the Impact of El Nino on Waterborne Diseases in South America
Urrutia, A. & Martinez-Urtaza, J.
Natural Environment Research Council
1/04/16 → 28/02/18
Project: Research council
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Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases
Rigby Dames, B. A., Kilili, H., Charvet, C. J., Díaz-Barba, K., Proulx, M. J., de Sousa, A. A. & Urrutia, A. O., 24 Feb 2023, In: Progress in Brain Research. 275, p. 165-215 51 p.Research output: Contribution to journal › Article › peer-review
3 Citations (SciVal) -
Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses
D'Angelo, A., Kilili, H., Chapman, R., Generali, D., Tinhofer, I., Luminari, S., Donati, B., Ciarrocchi, A., Giannini, R., Moretto, R., Cremolini, C., Pietrantonio, F., Sobhani, N., Bonazza, D., Prins, R., Song, S. G., Jeon, Y. K., Pisignano, G., Cinelli, M., Bagby, S., & 1 others , 17 Jan 2023, In: PLoS ONE. 18, 1, e0280364.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular mechanisms of Eda-mediated adaptation to freshwater in threespine stickleback
Rodríguez-Ramírez, C. E., Hiltbrunner, M., Saladin, V., Walker, S., Urrutia, A. & Peichel, C. L., 16 May 2023, (E-pub ahead of print) In: Molecular Ecology.Research output: Contribution to journal › Article › peer-review
Open Access -
Why should we compare morphological and molecular disparity?
Van Den Ende, C., Puttick, M., Urrutia, A. & Wills, M., 24 Jul 2023, (E-pub ahead of print) In: Methods in Ecology and Evolution. 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cancer risk across mammals
Vincze, O., Colchero, F., Lemaître, J. F., Conde, D. A., Pavard, S., Bieuville, M., Urrutia, A. O., Ujvari, B., Boddy, A. M., Maley, C. C., Thomas, F. & Giraudeau, M., 13 Jan 2022, In: Nature. 601, 7892, p. 263-267 5 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Citations (SciVal)