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Personal profile

Research interests

Research Interests

My research interests are in medication utilisation and medication safety in vulnerable populations, especially those not usually included in phase III clinical trials. I also undertake research into epidemiology of autoimmune diseases and occurrence of serious outcomes. I am a statistician and develop statistical models for these research projects. Most of the research that I do uses anonymised primary care records from the Clinical Practice Research Datalink (CPRD).

Medication use and safety in pregnancy

This research group has considerable experience in carrying out medication utilisation and safety studies in pregnant women using CPRD data. We have our own algorithm to identify pregnancies and outcomes that has been developed and refined over many years. We have used this to evaluate the prescribing and safety of medications for epilepsy, diabetes, high cholesterol, depression and asthma during pregnancy.

Medication use and safety in older people

Older people, especially those with many comorbidities, do not participate in clinical trials therefore being able to use the CPRD to investigate disease occurrence, prescribing and medication safety gives considerable insight into the health of these populations especially very frail or the oldest patients. Areas of interest include dementia, rheumatoid diseases, cerebrovascular disease and diabetes.

Epidemiology of autoimmune diseases

Current work includes evaluating incidence, prevalence and outcomes associated with systemic sclerosis to try to better understand prognosis of this disease and its effects. As a rare disease, work is being undertaken to evaluate different statistical models to use in evaluating time to event models that incorporate both incident and prevalent cases of disease and outcomes.

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  • 7 Similar Profiles
Pregnancy Medicine & Life Sciences
Incidence Medicine & Life Sciences
General Practice Medicine & Life Sciences
Research Medicine & Life Sciences
Cohort Studies Medicine & Life Sciences
Databases Medicine & Life Sciences
Autoimmune Diseases Medicine & Life Sciences
Hypoglycemic Agents Medicine & Life Sciences

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Projects 2011 2020

Research Output 2002 2017

Sensitivity of the UK Clinical Practice Research Datalink to detect neurodevelopmental effects of medicine exposure in utero: comparative analysis of an antiepileptic drug exposed cohort

Charlton, R., McGrogan, A., Snowball, J., Yates, L., Wood, A., Clayton-Smith, J., Smithson, H., Richardson, J., McHugh, N., Thomas, S., Baker, G. & Bromley, R. 1 May 2017 In : Drug Safety. 40, 5, p. 387-397

Research output: Contribution to journalArticle

Open Access
Prospective Studies
1 Citations
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
General Practice
Cohort Studies
5 Citations

Prescribing of antidiabetic medicines before, during and after pregnancy: a study in seven European regions

Charlton, R., Klungsoyr, K., Neville, A., Jordan, S., de Jong-van den Berg, L., Bos, H., Puccini, A., Engeland, A., Gini, R., Davies, G., Hansen, A., Wang, H., McGrogan, A., Andersen, A., Dolk, H. & Garne, E. 18 May 2016 In : PLoS ONE. 11, 5, e0155737

Research output: Contribution to journalArticle

Open Access
hypoglycemic agents
Hypoglycemic Agents
16 Citations
Raynaud Disease
Systemic Scleroderma
9 Citations

Pregnancy losses in women with type 1 or type 2 diabetes in the UK: an investigation using primary care records

McGrogan, A., Snowball, J. & De Vries, C. S. Mar 2014 In : Diabetic Medicine. 31, 3, p. 357-365

Research output: Contribution to journalArticle

Open Access
Type 2 Diabetes Mellitus
Primary Health Care
Type 1 Diabetes Mellitus