Araxi Urrutia

Senior Lecturer, Department of Biology & Biochemistry
Centre for Networks and Collective Behaviour
Milner Centre for Evolution

https://orcid.org/0000-0001-9011-8675

Phone+44 (0) 1225 383414
EmailA.Urrutia@bath.ac.uk

MILNER CENTRE 1.27

Accepting Doctoral Students

Research output per year

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Personal profile

Research interests

I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.

How and what drives gene expression evolution and what are the consequences of particular gene activity levels? Gene activity regulation is a major factor for understanding normal processes of development and senescence, disease states, and how individuals learn and cope with environmental events. Changes in gene activity are also thought to account for a large proportion of the differences in phenotype observed between species. Current research projects revolve around the following questions: Are the properties of highly expressed genes the result of ongoing selective pressures within mammalian lineages? What variables modulate patterns of gene activity divergence on a genomic scale? How do changes in gene context after gene duplication or genomic rearrangements affect gene transcription? Is gene expression noisy and is most co-expression a consequence of such noise owing to chromatin remodeling? What is the effect of repeats
insertion on gene regulation? To address these and related questions, I analyse large scale datasets using comparative genomics approaches and bioinformatics tools.

Willing to supervise doctoral students

I am always happy to hear from prospective graduate students and postdoctoral fellows, for more information please go to: http://people.bath.ac.uk/au207/

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Projects

2 Not started
2 Active
13 Finished

Imprinted genes defining a novel mammalian growth regulatory axis

Ward, A. & Urrutia, A.

Medical Research Council

1/06/19 → 26/08/22

Project: Research council

Transcriptional Signatures of Cignitive Decline in an Alzheimer's Disease Model

Urrutia, A.

The Royal Society

12/07/17 → 7/09/20

Project: Research council

Project: Other

Research Output

26 Article
2 Chapter
1 Review article

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journal › Article

Open Access

1 Citation (Scopus)

Conserved transcriptomic profiles underpin monogamy across vertebrates

Young, R. L., Ferkin, M. H., Ockendon-Powell, N. F., Orr, V. N., Phelps, S. M., Pogány, Á., Richards-Zawacki, C. L., Summers, K., Székely, T., Trainor, B. C., Urrutia, A. O., Zachar, G., O’Connell, L. A. & Hofmann, H. A., 22 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1331-1336 6 p.

Research output: Contribution to journal › Article

19 Citations (Scopus)

Postmitotic cell longevity–associated genes: a transcriptional signature of postmitotic maintenance in neural tissues

Castillo-Morales, A., Monzón-Sandoval, J., Urrutia, A. O. & Gutiérrez, H., 1 Feb 2019, In : Neurobiology of Aging. 74, p. 147-160 14 p.

Research output: Contribution to journal › Article

Alternative splicing and the evolution of phenotypic novelty

Bush, S. J., Chen, L., Tovar-Corona, J. M. & Urrutia, A. O., 5 Feb 2017, In : Proceedings of the Royal Society B: Biological Sciences. 372, 1713, 20150474.

Research output: Contribution to journal › Review article

29 Citations (Scopus)

Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era

Tickle, C. & Urrutia, A. O., 5 Feb 2017, In : Proceedings of the Royal Society B: Biological Sciences. 372, 1713, 20150473.

Research output: Contribution to journal › Article

1 Citation (Scopus)