• MILNER CENTRE 1.27

Accepting PhD Students

20012022

Research output per year

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Personal profile

Research interests

I’m interested in the evolution of genes and genomes and how it impacts on the evolution of phenotypes. My research projects relate to the study of gene transcription changes during evolution and disease states and the evolution of gene and genome’s sequence, structure and organisation.

How and what drives gene expression evolution and what are the consequences of particular gene activity levels? Gene activity regulation is a major factor for understanding normal processes of development and senescence, disease states, and how individuals learn and cope with environmental events. Changes in gene activity are also thought to account for a large proportion of the differences in phenotype observed between species. Current research projects revolve around the following questions: Are the properties of highly expressed genes the result of ongoing selective pressures within mammalian lineages? What variables modulate patterns of gene activity divergence on a genomic scale? How do changes in gene context after gene duplication or genomic rearrangements affect gene transcription? Is gene expression noisy and is most co-expression a consequence of such noise owing to chromatin remodeling? What is the effect of repeats
insertion on gene regulation? To address these and related questions, I analyse large scale datasets using comparative genomics approaches and bioinformatics tools.

 

Willing to supervise PhD

I am always happy to hear from prospective graduate students and postdoctoral fellows, for more information please go to: http://people.bath.ac.uk/au207/

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Projects

Research Output

Conditional expression explains molecular evolution of social genes in a microbe

de Oliveira, J. L., Morales, A. C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S. B., de Brito, R. A., Hurst, L. D., Urrutia, A. O., Thompson, C. R. L. & Wolf, J. B., 23 Jul 2019, In : Nature Communications. 10, 1, p. 1-12 12 p., 3284.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Conserved transcriptomic profiles underpin monogamy across vertebrates

Young, R. L., Ferkin, M. H., Ockendon-Powell, N. F., Orr, V. N., Phelps, S. M., Pogány, Á., Richards-Zawacki, C. L., Summers, K., Székely, T., Trainor, B. C., Urrutia, A. O., Zachar, G., O’Connell, L. A. & Hofmann, H. A., 22 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1331-1336 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Postmitotic cell longevity–associated genes: a transcriptional signature of postmitotic maintenance in neural tissues

Castillo-Morales, A., Monzón-Sandoval, J., Urrutia, A. O. & Gutiérrez, H., 1 Feb 2019, In : Neurobiology of Aging. 74, p. 147-160 14 p.

Research output: Contribution to journalArticle

Alternative splicing and the evolution of phenotypic novelty

Bush, S. J., Chen, L., Tovar-Corona, J. M. & Urrutia, A. O., 5 Feb 2017, In : Proceedings of the Royal Society B: Biological Sciences. 372, 1713, 20150474.

Research output: Contribution to journalReview article

  • 23 Citations (Scopus)
  • 1 Citation (Scopus)

    Thesis

    Assessing selective processes acting on allele frequencies, genomic organisation, gene expression profiles in eukaryotic genomes

    Author: Wang, W., 10 May 2015

    Supervisor: Urrutia, A. (Supervisor) & Hurst, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Brain transcriptome analyses of paternal-specific mutant GRB10KO and potential insights into dominance behaviour

    Author: Al Zadjali, A., 23 Aug 2018

    Supervisor: Urrutia, A. (Supervisor) & Ward, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Comparative analyses of adaptive phenomena in eukaryotic systems

    Author: Bush, S., 13 Feb 2015

    Supervisor: Urrutia, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Comparative and functional analysis of alternative splicing in eukaryotic genomes

    Author: Chen, L., 23 Mar 2012

    Supervisor: Urrutia, A. (Supervisor) & Hurst, L. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Comparative transcriptome profiling in wild species: uncovering gene expression signatures of mating systems

    Author: Ockendon, N., 2 Mar 2015

    Supervisor: Urrutia, A. (Supervisor) & Szekely, T. (Supervisor)

    Student thesis: Doctoral ThesisPhD

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