Projects per year
My research interests are in medication utilisation and medication safety in vulnerable populations, especially those not usually included in phase III clinical trials. I also undertake research into epidemiology of autoimmune diseases and occurrence of serious outcomes. I am a statistician and develop statistical models for these research projects. Most of the research that I do uses anonymised primary care records from the Clinical Practice Research Datalink (CPRD).
Medication use and safety in pregnancy
This research group has considerable experience in carrying out medication utilisation and safety studies in pregnant women using CPRD data. We have our own algorithm to identify pregnancies and outcomes that has been developed and refined over many years. We have used this to evaluate the prescribing and safety of medications for epilepsy, diabetes, high cholesterol, depression and asthma during pregnancy.
Medication use and safety in older people
Older people, especially those with many comorbidities, do not participate in clinical trials therefore being able to use the CPRD to investigate disease occurrence, prescribing and medication safety gives considerable insight into the health of these populations especially very frail or the oldest patients. Areas of interest include dementia, rheumatoid diseases, cerebrovascular disease and diabetes.
Epidemiology of autoimmune diseases
Current work includes evaluating incidence, prevalence and outcomes associated with systemic sclerosis to try to better understand prognosis of this disease and its effects. As a rare disease, work is being undertaken to evaluate different statistical models to use in evaluating time to event models that incorporate both incident and prevalent cases of disease and outcomes.
Artificial intelligence for identifying new disease clusters in patients with immune-mediated inflammatory conditions: A Proof-of-Concept Study
4/01/21 → 3/09/21
Project: Central government, health and local authorities
Simultaneous dynamic assessment of cutaneous perfusion in systemic sclerosis using 2 laser speckle contrast imaging devices
McGrogan, A., Pauling, J. D. & Domsic, R.
Project: UK charity
A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin in Older People with Atrial Fibrillation
18/09/17 → 17/09/20
Project: UK charity
McGrogan, A. & Mitchell, A., 30 Sep 2020, In: Age and ageing. 49, 5, p. 723-724 2 p.
Research output: Contribution to journal › Editorial › peer-review
Evaluating patient reported fatigue and serum biomarkers in axial spondyloarthritis: results from the PROgnostic Markers In axial Spondyloarthritis (PROMISE) studyReilly, E., McGrogan, A. & Sengupta, R., 31 Oct 2020, In: Rheumatology (United Kingdom). 59, 10, p. 3111-3113 3 p., RHE-20-0082.R1.
Research output: Contribution to journal › Letter › peer-reviewOpen AccessFile
User-testing guidelines to improve the safety of intravenous medicines administration: a randomised in-situ simulation studyJones, M., McGrogan, A., Raynor, DK., Watson, M. & Franklin, B. D., 11 Dec 2020, In: BMJ Quality and Safety. 30, 1, p. 17-26 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access
A Systematic Review of Observational Studies comparing Direct Oral Anticoagulants with Vitamin K Antagonists for Stroke Prevention in Older People with Atrial FibrillationMitchell, A., Watson, M. C., Welsh, T. & McGrogan, A., 3 Feb 2019, In: Journal of Pharmacy and Pharmacology. 71, S1, p. 6-7 S2.
Research output: Contribution to journal › Conference article › peer-review
Dataset for "User-testing guidelines to improve the safety of intravenous medicines administration: a randomised in-situ simulation study"