Projects per year
Personal profile
Research interests
Research Interests
My research interests are in medication utilisation and medication safety in vulnerable populations, especially those not usually included in phase III clinical trials. I also undertake research into epidemiology of autoimmune diseases and occurrence of serious outcomes. I am a statistician and develop statistical models for these research projects. Most of the research that I do uses anonymised primary care records from the Clinical Practice Research Datalink (CPRD).
Medication use and safety in pregnancy
This research group has considerable experience in carrying out medication utilisation and safety studies in pregnant women using CPRD data. We have our own algorithm to identify pregnancies and outcomes that has been developed and refined over many years. We have used this to evaluate the prescribing and safety of medications for epilepsy, diabetes, high cholesterol, depression and asthma during pregnancy.
Medication use and safety in older people
Older people, especially those with many comorbidities, do not participate in clinical trials therefore being able to use the CPRD to investigate disease occurrence, prescribing and medication safety gives considerable insight into the health of these populations especially very frail or the oldest patients. Areas of interest include dementia, rheumatoid diseases, cerebrovascular disease and diabetes.
Epidemiology of autoimmune diseases
Current work includes evaluating incidence, prevalence and outcomes associated with systemic sclerosis to try to better understand prognosis of this disease and its effects. As a rare disease, work is being undertaken to evaluate different statistical models to use in evaluating time to event models that incorporate both incident and prevalent cases of disease and outcomes.
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Projects 2011 2020
A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin in Older People with Atrial Fibrillation
Mitchell, A., McGrogan, A. & Watson, M.
18/09/17 → 17/09/20
Project: UK charity
Simultaneous dynamic assessment of cutaneous perfusion in systemic sclerosis using 2 laser speckle contrast imaging devices
McGrogan, A., Pauling, J. D. & Domsic, R.
Project: UK charity
Research Output 2002 2019
A Systematic Review of Observational Studies comparing Direct Oral Anticoagulants with Vitamin K Antagonists for Stroke Prevention in Older People with Atrial Fibrillation
Mitchell, A., Watson, M. C., Welsh, T. & McGrogan, A., 3 Feb 2019, In : Journal of Pharmacy and Pharmacology. 71, S1, p. 6-7 S2.Research output: Contribution to journal › Conference article
Effectiveness and Safety of Direct Oral Anticoagulants versus Vitamin K Antagonists for People Aged 75 Years and over with Atrial Fibrillation: A Systematic Review and Meta-Analyses of Observational Studies
Mitchell, A., Watson, M., Welsh, T. & McGrogan, A., 24 Apr 2019, In : Journal of Clinical Medicine. 8, 4, 21 p., 554.Research output: Contribution to journal › Review article
76 Developing a protocol for a systematic review and meta-analysis of observational studies comparing direct oral anticoagulants with vitamin K antagonists for stroke prevention in people aged over 75 with atrial fibrillation
Mitchell, A., Watson, M. C., Welsh, T. & McGrogan, A., 4 Aug 2018, In : Age and Ageing. 47, Supplement 3, p. iii28-iii30Research output: Contribution to journal › Conference article
Sensitivity of the UK Clinical Practice Research Datalink to detect neurodevelopmental effects of medicine exposure in utero: comparative analysis of an antiepileptic drug exposed cohort
Charlton, R., McGrogan, A., Snowball, J., Yates, L., Wood, A., Clayton-Smith, J., Smithson, H., Richardson, J., McHugh, N., Thomas, S., Baker, G. & Bromley, R., 1 May 2017, In : Drug Safety. 40, 5, p. 387-397Research output: Contribution to journal › Article
Statins during pregnancy: A cohort study using the General Practice Research Database to investigate pregnancy loss
McGrogan, A., Snowball, J. & Charlton, R., Jul 2017, In : Pharmacoepidemiology and Drug Safety. 26, 7, p. 843-852Research output: Contribution to journal › Article