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Personal profile

Research interests

I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.

How and what drives gene expression evolution and what are the consequences of particular gene activity levels? Gene activity regulation is a major factor for understanding normal processes of development and senescence, disease states, and how individuals learn and cope with environmental events. Changes in gene activity are also thought to account for a large proportion of the differences in phenotype observed between species. Current research projects revolve around the following questions: Are the properties of highly expressed genes the result of ongoing selective pressures within mammalian lineages? What variables modulate patterns of gene activity divergence on a genomic scale? How do changes in gene context after gene duplication or genomic rearrangements affect gene transcription? Is gene expression noisy and is most co-expression a consequence of such noise owing to chromatin remodeling? What is the effect of repeats
insertion on gene regulation? To address these and related questions, I analyse large scale datasets using comparative genomics approaches and bioinformatics tools.

 

Willing to supervise doctoral students

I am always happy to hear from prospective graduate students and postdoctoral fellows, for more information please go to: http://people.bath.ac.uk/au207/

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  • Emergence of co-expression in gene regulatory networks

    Yin, W., Mendoza, L., Monzon-Sandoval, J., Urrutia, A. O. & Gutierrez, H., Apr 2021, In: PLoS ONE. 16, 4 , e0247671.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • MeDAS: a Metazoan Developmental Alternative Splicing database

    Li, Z., Zhang, Y., Bush, S., Tang, C., Chen, L., Zhang, D., Urrutia, A., Lin, J-W. & Chen, L., 8 Jan 2021, In: Nucleic Acids Research. 49, D1, p. D144–D150 7 p., gkaa886.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Citation (Scopus)
  • Dense sampling of bird diversity increases power of comparative genomics

    Feng, S., Stiller, J., Deng, Y., Armstrong, J., Fang, Q., Reeve, A. H., Xie, D., Chen, G., Guo, C., Faircloth, B. C., Petersen, B., Wang, Z., Zhou, Q., Diekhans, M., Chen, W., Andreu-Sánchez, S., Margaryan, A., Howard, J. T., Parent, C., Pacheco, G. & 130 others, Sinding, M. H. S., Puetz, L., Cavill, E., Ribeiro, Â. M., Eckhart, L., Fjeldså, J., Hosner, P. A., Brumfield, R. T., Christidis, L., Bertelsen, M. F., Sicheritz-Ponten, T., Tietze, D. T., Robertson, B. C., Song, G., Borgia, G., Claramunt, S., Lovette, I. J., Cowen, S. J., Njoroge, P., Dumbacher, J. P., Ryder, O. A., Fuchs, J., Bunce, M., Burt, D. W., Cracraft, J., Meng, G., Hackett, S. J., Ryan, P. G., Jønsson, K. A., Jamieson, I. G., da Fonseca, R. R., Braun, E. L., Houde, P., Mirarab, S., Suh, A., Hansson, B., Ponnikas, S., Sigeman, H., Stervander, M., Frandsen, P. B., van der Zwan, H., van der Sluis, R., Visser, C., Balakrishnan, C. N., Clark, A. G., Fitzpatrick, J. W., Bowman, R., Chen, N., Cloutier, A., Sackton, T. B., Edwards, S. V., Foote, D. J., Shakya, S. B., Sheldon, F. H., Vignal, A., Soares, A. E. R., Shapiro, B., González-Solís, J., Ferrer-Obiol, J., Rozas, J., Riutort, M., Tigano, A., Friesen, V., Dalén, L., Urrutia, A. O., Székely, T., Liu, Y., Campana, M. G., Corvelo, A., Fleischer, R. C., Rutherford, K. M., Gemmell, N. J., Dussex, N., Mouritsen, H., Thiele, N., Delmore, K., Liedvogel, M., Franke, A., Hoeppner, M. P., Krone, O., Fudickar, A. M., Milá, B., Ketterson, E. D., Fidler, A. E., Friis, G., Parody-Merino, Á. M., Battley, P. F., Cox, M. P., Lima, N. C. B., Prosdocimi, F., Parchman, T. L., Schlinger, B. A., Loiselle, B. A., Blake, J. G., Lim, H. C., Day, L. B., Fuxjager, M. J., Baldwin, M. W., Braun, M. J., Wirthlin, M., Dikow, R. B., Ryder, T. B., Camenisch, G., Keller, L. F., DaCosta, J. M., Hauber, M. E., Louder, M. I. M., Witt, C. C., McGuire, J. A., Mudge, J., Megna, L. C., Carling, M. D., Wang, B., Taylor, S. A., Del-Rio, G., Aleixo, A., Vasconcelos, A. T. R., Mello, C. V., Weir, J. T., Haussler, D., Li, Q., Yang, H., Wang, J., Lei, F., Rahbek, C., Gilbert, M. T. P., Graves, G. R., Jarvis, E. D., Paten, B. & Zhang, G., 12 Nov 2020, In: Nature. 587, 7833, p. 252-257 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    23 Citations (Scopus)
  • Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals

    Martínez-Pacheco, M., Tenorio, M., Almonte, L., Fajardo, V., Godínez, A., Fernández, D., Cornejo-Páramo, P., Díaz-Barba, K., Halbert, J., Liechti, A., Székely, T., Urrutia, A. O. & Cortez, D., 3 Nov 2020, In: Genome biology and evolution. 12, 11, p. 2015-2028 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats

    Gutiérrez-Guerrero, Y. T., Ibarra-Laclette, E., Martínez Del Río, C., Barrera-Redondo, J., Rebollar, E. A., Ortega, J., León-Paniagua, L., Urrutia, A., Aguirre-Planter, E. & Eguiarte, L. E., 10 Jun 2020, In: GigaScience. 9, 6, giaa059.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Citations (Scopus)