Projects per year
My research interests are in medication utilisation and medication safety in vulnerable populations, especially those not usually included in phase III clinical trials. I also undertake research into epidemiology of autoimmune diseases and occurrence of serious outcomes. I am a statistician and develop statistical models for these research projects. Most of the research that I do uses anonymised primary care records from the Clinical Practice Research Datalink (CPRD).
Medication use and safety in pregnancy
This research group has considerable experience in carrying out medication utilisation and safety studies in pregnant women using CPRD data. We have our own algorithm to identify pregnancies and outcomes that has been developed and refined over many years. We have used this to evaluate the prescribing and safety of medications for epilepsy, diabetes, high cholesterol, depression and asthma during pregnancy.
Medication use and safety in older people
Older people, especially those with many comorbidities, do not participate in clinical trials therefore being able to use the CPRD to investigate disease occurrence, prescribing and medication safety gives considerable insight into the health of these populations especially very frail or the oldest patients. Areas of interest include dementia, rheumatoid diseases, cerebrovascular disease and diabetes.
Epidemiology of autoimmune diseases
Current work includes evaluating incidence, prevalence and outcomes associated with systemic sclerosis to try to better understand prognosis of this disease and its effects. As a rare disease, work is being undertaken to evaluate different statistical models to use in evaluating time to event models that incorporate both incident and prevalent cases of disease and outcomes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Using big data to investigate foetal and child outcomes following exposure to antiepileptics in pregnancy
1/09/23 → 28/02/26
Project: UK charity
1/01/22 → 31/12/24
Project: UK charity
4/05/21 → 3/08/21
Artificial intelligence for identifying new disease clusters in patients with immune-mediated inflammatory conditions: A Proof-of-Concept Study
4/01/21 → 31/12/21
Project: Central government, health and local authorities
Temporal and geographical variation in low carbon inhaler dispensing in England 2016 to 2021: an ecological studyTian, J., McGrogan, A. & Jones, M. D., 28 Feb 2023, In: Journal of the Royal Society of Medicine (JRSM). 116, 2, p. 65-75
Research output: Contribution to journal › Article › peer-reviewOpen Access
Assessment of dermal bioavailability: predicting the input function for topical glucocorticoids using stratum corneum samplingPensado-Lopez, A., McGrogan, A., White, J., Bunge, A. L., Guy, R. & Delgado-Charro, B., 1 Apr 2022, In: Drug Delivery and Translational Research. 12, 4, p. 851–861 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Citations (SciVal)
Correction: Skin Pharmacokinetics of Transdermal Scopolamine: Measurements and Modeling (Molecular Pharmaceutics (2021) 18:7 (2714-2723) DOI: 10.1021/acs.molpharmaceut.1c00238)Pensado, A., Hattam, L., White, K. A. J., McGrogan, A., Bunge, A. L., Guy, R. H. & Delgado-Charro, M. B., 4 Jul 2022, In: Molecular Pharmaceutics. 19, 7, p. 2681-2682 2 p.
Research output: Contribution to journal › Comment/debate › peer-review
Tian, J., McGrogan, A. & Jones, M., 1 Apr 2022.
Research output: Contribution to conference › AbstractOpen AccessFile38 Downloads (Pure)
Lalji, H. M., McGrogan, A. & Bailey, S., 31 Dec 2021, In: Journal of Affective Disorders Reports. 6, 100205.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Citations (SciVal)88 Downloads (Pure)
Dataset for "User-testing guidelines to improve the safety of intravenous medicines administration: a randomised in-situ simulation study"
Dataset for "Temporal and geographical variation in low carbon inhaler dispensing in England, 2016 to 2021: an ecological study"